Maternal depression treatment in HIV (M-DEPTH): Study protocol for a cluster randomized controlled trial.

Abstract:

INTRODUCTION:Over one-third of human immunodeficiency virus (HIV)-infected pregnant women are clinically depressed, increasing the risk of mother-to-child transmission (MTCT) of HIV, as well as negative birth and child development outcomes. This study will evaluate the efficacy and cost-effectiveness of an evidence-based stepped care treatment model for perinatal depression (maternal depression treatment in HIV [M-DEPTH]) to improve adherence to prevention of MTCT care among HIV+ women in Uganda. METHODS:Eight antenatal care (ANC) clinics in Uganda will be randomized to implement either M-DEPTH (n=4) or usual care (n=4) for perinatal depression among 400 pregnant women (n=50 per clinic) between June 2019 and August 2022. At each site, women who screen positive for potential depression will be enrolled and followed for 18 months post-delivery, assessed in 6-month intervals: baseline, within 1 month of child delivery or pregnancy termination, and months 6, 12, and 18 following delivery. Primary outcomes include adherence to the prevention of mother-to-child transmission (PMTCT) care continuum-including maternal antiretroviral therapy and infant antiretrovial prophylaxis, and maternal virologic suppression; while secondary outcomes will include infant HIV status, post-natal maternal and child health outcomes, and depression treatment uptake and response. Repeated-measures multivariable regression analyses will be conducted to compare outcomes between M-DEPTH and usual care, using 2-tailed tests and an alpha cut-off of P <.05. Using a micro-costing approach, the research team will relate costs to outcomes, examining the incremental cost-effectiveness ration (ICER) of M-DEPTH relative to care as usual. DISCUSSION:This cluster randomized controlled trial will be one of the first to compare the effects of an evidence-based depression care model versus usual care on adherence to each step of the PMTCT care continuum. If determined to be efficacious and cost-effective, this study will provide a model for integrating depression care into ANC clinics and promoting adherence to PMTCT. TRIAL REGISTRATION:NIH Clinical Trial Registry NCT03892915 (clinicaltrials.gov).

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Wagner GJ,McBain RK,Akena D,Ngo V,Nakigudde J,Nakku J,Chemusto H,Beyeza-Kashesya J,Gwokyalya V,Faherty LJ,Kyohangirwe L,Nabitaka LK,Lukwata H,Linnemayr S,Ghosh-Dastidar B,Businge J,Mukasa B,Wanyenze RK

doi

10.1097/MD.0000000000016329

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

e16329

issue

27

eissn

0025-7974

issn

1536-5964

pii

00005792-201907050-00095

journal_volume

98

pub_type

杂志文章,随机对照试验

相关文献

MEDICINE文献大全
  • Lower circulating angiotensin II levels are related to the severity of preeclampsia and its risk as disclosed by a specific bioassay.

    abstract::Preeclampsia is characterized by an increased sensitivity to angiotensin II (Ang II). We herein assessed whether serum Ang II levels measured by a new developed bioassay are associated with preeclampsia, its severity, and the risk for developing this disease.Using a cross-sectional design, we studied 90 pregnant women...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000012498

    authors: Leaños-Miranda A,Inova Campos-Galicia,Méndez-Aguilar F,Molina-Pérez CJ,Ramírez-Valenzuela KL,Sillas-Pardo LJ,Uraga-Camacho NC,Isordia-Salas I,Berumen-Lechuga MG

    更新日期:2018-09-01 00:00:00

  • Rare esophageal ulcers related to Behçet disease: A case report.

    abstract:RATIONALE:The fundamental pathogenesis of Behçet disease (BD) is still unclear and controversial. Many cases of oral aphthous ulcers and genital ulcers related to BD are reported; nevertheless, idiopathic giant esophageal ulcers related to BD are rare. A rare case for esophageal ulcers related to BD is presented. PATI...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000008469

    authors: Jia N,Tang Y,Liu H,Li Y,Liu S,Liu L

    更新日期:2017-11-01 00:00:00

  • Pancreatic carcinosarcoma mimics malignant intraductal papillary mucinous neoplasm: A rare case report and literature review.

