Abstract:
:Heart failure entails the inability of the heart to pump blood to vital organs. One of the main risk factors for heart failure is the development of pathological hypertrophy. In this issue of EMBO Molecular Medicine, Li and coworkers show that NCoR1, a co-repressor of transcription factors, inhibits the transcriptional activity of MEF2 by stabilizing its complex with class II HDACs. By this mechanism, NCoR1 was identified as potent inhibitor of pathological cardiac hypertrophy and dysfunction.
journal_name
EMBO Mol Medjournal_title
EMBO molecular medicineauthors
Grund A,Heineke Jdoi
10.15252/emmm.201911297subject
Has Abstractpub_date
2019-11-07 00:00:00pages
e11297issue
11eissn
1757-4676issn
1757-4684journal_volume
11pub_type
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