Priming effect of bivalent and quadrivalent vaccine for HPV 31/33/45/52: an exploratory analysis from two clinical trials.

abstract：:Raising high titer antibodies in animals is usually performed by protein immunization, which requires the long and sometimes difficult step of production of the recombinant protein. DNA immunization is an alternative to recombinant proteins, only requiring the building of an eukaryotic expression plasmid. Thanks to ef...

journal_title：Human vaccines & immunotherapeutics

authors： Burgain A,Rochard A,Trollet C,Mazuet C,Popoff MR,Escriou V,Scherman D,Bigey P

更新日期：2013-10-01 00:00:00

abstract：:Tumor cells escape from immune recognition by several mechanisms such as down-regulating of MHC class I molecules, losing of tumor antigens, etc. The purpose of cancer immunotherapy is to robust or reconstruct the capacity of the immune system to recognize and kill tumor cells by overwhelming the mechanisms by which t...

journal_title：Human vaccines & immunotherapeutics

authors： Sheikhi A,Jafarzadeh A

更新日期：2017-08-03 00:00:00

abstract：OBJECTIVE:To evaluate the incidence of adverse events following administration of an Inactivated poliomyelitis vaccine (IPV) manufactured by Serum Institute of India Pvt. Ltd., Pune, India. METHODS:A single 0.5 ml dose of the IPV was administered intramuscularly to children attending private clinics or out-patient dep...

journal_title：Human vaccines & immunotherapeutics

authors： Sharma H,Dhere R,Parekh S,Shewale S

更新日期：2017-11-02 00:00:00

abstract：:This was a randomized, placebo-controlled, Phase I/II study conducted in a Japanese cohort to assess the safety and immunogenicity of Clostridium difficile vaccine (the same formulation as that used in the ongoing global Phase III study). Healthy Japanese adults aged 40-75 years were randomized to receive either C. di...

journal_title：Human vaccines & immunotherapeutics

authors： Matsuoka O,Patel DM,Sasaki S,Oka H,Sasaki T,Pietrobon PJ,Laot T,Bouckenooghe A,Menezes J,de Bruyn G

更新日期：2018-02-01 00:00:00

abstract：:The aim of this Phase IIIb, open-label, randomized study was to demonstrate the non-inferiority of immune responses and to assess the safety of a purified chick-embryo cell rabies vaccine (PCECV) in healthy Chinese children (6 to 17 years) and older adults (≥51 years) following 2 alternative intramuscular (IM) simulat...

journal_title：Human vaccines & immunotherapeutics

authors： Li R,Li Y,Wen S,Wen H,Nong Y,Mo Z,Xie F,Pellegrini M

更新日期：2015-01-01 00:00:00

abstract：:Rubella is a contagious viral disease, which mainly affects the fetus, if the mother is infected in the 1st trimester of her pregnancy. All adolescent girls (aged 11 to 19 y) and women of childbearing age are at risk of developing rubella. This disease is mild and self-limiting, and incubation period is 2-3 weeks. Hum...

journal_title：Human vaccines & immunotherapeutics

authors： Verma R,Khanna P,Chawla S

更新日期：2012-06-01 00:00:00

abstract：:As a stepping stone toward evaluation in infants, the safety and immunogenicity of an investigational 12-valent pneumococcal non-typeable Haemophilus influenzae protein D-conjugate vaccine (12vPHiD-CV) was assessed in toddlers. 12vPHiD-CV contains CRM197-conjugated capsular polysaccharides of serotypes 6A and 19A in a...

journal_title：Human vaccines & immunotherapeutics

authors： Horn M,Behre U,Traskine M,Dobbelaere K,Borys D

更新日期：2020-11-11 00:00:00

abstract：:In patients undergoing immunotherapy, the quality of the immune response is reduced, which may negatively affect the efficacy of vaccination. This study was conducted in order to evaluate the efficacy of the hepatitis B virus (HBV) vaccine in patients using immunomodulators. Seronegative patients for HBV who were usin...

journal_title：Human vaccines & immunotherapeutics

authors： Haykir Solay A,Eser F

更新日期：2019-01-01 00:00:00

abstract：:Understanding motivators and barriers of health care worker (HCW) vaccination programs is important for determining strategies to improve uptake. The aim of this study was to explore key drivers and HCW decision making related to recommended vaccines and seasonal influenza vaccination programs. We used a qualitative a...

journal_title：Human vaccines & immunotherapeutics

authors： Tuckerman JL,Shrestha L,Collins JE,Marshall HS

更新日期：2016-07-02 00:00:00

abstract：:For the 2010/11 influenza season the prenatal vaccination program was extended to all women in England and Wales irrespective of gestational age--this was a considerable shift in practice for both pregnant women and healthcare providers where the emphasis previously had been only on targeted vaccination for pregnant w...

journal_title：Human vaccines & immunotherapeutics

authors： Baxter D

更新日期：2013-06-01 00:00:00

abstract：:The present study is to measure the expression of programmed death (PD)-1 / programmed death ligand-1 (PD-L1) negative costimulatory molecules, soluble format sPD-1 in patients with immune thrombocytopenia (ITP), and to investigate their correlation with the secretion of cytokines. A total of 35 patients with ITP were...