    abstract:RATIONALE:Carcinosarcoma, an extremely rare pancreatic primary tumor, is characterized by coexistence of both carcinomatous and sarcomatous components. Due to its rarity, the clinical manifestation and imaging features have not been recognized. An accurate diagnostic method has not been available and a widely accepted ...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MD.0000000000006961

    authors: Li BQ,Liu QF,Chang XY,Hu Y,Chen J,Guo JC

    更新日期:2017-06-01 00:00:00

  • Prevention of venous thromboembolism in patients with cancer with direct oral anticoagulants: A systematic review and meta-analysis.

    abstract:BACKGROUND:Patients with cancer are of a high level risk of venous thromboembolism (VTE). Low molecular weight heparin (LMWH) is recommended as the normal treatment for cancer-associated venous thrombosis. Recently, some studies suggest that patients with cancer-associated venous thrombosis can get a good efficacy and ...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000019000

    authors: Chen H,Tao R,Zhao H,Jiang J,Yang J

    更新日期:2020-01-01 00:00:00

  • Metastatic cardiac tumor presenting as atrial fibrillation in a previously healthy woman: A case report.

    abstract:RATIONALE:Metastatic cardiac tumor (MCT) is rare in clinical practice. MCT presenting initially as atrial fibrillation (AF) is even rarer. PATIENT CONCERNS:We report a 47-year-old woman with no previous medical history presented with intermittent palpitation for 3 days. DIAGNOSES:The electrocardiography showed AF wit...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000007649

    authors: Cheng CW,Yang NI,Ng KK,Cherng WJ

    更新日期:2017-08-01 00:00:00

  • Association of CD14 -159 (-260C/T) polymorphism and asthma risk: an updated genetic meta-analysis study.

    abstract:BACKGROUND:It has been reported that the cluster of differentiation 14 (CD14) gene -159C/T variant may be associated with asthma risk. However, some studies yielded conflicting results. Therefore, a comprehensive meta-analysis was designed to assess the precise association. METHODS:A systematic search in PubMed, Embas...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000004959

    authors: Wang D,Yang Y,Xu J,Zhou ZK,Yu HY

    更新日期:2016-09-01 00:00:00

  • Evidence-based practice: Knowledge, attitudes, implementation, facilitators, and barriers among community nurses-systematic review.

    abstract:BACKGROUND:This study is to summarize the status of knowledge, attitudes, implementation, facilitators, and barriers of evidence-based practice (EBP) in community nurses (CNs). EBP has been widely adopted but the knowledge, attitudes, and implementation of EBP among CNs, and the facilitators and barriers they perceived...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000017209

    authors: Li S,Cao M,Zhu X

    更新日期:2019-09-01 00:00:00

  • The relationship between hyperglycemia and the infection of COVID-19 in diabetic patients: A protocol for systematic review and meta-analysis.

    abstract:BACKGROUND:DM is a common chronic metabolic disease. COVID-19 is an infectious disease infected by enveloped single-stranded RNA coronavirus. Meanwhile, DM is a common comorbidity of SARS-CoV-2 infection. The virus can directly or indirectly damage the pancreatic islets and cause stress hyperglycemia by causing cytokin...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000021806

    authors: Liu Y,Yang Y,Chen Y,Zhou L,Xiong Q,Xie C

    更新日期:2020-09-04 00:00:00

  • Risk of hospitalization for hypoglycemia among older Korean people with diabetes mellitus: Interactions between treatment modalities and comorbidities.

    abstract::The objective of this study was to carry out a large population-based study to understand the factors associated with hypoglycemia-related hospitalizations among older Korean adults with diabetes mellitus.This study analyzed data from a subset of the 2013 Health Insurance and Review and Assessment service-Adult Patien...

    journal_title:Medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MD.0000000000005016

    authors: Kim HM,Seong JM,Kim J

    更新日期:2016-10-01 00:00:00

  • Role of immune cells in pancreatic cancer from bench to clinical application: An updated review.

