Lower circulating angiotensin II levels are related to the severity of preeclampsia and its risk as disclosed by a specific bioassay.


:Preeclampsia is characterized by an increased sensitivity to angiotensin II (Ang II). We herein assessed whether serum Ang II levels measured by a new developed bioassay are associated with preeclampsia, its severity, and the risk for developing this disease.Using a cross-sectional design, we studied 90 pregnant women (30 healthy pregnant and 60 with preeclampsia [30 with- and 30 without severe features]). We also used a nested case-control study with 30 women who eventually developed preeclampsia and 31 normotensive controls. Serum samples were collected at diagnosis of preeclampsia or at 4-week intervals (from weeks 12th to 36th). Ang II was measured using a bioassay.At diagnosis of preeclampsia, serum Ang II concentrations were significantly lower in preeclampsia without and with severe features (P = .001 and P < .001, respectively) than in healthy pregnancy. In addition, Ang II was different in preeclampsia with severe features than in those without severe features (P = .048). Women who subsequently developed preeclampsia had lower Ang II levels than women with normal pregnancies, and these changes became significant at 24 weeks onward. The risk to developing preeclampsia was higher among women with Ang II concentration values in the lowest quartile of the control distribution from 12 weeks onward (odds ratio ranging from 3.8 [95% CI 1.3-11.1] to 6.5 [95% CI 1.6-26.9]).We concluded that concentrations of Ang II are markedly diminished at diagnosis of preeclampsia and are closely associated with the severity of disease. Changes in circulating levels of Ang II precede the clinical presentation of preeclampsia.


Medicine (Baltimore)




Leaños-Miranda A,Inova Campos-Galicia,Méndez-Aguilar F,Molina-Pérez CJ,Ramírez-Valenzuela KL,Sillas-Pardo LJ,Uraga-Camacho NC,Isordia-Salas I,Berumen-Lechuga MG




Has Abstract


2018-09-01 00:00:00
















  • Congenital diaphragmatic hernia in association with congenital short esophagus: A case report.

    abstract:RATIONALE:Congenital diaphragmatic hernia (CDH) associated congenital anomalies are present in about 25%. Congenital short esophagus (CSE) is a relatively rare condition. Both CDH and congenital intrathoracic stomach caused by CSE can be diagnosed in utero. However, CSE can be easily misdiagnosed in utero. PATIENT CON...


    pub_type: 杂志文章


    authors: Xia B,Hong C,Tang J,Liu C,Yu G

    更新日期:2017-12-01 00:00:00

  • Contrast-enhanced ultrasound for determining muscular perfusion after oral intake of L-citrulline, L-arginine, and galloylated epicatechines: A study protocol.

    abstract:INTRODUCTION:The market for dietary supplements in the sports sector has been growing rapidly for several years, though there is still lacking evidence regarding their claimed benefits. One group is that of nitric oxide increasing supplements, so-called "NO-boosters," which are claimed to improve the supply of oxygen a...


    pub_type: 杂志文章


    authors: Doll J,Bürkle F,Neide A,Tsitlakidis S,Bruckner T,Schmidmaier G,Fischer C

    更新日期:2020-10-09 00:00:00

  • An ethmoid mucocele causing diplopia: A case report.

    abstract:RATIONALE:Mucocele is a disease lined primarily by epithelium, and occurs mainly when the sinus ostium is obstructed. PATIENT CONCERNS:We report a case of a 37-year-old man who presented with painless proptosis of the right eye and diplopia. DIAGNOSES:The preoperative finding was mucocele of the ethmoid sinus. INTER...


    pub_type: 杂志文章


    authors: Kim JS,Kim EJ,Kwon SH

    更新日期:2017-12-01 00:00:00

  • Gastrointestinal stromal tumor (GIST) with liver metastases: An 18-year experience from the GIST cooperation group in North China.

