Relationship between TGF-β1 + 869 T/C and + 915 G/C gene polymorphism and risk of acute rejection in renal transplantation recipients.

Abstract:

BACKGROUND:This meta-analysis was conducted to assess the relationship between the transforming growth factor-beta 1 (TGF-β1) + 869 T/C gene polymorphism, + 915 G/C gene polymorphism, and the susceptibility of acute rejection in the recipients with renal transplantation. METHODS:Relevant studies were searched and identified from the Cochrane Library and PubMed, and eligible investigations were recruited and data were calculated by meta-analysis. RESULTS:In this study, we found no relationship between either TGF-β1 + 869 T/C or TGF-β1 + 915 G/C gene polymorphism and acute rejection susceptibility in patients with renal transplantation. No association between either gene polymorphism and acute rejection susceptibility in patients with renal transplantation in Caucasian, Asian, or African populations individually was found. CONCLUSION:The TGF-β1 + 869 T/C and + 915 G/C gene polymorphisms are not associated with acute rejection susceptibility in recipients with renal transplantation.

journal_name

BMC Med Genet

journal_title

BMC medical genetics

authors

Li HY,Zhou T,Lin S,Lin W

doi

10.1186/s12881-019-0847-2

subject

Has Abstract

pub_date

2019-06-25 00:00:00

pages

113

issue

1

issn

1471-2350

pii

10.1186/s12881-019-0847-2

journal_volume

20

pub_type

杂志文章,meta分析,评审
  • Shine & Lal index as a predictor for early detection of β-thalassemia carriers in a limited resource area in Bandung, Indonesia.

    abstract:BACKGROUND:Thalassemia is the most common inherited disease in the world, involving α- or β-globin in red blood cells. Thalassemia cases rank fifth in the list of national catastrophic diseases in Indonesia; however, nationwide screening for thalassemia carriers is not yet mandatory. This study aimed to assess whether ...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/s12881-019-0868-x

    authors: Maskoen AM,Reniarti L,Sahiratmadja E,Sisca J,Effendi SH

    更新日期:2019-08-09 00:00:00

  • Variants of PLCXD3 are not associated with variant or sporadic Creutzfeldt-Jakob disease in a large international study.

    abstract:BACKGROUND:Human prion diseases are relentlessly progressive neurodegenerative disorders which include sporadic Creutzfeldt-Jakob disease (sCJD) and variant CJD (vCJD). Aside from variants of the prion protein gene (PRNP) replicated association at genome-wide levels of significance has proven elusive. A recent associat...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/s12881-016-0278-2

    authors: Balendra R,Uphill J,Collinson C,Druyeh R,Adamson G,Hummerich H,Zerr I,Gambetti P,Collinge J,Mead S

    更新日期:2016-04-07 00:00:00

  • Response to olaparib in metastatic castration-resistant prostate cancer with germline BRCA2 mutation: a case report.

    abstract:BACKGROUND:Prostate cancer is a heterogeneous disease, meaning patients would benefit from different treatment strategies based on their molecular stratification. In recent years, several genomic studies have identified prostate cancers with defects in DNA repair genes. It is known that the PARP inhibitor, olaparib, ha...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/s12881-018-0703-9

    authors: Ma Y,He L,Huang Q,Zheng S,Zhang Z,Li H,Liu S

    更新日期:2018-10-17 00:00:00

  • Factor VII deficiency and developmental abnormalities in a patient with partial monosomy of 13q and trisomy of 16p: case report and review of the literature.

    abstract:BACKGROUND:Unbalanced chromosomal translocations may present with a variety of clinical and laboratory findings and provide insight into the functions of genes on the involved chromosomal segments. CASE PRESENTATION:A 9 year-old boy presented to our clinic with Factor VII deficiency, microcephaly, a seizure disorder, ...

    journal_title:BMC medical genetics

    pub_type: 杂志文章,评审

    doi:10.1186/1471-2350-7-2

    authors: Brooks BP,Meck JM,Haddad BR,Bendavid C,Blain D,Toretsky JA

    更新日期:2006-01-13 00:00:00

  • The impact of down-regulated SK3 expressions on Hirschsprung disease.