    abstract:BACKGROUND:Pancreatic cancer (PC) remains difficult to treat, despite the recent advances in various anticancer therapies. Immuno-inflammatory response is considered to be a major risk factor for the development of PC in addition to a combination of genetic background and environmental factors. Although patients with P...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MD.0000000000005541

    authors: Chang JH,Jiang Y,Pillarisetty VG

    更新日期:2016-12-01 00:00:00

  • Effect of dexmedetomidine added to ropivicaine for caudal anesthesia in patients undergoing hemorrhoidectomy: A prospective randomized controlled trial.

    abstract:BACKGROUND:To assess the effect of dexmedetomidine added to ropivaccaine on the onset and duration of sensory block, as well as postoperative analgesia during caudal anesthesia in patients undergoing hemorrhoidectomy. METHODS:Fifty adult patients scheduled for hemorrhoidectomy were divided into 2 groups. The group R r...

    journal_title:Medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MD.0000000000011731

    authors: Xu D,Xiu M,Zhang X,Zhu P,Tian L,Feng J,Wu Y,Zhao Z,Luan H

    更新日期:2018-08-01 00:00:00

  • Efficacy and safety of traditional Chinese medicine for erosive oral lichen planus: A protocol for systematic review and meta analysis.

    abstract:BACKGROUND:Oral lichen planus (OLP) is a common disease among oral mucous membrane diseases. Erosive oral lichen planus (EOLP) is a type of OLP, it has a potential tendency of cancerization. There have been some randomized controlled trials (RCTs) using Traditional Chinese Medicine (TCM) to treat EOLP. No systematic re...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000023375

    authors: You Y,Huang X,Chen Y,You Y

    更新日期:2020-11-25 00:00:00

  • Association Between Race/Ethnicity and Survival of Melanoma Patients in the United States Over 3 Decades: A Secondary Analysis of SEER Data.

    abstract:UNLABELLED:Melanoma is a treatable and preventable skin cancer. It is responsible for 75% of deaths among all skin cancers. Previous studies have found that race/ethnicity may play a role in survival among melanoma patients. However, there are no studies that cover 30 years and take race into account for the U.S. POPU...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000003315

    authors: Ward-Peterson M,Acuña JM,Alkhalifah MK,Nasiri AM,Al-Akeel ES,Alkhaldi TM,Dawari SA,Aldaham SA

    更新日期:2016-04-01 00:00:00

  • Xiaoaiping injection as adjunct therapy for patients with advanced esophageal carcinoma: A protocol for a systematic review and meta-analysis.

    abstract:BACKGROUND:Esophageal carcinoma (EC) is one of the worst malignant digestive neoplasms with a strong tendency of invasion and metastasis. Despite the improvement of diagnostic and therapeutic methods in the past decades, the prognosis of EC remains unsatisfactory. Xiaoaiping injection (XAPI), a famous traditional Chine...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000020984

    authors: Liu Z,Dong Y,Zhu M,Mu Y,Chen L

    更新日期:2020-06-26 00:00:00

  • Why recurrence was initially suspected during colorectal cancer postoperative surveillance?: A retrospective analysis.

    abstract::Routine postoperative surveillance is recommended for the patients with colorectal cancer (CRC). This study aimed to clarify the conditions indicate initial suspicion of CRC recurrence in different preoperative serum carcinoembryonic antigen (CEA) level groups, including positive physical signs/symptoms, elevated CEA ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000022803

    authors: Hung H,You J,Chiang J,Hsieh P,Chiang S,Lai C,Tasi W,Yeh C

    更新日期:2020-10-23 00:00:00

  • Acupuncture on treating angina pectoris: A systematic review.

    abstract:BACKGROUND:Coronary heart disease angina pectoris is a common clinical symptom in patients with coronary heart disease, due to coronary atherosclerotic stenosis or sputum leading to coronary insufficiency, myocardial transient ischemia, hypoxia caused by precordial pain as the main clinical manifestations Group syndrom...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000018548

    authors: Wang JS,Yu XD,Deng S,Yuan HW,Li HS

    更新日期:2020-01-01 00:00:00

  • Inflammation-based Glasgow Prognostic Score in patients with acute ST-segment elevation myocardial infarction: A prospective cohort study.

