Association of tumor necrosis factor-α gene polymorphisms and coronary artery disease susceptibility: a systematic review and meta-analysis.


BACKGROUND:The goal of this study was to review relevant case-control studies to determine the association of tumor necrosis factor-α (TNF-α) gene polymorphisms and coronary artery disease (CAD) susceptibility. METHODS:Using appropriate keywords, we identified relevant studies using PubMed, Cochrane, Embase, CNKI, VANFUN, and VIP. Key pertinent sources in the literature were also reviewed, and all articles published through April 2019 were considered for inclusion. Based on eligible studies, we performed a meta-analysis of association between 308G/A, 238G/A, 857C/T, 863C/A and 1031 T/C polymorphisms in TNF-α and risk of CAD. RESULTS:We found 25 studies that were consistent with this meta-analysis, including 7697 patients in the CAD group and 9655 control patients. TNF-α 308G/A locus A showed no significant association with CAD susceptibility by the five models in the analysis of the overall population, European, African, South Asian, and North Asian patients. TNF-α 863C/A locus A and 1031 T/C locus C exhibited no significant association with CAD susceptibility. TNF-α 238G/A locus A had no significant association with CAD susceptibility in the overall population. However, TNF-α 238G/A locus A showed significant association with higher CAD susceptibility in the subgroup of Europeans and north Asians. TNF-α 857C/T locus T had no significant association with CAD susceptibility in the analysis of the overall population and Europeans. In the north Asian population, TNF-α 857C/T locus T was associated with lower CAD susceptibility by the heterozygote model. CONCLUSION:TNF-α 308G/A, 857C/T, 863C/A, and 1031 T/C has no significant association with CAD susceptibility. TNF-α 238G/A locus A has significant association with CAD susceptibility in Europeans and north Asians, but has no significant association in the overall population. Studies with a larger sample size are required to confirm the association between TNF-α 238G/A and CAD susceptibility.


BMC Med Genet


BMC medical genetics


Huang R,Zhao SR,Li Y,Liu F,Gong Y,Xing J,Xu ZS




Has Abstract


2020-02-11 00:00:00












  • Genetic susceptibility of intervertebral disc degeneration among young Finnish adults.

    abstract:BACKGROUND:Disc degeneration (DD) is a common condition that progresses with aging. Although the events leading to DD are not well understood, a significant genetic influence has been found. This study was undertaken to assess the association between relevant candidate gene polymorphisms and moderate DD in a well-defin...

    journal_title:BMC medical genetics

    pub_type: 杂志文章


    authors: Kelempisioti A,Eskola PJ,Okuloff A,Karjalainen U,Takatalo J,Daavittila I,Niinimäki J,Sequeiros RB,Tervonen O,Solovieva S,Kao PY,Song YQ,Cheung KM,Chan D,Ala-Kokko L,Järvelin MR,Karppinen J,Männikkö M

    更新日期:2011-11-22 00:00:00

  • Influence of FTO variants on obesity, inflammation and cardiovascular disease risk biomarkers in Spanish children: a case-control multicentre study.

    abstract:BACKGROUND:Variants in the FTO gene have been associated with obesity in children, but this association has not been shown with other biomarkers. We assessed the association of 52 FTO polymorphisms, spanning the whole gene, with obesity and estimated the influence of these polymorphisms on anthropometric, clinical and ...

    journal_title:BMC medical genetics

    pub_type: 杂志文章,多中心研究


    authors: Olza J,Ruperez AI,Gil-Campos M,Leis R,Fernandez-Orth D,Tojo R,Cañete R,Gil A,Aguilera CM

    更新日期:2013-12-01 00:00:00

  • Low incidence of limb-girdle muscular dystrophy type 2C revealed by a mutation study in Japanese patients clinically diagnosed with DMD.

    abstract:BACKGROUND:Limb-girdle muscular dystrophy type 2C (LGMD2C) is an autosomal recessive muscle dystrophy that resembles Duchenne muscular dystrophy (DMD). Although DMD is known to affect one in every 3500 males regardless of race, a widespread founder mutation causing LGMD2C has been described in North Africa. However, th...

    journal_title:BMC medical genetics

    pub_type: 杂志文章


    authors: Okizuka Y,Takeshima Y,Itoh K,Zhang Z,Awano H,Maruyama K,Kumagai T,Yagi M,Matsuo M

    更新日期:2010-03-30 00:00:00

  • First case report of Cohen syndrome in the Tunisian population caused by VPS13B mutations.

