Microglia-derived TNF-α mediates endothelial necroptosis aggravating blood brain-barrier disruption after ischemic stroke.

abstract：:Bone marrow mesenchymal stem cells (MSCs) have demonstrated therapeutic effects for colitis through immunomodulation and anti-inflammation. However, whether MSC-derived exosomes possessed the similar function remains unclear. In present study, exosomes were isolated from control and IFN-γ-primed MSCs and was verified ...

journal_title：Cell death & disease

authors： Yang R,Huang H,Cui S,Zhou Y,Zhang T,Zhou Y

更新日期：2020-07-30 00:00:00

abstract：:Malignant gliomas, the most common solid tumors in the central nervous system, are essentially incurable due to their rapid growth and very invasive nature. One potential approach to eradicating glioma cells is to force these cells to undergo terminal differentiation and, in the process, to irreversible postmitotic ar...

journal_title：Cell death & disease

authors： Su Z,Zang T,Liu ML,Wang LL,Niu W,Zhang CL

更新日期：2014-10-16 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a highly aggressive tumor characterized by distant metastasis. Deletion or down-regulation of the tumor suppressor protein ras-association domain family protein1 isoform A (RASSF1A) has been confirmed to be a key event in NPC progression; however, little is known about the effects or ...

journal_title：Cell death & disease

authors： Liang YY,Deng XB,Lin XT,Jiang LL,Huang XT,Mo ZW,Yuan YW,Teh MT

更新日期：2020-10-14 00:00:00

abstract：:Homeostatic chemokines, such as CXCL12, can affect neuronal activity by the regulation of inhibitory and excitatory neurotransmission, but the mechanisms involved are still undefined. Our previous studies have shown that CXCL12 protects cortical neurons from excitotoxicity by promoting the function of the gene-repress...

journal_title：Cell death & disease

authors： Nicolai J,Burbassi S,Rubin J,Meucci O

更新日期：2010-04-01 00:00:00

abstract：:Protein tyrosine kinase 7 (PTK7) and cancer-associated fibroblasts (CAFs) play important roles in cancer stemness, respectively. However, little is known about interaction between CAFs and PTK7 in cancers. In this study, we showed that PTK7 was significantly correlated with the Wnt/β-Catenin pathway and aggressive cli...

journal_title：Cell death & disease

authors： Yu B,Wu K,Wang X,Zhang J,Wang L,Jiang Y,Zhu X,Chen W,Yan M

更新日期：2018-10-22 00:00:00

abstract：:As a key member of the forkhead box transcription factors, forkhead box F2 (FOXF2) serves as a transcriptional regulator and regulates downstream gene expression in embryonic development, metabolism and in some common diseases, such as stroke and gastroparesis. Recent studies have shown that aberrant expression of FOX...

journal_title：Cell death & disease

authors： He W,Kang Y,Zhu W,Zhou B,Jiang X,Ren C,Guo W

更新日期：2020-06-05 00:00:00

abstract：:The serine protease hepsin is frequently overexpressed in human prostate cancer (PCa) and is associated with matrix degradation and PCa progression in mice. Curiously, low expression of hepsin is associated with poor survival in different cancer types, and transgenic overexpression of hepsin leads to loss of viability...

journal_title：Cell death & disease

authors： Willbold R,Wirth K,Martini T,Sültmann H,Bolenz C,Wittig R

更新日期：2019-08-09 00:00:00

abstract：:The proteins of the Bcl-2 family have a crucial role in mitochondrial outer membrane permeabilization during apoptosis and in the regulation of mitochondrial dynamics. Current models consider that Bax forms toroidal pores at mitochondria that are responsible for the release of cytochrome c, whereas Bcl-xL inhibits por...

journal_title：Cell death & disease

authors： Bleicken S,Hofhaus G,Ugarte-Uribe B,Schröder R,García-Sáez AJ

更新日期：2016-02-25 00:00:00

abstract：:Autophagy has a fundamental role in maintaining cell homeostasis. Although autophagy has been implicated in glaucomatous pathology, how it regulates retinal ganglion cell (RGC) injury is largely unknown. In the present work, we found that biphasic autophagy in RGCs occurred in a mouse model of chronic ocular hypertens...

journal_title：Cell death & disease

authors： Zhang ML,Zhao GL,Hou Y,Zhong SM,Xu LJ,Li F,Niu WR,Yuan F,Yang XL,Wang Z,Miao Y

更新日期：2020-09-10 00:00:00

abstract：:Glucocorticoids (GCs) are metabolic hormones with immunosuppressive effects that have proven effective drugs against childhood acute lymphoblastic leukemia (ALL). Yet, the role of metabolic reprogramming in GC-induced ALL cell death is poorly understood. GCs efficiently block glucose uptake and metabolism in ALL cells...

journal_title：Cell death & disease

authors： Dyczynski M,Vesterlund M,Björklund AC,Zachariadis V,Janssen J,Gallart-Ayala H,Daskalaki E,Wheelock CE,Lehtiö J,Grandér D,Tamm KP,Nilsson R

