Abstract：
BACKGROUND:Pneumococcus is exposed to a variety of temperature and oxygen levels in the upper respiratory tract and as it invades the lung, tissues, and blood. We sought to determine the effect of environmental variability on growth in vitro and to assess variability between strains. We evaluated the effect of temperature and oxygen on the growth of 256 isolates representing 53 serotypes, recovered from healthy carriers and disease patients. Strains were grown at a range of temperatures, anaerobically or in ambient air with catalase, and were monitored by reading the optical density. Regression models evaluated variation in the characteristics of the growth curves. RESULTS:Most isolates grew to the maximal density at low temperatures (~33C) and under aerobic conditions. There was considerable variability between strains, and some of this variability was linked to serotype. However, capsule-switch experiments suggest that the production of different capsules might not be sufficient to explain this variation, suggesting there could be interactions between the capsule and genetic background. CONCLUSIONS:Pneumococcal strains vary in how they respond to environmental variations, some of this variation can be explained by the capsule type being produced, but capsule production itself is not sufficient to explain the variability. This variability could help to explain why different lineages of pneumococcus are more common in carriage or disease.
journal_name
BMC Microbioljournal_title
BMC microbiologyauthors
Tóthpál A,Desobry K,Joshi SS,Wyllie AL,Weinberger DMdoi
10.1186/s12866-019-1671-8subject
Has Abstractpub_date
2019-12-26 00:00:00pages
304issue
1issn
1471-2180pii
10.1186/s12866-019-1671-8journal_volume
19pub_type
杂志文章相关文献
BMC MICROBIOLOGY文献大全abstract：BACKGROUND:Cow manure is not only an agricultural waste, but also an organic fertilizer resource. The application of organic fertilizer is a feasible practice to mitigate the soil degradation caused by overuse of chemical fertilizers, which can affect the bacterial diversity and community composition in soils. However,...
journal_title：BMC microbiology
pub_type： 杂志文章
doi：10.1186/s12866-020-01871-y
更新日期：2020-07-01 00:00:00
abstract：BACKGROUND:Enterobacterial common antigen (ECA) is a family-specific surface antigen shared by all members of the Enterobacteriaceae family. Previous studies showed that the loss of ECA results in Salmonella attenuation, indicating its usefulness as a vaccine candidate for Salmonella infection, but no studies have show...
journal_title：BMC microbiology
pub_type： 杂志文章
doi：10.1186/s12866-020-01837-0
更新日期：2020-06-08 00:00:00
abstract：BACKGROUND:It is well known that expression of certain bacterial genes responds rapidly to such stimuli as exposure to toxic chemicals and physical agents. It is generally believed that the proteins encoded in these genes are important for successful survival of the organism under the hostile conditions. Analogously, t...
journal_title：BMC microbiology
pub_type： 杂志文章
doi：10.1186/1471-2180-3-16
更新日期：2003-08-12 00:00:00
abstract：BACKGROUND:The Gram-negative bacterium Erwinia amylovora is the causal agent of the devastating disease fire blight in rosaceous plants such as apple, pear, quince, raspberry, and cotoneaster. In order to survive and multiply in a host, microbes must be able to circumvent the toxic effects of antimicrobial plant compou...
journal_title：BMC microbiology
pub_type： 杂志文章
doi：10.1186/1471-2180-14-185
更新日期：2014-07-11 00:00:00
abstract：BACKGROUND:Staphylococcus aureus methicillin-resistant (MRSA) has been frequently isolated from endotracheal and lung puncture aspirates in malnourished children with pneumonia. In this work we evaluated the susceptibility of undernourished BALB/c mice and its ability to mount a protective immunity against MRSA with em...
journal_title：BMC microbiology
pub_type： 杂志文章
doi：10.1186/1471-2180-9-240
更新日期：2009-11-23 00:00:00
abstract：BACKGROUND:Compared with many protists, Giardia lamblia has a simple life cycle alternating between cyst and trophozoite. Most research on the molecular biology of Giardia parasites has focused on trophozoites and the processes of excystation and encystation, whereas cysts have attracted less interest. The striking mor...
journal_title：BMC microbiology
pub_type： 杂志文章
doi：10.1186/1471-2180-11-91
更新日期：2011-05-04 00:00:00
abstract：BACKGROUND:Comparative knowledge of microbiomes and resistomes across environmental interfaces between animal production systems and urban settings is lacking. In this study, we executed a comparative analysis of the microbiota and resistomes of metagenomes from cattle feces, catch basin water, manured agricultural soi...
journal_title：BMC microbiology
pub_type： 杂志文章
doi：10.1186/s12866-019-1548-x
更新日期：2019-08-27 00:00:00
abstract：BACKGROUND:Microbiome and metagenomic studies have given rise to a new understanding of microbial colonization of various human tissues and their ability to impact our health. One human microbiome growing in notoriety, the vaginal microbiome, stands out given its importance for women's health, and is peculiar in terms ...
