Abstract:
:Macroautophagy (hereafter referred to as autophagy, a word derived from Greek meaning "auto-digestion") is a lysosome-dependent quality control process to degrade and turnover damaged or senescent organelles and proteins for cellular renewal [...].
journal_name
Cellsjournal_title
Cellsauthors
Lin PHdoi
10.3390/cells8070743subject
Has Abstractpub_date
2019-07-19 00:00:00issue
7issn
2073-4409pii
cells8070743journal_volume
8pub_type
社论相关文献
Cells文献大全abstract::The family of heterochromatin protein 1 (HP1) isoforms is essential for chromatin packaging, regulation of gene expression, and repair of damaged DNA. Here we document that γ-radiation reduced the number of HP1α-positive foci, but not HP1β and HP1γ foci, located in the vicinity of the fibrillarin-positive region of th...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8091097
更新日期:2019-09-17 00:00:00
abstract::Brain injury exosomal proteins are promising blood biomarker candidates in traumatic brain injury (TBI). A better understanding of their role in the diagnosis, characterization, and management of TBI is essential for upcoming clinical implementation. In the current investigation, we aimed to explore longitudinal traje...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9040977
更新日期:2020-04-15 00:00:00
abstract::MicroRNAs (miRNAs) have emerged as key players in tumor angiogenesis. Interleukin-17C (IL-17C) was identified to promote colorectal cancer (CRC) progression. Therefore, we aimed to investigate the effect of IL-17C on tumor angiogenesis, the involvement of miR-23a-3p in IL-17C signaling, and the direct target gene of m...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9061363
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Human Vγ9Vδ2 γδ T cells can kill a variety of cancer cells and have attracted substantial interest for cancer immunotherapy. Toll-like receptor (TLR) ligands are promising adjuvants for cancer immunotherapy, but TLR7/8 ligand Resiquimod has been shown to inhibit CD4 T-cell activation in a monocyte-dependent ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9030713
更新日期:2020-03-13 00:00:00
abstract::Detachment and the formation of spheroids under microgravity conditions can be observed with various types of intrinsically adherent human cells. In particular, for cancer cells this process mimics metastasis and may provide insights into cancer biology and progression that can be used to identify new drug/target comb...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9020367
更新日期:2020-02-05 00:00:00
abstract::Ulcerative colitis is a chronic inflammatory disease confined to the colon. Although the etiopathogenesis remains unknown, small bowel dysfunctions like histological and permeability alterations have been described in ulcerative colitis. We evaluated the molecular gene signature in the non-inflamed terminal ileum of 3...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9081793
更新日期:2020-07-28 00:00:00
abstract::Stem cell therapy represents a promising approach in the treatment of several neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). The beneficial effect of stem cells is exerted by paracrine mediators, as exosomes, suggesting a possible potential use of these extracellular vesicles as non-cell b...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8091087
更新日期:2019-09-14 00:00:00
abstract::Induced pluripotent stem cells (iPSCs) and induced neuronal (iN) cells are very much touted in terms of their potential promises in therapeutics. However, from a more fundamental perspective, iPSCs and iNs are invaluable tools for the postnatal generation of specific diseased cell types from patients, which may offer ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells7050038
更新日期:2018-05-08 00:00:00
abstract::The Epithelial Cell Adhesion Molecule or EpCAM is a well-known marker highly expressed in carcinomas and showing a strong correlation with poor cancer prognosis. While its name relates to its proposed function as a cell adhesion molecule, EpCAM has been shown to have various signalling functions. In particular, it has...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9092128
更新日期:2020-09-19 00:00:00
abstract::Extracellular vesicles (EVs) are involved in intercellular communication during carcinogenesis, and cancer cells are able to secrete EVs, in particular exosomes containing molecules, that can be transferred to recipient cells to induce pathological processes and significant modifications, as metastasis, increase of pr...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8080777
更新日期:2019-07-25 00:00:00
abstract::We have previously discovered that HDAC6 regulates the DNA damage response (DDR) via modulating the homeostasis of a DNA mismatch repair protein, MSH2, through HDAC6's ubiquitin E3 ligase activity. Here, we have reported HDAC6's second potential E3 ligase substrate, a critical cell cycle checkpoint protein, Chk1. We h...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9102237
更新日期:2020-10-04 00:00:00
abstract::The proliferation of molds in domestic environments can lead to uncontrolled continuous exposure to mycotoxins. Even if not immediately symptomatic, this may result in chronic effects, such as, for instance, immunosuppression or allergenic promotion. Alternariol (AOH) is one of the most abundant mycotoxins produced by...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9040847
更新日期:2020-03-31 00:00:00
abstract::The tumor microenvironment is a complex ecosystem comprised of many different cell types, abnormal vasculature and immunosuppressive cytokines. The irregular growth kinetics with which tumors grow leads to increased oxygen consumption and, in turn, hypoxic conditions. Hypoxia has been associated with poor clinical out...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9040992
更新日期:2020-04-16 00:00:00
abstract::Differentiation therapy is an alternative strategy used to induce the differentiation of blast cells toward mature cells and to inhibit tumor cell proliferation for cancer treatment. Nobiletin (NOB), a polymethoxyflavone phytochemical, is present abundantly in citrus peels and has been reported to possess anti-cancer ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9040877
更新日期:2020-04-03 00:00:00
abstract::CCN1 and CCN2 are members of the CCN family and play essential roles in the regulation of multiple female reproductive functions, including ovulation. Cyclooxygenase-2 (COX2) is a critical mediator of ovulation and can be induced by sphingosine-1-phosphate (S1P) through the S1P1/3-mediated Yes-associated protein (YAP)...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8111445
更新日期:2019-11-15 00:00:00
abstract::The Drosophila ovary offers a suitable model system to study the mechanisms that orchestrate diverse cellular processes. Oogenesis starts from asymmetric stem cell division, proper differentiation and the production of fully patterned oocytes equipped with all the maternal information required for embryogenesis. Spati...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9020274
更新日期:2020-01-22 00:00:00
abstract::Despite major advances in the last 10 years, whether in terms of prevention or treatment, the 5 year survival rate remains relatively low for a large number of cancers. These therapeutic failures can be the consequence of several factors associated with the cellular modifications or with the host by itself, especially...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9020362
更新日期:2020-02-04 00:00:00
abstract::Small GTPases regulate cytoskeletal dynamics, cell motility, and division under precise spatiotemporal control. Different small GTPases exhibit cross talks to exert feedback response or to act in concert during signal transduction. However, whether and how specific cytoskeletal components' feedback to upstream signali...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8101264
更新日期:2019-10-16 00:00:00
abstract::The present Special Issue on "Cells in Cardiovascular Disease" wants to offer a general overview of current cardiovascular research and illustrate how advances in the molecular characterization at the cellular level are providing unique insights into pathologies of the circulatory system [...]. ...
