Abstract:
PURPOSE:The objective of this overview was to critically evaluate the effect of polyethylene glycol (PEG)-based hydrogel spacers during prostate brachytherapy with regard to dosimetric and clinical benefits, as well as procedure-related toxicity. METHODS AND MATERIALS:A systematic search in the PubMed database was performed. RESULTS:A total of 12 studies, involving 615 patients with PEG hydrogel injection, were included. Overall, patients well tolerated the implantation of PEG hydrogel spacers with an excellent safety profile. However, although there were some procedure-related complications, rates of these complications were very rare. Toxicities related to the spacer were limited to Grade 1 rectal discomfort and pain (9/615 patients), Grade 2 rectal ulceration (1 in 615 patients), perineal abscess (1 in 615 patients), and bacterial prostatitis (2/615 patients) according to Common Terminology Criteria for Adverse Events v4.0 grading scheme. The application of PEG hydrogel spacers significantly reduced radiation doses to the rectum during prostate brachytherapy in the different setting. Although there was no prospective randomized clinical trial, retrospective studies showed that reducing rectal doses by the implantation of PEG hydrogel may result in an improvement in rectal toxicity. CONCLUSIONS:The insertion of hydrogel spacers is safe, resulting in a significant decrease in rectal doses. This may lead to a reduction in rectal or gastrointestinal toxicity. Prospective randomized clinical trials are warranted to confirm the clinical impact of rectal dosimetric improvements.
journal_name
Brachytherapyjournal_title
Brachytherapyauthors
Afkhami Ardekani M,Ghaffari Hdoi
10.1016/j.brachy.2019.08.009subject
Has Abstractpub_date
2020-01-01 00:00:00pages
13-23issue
1eissn
1538-4721issn
1873-1449pii
S1538-4721(19)30574-4journal_volume
19pub_type
杂志文章相关文献
Brachytherapy文献大全abstract:PURPOSE:With an aim to evaluate and report high dose date interstitial brachytherapy (HDR-ISBT) in vulvar cancers, we undertook this retrospective analysis. METHODS AND MATERIALS:Histologically proven vulvar cancers treated with HDR-ISBT between 2001 and 2016 were analyzed. Radiotherapy details, clinical outcome in te...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2016.10.003
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the interim outcomes of low-dose-rate permanent brachytherapy (PB) combined with short-term androgen deprivation therapy (ADT) in Japanese men with intermediate-risk prostate cancer excluding those with a Gleason score of 4+3. METHODS:The Protocol-intermediate-risk group (Protocol-IRG) was defin...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2014.09.001
更新日期:2015-03-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy and side effect profile of adjuvant vaginal vault brachytherapy alone after hysterectomy in Stage I endometrial carcinoma. METHODS AND MATERIALS:Between 23/11/1992 and 16/05/2005, a total of 173 patients with early endometrial carcinoma treated with vaginal vault brachytherapy alone po...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2008.01.001
更新日期:2008-04-01 00:00:00
abstract:PURPOSE:To assess the feasibility and tumor outcome of re-irradiation with low-dose-rate brachytherapy for macroscopic local recurrences after radical prostatectomy (RP) followed by adjuvant or salvage external beam radiation therapy (EBRT). METHODS AND MATERIALS:Between 2011 and 2018, five men with histologically pro...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2020.07.001
更新日期:2021-01-01 00:00:00
abstract:PURPOSE:High-dose-rate (HDR) brachytherapy boost is a treatment of intermediate- to high-risk prostate cancer, but long-term clinical outcome data are sparse. We report long-term survival and toxicity data in a cohort of patients treated in a single institution. METHODS:Between 1998 and 2004, 654 patients with localiz...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2019.01.013
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:Persistent disease after definitive external beam radiation therapy for head and neck (H&N) malignancies negatively impacts survival. In this series, the effectiveness of low-dose-rate brachytherapy in the management of persistent H&N disease is explored. METHODS:All patients who received brachytherapy for per...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2008.12.007
更新日期:2009-07-01 00:00:00
abstract:PURPOSE:Certain subsets of patients have an increased risk of all-cause mortality when androgen deprivation therapy (ADT) is used with definitive radiotherapy. We evaluated the relationship between pretreatment serum testosterone, age, and comorbidities on survival after prostate brachytherapy in men treated with and w...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2009.06.008
更新日期:2010-01-01 00:00:00
abstract:PURPOSE:Accurate patient-specific dosimetry in intravascular brachytherapy (IVBT) is generally difficult due to the extremely high-dose gradient, complexity of treatment device, and patient-specific geometry (e.g., calcification, stent, curvature, movement of target). The purpose of this study is to analyze quantitativ...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2005.07.004
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:To develop an improved Xoft electronic skin brachytherapy process and identify areas of further improvement. METHODS AND MATERIALS:A multidisciplinary team conducted a failure modes and effects analysis (FMEA) by developing a process map and a corresponding list of failure modes. The failure modes were scored ...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2018.04.002
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:To improve efficiency, convenience, and cost, a prospective phase II trial was initiated to evaluate accelerated partial breast irradiation delivered with noninvasive image-guided breast brachytherapy (NIBB) via five once-daily fractions. METHODS AND MATERIALS:Women ≥50 years old with early-stage breast cancer...