更新日期：2018-08-28 00:00:00

abstract：:HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome represents a life-threatening pregnancy disorder with high fetal and maternal mortality, but its underlying molecular mechanisms remain unknown. Although apoptosis has been implicated in HELLP syndrome, its pathogenic role remains largely unclear. In th...

journal_title：Cell death & disease

authors： John K,Wielgosz S,Schulze-Osthoff K,Bantel H,Hass R

更新日期：2013-10-24 00:00:00

abstract：:Growing evidence indicates that cell adhesion to extracellular matrix (ECM) plays an important role in cancer chemoresistance. Leukemic T cells express several adhesion receptors of the β1 integrin subfamily with which they interact with ECM. However, the role of β1 integrins in chemoresistance of T-cell acute lymphob...

journal_title：Cell death & disease

authors： Berrazouane S,Boisvert M,Salti S,Mourad W,Al-Daccak R,Barabé F,Aoudjit F

更新日期：2019-05-01 00:00:00

abstract：:WD repeat protein 79 (WDR79) is a member of the WD-repeat protein family and functions as a scaffold protein during telomerase assembly, Cajal body formation and DNA double strand break repair. We have previously shown that WDR79 is frequently overexpressed in cell lines and tissues derived from non-small cell lung ca...

journal_title：Cell death & disease

authors： Sun Y,Cao L,Sheng X,Chen J,Zhou Y,Yang C,Deng T,Ma H,Feng P,Liu J,Tan W,Ye M

更新日期：2017-04-13 00:00:00

abstract：:Mitochondrial apoptosis-inducing factor (AIF) influences the oxidative phosphorylation (OXPHOS) system and can be recruited as a mediator of cell death. Pathogenic mutations in the AIFM1 gene cause severe human diseases. Clinical manifestations include inherited peripheral neuropathies, prenatal cerebral abnormalities...

journal_title：Cell death & disease

authors： Meyer K,Buettner S,Ghezzi D,Zeviani M,Bano D,Nicotera P

更新日期：2015-07-09 00:00:00

abstract：:Plant-derived dietary antioxidants have attracted considerable interest in recent past for their chemopreventive and cancer therapeutic abilities in animal models. Thymoquinone (TQ) is the major bioactive constituent of volatile oil of Nigella sativa and has been shown to exert various pharmacological properties, such...

journal_title：Cell death & disease

authors： Zubair H,Khan HY,Sohail A,Azim S,Ullah MF,Ahmad A,Sarkar FH,Hadi SM

更新日期：2013-06-06 00:00:00

abstract：:Vascular endothelial growth factor receptor (VEGFR) and neuropilins (NRPs), a co-receptor of VEGF, play a key role in the formation and development of blood vessels and in tumour growth and metastasis. However, whether VEGFR1/2 and NRP1 are regulated by the same upstream mechanism is unclear, especially in gastric can...

journal_title：Cell death & disease

authors： Mei B,Chen J,Yang N,Peng Y

更新日期：2020-04-17 00:00:00

abstract：:Lung adenocarcinoma remains a threat to human health due to its high rate of recurrence and distant metastasis. However, the molecular mechanism underlying lung adenocarcinoma metastasis remains yet incompletely understood. Here, we show that upregulated expression of polypeptide N-acetylgalactosaminyltransferase6 (GA...

journal_title：Cell death & disease

authors： Song J,Liu W,Wang J,Hao J,Wang Y,You X,Du X,Zhou Y,Ben J,Zhang X,Ye M,Wang Q

更新日期：2020-05-11 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Cell death & disease

authors： Moon H-,Cao Y,Yang J,Lee JH,Choi HS,Jin Y

更新日期：2020-02-12 00:00:00

abstract：:Although numerous pathogenic changes within the mitochondrial respiratory chain (RC) have been associated with an elevated occurrence of apoptosis within the affected tissues, the mechanistic insight into how mitochondrial dysfunction initiates apoptotic cell death is still unknown. In this study, we show that the spe...

journal_title：Cell death & disease

authors： Schüll S,Günther SD,Brodesser S,Seeger JM,Tosetti B,Wiegmann K,Pongratz C,Diaz F,Witt A,Andree M,Brinkmann K,Krönke M,Wiesner RJ,Kashkar H

更新日期：2015-03-12 00:00:00

abstract：:Unloading-induced bone loss is a threat to human health and can eventually result in osteoporotic fractures. Although the underlying molecular mechanism of unloading-induced bone loss has been broadly elucidated, the pathophysiological role of long noncoding RNAs (lncRNAs) in this process is unknown. Here, we identifi...

journal_title：Cell death & disease

authors： Wang K,Wang Y,Hu Z,Zhang L,Li G,Dang L,Tan Y,Cao X,Shi F,Zhang S,Zhang G

更新日期：2020-05-19 00:00:00

abstract：:Despite decades of research, the pathogenesis of acute respiratory distress syndrome (ARDS) remains poorly understood, thus impeding the development of effective treatment. Diffuse alveolar damage (DAD) and lung epithelial cell death are prominent features of ARDS. Lung epithelial cells are the first line of defense a...