    abstract:BACKGROUND:Cohen syndrome is a rare autosomal recessive developmental disorder that comprises variable clinical features counting developmental delay, pigmentary retinopathy, myopia, acquired microcephaly, truncal obesity, joint hypermobility, friendly disposition and intermittent neutropenia. VPS13B (vacuolar protein ...

    journal_title:BMC medical genetics

    pub_type: 杂志文章


    authors: Rejeb I,Jilani H,Elaribi Y,Hizem S,Hila L,Zillahrdt JL,Chelly J,Benjemaa L

    更新日期:2017-11-17 00:00:00

  • Osteopoikilosis and multiple exostoses caused by novel mutations in LEMD3 and EXT1 genes respectively--coincidence within one family.

    abstract:BACKGROUND:Osteopoikilosis is a rare autosomal dominant genetic disorder, characterised by the occurrence of the hyperostotic spots preferentially localized in the epiphyses and metaphyses of the long bones, and in the carpal and tarsal bones 1. Heterozygous LEMD3 gene mutations were shown to be the primary cause of th...

    journal_title:BMC medical genetics

    pub_type: 杂志文章


    authors: Baasanjav S,Jamsheer A,Kolanczyk M,Horn D,Latos T,Hoffmann K,Latos-Bielenska A,Mundlos S

    更新日期:2010-07-09 00:00:00

  • Gene sequence variations of the platelet P2Y12 receptor are associated with coronary artery disease.

    abstract:BACKGROUND:The platelet P2Y12 receptor plays a key role in platelet activation. The H2 haplotype of the P2Y12 receptor gene (P2RY12) has been found to be associated with maximal aggregation response to adenosine diphosphate (ADP) and with increased risk for peripheral arterial disease. No data are available on its asso...

    journal_title:BMC medical genetics

    pub_type: 杂志文章


    authors: Cavallari U,Trabetti E,Malerba G,Biscuola M,Girelli D,Olivieri O,Martinelli N,Angiolillo DJ,Corrocher R,Pignatti PF

    更新日期:2007-09-05 00:00:00

  • Lack of association between the CALM1 core promoter polymorphism (-16C/T) and susceptibility to knee osteoarthritis in a Chinese Han population.

    abstract:BACKGROUND:CALM1 gene encodes calmodulin (CaM), an important and ubiquitous eukaryotic Ca2+-binding protein. Several studies have indicated that a deficient CaM function is likely to be involved in the pathogenesis of osteoarthritis (OA). Using a convincing genome-wide association study, a Japanese group has recently d...

    journal_title:BMC medical genetics

    pub_type: 杂志文章


    authors: Shi D,Ni H,Dai J,Qin J,Xu Y,Zhu L,Yao C,Shao Z,Chen D,Xu Z,Yi L,Ikegawa S,Jiang Q

    更新日期:2008-10-22 00:00:00

  • Response to olaparib in metastatic castration-resistant prostate cancer with germline BRCA2 mutation: a case report.

    abstract:BACKGROUND:Prostate cancer is a heterogeneous disease, meaning patients would benefit from different treatment strategies based on their molecular stratification. In recent years, several genomic studies have identified prostate cancers with defects in DNA repair genes. It is known that the PARP inhibitor, olaparib, ha...

    journal_title:BMC medical genetics

    pub_type: 杂志文章


    authors: Ma Y,He L,Huang Q,Zheng S,Zhang Z,Li H,Liu S

    更新日期:2018-10-17 00:00:00

  • SRY mutation analysis by next generation (deep) sequencing in a cohort of chromosomal Disorders of Sex Development (DSD) patients with a mosaic karyotype.

    abstract:BACKGROUND:The presence of the Y-chromosome or Y chromosome-derived material is seen in 4-60% of Turner syndrome patients (Chromosomal Disorders of Sex Development (DSD)). DSD patients with specific Y-chromosomal material in their karyotype, the GonadoBlastoma on the Y-chromosome (GBY) region, have an increased risk of...

    journal_title:BMC medical genetics

    pub_type: 杂志文章


    authors: Hersmus R,Stoop H,Turbitt E,Oosterhuis JW,Drop SL,Sinclair AH,White SJ,Looijenga LH

    更新日期:2012-11-16 00:00:00

  • Gene spectrum analysis of thalassemia for people residing in northern China.

    abstract:BACKGROUND:Southern China provinces have high incidence of thalassemia, however, sporadic cases can be found in northern China as well. METHODS:People resided in north China who were suspected to have thalassemia were detected mutations by gap-polymerase chain reaction (Gap-PCR) and reverse dot blot (RDB) analyses. Th...

    journal_title:BMC medical genetics

    pub_type: 杂志文章


    authors: Yang Z,Zhou W,Cui Q,Qiu L,Han B

    更新日期:2019-05-22 00:00:00

  • Glucocorticoid receptor gene polymorphisms do not affect growth in fetal and early postnatal life. The Generation R Study.