journal_title:Brachytherapy
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.brachy.2018.05.006
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:To compare dosimetrically the stereotactic CyberKnife (CK) therapy and multicatheter high-dose-rate (HDR) brachytherapy (BT) for accelerated partial breast irradiation (APBI). METHODS:Treatment plans of 25 patients treated with CK were selected, and additional plans using multicatheter HDR BT were created on...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2020.10.003
更新日期:2020-11-18 00:00:00
abstract:PURPOSE:To assess the impact of experience and technical changes on morbidity during the first year after permanent prostate brachytherapy. METHODS AND MATERIALS:From July 2003 to May 2010, 150 patients with prostate cancer underwent low-dose iodine-125 prostate brachytherapy as a monotherapy by the same medical team ...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2013.04.002
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Cervical cancer patients are faced with an enormous amount of medical information in a complex oncology field with sophisticated treatments including brachytherapy. We investigated the use of enhanced vs. standard brachytherapy-specific educational materials on patient-reported satisfaction during the inform...
journal_title:Brachytherapy
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.brachy.2015.09.007
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:This is a retrospective review of our experience using high-dose-rate (HDR) brachytherapy boost for prostate cancer. METHODS AND MATERIALS:During the study period, we recommended external beam radiotherapy (45 Gy) and HDR boost (18 Gy in three fractions) combined with hormonal therapy (HT) for 2 months before ...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2005.03.005
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:To explore the dosimetric advantage of target volume and surrounding normal tissue by using interstitial (IS) brachytherapy (BT) based on three-dimensional CT in locally advanced cervical cancer, as a simple and effective clinical treatment approach. METHODS AND MATERIALS:Fifty-two patients with poor tumor res...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2016.06.004
更新日期:2016-09-01 00:00:00
abstract::MRI produces better soft tissue contrast than does ultrasonography or computed tomography for visualizing male pelvic anatomy and prostate cancer. Better visualization of the tumor and organs at risk could allow better conformation of the dose to the target volumes while at the same time minimizing the dose to critica...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2016.11.012
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:Education and training on prostate brachytherapy for radiation oncology and medical physics residents in the United States is inadequate, resulting in fewer competent radiation oncology personnel to perform implants, and is a factor in the subsequent decline of an important, potentially curative cancer treatmen...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2020.10.001
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:The aim of the study was to assess the impact of high-dose-rate (HDR) interstitial brachytherapy on quality of life (QOL) in oral cancer. METHODS AND MATERIALS:Thirty-two patients of oral cancer treated at our institute from January 2010 to December 2014 with radical radiotherapy (external beam radiotherapy + ...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2016.02.002
更新日期:2016-05-01 00:00:00
abstract:PURPOSE:To analyze the dosimetric impact and periprocedural outcomes with a bioabsorbable hydrogel rectal spacer injected during low-dose-rate (LDR) prostate brachytherapy implants. METHODS AND MATERIALS:A consecutive series of 80 patients implanted with stranded I-125 LDR brachytherapy seeds were evaluated, of which ...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2019.11.002
更新日期:2020-01-01 00:00:00
abstract:UNLABELLED:PURPOSE/INTRODUCTION: To safely irradiate retroperitoneal targets as paraaortic lymph node by separating abdominal at-risk organs from the target during irradiation, we created a percutaneous paravertebral approach of high-dose-rate brachytherapy with hyaluronate gel injection (HGI). We report a case treated...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2011.12.004
