Abstract：
STUDY OBJECTIVES:Sleep disorders are significant problems in patients with rheumatoid arthritis (RA) and are associated with poor quality of life. Irisin is myokine which may have anti-inflammatory and energy regulatory roles. This study assessed the association of serum irisin levels with the quality of sleep and disease activity in RA patients. METHODS:In sum, 58 RA patients and 30 matched healthy controls were included. Disease activity score in 28 joints (DAS28-ESR) and the patients' global score were calculated. RA patients were grouped according to the Pittsburgh Sleep Quality Index score (PSQI) into good-sleepers (group 1) defined as a PQSI score≤5 and poor sleepers (group 2) with a PSQI > 5. Serum irisin levels were measured for both patients and controls by commercially available enzyme-linked immunosorbent assay kits. RESULTS:Poor sleep quality was found in 26 (45%) of the RA patients. Irisin levels were significantly lower in RA patients with poor sleep compared to those with good sleep and healthy controls (p < 0.001). Serum irisin levels correlated inversely with disease duration, morning stiffness duration, DAS28-ESR, global score, and total PSQI score (r = -0.722 to -0.263 & p values≤0.001-0.04) indicating a possible anti-inflammatory role of irisin in RA patients. The analysis employed Student's t-test, ANOVA, and Pearson correlation. CONCLUSIONS:Irisin levels were decreased in RA patients with poor sleep quality compared to RA patients with good sleep quality and healthy controls, indicating a possible association of decreased serum irisin with sleep impairment in RA patients.
journal_name
Sleep Medjournal_title
Sleep medicineauthors
Gamal RM,Mohamed ME,Hammam N,El Fetoh NA,Rashed AM,Furst DEdoi
10.1016/j.sleep.2019.10.021subject
Has Abstractpub_date
2020-03-01 00:00:00pages
71-76eissn
1389-9457issn
1878-5506pii
S1389-9457(18)30858-Xjournal_volume
67pub_type
杂志文章相关文献
SLEEP MEDICINE文献大全abstract：:Depression is a significant public health issue, made worse by the absence of response to antidepressant medications by many patients. Given the high degree of overlap between sleep and circadian complaints and depression, chronotherapies are a promising avenue for novel, effective, and fast-acting treatments for depr...
journal_title：Sleep medicine
pub_type： 杂志文章,评审
doi：10.1016/j.sleep.2019.04.012
更新日期：2019-09-01 00:00:00
abstract：BACKGROUND:Population-based studies of insomnia among adults residing in communities in developing countries are rare. The objectives of this population-based study were to determine the prevalence and factors associated with insomnia among adults (18 years and over) living in a Brazilian town with 15,000 inhabitants (...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/s1389-9457(01)00119-8
更新日期：2002-03-01 00:00:00
abstract：OBJECTIVE:To report our findings from a sample of narcoleptic children and adolescents evaluated in our unit from 1988 to 2005. PATIENTS AND METHODS:The sample was composed of nine children (5 boys) with a mean age of 14.5 years at diagnosis. The protocol included the following: Epworth, Ullanlinna narcolepsy scale, a...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2010.02.017
更新日期：2011-01-01 00:00:00
abstract：OBJECTIVES:Difficult awakening is a key symptom of delayed sleep phase disorder (DSPD), but no studies have quantified awakening thresholds in a sleep laboratory. This study assessed whether cognitive function was impaired after awakening and whether difficult awakening was associated with specific polysomnographic fea...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2014.05.024
更新日期：2014-10-01 00:00:00
abstract：OBJECTIVES:Important adjustments in the autonomic nervous system occur during sleep. Bradycardia, due to increased vagal tone, and hypotension, caused by reduction of sympathetic activity, may occur during non rapid eye movement (REM) sleep (NREM). Increased sympathetic activity, causing increased heart rate, is conver...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2012.03.001
更新日期：2012-06-01 00:00:00
abstract：OBJECTIVES:The doctor-patient relationship has an important role in the delivery of high-quality healthcare. The aim of the present study was to explore and evaluate the impact of sleep severity and fatigue manifestations on doctor-patient relationships. METHODS:The present study was an analysis of a cross-sectional s...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2019.02.015
更新日期：2019-06-01 00:00:00
abstract：AIM:The aim of this study is to assess the effect of switching to rotigotine transdermal patch on severity of restless legs syndrome (RLS) in patients who experienced acute augmentation with previous oral dopaminergics. METHODS:In this 13-month observational study, adults with moderate-to-severe RLS and augmentation w...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2015.10.006
更新日期：2017-02-01 00:00:00
abstract：OBJECTIVE:Nocturnal eating behavior is shared by patients affected by a parasomnia, sleep-related eating disorder (SRED), and several eating disorders such as night eating syndrome (NES) and binge-eating disorder (BED); however, the differential clinical features of these patients have been poorly studied, with persist...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2014.12.020
更新日期：2015-06-01 00:00:00
abstract：:A relationship between evening technology use and sleep has been established, and models suggest various mechanisms to explain this relationship. Recent updates to these models also suggest the influence of individual difference factors, such that the relationship between technology and sleep varies between young peop...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2017.09.002
更新日期：2017-11-01 00:00:00
abstract：:This article focuses on the contributions made by Michel Jouvet concerning the systems responsible for the muscle atonia of paradoxical sleep (REM sleep). He was the first to describe the brainstem system mechanisms responsible for muscle atonia during paradoxical sleep using pontine cats and localized pontine lesions...