    abstract:BACKGROUND:Glucocorticoids have an important role in early growth and development. Glucocorticoid receptor gene polymorphisms have been identified that contribute to the variability in glucocorticoid sensitivity. We examined whether these glucocorticoid receptor gene polymorphisms are associated with growth in fetal an...

    journal_title:BMC medical genetics

    pub_type: 杂志文章


    authors: Geelhoed MJ,Steegers EA,Koper JW,van Rossum EF,Moll HA,Raat H,Tiemeier H,Hofman A,Jaddoe VW

    更新日期:2010-03-03 00:00:00

  • Temple-Baraitser Syndrome and Zimmermann-Laband Syndrome: one clinical entity?

    abstract:BACKGROUND:KCNH1 encodes a voltage-gated potassium channel that is predominantly expressed in the central nervous system. Mutations in this gene were recently found to be responsible for Temple-Baraitser Syndrome (TMBTS) and Zimmermann-Laband syndrome (ZLS). METHODS:Here, we report a new case of TMBTS diagnosed in a L...

    journal_title:BMC medical genetics

    pub_type: 杂志文章


    authors: Mégarbané A,Al-Ali R,Choucair N,Lek M,Wang E,Ladjimi M,Rose CM,Hobeika R,Macary Y,Temanni R,Jithesh PV,Chouchane A,Sastry KS,Thomas R,Tomei S,Liu W,Marincola FM,MacArthur D,Chouchane L

    更新日期:2016-06-10 00:00:00

  • The impact of down-regulated SK3 expressions on Hirschsprung disease.

    abstract:BACKGROUND:Some Hirschsprung's disease (HSCR) patients showed persistent bowel symptoms following an appropriately performed pull-through procedure. The mechanism is presumed to be down-regulated small-conductance calcium-activated potassium channel 3 (SK3) expression in the HSCR ganglionic intestines. We aimed to inve...

    journal_title:BMC medical genetics

    pub_type: 杂志文章


    authors: Gunadi,Sunardi M,Budi NYP,Kalim AS,Iskandar K,Dwihantoro A

    更新日期:2018-02-13 00:00:00

  • A 4q35.2 subtelomeric deletion identified in a screen of patients with co-morbid psychiatric illness and mental retardation.

    abstract:BACKGROUND:Cryptic structural abnormalities within the subtelomeric regions of chromosomes have been the focus of much recent research because of their discovery in a percentage of people with mental retardation (UK terminology: learning disability). These studies focused on subjects (largely children) with various sev...

    journal_title:BMC medical genetics

    pub_type: 杂志文章


    authors: Pickard BS,Hollox EJ,Malloy MP,Porteous DJ,Blackwood DH,Armour JA,Muir WJ

    更新日期:2004-08-13 00:00:00

  • Clinical and whole-exome sequencing findings in two siblings from Hani ethnic minority with congenital glycosylation disorders.

    abstract:BACKGROUND:PMM2-CDG, is the most common N-linked glycosylation disorder and subtype among all CDG syndromes, which are a series of genetic disorders involving the synthesis and attachment of glycoproteins and glycolipid glycans. The mutations of PMM2-CDG might lead to the loss of PMM2, which is responsible for the conv...

    journal_title:BMC medical genetics

    pub_type: 杂志文章


    authors: Zhang Z,Huang TL,Ma J,He WJ,Gu H

    更新日期:2019-11-14 00:00:00

  • Impact of PTBP1 rs11085226 on glucose-stimulated insulin release in adult Danes.

    abstract:BACKGROUND:The variant rs11085226 (G) within the gene encoding polypyrimidine tract binding protein 1 (PTBP1) was reported to associate with reduced insulin release determined by an oral glucose tolerance test (OGTT) as well as an intravenous glucose tolerance test (IVGTT). The aim of the present study was to validate ...

    journal_title:BMC medical genetics

    pub_type: 杂志文章


    authors: Hansen TH,Vestergaard H,Jørgensen T,Jørgensen ME,Lauritzen T,Brandslund I,Christensen C,Pedersen O,Hansen T,Gjesing AP

    更新日期:2015-03-20 00:00:00

  • Pilot study indicate role of preferentially transmitted monoamine oxidase gene variants in behavioral problems of male ADHD probands.

    abstract:BACKGROUND:Attention deficit hyperactivity disorder (ADHD) is an etiologically complex childhood onset neurobehavioral disorder characterized by age-inappropriate inattention, hyperactivity, and impulsivity. Symptom severity varies widely and boys are diagnosed more frequently than girls. ADHD probands were reported to...

