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SIGNOR 2.0, the SIGnaling Network Open Resource 2.0: 2019 update.

Abstract：

:The SIGnaling Network Open Resource 2.0 (SIGNOR 2.0) is a public repository that stores signaling information as binary causal relationships between biological entities. The captured information is represented graphically as a signed directed graph. Each signaling relationship is associated to an effect (up/down-regulation) and to the mechanism (e.g. binding, phosphorylation, transcriptional activation, etc.) causing the up/down-regulation of the target entity. Since its first release, SIGNOR has undergone a significant content increase and the number of annotated causal interactions have almost doubled. SIGNOR 2.0 now stores almost 23 000 manually-annotated causal relationships between proteins and other biologically relevant entities: chemicals, phenotypes, complexes, etc. We describe here significant changes in curation policy and a new confidence score, which is assigned to each interaction. We have also improved the compliance to the FAIR data principles by providing (i) SIGNOR stable identifiers, (ii) programmatic access through REST APIs, (iii) bioschemas and (iv) downloadable data in standard-compliant formats, such as PSI-MI CausalTAB and GMT. The data are freely accessible and downloadable at https://signor.uniroma2.it/.

journal_name

Nucleic Acids Res

journal_title

Nucleic acids research

authors

Licata L,Lo Surdo P,Iannuccelli M,Palma A,Micarelli E,Perfetto L,Peluso D,Calderone A,Castagnoli L,Cesareni G

doi

10.1093/nar/gkz949

subject

Has Abstract

pub_date

2020-01-08 00:00:00

pages

D504-D510

issue

D1

eissn

0305-1048

issn

1362-4962

pii

5608992

journal_volume

48

pub_type

杂志文章

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