    abstract::Approximately 40% to 50% of gastrointestinal stromal tumor (GIST) patients will have recurrence or metastases after resection of the primary lesion, and the most common affected sites will be liver and peritoneum. Imatinib has been considered as the first-line therapy of metastatic GIST. Surgery for metastases is prop...


    pub_type: 杂志文章,多中心研究


    authors: Shi YN,Li Y,Wang LP,Wang ZH,Liang XB,Liang H,Zhang L,Li B,Fan LQ,Zhao Q,Ma ZX,Zhao XF,Zhang ZD,Liu Y,Tan BB,Wang D,Wang LL,Hao YJ,Jia N

    更新日期:2017-11-01 00:00:00

  • The effects of exercise therapy on the prognosis of patients with COVID-19: A protocol for systematic review.

    abstract:BACKGROUND:Since the COVID-19 outbreak in 2020, more than 20 million people worldwide have been diagnosed with COVID-19, and all health care workers are looking for ways to improve the cure rate of the disease. As an important method of rehabilitation therapy, exercise therapy has been proved to improve the level of hu...


    pub_type: 杂志文章


    authors: Qiu G,Ji Y,Tan Y,He B,Tan C,Wang Z,Gao H

    更新日期:2020-12-18 00:00:00

  • Serum gamma-glutamyl transferase is a predictor of mortality in patients with acute myocardial infarction.

    abstract::Gamma-glutamyl transferase (GGT) is involved in the pathogenesis of atherosclerosis and has been associated with adverse cardiovascular outcomes in patients with ischemic heart disease. However, the association between GGT and long-term mortality has not been studied in patients with acute myocardial infarction (AMI)....


    pub_type: 杂志文章


    authors: Kim JG,Chang K,Choo EH,Lee JM,Seung KB

    更新日期:2018-07-01 00:00:00

  • Effect of probiotics on lipid profiles and blood pressure in patients with type 2 diabetes: A meta-analysis of RCTs.

    abstract:BACKGROUND:This meta-analysis aimed to systematically evaluate the effects of probiotics on blood lipid and blood pressure among patients with type 2 diabetes mellitus (T2DM) based on the randomized controlled studies. METHODS:PubMed, Cochrane, Embase, Wanfang, China National Knowledge Infrastructure, and VIP database...


    pub_type: 杂志文章,meta分析,评审


    authors: He J,Zhang F,Han Y

    更新日期:2017-12-01 00:00:00

  • Effect of social support and health education on depression scale scores of chronic stroke patients.

    abstract::Post-stroke depression (PSD) constitutes an important complication of stroke, leading to great disability. After stroke, the prevalence rate of depression is about 30%. Depression also affects rehabilitation motivation, delays function recovery, and increases family and social burden. The objective of this study was t...


    pub_type: 杂志文章,随机对照试验


    authors: Lin FH,Yih DN,Shih FM,Chu CM

    更新日期:2019-11-01 00:00:00

  • Gegen huangqin huanglian decoction for children rotavirus enteritis: A protocol for systematic review and meta-analysis.

    abstract:BACKGROUND:Rotavirus infection is the main cause of severe dehydration enteritis in children under 5 years old. It gives rise to malnutrition and even death in children even though there were rotavirus vaccines. However, there is no effective anti-virus drugs for rotavirus, supporting treatments are used in the clinics...


    pub_type: 杂志文章,meta分析


    authors: Wu Y,Tu X,Liang X,Chen J,Wan X,Zhang T,Jiang J,Zhong S

    更新日期:2020-12-04 00:00:00

  • Preoperative lymphocyte-to-monocyte ratio (LMR) could independently predict overall survival of resectable gastric cancer patients.

    abstract::Preoperational hemogram parameters have been reported to be associated with the prognosis of several types of cancers. This study aimed to investigate the prognostic value of hematological parameters in gastric cancer in a Chinese population. A total of 870 gastric cancer patients who underwent radical tumorectomy wer...