journal_title：Human vaccines & immunotherapeutics

authors： Wang Y,Pang N,Wang X,Liu Y,Wang X,Wang L,Sun M,Yasen H,Zhao F,Fan W,Guo X,Ding J

更新日期：2018-04-03 00:00:00

abstract：:Compared with the general population, patients with cancer in general are more susceptible to vaccine-preventable infections, either by an increased risk due to the malignancy itself or immunosuppressive treatment. The goal of immunizations in these patients is therefore to provide protection against these infections,...

journal_title：Human vaccines & immunotherapeutics

authors： Ariza-Heredia EJ,Chemaly RF

更新日期：2015-01-01 00:00:00

abstract：:While the Saudi Arabian Ministry of Health has made seasonal influenza vaccination available for several years, there remains a scarcity of vaccination coverage reports outside of the capital city. Understanding factors that affect vaccine uptake is important in developing strategies to improve coverage. This analytic...

journal_title：Human vaccines & immunotherapeutics

authors： Al Hassan YT,Fabella EL,Estrella ED,Al Ramadan HA,Al Rajeh AM,Al Saleh FH

更新日期：2021-01-30 00:00:00

abstract：:Vaccination is an indisputable intervention that has tremendously mitigated the global burden of vaccine-preventable diseases (VPDs). The number of armed conflicts globally seems to be at an all-time high, with devastating effects on vaccination coverage. This paper will examine how armed conflicts affect childhood va...

journal_title：Human vaccines & immunotherapeutics

authors： Ngo NV,Pemunta NV,Muluh NE,Adedze M,Basil N,Agwale S

更新日期：2020-06-02 00:00:00

abstract：:The study of influenza virus evolution in humans has revealed a significant role of glycosylation profile alterations in the viral glycoproteins - hemagglutinin (HA) and neuraminidase (NA), in the emergence of both seasonal and pandemic strains. Viral antigenic drift can modify the number and location of glycosylation...

journal_title：Human vaccines & immunotherapeutics

authors： Cruz E,Cain J,Crossett B,Kayser V

更新日期：2018-03-04 00:00:00

abstract：:Leukemia-associated antigens such as proteinase-3 (PR3) and Wilms' tumor protein-1 (WT-1) are potential targets of T-cell responses, which can be monitored by T-cell assays within vaccination trials and after allogeneic stem cell transplantation (SCT). In chronic myeloid leukemia (CML) an aberrant cytokine profile of ...

journal_title：Human vaccines & immunotherapeutics

authors： Flörcken A,van Lessen A,Terwey TH,Dörken B,Arnold R,Pezzutto A,Westermann J

更新日期：2013-06-01 00:00:00

abstract：:Human papilloma viruses (HPVs) infect the skin and mucosal epithelium of both men and women. There are about 100 types of HPVs, which are differentiated by the genetic sequence of the outer capsid protein L1. More than 30 types of HPVs are sexually transmitted. Most cases of carcinoma of the cervix are caused by HPV. ...

journal_title：Human vaccines & immunotherapeutics

authors： Verma R,Khanna P

更新日期：2013-01-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is an aggressive tumor that is associated with high rates of recurrence and mortality. This is due, in part, to the fact that CCA cells and their microenvironment secrete immunosuppressive cytokines, transforming growth factor-β (TGF-β) and interleukin-10 (IL-10), that inhibit dendritic cell (...

journal_title：Human vaccines & immunotherapeutics

authors： Thepmalee C,Panya A,Sujjitjoon J,Sawasdee N,Poungvarin N,Junking M,Yenchitsomanus PT

更新日期：2020-10-02 00:00:00

abstract：:Measles virus (MV) is the only human virus within the morbillivirus genus of the Paramyxoviridae. The veterinary members are canine distemper virus (CDV), peste des petits ruminants virus (PPRV), Rinderpest Virus (RPV) as well as the marine morbilliviruses phocine distemper virus (PDV), dolphin morbillivirus (DMV) and...

journal_title：Human vaccines & immunotherapeutics

authors： Cosby SL,Weir L

更新日期：2018-01-02 00:00:00

abstract：:We aimed to determine the efficacy of the 10-valent pneumococcal-Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) in children aged 18-months to <18-years with recurrent protracted bacterial bronchitis (rPBB), chronic suppurative lung disease (CSLD) or bronchiectasis. In a multi-centre, double-blind randomi...

journal_title：Human vaccines & immunotherapeutics

authors： O'Grady KF,Chang AB,Cripps A,Mulholland EK,Smith-Vaughan H,Wood N,Danchin M,Thornton R,Wilson A,Torzillo PJ,Morris PM,Richmond P,Rablin S,Arnold D,Connor A,Goyal V,Stoney T,Perrett K,Grimwood K

更新日期：2018-01-01 00:00:00

abstract：:Tetanus, diphtheria, and acellular pertussis (Tdap) vaccination is recommended for all women during each pregnancy to prevent pertussis in young infants. However, data on the safety of this protective measure are limited and conflicting. To assess maternal and infant outcomes associated with administration of this vac...

