Abstract:
BACKGROUND:We tested whether work of breathing in premature newborns estimated by phase angle (θ) by using respiratory inductance plethysmography is decreased during neurally-adjusted ventilatory assist (NAVA) noninvasive ventilation (NIV) versus NIV alone. METHODS:NAVA NIV and NIV were applied in random order while using respiratory inductance plethysmography to measure the phase angle. RESULTS:Patient-ventilator asynchrony was decreased during NAVA NIV; however, the phase angle was not different between the modes. A large number of repeated assists with switches to backup were found when using NAVA NIV. Results of the analysis indicated these were due to the apnea alarm limit set during NAVA NIV. CONCLUSIONS:The improvement in patient-ventilator synchrony supports the hypothesis that work of breathing may be decreased with NAVA NIV; however, we were unable to demonstrate this with our study design. Short apnea time settings with NAVA NIV led to a large number of switches to backup and repeated assists during the same neural effort. (ClinicalTrials.gov registration NCT02788110.).
journal_name
Respir Carejournal_title
Respiratory careauthors
Matlock DN,Bai S,Weisner MD,Comtois N,Beck J,Sinderby C,Courtney SEdoi
10.4187/respcare.07257subject
Has Abstractpub_date
2020-07-01 00:00:00pages
946-953issue
7eissn
0020-1324issn
1943-3654pii
respcare.07257journal_volume
65pub_type
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