    abstract::The inflammation-based Glasgow Prognostic Score (GPS), which involves C-reactive protein and serum albumin levels, has been reported to be a strong independent predictor of mortality in many cancers. This study aimed to investigate whether the GPS is associated with mortality in patients with acute ST-segment elevatio...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000013615

    authors: Jia Y,Li D,Cao Y,Cheng Y,Xiao L,Gao Y,Zhang L,Zeng Z,Wan Z,Zeng R

    更新日期:2018-12-01 00:00:00

  • Bacteremic Urinary Tract Infection Caused by Multidrug-Resistant Enterobacteriaceae Are Associated With Severe Sepsis at Admission: Implication for Empirical Therapy.

    abstract::The purpose of this study is to compare the clinical features and treatment outcomes among patients with bacteremic urinary tract infection (UTI) caused by multidrug-resistant (MDR) and non-MDR Enterobacteriaceae and to identify whether MDR pathogens were independently associated with severe sepsis or septic shock at ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000003694

    authors: Lee YC,Hsiao CY,Hung MC,Hung SC,Wang HP,Huang YJ,Wang JT

    更新日期:2016-05-01 00:00:00

  • The role of acupotomy in treatment of patients with lumbar spinal stenosis: A protocol for a randomized study.

    abstract:BACKGROUND:Currently, there is some clinical evidence supporting the use of acupuncture in alleviating pain and dysfunction in patients with lumbar spinal stenosis (LSS). However, the question of whether acupuncture could be efficacious for ageing patients remains unanswered. We designed a randomized controlled study t...

    journal_title:Medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MD.0000000000021444

    authors: Chen Y,Song H,Chen M,Xu H

    更新日期:2020-07-31 00:00:00

  • Gastric mucormycosis complicated by a gastropleural fistula: A case report and review of the literature.

    abstract:RATIONALE:Mucormycosis is a rare opportunistic fungal infection with poor prognosis. The incidence of mucormycosis has been increasing, and it is a threat to immunocompromised hosts. We present a case of gastric mucormycosis complicated by a gastropleural fistula during immunosuppressive treatment for adult-onset Still...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MD.0000000000018142

    authors: Uchida T,Okamoto M,Fujikawa K,Yoshikawa D,Mizokami A,Mihara T,Kondo A,Ohba K,Kurohama K,Nakashima M,Sekine I,Nakamura S,Miyazaki Y,Kawakami A

    更新日期:2019-11-01 00:00:00

  • Impressive long-term response with chemo-endocrine therapy in a premenopausal patient with metastatic breast cancer: A case report.

    abstract:RATIONALE:Patients with, or who develop, metastatic breast cancer have a 5-year relative survival of about 25%. Endocrine therapy clearly improves outcomes in patients with estrogen receptor-positive breast cancer. In the metastatic setting, the primary goal of treatment is to maintain long-term disease control with go...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000020396

    authors: Maltoni R,Palleschi M,Gallerani G,Bravaccini S,Cecconetto L,Melegari E,Altini M,Rocca A

    更新日期:2020-06-12 00:00:00

  • The association of hypernatremia and hypertonic saline irrigation in hepatic hydatid cysts: A case report and retrospective study.

    abstract:RATIONALE:Hypernatremia is a rare but fatal complication of hypertonic saline (HS) irrigation in hepatic hydatid disease. It needs careful monitoring and treatment. PATIENT CONCERNS:A 28-year-old woman with hepatic hydatid cysts who received operation treatment developed electrolyte disturbances. We also conducted a r...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000007889

    authors: Zeng R,Wu R,Lv Q,Tong N,Zhang Y

    更新日期:2017-09-01 00:00:00

  • Rare purulent pericarditis caused by carbapenem-resistant Acinetobacter baumannii: A case report.

    abstract:BACKGROUND:Pericardial infection caused by Acinetobacter baumannii is rare, particularly that of carbapenem-resistant A baumannii (CRAB). CASE PRESENTATION:We describe a rare case of purulent pericarditis due to CRAB in a 76-year-old man with acute myocardial infarction and acute kidney injury. The man was admitted to...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000017034

    authors: Liu J,Xiao X,Cen C,Yuan H,Yang M

    更新日期:2019-09-01 00:00:00

  • Risk of rash associated with vandetanib treatment in non-small-cell lung cancer patients: A meta-analysis of 9 randomized controlled trials.

