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CircAtlas: an integrated resource of one million highly accurate circular RNAs from 1070 vertebrate transcriptomes.

Abstract：

:Existing circular RNA (circRNA) databases have become essential for transcriptomics. However, most are unsuitable for mining in-depth information for candidate circRNA prioritization. To address this, we integrate circular transcript collections to develop the circAtlas database based on 1070 RNA-seq samples collected from 19 normal tissues across six vertebrate species. This database contains 1,007,087 highly reliable circRNAs, of which over 81.3% have been assembled into full-length sequences. We profile their expression pattern, conservation, and functional annotation. We describe a novel multiple conservation score, co-expression, and regulatory networks for circRNA annotation and prioritization. CircAtlas can be accessed at http://circatlas.biols.ac.cn/.

journal_name

Genome Biol

journal_title

Genome biology

authors

Wu W,Ji P,Zhao F

doi

10.1186/s13059-020-02018-y

subject

Has Abstract

pub_date

2020-04-28 00:00:00

pages

101

issue

1

eissn

1474-7596

issn

1474-760X

pii

10.1186/s13059-020-02018-y

journal_volume

21

pub_type

杂志文章

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