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:Dose escalation has been shown beneficial in prostate cancer. Brachytherapy (BT) provides an opportunity for dose escalation beyond what can be safely delivered using only teletherapy methods. The purpose of this study was to determine cancer control and morbidity of external beam radiation therapy (EBRT) plus ...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2009.01.002
更新日期:2009-04-01 00:00:00
abstract:PURPOSE:To assess the difference in prostate-specific antigen (PSA) response kinetics in patients undergoing either (125)I or (103)Pd permanent prostate brachytherapy (PPB). METHODS AND MATERIALS:Between 1997 and 1999, 333 patients underwent PPB as monotherapy. Forty-eight patients received a (125)I implant, and 285 r...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/S1538-4721(03)00004-7
更新日期:2003-01-01 00:00:00
abstract:PURPOSE:Brachytherapy (BrT) is a standard treatment for low-risk to favorable-intermediate-risk prostate cancer but is a relative contraindication for patients with obstructive symptoms. We aimed to assess the feasibility and urinary toxicity of a minimal photovaporization (mPVP) before implantation. MATERIALS AND MET...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2020.08.003
更新日期:2021-01-01 00:00:00
abstract:PURPOSE:To develop a dose verification tool for high-dose-rate interstitial brachytherapy treatment planning in accelerated partial breast irradiation. METHODS AND MATERIALS:We have developed a software tool for interstitial brachytherapy treatment planning assessment. The software contains a database of seven (192)Ir...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2012.03.008
更新日期:2012-09-01 00:00:00
abstract:PURPOSE:The purpose of this study was to prospectively assess the variations in health-related quality of life (HR-QoL) in patients who underwent low-dose rate prostate brachytherapy using iodine-125 seed source during the first year after seed implantation. METHODS AND MATERIALS:Between July 2004 and December 2006, 1...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2009.07.013
更新日期:2010-10-01 00:00:00
abstract:PURPOSE:To compare clinical outcomes between low-dose-rate (LDR) brachytherapy and high-dose-rate (HDR) brachytherapy for cervical cancer patients. METHODS AND MATERIALS:All consecutive newly diagnosed cervical cancer patients undergoing pretreatment 18-fluorodeoxyglucose positron emission tomography imaging and treat...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2018.11.008
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:For selected early breast cancers, intraoperative radiation therapy (IORT) at the time of lumpectomy can be an efficient alternative to fractionated whole breast radiation therapy (WBRT). However, some patients are later recommended WBRT after IORT due to surgical pathologic findings. To understand risk factor ...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2016.09.012
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:High-dose-rate (HDR) brachytherapy is a convenient treatment option for selected patients with T1-T2 penile squamous cell carcinoma (SCC), providing high rates of penile preservation and tumor control. We present the results of penile SCC treated with HDR brachytherapy either interstitially or via a surface mol...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2019.12.003
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:To determine the usefulness of prostate-specific antigen (PSA) percentage (vs. pretreatment value assumed as 100%) in prediction of biochemical relapse, after iodine-125 ((125)I) permanent brachytherapy for prostate cancer, to employ a parameter independent by the initial PSA amount and by the individual pros...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2011.08.008
更新日期:2012-07-01 00:00:00
abstract:PURPOSE:Determine whether fat distribution, body mass index, or clinical and dosimetric factors are associated with prostate specific antigen (PSA) bounce (PSAb) of ≥1.6 ng/mL in patients treated with permanent seed (125)I prostate brachytherapy (PB). METHODS AND MATERIALS:We identified 23 patients with a PSAb of ≥1.6...
journal_title:Brachytherapy
pub_type: 杂志文章
doi:10.1016/j.brachy.2013.05.005
更新日期:2013-11-01 00:00:00