    pub_type: 杂志文章


    authors: Pan YC,Jia ZF,Cao DH,Wu YH,Jiang J,Wen SM,Zhao D,Zhang SL,Cao XY

    更新日期:2018-12-01 00:00:00

  • A controlled study on the efficacy and quality of life of laparoscopic intersphincteric resection (ISR) and extralevator abdominoperineal resection (ELAPE) in the treatment of extremely low rectal cancer.

    abstract:BACKGROUND:The aim of this study is to compare the postoperative quality of life (QoL) and survival outcomes in lower rectal cancer (LRC) patients who undergo either laparoscopic- intersphincteric resection or extralevator abdominoperineal excision (L-ELAPE) after long-course neoadjuvant chemoradiation therapy (nCRT). ...


    pub_type: 杂志文章


    authors: Yang W,Huang L,Chen P,Yang Y,Liu X,Wang C,Yu Y,Yang L,Wang Z,Zhou Z

    更新日期:2020-05-29 00:00:00

  • The effect of platelet-rich plasma on reducing blood loss after total knee arthroplasty: A systematic review and meta-analysis.

    abstract:BACKGROUND:Efficacy and safety of platelet-rich plasma (PRP) compared with control for preventing postoperative bleeding after total knee arthroplasty (TKA) is controversial. We performed a meta-analysis of randomized controlled trials (RCTs) to determine whether PRP might reduce blood loss and improve function followi...


    pub_type: 杂志文章,meta分析,评审


    authors: Ma J,Sun J,Guo W,Li Z,Wang B,Wang W

    更新日期:2017-06-01 00:00:00

  • Systemic strongyloidiasis in patients infected with the human immunodeficiency virus. A report of 3 cases and review of the literature.

    abstract::We report 3 cases of systemic strongyloidiasis in HIV-infected individuals and review 11 additional cases reported in the English-language literature. Systemic strongloidiasis is a rare and potentially fatal complication of late-stage HIV disease. A combination of gastrointestinal and respiratory symptoms in an HIV-in...


    pub_type: 杂志文章,评审


    authors: Celedon JC,Mathur-Wagh U,Fox J,Garcia R,Wiest PM

    更新日期:1994-09-01 00:00:00

  • Migration inhibitory factor in spinal tuberculosis: -173G/C polymorphisms, and transcript and protein levels in a northern province of China.

    abstract::The aim of this study was to elucidate the possible association between migration inhibitory factor (MIF)-173G/C gene polymorphisms and transcript and plasma levels of MIF in spinal tuberculosis (TB) patients. Clinical data were collected from 254 spinal TB patients and 262 healthy controls participating in the study....


    pub_type: 杂志文章


    authors: Wang J,Sheng B,Li X,Sun J,Shi L,Wei W,Wang G,Cao X

    更新日期:2020-07-24 00:00:00

  • Grip strength can be used to evaluate postoperative residual neuromuscular block recovery in patients undergoing general anesthesia.

    abstract:BACKGROUND:Residual postoperative neuromuscular blockade is an important clinical issue. Neuromuscular monitoring is usually used to evaluate neuromuscular recovery in patients undergoing general anesthesia. However, this procedure is inconvenient and not widely adopted. We aimed to examine the correlation between grip...


    pub_type: 杂志文章,随机对照试验


    authors: Pei DQ,Zhou HM,Zhou QH

    更新日期:2019-01-01 00:00:00

  • Effect of Dexmedetomidine Alone for Intravenous Patient-Controlled Analgesia After Gynecological Laparoscopic Surgery: A Consort-Prospective, Randomized, Controlled Trial.

    abstract::Gynecological laparoscopic surgery is minimally invasive compared with open surgical approaches, but postoperative pain is generally undermanaged. Pain management strategies related to the procedure-specific efficacy are needed. Many studies have shown that dexmedetomidine (DEX) has opioid-sparing properties. It is no...


    pub_type: 杂志文章,随机对照试验


    authors: Wang X,Liu W,Xu Z,Wang F,Zhang C,Wang B,Wang K,Yu J

    更新日期:2016-05-01 00:00:00

  • Effectiveness of physiotherapy on quality of life in children with asthma: Study protocol for a systematic review and meta-analysis.