journal_title：Human vaccines & immunotherapeutics

authors： Berenson AB,Hirth JM,Rahman M,Laz TH,Rupp RE,Sarpong KO

更新日期：2016-08-02 00:00:00

abstract：:Both our research and that published by Sticchi et al. on immunological memory against hepatitis B virus (HBV) in health-care workers (HCWs) vaccinated as infants or adolescents confirm that in those testing negative after the primary course, one additional (fourth) booster dose is able to elicit an anti-HBs response ...

journal_title：Human vaccines & immunotherapeutics

authors： Bechini A,Bonanni P,Grazzini M,Paolini D,Arcangeli G,Mucci N,Bini C,Tiscione E,Zanella B,Boccalini S

更新日期：2020-12-03 00:00:00

abstract：:In 1796, Edward Jenner introduced the concept of vaccination with cowpox virus, an Orthopoxvirus within the family Poxviridae that elicits cross protective immunity against related orthopoxviruses, including smallpox virus (variola virus). Over time, vaccinia virus (VACV) replaced cowpox virus as the smallpox vaccine,...

journal_title：Human vaccines & immunotherapeutics

authors： Verardi PH,Titong A,Hagen CJ

更新日期：2012-07-01 00:00:00

abstract：:Hepatitis B virus (HBV) remains a challenging public-health issue in China. Hepatitis B carriers and patients suffer not only physically but also experience strong discrimination and stigma. China's rural population is 629 million. Thus, there is a great need to understand the situation surrounding HBV-related discrim...

journal_title：Human vaccines & immunotherapeutics

authors： Yu L,Wang J,Zhu D,Leng A,Wangen KR

更新日期：2016-01-01 00:00:00

abstract：:A universal vaccine that provides long-lasting protection from both epidemic and pandemic influenza viruses remains the "holy grail" of influenza vaccine research. Though virus neutralization assays are the current benchmark of measuring vaccine effectiveness, it is clear that Fc-receptor functions can drastically imp...

journal_title：Human vaccines & immunotherapeutics

authors： Jegaskanda S,Vanderven HA,Wheatley AK,Kent SJ

更新日期：2017-06-03 00:00:00

abstract：:The ESCULAPIO Project aims at increasing awareness on vaccine preventable infectious diseases (VPID) and vaccinations in different target populations and to spread the culture of prevention. Information/training interventions on VPID have been developed and health promotion activities for the general population, stude...

journal_title：Human vaccines & immunotherapeutics

authors： Bechini A,Bonanni P,Lauri S,Tiscione E,Levi M,Prato R,Fortunato F,Martinelli D,Gasparini R,Panatto D,Amicizia D,Coppola RC,Pellizzari B,Tabacchi G,Costantino C,Vitale F,Iannazzo S,Boccalini S

更新日期：2017-02-01 00:00:00

abstract：:Limited safety data are available on inadvertent exposure to quadrivalent human papillomavirus vaccine (4vHPV) during pregnancy. We conducted a descriptive observational postlicensure safety surveillance study in Kaiser Permanente Southern California and Northern California to assess congenital anomaly and miscarriage...

journal_title：Human vaccines & immunotherapeutics

authors： Sy LS,Meyer KI,Klein NP,Chao C,Velicer C,Cheetham TC,Ackerson BK,Slezak JM,Takhar HS,Hansen J,Deosaransingh K,Liaw KL,Jacobsen SJ

更新日期：2018-02-01 00:00:00

abstract：:School-based vaccination, as a means to mitigate seasonal influenza outbreak, depends on attaining adequate coverage rate. We evaluated the potential of a fully subsidized school outreach vaccination (SOV) program to achieve epidemic prevention potential in Hong Kong. The purpose of this study was to evaluate the impa...

journal_title：Human vaccines & immunotherapeutics

authors： Lau YL,Wong WHS,Hattangdi-Haridas SR,Chow CB

更新日期：2020-04-02 00:00:00

abstract：BACKGROUND:The prevalence of occult hepatitis B (HB) infection (OBI) in HB-vaccinated diabetic children has not yet been tested. Here, we aimed to determine the prevalence of OBI among HB-vaccinated children and adolescents with insulin-dependent diabetes mellitus (IDDM). RESULTS:Eighty-seven (51.2%) children had a ti...

journal_title：Human vaccines & immunotherapeutics

authors： Elrashidy H,El-Didamony G,Elbahrawy A,Hashim A,Alashker A,Morsy MH,Elwassief A,Elmestikawy A,Abdallah AM,Mohammad AG,Mostafa M,George NM,Abdelhafeez H

更新日期：2014-01-01 00:00:00

abstract：:Influenza vaccination is the most effective way of preventing influenza infections but its coverage is extremely low in China. Poor influenza vaccine effectiveness (VE) was reported in the 2014/15 season in some Northern Hemisphere countries with a predominance of H3N2 viruses belonging to the 3C.2a clade. However, th...

journal_title：Human vaccines & immunotherapeutics

authors： Ma C,Pan Y,Zhang L,Zhang Y,Wu S,Sun Y,Duan W,Zhang M,Wang Q,Yang P

更新日期：2017-10-03 00:00:00