journal_title:Cells
pub_type: 社论
doi:10.3390/cells9102192
更新日期:2020-09-29 00:00:00
abstract::Human mesenchymal stromal/stem cells (hMSCs) show great promise in cell therapy due to their immunomodulatory properties. The overall immunomodulatory response of hMSCs resembles the resolution of inflammation, in which lipid mediators and regulatory macrophages (Mregs) play key roles. We investigated the effect of hM...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9092142
更新日期:2020-09-22 00:00:00
abstract::: T-cell mediated immune responses should be regulated to avoid the development of autoimmune or chronic inflammatory diseases. Several mechanisms have been described to regulate this process, namely death of overactivated T cells by cytokine deprivation, suppression by T regulatory cells (Treg), induction of expressi...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8020154
更新日期:2019-02-12 00:00:00
abstract::Membrane-bound proteases play a key role in biology by degrading matrix proteins or shedding adhesion receptors. MT1-MMP metalloproteinase is critical during cancer invasion, angiogenesis, and development. MT1-MMP activity is strictly regulated by internalization, recycling, autoprocessing but also through its incorpo...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9020348
更新日期:2020-02-03 00:00:00
abstract::Vector transmission of plant viruses is basically of two types that depend on the virus helper component proteins or the capsid proteins. A number of plant viruses belonging to disparate groups have developed unusual capsid proteins providing for interactions with the vector. Thus, cauliflower mosaic virus, a plant pa...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells10010090
更新日期:2021-01-07 00:00:00
abstract::In contrast to the programmed nature of development, it is still a matter of debate whether aging is an adaptive and regulated process, or merely a consequence arising from a stochastic accumulation of harmful events that culminate in a global state of reduced fitness, risk for disease acquisition, and death. Similarl...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8111446
更新日期:2019-11-15 00:00:00
abstract::Hypoxia-inducible transcription factors 1 and 2 (HIFs) are major mediators of cancer development and progression and validated targets for cancer therapy. Although calcitriol, the biologically active metabolite of vitamin D, was attributed with anticancer properties, there is little information on the effect of calcit...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9112440
更新日期:2020-11-09 00:00:00
abstract::The xCELLigence real-time cell analysis (RTCA) system has the potential to detect cellular proliferation, migration, cytotoxicity, adherence, and remodeling. Although the RTCA system is widely recognized as a noninvasive and efficient tool for real-time monitoring of cellular fate, it cannot describe detailed cell mor...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8101287
更新日期:2019-10-21 00:00:00
abstract::The discovery of the isocitrate dehydrogenase (IDH) mutation in glioma led to a paradigm shift on how we see glioma biology. Difficulties in cultivating IDH mutant glioma stem cells (IDHmut GSCs) resulted in a paucity of preclinical models in IDHmut glioma, limiting the discovery of new effective chemotherapeutic agen...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9061389
更新日期:2020-06-03 00:00:00
abstract::Previously, we used a lentiviral vector to deliver furin-cleavable human insulin (INS-FUR) to the livers in several animal models of diabetes using intervallic infusion in full flow occlusion (FFO), with resultant reversal of diabetes, restoration of glucose tolerance and pancreatic transdifferentiation (PT), due to t...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9102227
更新日期:2020-10-02 00:00:00
abstract::Cathepsin S (CatS) is a secreted cysteine protease that cleaves certain extracellular matrix proteins, regulates antigen presentation in antigen-presenting cells (APC), and promotes M2-type macrophage and dendritic cell polarization. CatS is overexpressed in many solid cancers, and overall, it appears to promote an im...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9092021
更新日期:2020-09-02 00:00:00
abstract::Exosomes are endosome-derived nanovesicles produced by healthy as well as diseased cells. Their proteic, lipidic and nucleic acid composition is related to the cell of origin, and by vehiculating bioactive molecules they are involved in cell-to-cell signaling, both in healthy and pathologic conditions. Being nano-size...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9122569
更新日期:2020-12-01 00:00:00