    abstract:BACKGROUND:Asthma is the most common chronic lung disease in childhood, leading to a great burden to the healthcare system worldwide. Despite the medication treatment, physiotherapy is now applied for asthmatic children aiming to improve their lung function and life quality. However, the effectiveness of physiotherapy ...


    pub_type: 杂志文章


    authors: Zhang W,Liu L,Yang W,Liu H

    更新日期:2019-06-01 00:00:00

  • Altered Spontaneous Brain Activity in Betel Quid Dependence: A Resting-state Functional Magnetic Resonance Imaging Study.

    abstract::It has been suggested by the first voxel-based morphometry investigation that betel quid dependence (BQD) individuals are presented with brain structural changes in previous reports, and there may be a neurobiological basis for BQD individuals related to an increased risk of executive dysfunction and disinhibition, su...


    pub_type: 杂志文章


    authors: Liu T,Li JJ,Zhao ZY,Yang GS,Pan MJ,Li CQ,Pan SY,Chen F

    更新日期:2016-02-01 00:00:00

  • Impact of neurological diseases on family planning: A single-center experience.

    abstract::This cross-sectional study aimed to assess the impact of epilepsy, myasthenia gravis (MG), and multiple sclerosis (MS) on pregnancy and family planning decision-making in a cohort of Saudi women. Women with epilepsy, MG, and MS were recruited consecutively at the time of their follow-up visits at a neurology clinic. D...


    pub_type: 杂志文章


    authors: Alanazy MH,Asiri A,Edrees MF,Abuzinadah AR

    更新日期:2020-10-30 00:00:00

  • Prediction of the outcome of bladder dysfunction based on electrically induced reflex findings in patients with cauda equina syndrome: A retrospective study.

    abstract::The evaluation of the electrically induced bulbocavernosus reflex (BCR) using electromyography (EMG) is a useful tool for evaluating the integrity of sacral spinal segments 2 to 4, and that of their afferent and efferent connections in the urogenital region. In the current retrospective study, the value of this techni...


    pub_type: 杂志文章


    authors: Lee DG,Kwak SG,Chang MC

    更新日期:2017-05-01 00:00:00

  • Unmet challenges in treating hypertension in patients with borderline personality disorder: A systematic review.

    abstract:BACKGROUND:Caregivers encounter serious and substantial challenges in managing hypertension in patients with subclinical or clinical borderline personality disorder (BPD). These challenges include therapeutic conflicts resulting from harmful drug-drug, and drug-disease interactions. Current guidelines provide no recomm...


    pub_type: 杂志文章


    authors: Roininen SM,Cheetham M,Mueller BU,Battegay E

    更新日期:2019-09-01 00:00:00

  • Histoplasmosis among human immunodeficiency virus-infected people in Europe: report of 4 cases and review of the literature.

    abstract::We reviewed the clinical, microbiologic, and outcome characteristics of 72 patients with human immunodeficiency virus (HIV)-associated histoplasmosis (4 newly described) reported in Europe over 20 years (1984-2004). Seven cases (9.7%) were acquired in Europe (autochthonous), whereas the majority involved a history of ...


    pub_type: 杂志文章,评审


    authors: Antinori S,Magni C,Nebuloni M,Parravicini C,Corbellino M,Sollima S,Galimberti L,Ridolfo AL,Wheat LJ

    更新日期:2006-01-01 00:00:00

  • New vertebral fractures after osteoporotic vertebral compression fracture between balloon kyphoplasty and nonsurgical treatment PRISMA.

    abstract:BACKGROUND:Because of aging of population, osteoporotic vertebral compression fracture (OVCF) appears an increasing incidence rate. Conservative therapy (CT) and balloon kyphoplasty (BKP) have been used to treat OVCFs. However, an increase in new vertebral compression fractures at nontreated levels following BKP is of ...