    abstract:BACKGROUND:Some Hirschsprung's disease (HSCR) patients showed persistent bowel symptoms following an appropriately performed pull-through procedure. The mechanism is presumed to be down-regulated small-conductance calcium-activated potassium channel 3 (SK3) expression in the HSCR ganglionic intestines. We aimed to inve...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/s12881-018-0539-3

    authors: Gunadi,Sunardi M,Budi NYP,Kalim AS,Iskandar K,Dwihantoro A

    更新日期:2018-02-13 00:00:00

  • Understanding the molecular association between hyperkalemia and lung squamous cell carcinomas.

    abstract:BACKGROUND:Previous studies indicated a strong association between hyperkalemia and lung squamous cell carcinomas (LSCC). However, the underlying mechanism is not fully understood so far. METHODS:Literature-based data mining was conducted to identify genes, molecule, and cell processes linked to both hyperkalemia and ...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/s12881-020-01099-7

    authors: Meng X,Lu H,Jiang X,Huang B,Wu S,Yu G,Cao H

    更新日期:2020-10-22 00:00:00

  • First case report of cerebral folate deficiency caused by a novel mutation of FOLR1 gene in a Chinese patient.

    abstract:BACKGROUND:Cerebral folate deficiency (CFD) is a neurological disease, hallmarked by remarkable low concentrations of 5-methyltetrahydrofolic acid (5-MTHF) in cerebrospinal fluid (CSF). The primary causes of CFD include the presence of folate receptor (FR) autoantibodies, defects of FR encoding gene FOLR1, mitochondria...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/s12881-020-01162-3

    authors: Zhang C,Deng X,Wen Y,He F,Yin F,Peng J

    更新日期:2020-11-26 00:00:00

  • Osteopoikilosis and multiple exostoses caused by novel mutations in LEMD3 and EXT1 genes respectively--coincidence within one family.

    abstract:BACKGROUND:Osteopoikilosis is a rare autosomal dominant genetic disorder, characterised by the occurrence of the hyperostotic spots preferentially localized in the epiphyses and metaphyses of the long bones, and in the carpal and tarsal bones 1. Heterozygous LEMD3 gene mutations were shown to be the primary cause of th...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2350-11-110

    authors: Baasanjav S,Jamsheer A,Kolanczyk M,Horn D,Latos T,Hoffmann K,Latos-Bielenska A,Mundlos S

    更新日期:2010-07-09 00:00:00

  • Mutation affecting the proximal promoter of Endoglin as the origin of hereditary hemorrhagic telangiectasia type 1.

    abstract:BACKGROUND:Hereditary hemorrhagic telangiectasia (HHT) is a vascular multi-organ system disorder. Its diagnostic criteria include epistaxis, telangiectases in mucocutaneous sites, arteriovenous malformations (AVMs), and familial inheritance. HHT is transmitted as an autosomal dominant condition, caused in 85% of cases ...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/s12881-017-0380-0

    authors: Albiñana V,Zafra MP,Colau J,Zarrabeitia R,Recio-Poveda L,Olavarrieta L,Pérez-Pérez J,Botella LM

    更新日期:2017-02-23 00:00:00

  • Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CAD.

    abstract:BACKGROUND:The lectin-like oxidized LDL receptor LOX-1 (encoded by OLR1) is believed to play a key role in atherogenesis and some reports suggest an association of OLR1 polymorphisms with myocardial infarction (MI). We tested whether single nucleotide polymorphisms (SNPs) in OLR1 are associated with clinically signific...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2350-9-23

    authors: Knowles JW,Assimes TL,Boerwinkle E,Fortmann SP,Go A,Grove ML,Hlatky M,Iribarren C,Li J,Myers R,Risch N,Sidney S,Southwick A,Volcik KA,Quertermous T

    更新日期:2008-04-02 00:00:00

  • Neuronal migration genes and a familial translocation t (3;17): candidate genes implicated in the phenotype.

    abstract:BACKGROUND:While Miller-Dieker syndrome critical region deletions are well known delineated anomalies, submicroscopic duplications in this region have recently emerged as a new distinctive syndrome. So far, only few cases have been described overlapping 17p13.3 duplications. METHODS:In this study, we report on clinica...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/s12881-020-0966-9

    authors: Hadj Amor M,Dimassi S,Taj A,Slimani W,Hannachi H,Mlika A,Ben Helel K,Saad A,Mougou-Zerelli S