    journal_title:BMC medical genetics

    pub_type: 杂志文章


    authors: Karmakar A,Goswami R,Saha T,Maitra S,Roychowdhury A,Panda CK,Sinha S,Ray A,Mohanakumar KP,Rajamma U,Mukhopadhyay K

    更新日期:2017-10-05 00:00:00

  • A case report of novel mutation in PRF1 gene, which causes familial autosomal recessive hemophagocytic lymphohistiocytosis.

    abstract:BACKGROUND:Hemophagocytic Lymphohistiocytosis (HLH) is a life-threatening immunodeficiency and multi-organ disease that affects people of all ages and ethnic groups. Common symptoms and signs of this disease are high fever, hepatosplenomegaly, and cytopenias. Familial form of HLH disease, which is an autosomal recessiv...

    journal_title:BMC medical genetics

    pub_type: 杂志文章


    authors: Bordbar MR,Modarresi F,Farazi Fard MA,Dastsooz H,Shakib Azad N,Faghihi MA

    更新日期:2017-05-03 00:00:00

  • Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CAD.

    abstract:BACKGROUND:The lectin-like oxidized LDL receptor LOX-1 (encoded by OLR1) is believed to play a key role in atherogenesis and some reports suggest an association of OLR1 polymorphisms with myocardial infarction (MI). We tested whether single nucleotide polymorphisms (SNPs) in OLR1 are associated with clinically signific...

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    pub_type: 杂志文章


    authors: Knowles JW,Assimes TL,Boerwinkle E,Fortmann SP,Go A,Grove ML,Hlatky M,Iribarren C,Li J,Myers R,Risch N,Sidney S,Southwick A,Volcik KA,Quertermous T

    更新日期:2008-04-02 00:00:00

  • Using KASP technique to screen LRRK2 G2019S mutation in a large Tunisian cohort.

    abstract:BACKGROUND:In North African populations, G2019S mutation in LRRK2 gene, encoding for the leucine-rich repeat kinase 2, is the most prevalent mutation linked to familial and sporadic Parkinson's disease (PD). Early detection of G2019S by fast genetic testing is very important to guide PD's diagnosis and support patients...

    journal_title:BMC medical genetics

    pub_type: 杂志文章


    authors: Landoulsi Z,Benromdhan S,Ben Djebara M,Damak M,Dallali H,Kefi R,Abdelhak S,Gargouri-Berrechid A,Mhiri C,Gouider R

    更新日期:2017-07-06 00:00:00

  • HLA haplotypes associated with hemochromatosis mutations in the Spanish population.

    abstract:BACKGROUND:The present study is an analysis of the frequencies of HLA-A and -B antigens and HLA haplotypes in two groups of individuals homozygous for the two main HFE mutations (C282Y and H63D) and a group heterozygous for the S65C mutation. METHODS:The study population includes: 1123 healthy individuals, 100 homozyg...

    journal_title:BMC medical genetics

    pub_type: 杂志文章


    authors: Pacho A,Mancebo E,del Rey MJ,Castro MJ,Oliver D,García-Berciano M,González L,Morales P

    更新日期:2004-10-21 00:00:00

  • Differentially expressed alternatively spliced genes in malignant pleural mesothelioma identified using massively parallel transcriptome sequencing.

    abstract:BACKGROUND:Analyses of Expressed Sequence Tags (ESTs) databases suggest that most human genes have multiple alternative splice variants. The alternative splicing of pre-mRNA is tightly regulated during development and in different tissue types. Changes in splicing patterns have been described in disease states. Recentl...

    journal_title:BMC medical genetics

    pub_type: 杂志文章


    authors: Dong L,Jensen RV,De Rienzo A,Gordon GJ,Xu Y,Sugarbaker DJ,Bueno R

    更新日期:2009-12-31 00:00:00

  • Association of autism with polymorphisms in the paired-like homeodomain transcription factor 1 (PITX1) on chromosome 5q31: a candidate gene analysis.

    abstract:BACKGROUND:Autism is a complex, heterogeneous, behaviorally-defined disorder characterized by disruptions of the nervous system and of other systems such as the pituitary-hypothalamic axis. In a previous genome wide screen, we reported linkage of autism with a 1.2 Megabase interval on chromosome 5q31. For the current s...

    journal_title:BMC medical genetics

    pub_type: 杂志文章


    authors: Philippi A,Tores F,Carayol J,Rousseau F,Letexier M,Roschmann E,Lindenbaum P,Benajjou A,Fontaine K,Vazart C,Gesnouin P,Brooks P,Hager J