journal_title：Cell death & disease

authors： Moon HG,Cao Y,Yang J,Lee JH,Choi HS,Jin Y

更新日期：2015-12-10 00:00:00

abstract：:Previously, we confirmed that sphingosine kinase 1 (SphK1) inhibition improves sepsis-associated liver injury. High-mobility group box 1 (HMGB1) translocation participates in the development of acute liver failure. However, little information is available on the association between SphK1 and HMGB1 translocation during...

journal_title：Cell death & disease

authors： Tian T,Yao D,Zheng L,Zhou Z,Duan Y,Liu B,Wang P,Li Y

更新日期：2020-12-06 00:00:00

abstract：:Ewing sarcoma (ES) is the second most frequent childhood bone cancer driven by the EWS/FLI1 (EF) fusion protein. Genetically defined ES models are needed to understand how EF expression changes bone precursor cell differentiation, how ES arises and through which mechanisms of inhibition it can be targeted. We used mes...

journal_title：Cell death & disease

authors： Javaheri T,Kazemi Z,Pencik J,Pham HT,Kauer M,Noorizadeh R,Sax B,Nivarthi H,Schlederer M,Maurer B,Hofbauer M,Aryee DN,Wiedner M,Tomazou EM,Logan M,Hartmann C,Tuckermann JP,Kenner L,Mikula M,Dolznig H,Üren A,Richt

更新日期：2016-10-13 00:00:00

abstract：:An increasing interest in liver cancer stemness arises owing to its aggressive behavior and poor prognosis. CD133, a widely known liver cancer stem cell marker, plays critical roles in the maintenance of liver cancer stemness. Thus, exploring the regulatory mechanism of CD133 expression is significant. In the present ...

journal_title：Cell death & disease

authors： Wang Y,Wu G,Fu X,Xu S,Wang T,Zhang Q,Yang Y

更新日期：2019-06-13 00:00:00

abstract：:The control of glucose metabolism and the cell cycle must be coordinated in order to guarantee sufficient ATP and anabolic substrates at distinct phases of the cell cycle. The family of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFKFB1-4) are well established regulators of glucose metabolism via their synt...

journal_title：Cell death & disease

authors： Yalcin A,Clem BF,Imbert-Fernandez Y,Ozcan SC,Peker S,O'Neal J,Klarer AC,Clem AL,Telang S,Chesney J

更新日期：2014-07-17 00:00:00

abstract：:Interleukin-8 (IL-8) expression correlates with poor prognosis in many cancers, including head and neck squamous cell carcinoma (HNSCC), but the underlying mechanism is poorly understood. In this study, we found that overexpression of IL-8 correlated with poor outcome in HNSCC patients. IL-8 significantly increased ce...

journal_title：Cell death & disease

authors： Xu Q,Ma H,Chang H,Feng Z,Zhang C,Yang X

更新日期：2020-05-29 00:00:00

abstract：:Acute lung injury (ALI) is a pulmonary disorder, which can result in fibrosis of the lung tissues. Recently, mesenchymal stem cell (MSC) has become a novel therapeutic method for ALI. However, the potential mechanism by which MSC regulates the progression of ALI remains blurry. The present study focused on investigati...

journal_title：Cell death & disease

authors： Xiao K,He W,Guan W,Hou F,Yan P,Xu J,Zhou T,Liu Y,Xie L

更新日期：2020-10-15 00:00:00

abstract：:The process by which epithelial features are lost in favor of a mesenchymal phenotype is referred to as epithelial-mesenchymal transition (EMT). Most carcinomas use this mechanism to evade into neighboring tissues. Reduction or a loss of E-cadherin expression is a well-established hallmark of EMT. As a potent suppress...

journal_title：Cell death & disease

authors： Meng X,Kong DH,Li N,Zong ZH,Liu BQ,Du ZX,Guan Y,Cao L,Wang HQ

更新日期：2014-02-27 00:00:00

abstract：:Glioblastoma multiforme (GBM) are resistant to TNFα-induced apoptosis and blockade of TNFα-induced NF-κB activation sensitizes glioma cells to apoptosis. As Casein kinase-2 (CK2) induces aberrant NF-κB activation and as we observed elevated CK2 levels in GBM tumors, we investigated the potential of CK2 inhibitors (CK2...

journal_title：Cell death & disease

authors： Dixit D,Sharma V,Ghosh S,Mehta VS,Sen E

更新日期：2012-02-09 00:00:00

abstract：:Microglia serve as the innate immune cells of the central nervous system (CNS) by providing continuous surveillance of the CNS microenvironment and initiating defense mechanisms to protect CNS tissue. Upon injury, microglia transition into an activated state altering their transcriptional profile, transforming their m...

journal_title：Cell death & disease

authors： Hagan N,Kane JL,Grover D,Woodworth L,Madore C,Saleh J,Sancho J,Liu J,Li Y,Proto J,Zelic M,Mahan A,Kothe M,Scholte AA,Fitzgerald M,Gisevius B,Haghikia A,Butovsky O,Ofengeim D

更新日期：2020-10-23 00:00:00