    更新日期:2020-02-06 00:00:00

  • Nitric oxide synthase 2A (NOS2A) polymorphisms are not associated with invasive pneumococcal disease.

    abstract:BACKGROUND:Streptococcus pneumoniae (pneumococcus) is responsible for over one million deaths per year, with young children, the elderly and immunocompromised individuals being most at risk. Approximately half of East African children have been reported to be asymptomatic carriers of pneumococcus with invasive infectio...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2350-10-28

    authors: Payton A,Payne D,Mankhambo LA,Banda DL,Hart CA,Ollier WE,Carrol ED

    更新日期:2009-03-23 00:00:00

  • CXCR1 and SLC11A1 polymorphisms affect susceptibility to cutaneous leishmaniasis in Brazil: a case-control and family-based study.

    abstract:BACKGROUND:L. braziliensis causes cutaneous (CL) and mucosal (ML) leishmaniasis. Wound healing neutrophil (PMN) and macrophage responses made following the bite of the vector sand fly contribute to disease progression in mice. To look at the interplay between PMN and macrophages in disease progression in humans we aske...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2350-11-10

    authors: Castellucci L,Jamieson SE,Miller EN,Menezes E,Oliveira J,Magalhães A,Guimarães LH,Lessa M,de Jesus AR,Carvalho EM,Blackwell JM

    更新日期:2010-01-20 00:00:00

  • Incidence of hereditary amyloidosis and autoinflammatory diseases in Sweden: endemic and imported diseases.

    abstract:BACKGROUND:Amyloidoses are a heterogeneous group of progressive diseases caused by tissue deposition of misfolded proteins. According to the International Classification of Diseases, hereditary amyloidosis is divided into neuropathic and non-neuropathic forms. In Sweden, neuropathic heredofamilial amyloidosis has been ...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2350-14-88

    authors: Hemminki K,Li X,Försti A,Sundquist J,Sundquist K

    更新日期:2013-09-03 00:00:00

  • Gene sequence variations of the platelet P2Y12 receptor are associated with coronary artery disease.

    abstract:BACKGROUND:The platelet P2Y12 receptor plays a key role in platelet activation. The H2 haplotype of the P2Y12 receptor gene (P2RY12) has been found to be associated with maximal aggregation response to adenosine diphosphate (ADP) and with increased risk for peripheral arterial disease. No data are available on its asso...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2350-8-59

    authors: Cavallari U,Trabetti E,Malerba G,Biscuola M,Girelli D,Olivieri O,Martinelli N,Angiolillo DJ,Corrocher R,Pignatti PF

    更新日期:2007-09-05 00:00:00

  • Association of interleukin 2, interleukin 12, and interferon-γ with intervertebral disc degeneration in Iranian population.

    abstract:BACKGROUND:Intervertebral disc degeneration (IVDD) is an age-related degenerative disease, presenting with low back pain or radicular pain. The inflammatory changes would occur in discs in the process of IVDD. Therefore, the inflammatory and anti-inflammatory cytokines, as well as their respective genes, have been prop...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/s12881-020-01081-3

    authors: Hanaei S,Abdollahzade S,Sadr M,Mirbolouk MH,Fattahi E,Khoshnevisan A,Rezaei N

    更新日期:2020-07-03 00:00:00

  • Association of novel polymorphisms in TMEM39A gene with systemic lupus erythematosus in a Chinese Han population.

    abstract:BACKGROUND:This study aimed to assess the association between 14 single nucleotide polymorphisms (SNPs) in six genes (IRF8, TMEM39A, IKZF3, ORMDL3, GSDMB, and ZPBP2) and systemic lupus erythematosus (SLE) in a Chinese Han population sample. METHODS:We carried out a case-control study of 415 patients with SLE and 470 h...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/s12881-017-0405-8

    authors: Cai X,Huang W,Liu X,Wang L,Jiang Y

    更新日期:2017-04-20 00:00:00

  • Impacts of CR1 genetic variants on cerebrospinal fluid and neuroimaging biomarkers in alzheimer's disease.