journal_title：Sleep medicine
pub_type： 传,历史文章,杂志文章
doi：10.1016/j.sleep.2018.05.026
更新日期：2018-09-01 00:00:00
abstract：OBJECTIVES:Nightmares are extremely unpleasant and vivid recurring dreams that are accompanied with awakening during sleep. However, earlier studies were mostly conducted with children and adults, with very few studies on nightmares in older adults. This population-based study aims to investigate the prevalence of nigh...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2020.11.039
更新日期：2020-12-04 00:00:00
abstract：OBJECTIVE:The Japanese Sleep Questionnaire for Elementary Schoolers (JSQ-ES) was developed to measure the sleep habits and disturbances of Japanese children. The current study aimed to present psychometric properties and describe the score distribution of the JSQ-ES. In addition, it examined correlations between the sl...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2017.07.025
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:The coronavirus pandemic presented a unique opportunity to study the daily temporal patterns and sleep habits of humans. The question to be explored was: Are there discernible differences in sleep between the normal operational environment and the stay-at-home condition? METHODS:This international prospecti...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2020.09.003
更新日期：2020-09-15 00:00:00
abstract：OBJECTIVE:Although there is a growing interest in the independent effect of snoring on carotid atherosclerosis, few studies have observed the relationship between snoring and change in carotid atherosclerosis prospectively. Therefore, the present study aimed to prospectively examine the association of snoring with subc...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2014.03.009
更新日期：2014-07-01 00:00:00
abstract：BACKGROUND:Adaptive servo-ventilation (ASV) is a well-established treatment of central sleep apnea (CSA) related to congestive heart failure (CHF). Few studies have evaluated the effectiveness and adherence in patients with CSA of other etiologies, and even less is known about treatment of CSA in patients of post ische...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2014.06.013
更新日期：2014-11-01 00:00:00
abstract：:Obstructive sleep apnea syndrome (OSA) is a common respiratory sleep disorder in children that is believed to adversely affect both quality of life and cognition. The purpose of the present systematic review was to obtain evidence of the impact of OSA on children's cognitive/behavioral abilities from primary studies p...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2017.12.020
更新日期：2018-06-01 00:00:00
abstract：OBJECTIVE/BACKGROUND:Daytime napping longer than one hour has been associated with an increased risk for all-cause mortality. Associations between cytokine polymorphisms and daytime napping in chronic illnesses such as HIV, however, have not been well described. The purpose of this study was to examine cytokine polymor...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2016.12.021
更新日期：2017-04-01 00:00:00
abstract：OBJECTIVES:Restless legs syndrome (RLS) is a common neurological disorder but it is not sufficiently recognized in children and adolescents. It often overlaps with growing pains in children, and as a result the clinical characteristics of pediatric RLS are not well studied, especially in Asia. The purpose of this study...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2019.12.016
更新日期：2020-05-01 00:00:00
abstract：BACKGROUND AND PURPOSE:To document and provide a micro analysis of the relationship between insomnia and health problems, health-care use, absenteeism, productivity and accidents. PARTICIPANTS AND METHODS:A population-based sample of 953 French-speaking adults from Québec, Canada. Participants were categorized as havi...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2008.04.005
更新日期：2009-04-01 00:00:00
abstract：:Infrequently in adults, isolated lesions of the upper airway, larynx, and trachea can produce obstructive sleep apnea (OSA). We describe a case of OSA found to be caused by tonsillar lymphoma presenting as asymmetric tonsillar hypertrophy. Tonsillar lymphoma is rare, but can present as hypertrophied tonsils and/or ade...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/s1389-9457(02)00079-5