    pub_type: 杂志文章,meta分析,评审


    authors: Li HM,Zhang RJ,Gao H,Jia CY,Zhang JX,Dong FL,Shen CL

    更新日期:2018-10-01 00:00:00

  • Application of enamel matrix derivative and deproteinized bovine bone for the treatment of peri-implantitis after decontamination with an ultrasonic scaler: A case report.

    abstract:RATIONALE:The purpose of this report is to present a case of peri-implantitis with successful regeneration. The surface of the affected dental implant was decontaminated with an ultrasonic scaler and treated with bovine-derived hydroxyapatite and enamel matrix derivative. PATIENT CONCERNS:A 52-year-old male was referr...


    pub_type: 杂志文章


    authors: Park JB

    更新日期:2018-11-01 00:00:00

  • Renal transplantation in scleroderma.

    abstract::Although the outcome of renal transplantation in patients with systemic lupus erythematosus (SLE) has been studied, there are few reports about the outcome of patients with systemic sclerosis who have undergone renal transplantation. We retrospectively collected data from the United Network for Organ Sharing (UNOS) Sc...


    pub_type: 杂志文章


    authors: Chang YJ,Spiera H

    更新日期:1999-11-01 00:00:00

  • Association of Histone Methyltransferase G9a and Overall Survival After Liver Resection of Patients With Hepatocellular Carcinoma With a Median Observation of 40 Months.

    abstract::Approximately 50% of patients with hepatocellular carcinoma (HCC) reside in China. HCC is associated with very high mortality compared with other cancers. Although numerous factors influence the survival of patients with HCC who undergo liver resection, the role of the tumor biomarker histone methyltransferase (G9a) i...


    pub_type: 杂志文章


    authors: Bai K,Cao Y,Huang C,Chen J,Zhang X,Jiang Y

    更新日期:2016-01-01 00:00:00

  • Emergency department companions of stroke patients: implications on quality of care.

    abstract::Acute care of stroke victims largely relies on the rapid identification and timely clinical and radiological assessment. We evaluated the effect of the number of patient companions on the efficiency of the diagnostic process in the emergency department (ED).Consecutive stroke patients admitted to the ED between August...


    pub_type: 杂志文章


    authors: Ashkenazi L,Toledano R,Novack V,EIluz E,Abu-Salamae I,Ifergane G

    更新日期:2015-03-01 00:00:00

  • Computed tomographic findings of chest injuries following cardiopulmonary resuscitation: More complications for prolonged chest compressions?

    abstract::Chest injuries are common and inevitable complications of chest compressions during cardiopulmonary resuscitation (CPR). This study aimed to investigate lung parenchymal and thoracic skeletal injuries after CPR by using computed tomography (CT) and to analyze the correlation between the duration of CPR and related com...


    pub_type: 杂志文章


    authors: Jang SJ,Cha YK,Kim JS,Do HH,Bak SH,Kwack WG

    更新日期:2020-08-14 00:00:00

  • Ultrasound follow-up of spontaneous tears of the plantar fascia treated with conservative therapies: Two case reports.

    abstract:RATIONALE:The plantar fascia (PF) is an important anatomical structure that stabilizes the longitudinal arch of the foot. While plantar fasciitis is a common pathology affecting the foot, tears of the PF are uncommon injuries characterized by acute pain in the plantar aspect of the foot. The main purpose of this paper ...


    pub_type: 杂志文章


    authors: Cocco G,Ricci V,Boccatonda A,Abate M,Guagnano MT,Schiavone C

    更新日期:2019-12-01 00:00:00

  • Effect of prenatal and postnatal malnutrition on intellectual functioning in early school-aged children in rural western China.

    abstract::The aim of this study was to evaluate the effect of prenatal and postnatal malnutrition on the intellectual functioning of early school-aged children. We followed the offspring of women who had participated in a trial of prenatal supplementation with different combinations of micronutrients and who remained resident i...


    pub_type: 杂志文章


    authors: Li C,Zhu N,Zeng L,Dang S,Zhou J,Yan H

    更新日期:2016-08-01 00:00:00