    abstract:BACKGROUND:The complement component (3b/4b) receptor 1 gene (CR1) gene has been proved to affect the susceptibility of Alzheimer's disease (AD) in different ethnic and districts groups. However, the effect of CR1 genetic variants on amyloid β (Aβ) metabolism of AD human is still unclear. Hence, the aim of this study wa...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/s12881-020-01114-x

    authors: Zhu XC,Dai WZ,Ma T

    更新日期:2020-09-12 00:00:00

  • Folate network genetic variation, plasma homocysteine, and global genomic methylation content: a genetic association study.

    abstract:BACKGROUND:Sequence variants in genes functioning in folate-mediated one-carbon metabolism are hypothesized to lead to changes in levels of homocysteine and DNA methylation, which, in turn, are associated with risk of cardiovascular disease. METHODS:330 SNPs in 52 genes were studied in relation to plasma homocysteine ...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2350-12-150

    authors: Wernimont SM,Clark AG,Stover PJ,Wells MT,Litonjua AA,Weiss ST,Gaziano JM,Tucker KL,Baccarelli A,Schwartz J,Bollati V,Cassano PA

    更新日期:2011-11-21 00:00:00

  • Novel loss-of-function variants in TRIO are associated with neurodevelopmental disorder: case report.

    abstract:BACKGROUND:Damaging variants in TRIO have been associated with moderate to severe neurodevelopmental disorders in humans. While recent work has delineated the positional effect of missense variation on the resulting phenotype, the clinical spectrum associated with loss-of-function variation has yet to be fully defined....

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/s12881-020-01159-y

    authors: Schultz-Rogers L,Muthusamy K,Pinto E Vairo F,Klee EW,Lanpher B

    更新日期:2020-11-10 00:00:00

  • Pitfalls in mutational testing and reporting of common KIT and PDGFRA mutations in gastrointestinal stromal tumors.

    abstract:BACKGROUND:Mutation analysis of KIT and PDGFRA genes in gastrointestinal stromal tumors is gaining increasing importance for prognosis of GISTs and for prediction of treatment response. Several groups have identified specific mutational subtypes in KIT exon 11 associated with an increased risk of metastatic disease whe...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2350-11-106

    authors: Merkelbach-Bruse S,Dietmaier W,Füzesi L,Gaumann A,Haller F,Kitz J,Krohn A,Mechtersheimer G,Penzel R,Schildhaus HU,Schneider-Stock R,Simon R,Wardelmann E

    更新日期:2010-07-04 00:00:00

  • Association of tumor necrosis factor-α gene polymorphisms and coronary artery disease susceptibility: a systematic review and meta-analysis.

    abstract:BACKGROUND:The goal of this study was to review relevant case-control studies to determine the association of tumor necrosis factor-α (TNF-α) gene polymorphisms and coronary artery disease (CAD) susceptibility. METHODS:Using appropriate keywords, we identified relevant studies using PubMed, Cochrane, Embase, CNKI, VAN...

    journal_title:BMC medical genetics

    pub_type: 杂志文章,meta分析

    doi:10.1186/s12881-020-0952-2

    authors: Huang R,Zhao SR,Li Y,Liu F,Gong Y,Xing J,Xu ZS

    更新日期:2020-02-11 00:00:00

  • PedHunter 2.0 and its usage to characterize the founder structure of the Old Order Amish of Lancaster County.

    abstract:BACKGROUND:Because they are a closed founder population, the Old Order Amish (OOA) of Lancaster County have been the subject of many medical genetics studies. We constructed four versions of Anabaptist Genealogy Database (AGDB) using three sources of genealogies and multiple updates. In addition, we developed PedHunter...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2350-11-68

    authors: Lee WJ,Pollin TI,O'Connell JR,Agarwala R,Schäffer AA

    更新日期:2010-05-02 00:00:00

  • Multiplex pyrosequencing assay using AdvISER-MH-PYRO algorithm: a case for rapid and cost-effective genotyping analysis of prostate cancer risk-associated SNPs.