    abstract:BACKGROUND:Vandetanib is a promising anticancer target agent for treating advanced carcinomas, such as non-small-cell lung cancer (NSCLC) and breast cancer. Rash is a frequently reported adverse event of vandetanib. We conducted this meta-analysis to determine the incidence rate and overall risks of all-grade and high-...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000008345

    authors: Liu Y,Qi M,Hou S,Shao L,Zhang J,Li Y,Liu Q

    更新日期:2017-10-01 00:00:00

  • Association between tumor necrosis factor-alpha G-308A polymorphism and dental peri-implant disease risk: A meta-analysis.

    abstract:BACKGROUND:Tumor necrosis factor-alpha (TNF-α) is a potent immune-inflammatory mediator involved in the regulation of bone resorption. The single nucleotide polymorphism G-308A in the TNF-α gene increases the level of this cytokine. This phenomenon is also related to several diseases. Although the association between T...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MD.0000000000004425

    authors: Mo YY,Zeng XT,Weng H,Cen Y,Zhao Q,Wen X

    更新日期:2016-08-01 00:00:00

  • Topical use of tranexamic acid can effectively decrease hidden blood loss during posterior lumbar spinal fusion surgery: A retrospective study.

    abstract::In spinal fusion surgery, total blood loss (TBL) is composed of visible blood loss from the surgical field and wound drainage, and hidden blood loss (HBL). Until now, no published studies exist reporting the effect of topical use of tranexamic acid (tTXA) on HBL in patients undergoing posterior lumbar spinal fusion su...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000008233

    authors: Ren Z,Li S,Sheng L,Zhuang Q,Li Z,Xu D,Chen X,Jiang P,Zhang X

    更新日期:2017-10-01 00:00:00

  • Orofacial granulomatosis: A case report of three cases may be caused by apical periodontitis.

    abstract:RATIONALE:Orofacial granulomatosis (OFG) is a rare disease characterized by noncaseating granulomatous inflammation. The most common clinical presentation is persistent swelling of the soft tissues in the oral and maxillofacial regions. The precise cause of OFG is unknown. Corticosteroids are the first-line and best tr...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000008102

    authors: Zhang W,Wang J,Yu X,Wang W

    更新日期:2017-09-01 00:00:00

  • Adrenomedullin for Risk Stratification of Emergency Patients With Nonspecific Complaints: An Interventional Multicenter Pilot Study.

    abstract::Patients with nonspecific complaints (NSC) presenting to the emergency department (ED) are at risk of life-threatening conditions. New stress biomarkers such as the midregional portion of adrenomedullin (MR-proADM) promise to support decision-making. This study tested the following hypotheses: biomarker-assisted dispo...

    journal_title:Medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/MD.0000000000002395

    authors: Nickel CH,Messmer AS,Ghanim L,Ilsemann-Karakoumis J,Giersdorf S,Hertel S,Ernst S,Geigy N,Bingisser R

    更新日期:2016-01-01 00:00:00

  • Treatment of Type 2 diabetes with Tianqi Jiangtang Capsule: A systematic review and meta-analysis of randomized controlled trials.

    abstract:BACKGROUND:Tianqi Jiangtang Capsule is a commonly used Chinese patent medicine for the treatment of type 2 diabetes mellitus (T2DM) in China. The purpose of this study is to systematically evaluate the clinical efficacy and safety of Tianqi Jiangtang Capsule in the treatment of type 2 diabetes mellitus. METHODS:Random...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000019702

    authors: Piao C,Zhang Q,Jin,Shao M,Bi C,Wang L,Tang C,Lian F,Tong X

    更新日期:2020-05-22 00:00:00

  • Alström syndrome: A novel mutation in Saudi girl with insulin-resistant diabetes.

    abstract:RATIONALE:Alström syndrome is an autosomal recessive disorder characterized by hearing loss, blindness, obesity, non-insulin dependent diabetes, and others. PATIENT CONCERN:A 10 years old Saudi girl, who presented with diabetic ketoacidosis and found to have hearing loss and blindness. DIAGNOSIS:Alström syndrome. IN...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000006192

    authors: Bakar AA,Kamal NM,Alsaedi A,Turkistani R,Aldosari D

    更新日期:2017-03-01 00:00:00