更新日期：2002-09-01 00:00:00
abstract：OBJECTIVES:Sleep-disordered breathing (SDB) is very common in acute stroke patients and has been related to poor outcome. However, there is a lack of data about the association between SDB and stroke in developing countries. The study aims to characterize the frequency and severity of SDB in Brazilian patients during t...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2015.11.008
更新日期：2016-03-01 00:00:00
abstract：STUDY OBJECTIVES:To evaluate the objective and subjective long-term outcome of maxillomandibular advancement (MMA) in Far-East Asian patients with moderate to severe obstructive sleep apnea (OSA). METHODS:This is a long-term follow-up study to evaluate the treatment outcome of MMA in OSA patients by objective polysomn...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2020.05.024
更新日期：2020-10-01 00:00:00
abstract：OBJECTIVES:Arousal dysregulation has been speculated to be involved in the pathological mechanism of attention deficit/hyperactivity disorder (ADHD). However, there has been no epidemiological study assessing the real condition of excessive daytime sleepiness (EDS) in adults with ADHD. This study investigated the preva...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2016.04.008
更新日期：2017-04-01 00:00:00
abstract：OBJECTIVE:to explore the status of concentration of klotho and fibroblast growth factor 23 (FGF23) in cerebrospinal fluid (CSF) of patients with narcolepsy. PATIENTS/METHODS:59 patients with narcolepsy and 17 control individuals were enrolled. We used radioimmunoassay, human klotho enzyme-linked immunosorbent assay (E...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2020.11.037
更新日期：2020-12-15 00:00:00
abstract：AIM:The aim of this study was to evaluate the National Institute of Health (NIH)-funded PRIDE Institute in Behavioral Medicine and Sleep Disorders Research at New York University (NYU) Langone Medical Center. The NYU PRIDE Institute provides intensive didactic and mentored research training to junior underrepresented m...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2015.09.010
更新日期：2016-02-01 00:00:00
abstract：BACKGROUND AND PURPOSE:To evaluate the test-to-test variability of the suggested immobilization test (SIT) in patients with restless legs syndrome (RLS). PATIENTS AND METHODS:Twenty patients with primary RLS (12 men and eight women; age: 53.3+/-11.3 years) were selected for the study. We compared the results of two SI...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2006.02.007
更新日期：2006-10-01 00:00:00
abstract：OBJECTIVES:The present study aimed to clarify the prevalence and risk factors of insomnia among public school teachers in Japan by examining the relationships between working hours, commuting time, and insomnia. Time spent on work activities among teachers with insomnia was also investigated. METHODS:This study was a ...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2019.09.017
更新日期：2020-11-01 00:00:00
abstract：OBJECTIVE:Ramelteon, an MT(1)/MT(2) melatonin receptor agonist, was evaluated for its ability to reduce sleep-onset difficulties associated with eastward jet travel. METHODS:Healthy adults (n=110) with a history of jet lag sleep disturbances were flown eastward across five time zones from Hawaii to the east coast of t...
journal_title：Sleep medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.sleep.2010.03.010
更新日期：2010-06-01 00:00:00
abstract：BACKGROUND:Sleep-disordered breathing (SDB) is often co-morbid with conductive hearing loss in early childhood due to a shared aetiology of adenotonsillar hypertrophy. Hearing loss is independently associated with impairment of executive function and behavioural difficulties. We hypothesised that these impairments in c...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2017.02.008
更新日期：2017-06-01 00:00:00
abstract：:Objective: To compare treatment outcomes associated with combined pharmacologic and non-pharmacologic treatments for psychophysiological insomnia.Background: Treatments for insomnia have included a variety of pharmacotherapy and cognitive-behavioral interventions, although few studies have investigated the combined ef...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/s1389-9457(00)00042-3
更新日期：2000-10-01 00:00:00
