The Added Value of Tau-PET in the Assessment of Progressive Supranuclear Palsy.

Abstract:

:Progressive supranuclear palsy (PSP) is rare neurodegenerative disorder characterized by deposition of fibrillar aggregates of 4R tau-protein in neurons and glial cells. This disorder is underdiagnosed due to the overlap of the clinical syndrome with other related conditions. The clinical manifestations include cognitive impairment associated with behavioral changes, akinetic rigid syndrome, and prominent oculomotor dysfunction. We present the F-FDG and F-THK5351 PET images of a 71-year-old man diagnosed of probable PSP. This image highlights the hopeful results of the new tau-PET ligands radiotracers, because it allows to assess the distribution of tau-protein over time, closely associated with neurodegeneration in PSP.

journal_name

Clin Nucl Med

authors

López-Mora DA,Fernández León A,Lleó A,Blesa R,Camacho V

doi

10.1097/RLU.0000000000002977

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

e239-e240

issue

5

eissn

0363-9762

issn

1536-0229

journal_volume

45

pub_type

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