Abstract：
:Disentangling the separate and synergistic effects of chemicals poses methodological challenges for accurate exposure assessment and for investigating epidemiologically how chemicals affect reproduction. We investigated combined exposures to ubiquitous contemporary use pesticides, specifically organophosphates (OP) and pyrethroids (PYR), and their association with germ cell abnormalities among adult men. Fluorescence in situ hybridization was used to determine disomy in sperm nuclei and urine was analyzed for concentrations of PYR metabolites (3-phenoxybenzoic acid; 3PBA) and OP dialkyl phosphate (DAP) metabolites. Incidence rate ratios using Poisson models were estimated for each disomy type by exposure quartile of DAP metabolites and 3PBA, controlling for confounders. The shape of the associations between PYRs, OPs and disomy were frequently nonmonotonic. There were consistent interactions between OP and PYR metabolite concentrations and the risk for sperm abnormalities. Taking both chemicals into account simultaneously resulted in quantitatively different associations than what was reported previously for OPs and PYRs separately, demonstrating the importance of modeling multiple concentrations simultaneously. Methods investigating interactions using Poisson models are needed to better quantify chemical interactions and their effects on count-based health outcomes, the importance of which was shown here for germ cell abnormalities.
journal_name
Int J Hyg Environ Healthauthors
Figueroa ZI,Young HA,Mumford SL,Meeker JD,Barr DB,Gray GM,Perry MJdoi
10.1016/j.ijheh.2019.07.001subject
Has Abstractpub_date
2019-08-01 00:00:00pages
1021-1029issue
7eissn
1438-4639issn
1618-131Xpii
S1438-4639(18)30830-7journal_volume
222pub_type
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journal_title：International journal of hygiene and environmental health
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journal_title：International journal of hygiene and environmental health
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journal_title：International journal of hygiene and environmental health
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journal_title：International journal of hygiene and environmental health
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journal_title：International journal of hygiene and environmental health
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journal_title：International journal of hygiene and environmental health
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journal_title：International journal of hygiene and environmental health
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pub_type： 杂志文章,评审
doi：10.1016/j.ijheh.2018.12.012
更新日期：2019-04-01 00:00:00