journal_title：BMC microbiology
pub_type： 杂志文章
doi：10.1186/s12866-020-02027-8
更新日期：2020-11-10 00:00:00
abstract：BACKGROUND:Quinolone resistant Escherichia coli (QREC) have been found in samples from Norwegian broiler chicken, despite quinolones not being administered to poultry in Norway. Biofilm production may be one factor contributing to the observed persistence in the broiler production chain. In the present study, 158 QREC ...
journal_title：BMC microbiology
pub_type： 杂志文章
doi：10.1186/s12866-020-01730-w
更新日期：2020-03-04 00:00:00
abstract：BACKGROUND:Most of the studies evaluating the secular trends of blood isolates come from tertiary hospitals in urban areas. We sought to study the trends of the antimicrobial resistance of blood isolates in patients from a rural population hospitalized in a tertiary hospital in a small city in Greece. METHODS:We retro...
journal_title：BMC microbiology
pub_type： 杂志文章
doi：10.1186/1471-2180-6-41
更新日期：2006-05-02 00:00:00
abstract：BACKGROUND:The evolution of mycoplasmas from a common ancestor with Firmicutes has been characterized not only by genome down-sizing but also by horizontal gene transfer between mycoplasma species sharing a common host. The mechanisms of these gene transfers remain unclear because our knowledge of the mycoplasma mobile...
journal_title：BMC microbiology
pub_type： 杂志文章
doi：10.1186/1471-2180-12-257
更新日期：2012-11-12 00:00:00
abstract：BACKGROUND:Saccharomyces cerevisiae multicellular communities are sustained by a scaffolding extracellular matrix, which provides spatial organization, and nutrient and water availability, and ensures group survival. According to this tissue-like biology, the yeast extracellular matrix (yECM) is analogous to the higher...
journal_title：BMC microbiology
pub_type： 杂志文章
doi：10.1186/s12866-015-0550-1
更新日期：2015-11-25 00:00:00
abstract：BACKGROUND:With the growing demand for fossil fuels and the severe energy crisis, lignocellulose is widely regarded as a promising cost-effective renewable resource for ethanol production, and the use of lignocellulose residues as raw material is remarkable. Polar organisms have important value in scientific research a...
journal_title：BMC microbiology
pub_type： 杂志文章
doi：10.1186/s12866-017-1028-0
更新日期：2017-05-30 00:00:00
abstract：BACKGROUND:Microbial biofilms are known to cause an increasing number of chronic inflammatory and infectious conditions. A classical example is chronic periodontal disease, a condition initiated by the subgingival dental plaque biofilm on gingival epithelial tissues. We describe here a new model that permits the examin...
journal_title：BMC microbiology
pub_type： 杂志文章
doi：10.1186/1471-2180-9-280
更新日期：2009-12-31 00:00:00
abstract：BACKGROUND:Listeria monocytogenes is the causative agent of listeriosis, a serious disease affecting both animals and humans. Here, multilocus sequence typing (MLST) was used to characterize the genetic diversity of Listeria monocytogenes strains isolated from the natural environment and animal clinical cases in Europe...
journal_title：BMC microbiology
pub_type： 杂志文章
doi：10.1186/s12866-019-1676-3
更新日期：2019-12-18 00:00:00
abstract：BACKGROUND:Candida parapsilosis typically is a commensal of human skin. However, when host immune defense is compromised or the normal microflora balance is disrupted, C. parapsilosis transforms itself into an opportunistic pathogen. Candida-derived lipase has been identified as potential virulence factor. Even though ...
journal_title：BMC microbiology
pub_type： 杂志文章
doi：10.1186/1471-2180-11-122
更新日期：2011-05-29 00:00:00
abstract：BACKGROUND:Streptomyces lividans is an appealing host for the production of proteins of biotechnological interest due to its relaxed exogenous DNA restriction system and its ability to secrete proteins directly to the medium through the major Sec or the minor Tat routes. Often, protein secretion displays non-uniform ti...
journal_title：BMC microbiology
pub_type： 杂志文章
doi：10.1186/s12866-019-1591-7
更新日期：2019-10-26 00:00:00
abstract：BACKGROUND:Alpha-isopropylmalate synthase (alpha-IPMS) is the key enzyme that catalyzes the first committed step in the leucine biosynthetic pathway. The gene encoding alpha-IPMS in Mycobacterium tuberculosis, leuA, is polymorphic due to the insertion of 57-bp repeat units referred to as Variable Number of Tandem Repea...
journal_title：BMC microbiology
pub_type： 杂志文章
doi：10.1186/1471-2180-9-122
更新日期：2009-06-09 00:00:00
abstract：BACKGROUND:The currently used genotyping system for the avian zoonotic pathogen Chlamydophila (C.) psittaci has evolved from serology and is based on ompA sequence variations. It includes seven avian and two non-avian genotypes. Restriction enzyme cleavage of the amplified ompA gene and, less frequently, ompA sequencin...