    更新日期:2007-12-06 00:00:00

  • Association of BAK1 single nucleotide polymorphism with a risk for dengue hemorrhagic fever.

    abstract:BACKGROUND:Dengue hemorrhagic fever (DHF) is a severe life-threatening form of dengue infection. Low platelet count is one of the characteristic clinical manifestations in patients with severe dengue. However, little is known about genetic factors in the host that cause low platelet count in patients with dengue. METH...

    journal_title:BMC medical genetics

    pub_type: 杂志文章


    authors: Dang TN,Naka I,Sa-Ngasang A,Anantapreecha S,Wichukchinda N,Sawanpanyalert P,Patarapotikul J,Tsuchiya N,Ohashi J

    更新日期:2016-07-11 00:00:00

  • Shine & Lal index as a predictor for early detection of β-thalassemia carriers in a limited resource area in Bandung, Indonesia.

    abstract:BACKGROUND:Thalassemia is the most common inherited disease in the world, involving α- or β-globin in red blood cells. Thalassemia cases rank fifth in the list of national catastrophic diseases in Indonesia; however, nationwide screening for thalassemia carriers is not yet mandatory. This study aimed to assess whether ...

    journal_title:BMC medical genetics

    pub_type: 杂志文章


    authors: Maskoen AM,Reniarti L,Sahiratmadja E,Sisca J,Effendi SH

    更新日期:2019-08-09 00:00:00

  • A novel genetic variant in DNAI2 detected by custom gene panel in a newborn with Primary Ciliary Dyskinesia: case report.

    abstract:BACKGROUND:Primary ciliary dyskinesia (PCD) is a highly heterogeneous genetic disorder caused by defects in motile cilia. The hallmark features of PCD are the chronic infections of the respiratory tract, moreover, clinical manifestations include also laterality defects and risk of male infertility. Clinical phenotypes ...

    journal_title:BMC medical genetics

    pub_type: 杂志文章


    authors: Rocca MS,Piatti G,Michelucci A,Guazzo R,Bertini V,Vinanzi C,Caligo MA,Valetto A,Foresta C

    更新日期:2020-11-10 00:00:00

  • NGS in argininosuccinic aciduria detects a mutation (D145G) which drives alternative splicing of ASL: a case report study.

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    journal_title:BMC medical genetics

    pub_type: 杂志文章


    authors: Wen W,Yin D,Huang F,Guo M,Tian T,Zhu H,Yang Y

    更新日期:2016-02-03 00:00:00

  • No association between TGF-β1 polymorphisms and risk of nasopharyngeal carcinoma in a large North African case-control study.

    abstract:BACKGROUND:Genetic susceptibility plays a key role in the development of nasopharyngeal carcinoma (NPC) and in fact the disease presents with an unusually high incidence in certain regions of the world like North Africa. We investigated the association between polymorphism of the Transforming growth factor-β1 (TGF-β1) ...

    journal_title:BMC medical genetics

    pub_type: 杂志文章


    authors: Khaali W,Moumad K,Ben Driss EK,Benider A,Ben Ayoub W,Hamdi-Cherif M,Boualga K,Hassen E,Corbex M,Khyatti M

    更新日期:2016-10-12 00:00:00

  • CXCR1 and SLC11A1 polymorphisms affect susceptibility to cutaneous leishmaniasis in Brazil: a case-control and family-based study.

    abstract:BACKGROUND:L. braziliensis causes cutaneous (CL) and mucosal (ML) leishmaniasis. Wound healing neutrophil (PMN) and macrophage responses made following the bite of the vector sand fly contribute to disease progression in mice. To look at the interplay between PMN and macrophages in disease progression in humans we aske...

    journal_title:BMC medical genetics

    pub_type: 杂志文章


    authors: Castellucci L,Jamieson SE,Miller EN,Menezes E,Oliveira J,Magalhães A,Guimarães LH,Lessa M,de Jesus AR,Carvalho EM,Blackwell JM

    更新日期:2010-01-20 00:00:00

  • Search for cardiac calcium cycling gene mutations in familial ventricular arrhythmias resembling catecholaminergic polymorphic ventricular tachycardia.

    abstract:BACKGROUND:Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a severe inherited cardiac disorder caused by mutations predominantly in the ryanodine receptor (RyR2) gene. We sought to identify mutations in genes affecting cardiac calcium cycling in patients with CPVT and in less typical familial exercise-r...

    journal_title:BMC medical genetics

    pub_type: 杂志文章


    authors: Marjamaa A,Laitinen-Forsblom P,Lahtinen AM,Viitasalo M,Toivonen L,Kontula K,Swan H

    更新日期:2009-02-12 00:00:00