    abstract:BACKGROUND:Single Nucleotide Polymorphisms (SNPs) identified in Genome Wide Association Studies (GWAS) have generally moderate association with related complex diseases. Accordingly, Multilocus Genetic Risk Scores (MGRSs) have been computed in previous studies in order to assess the cumulative association of multiple S...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/s12881-015-0186-x

    authors: Ambroise J,Butoescu V,Robert A,Tombal B,Gala JL

    更新日期:2015-06-25 00:00:00

  • Clinical characterization of int22h1/int22h2-mediated Xq28 duplication/deletion: new cases and literature review.

    abstract:BACKGROUND:Int22h1/int22h2-mediated Xq28 duplication syndrome is caused by ~0.5 Mb chromosomal duplications mediated by nonallelic homologous recombination between intron 22 homologous region 1 (int22h1) and 2 (int22h2), which, in addition to int22h3, are also responsible for inversions disrupting the F8 gene in hemoph...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/s12881-015-0157-2

    authors: El-Hattab AW,Schaaf CP,Fang P,Roeder E,Kimonis VE,Church JA,Patel A,Cheung SW

    更新日期:2015-03-14 00:00:00

  • The TCF7L2 rs7903146 (T) allele is associated with type 2 diabetes in urban Ghana: a hospital-based case-control study.

    abstract:BACKGROUND:Type 2 diabetes mellitus is increasing dramatically in sub-Saharan Africa, and genetic predisposition is likely involved in that. Yet, genetic variants known to confer increased susceptibility among Caucasians are far from being established in African populations. In Ghanaian adults, we examined associations...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2350-14-96

    authors: Danquah I,Othmer T,Frank LK,Bedu-Addo G,Schulze MB,Mockenhaupt FP

    更新日期:2013-09-23 00:00:00

  • FANCM and RECQL genetic variants and breast cancer susceptibility: relevance to South Poland and West Ukraine.

    abstract:BACKGROUND:FANCM and RECQL have recently been reported as breast cancer susceptibility genes and it has been suggested that they should be included on gene panel tests for breast cancer predisposition. However, the clinical value of testing for mutations in RECQL and FANCM remains to be determined. In this study, we ha...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/s12881-018-0524-x

    authors: Nguyen-Dumont T,Myszka A,Karpinski P,Sasiadek MM,Akopyan H,Hammet F,Tsimiklis H,Park DJ,Pope BJ,Slezak R,Kitsera N,Siekierzynska A,Southey MC

    更新日期:2018-01-19 00:00:00

  • First case report of Cohen syndrome in the Tunisian population caused by VPS13B mutations.

    abstract:BACKGROUND:Cohen syndrome is a rare autosomal recessive developmental disorder that comprises variable clinical features counting developmental delay, pigmentary retinopathy, myopia, acquired microcephaly, truncal obesity, joint hypermobility, friendly disposition and intermittent neutropenia. VPS13B (vacuolar protein ...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/s12881-017-0493-5

    authors: Rejeb I,Jilani H,Elaribi Y,Hizem S,Hila L,Zillahrdt JL,Chelly J,Benjemaa L

    更新日期:2017-11-17 00:00:00

  • Two monogenic disorders masquerading as one: severe congenital neutropenia with monocytosis and non-syndromic sensorineural hearing loss.

    abstract:BACKGROUND:We report a large family with four successive generations, presenting with a complex phenotype of severe congenital neutropenia (SCN), partially penetrant monocytosis, and hearing loss of varying severity. METHODS:We performed whole exome sequencing to identify the causative variants. Sanger sequencing was ...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/s12881-020-0971-z

    authors: Venugopal P,Gagliardi L,Forsyth C,Feng J,Phillips K,Babic M,Poplawski NK,Rienhoff HY Jr,Schreiber AW,Hahn CN,Brown AL,Scott HS

    更新日期:2020-02-17 00:00:00

  • Investigating highly replicated asthma genes as candidate genes for allergic rhinitis.

    abstract:BACKGROUND:Asthma genetics has been extensively studied and many genes have been associated with the development or severity of this disease. In contrast, the genetic basis of allergic rhinitis (AR) has not been evaluated as extensively. It is well known that asthma is closely related with AR since a large proportion o...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2350-14-51

    authors: Andiappan AK,Nilsson D,Halldén C,Yun WD,Säll T,Cardell LO,Tim CF

    更新日期:2013-05-10 00:00:00