journal_title：BMC microbiology
pub_type： 杂志文章
doi：10.1186/1471-2180-8-63
更新日期：2008-04-17 00:00:00
abstract：BACKGROUND:H-NS is a DNA-binding protein with central roles in gene regulation and nucleoid structuring in Escherichia coli. There are over 60 genes that are influenced by H-NS many of which are involved in metabolism. To determine the significance of H-NS-regulated genes in metabolism and stress tolerance, an hns muta...
journal_title：BMC microbiology
pub_type： 杂志文章
doi：10.1186/1471-2180-6-72
更新日期：2006-08-15 00:00:00
abstract：BACKGROUND:Fluconazole (FLC), a triazole antifungal drug, is widely used for the maintenance therapy of cryptococcal meningoencephalitis, the most common opportunistic infection in AIDS patients. In this study, we examined changes in the gene expression profile of the C. neoformans reference strain H99 (serotype A) fol...
journal_title：BMC microbiology
pub_type： 杂志文章
doi：10.1186/1471-2180-11-97
更新日期：2011-05-11 00:00:00
abstract：BACKGROUND:Streptococcus agalactiae or Group B Streptococci (GBS) have the ability to access various host sites, which reflects its adaptability to different environments during the course of infection. This adaptation is due to the expression of virulence factors that are involved with survival, invasion and bacterial...
journal_title：BMC microbiology
pub_type： 杂志文章
doi：10.1186/1471-2180-13-297
更新日期：2013-12-21 00:00:00
abstract：BACKGROUND:Total community rDNA was used to determine the diversity of bacteria and archaea from water, wet sediment and microbial mats samples of hot springs in the Eastern lowlands of Eritrea. The temperatures of the springs range from 49.5 °C to 100 °C while pH levels varied from 6.97 to 7.54. Akwar and Maiwooi have...
journal_title：BMC microbiology
pub_type： 杂志文章
doi：10.1186/s12866-017-1113-4
更新日期：2017-09-22 00:00:00
abstract：BACKGROUND:Since bacteria embedded in biofilms are far more difficult to eradicate than planktonic infections, it would be useful to know whether certain Staphylococcus aureus lineages are especially involved in strong biofilm formation. For this reason, in vitro biofilm formation of 228 clinical S. aureus isolates of ...
journal_title：BMC microbiology
pub_type： 杂志文章
doi：10.1186/1471-2180-9-229
更新日期：2009-10-28 00:00:00
abstract：BACKGROUND:The dspA (hik33) gene, coding for a putative sensory histidine kinase, is conserved in plastids (ycf26) and cyanobacteria. It has been linked with a number of different stress responses in cyanobacteria. RESULTS:We constructed an insertional mutant of dspA (ycf26) in Synechocystis 6803. We found little phen...
journal_title：BMC microbiology
pub_type： 杂志文章
doi：10.1186/1471-2180-5-47
更新日期：2005-08-02 00:00:00
abstract：BACKGROUND:Pyruvate oxidase (Pox) is an important enzyme in bacterial metabolism for increasing ATP production and providing a fitness advantage via hydrogen peroxide production. However, few Pox enzymes have been characterized from bacterial species. The tetrameric non-hydrogen-peroxide producing Pox from E. coli is a...
journal_title：BMC microbiology
pub_type： 杂志文章
doi：10.1186/s12866-020-01788-6
更新日期：2020-05-24 00:00:00
abstract：BACKGROUND:adhC from Haemophilus influenzae encodes a glutathione-dependent alcohol dehydrogenase that has previously been shown to be required for protection against killing by S-nitrosoglutathione (GSNO). This group of enzymes is known in other systems to be able to utilize substrates that form adducts with glutathio...
journal_title：BMC microbiology
pub_type： 杂志文章
doi：10.1186/1471-2180-12-159
更新日期：2012-07-31 00:00:00
abstract：BACKGROUND:The taxonomy of tintinnine ciliates is vastly unresolved because it has traditionally been based on the lorica (a secreted shell) and it has only recently incorporated cytological and molecular information. Tintinnopsis, the most speciose tintinnine genus, is also the most problematic: it is known to be non-...
journal_title：BMC microbiology
pub_type： 杂志文章
doi：10.1186/s12866-020-02057-2
更新日期：2020-12-14 00:00:00
abstract：BACKGROUND:The last step in the maturation process of the large subunit of [NiFe]-hydrogenases is a proteolytic cleavage of the C-terminal by a hydrogenase specific protease. Contrary to other accessory proteins these hydrogenase proteases are believed to be specific whereby one type of hydrogenases specific protease o...
journal_title：BMC microbiology
pub_type： 杂志文章
doi：10.1186/1471-2180-9-53
更新日期：2009-03-11 00:00:00
abstract：BACKGROUND:Typically, raw meat can be contaminated with antibiotic resistant pathogens at unhygienic slaughter and sale points. Consumption of meat contaminated with antibiotic resistant E. coli is associated with grave health care consequences. The aim of this study was to determine the microbial quality of raw meat, ...
journal_title：BMC microbiology
pub_type： 杂志文章
doi：10.1186/s12866-020-01935-z
更新日期：2020-08-14 00:00:00
