Abstract:
:Interleukin-8 (IL-8) expression correlates with poor prognosis in many cancers, including head and neck squamous cell carcinoma (HNSCC), but the underlying mechanism is poorly understood. In this study, we found that overexpression of IL-8 correlated with poor outcome in HNSCC patients. IL-8 significantly increased cellular proliferation, migration, and invasion ability both in vitro and in vivo, which could be blocked by a CXCR1/2 inhibitor. IL-8 promoted the expression of MMP2, MMP9, snail, and vimentin in HNSCC cells. Furthermore, IL-8 could inactivate PTEN via phosphorylation, and then inactivated PTEN affected the phosphorylation of STAT3. Recombinant PTEN that internalized in cytoplasm decreased the expression of phosphorylated STAT3, while knockdown of PTEN led to the increased expression of phosphorylated STAT3. A STAT3 inhibitor could reverse the upregulation of invasion-associated proteins mediated by IL-8 stimulation. Furthermore, overexpression of snail and inactivated PTEN jointly promoted the autocrine effect of IL-8 on tumor cells. Last, there were positive correlations between IL-8 and snail, vimentin expression in HNSCC tissues. In summary, our study demonstrates that PTEN acts as a novel "molecular switch" to regulate IL-8/STAT3 signaling, promoting the progression of HNSCC, and indicating that this pathway may be a potential therapeutic target for HNSCC.
journal_name
Cell Death Disjournal_title
Cell death & diseaseauthors
Xu Q,Ma H,Chang H,Feng Z,Zhang C,Yang Xdoi
10.1038/s41419-020-2627-5subject
Has Abstractpub_date
2020-05-29 00:00:00pages
405issue
5issn
2041-4889pii
10.1038/s41419-020-2627-5journal_volume
11pub_type
杂志文章abstract::Glioblastoma (GBM) is the most common and aggressive brain tumor and is associated with poor prognosis. GBM cells are frequently resistant to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and finding new combinatorial therapies to sensitize glioma cells to TRAIL remains an important challenge. PIM ki...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-1293-3
更新日期:2019-01-18 00:00:00
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journal_title:Cell death & disease
pub_type: 临床试验,杂志文章
doi:10.1038/cddis.2014.256
更新日期:2014-06-26 00:00:00
abstract::Renal tubular cell death is the key factor of the pathogenesis of ischemia/reperfusion (I/R) kidney injury. Ferroptosis is a type of regulated cell death (RCD) found in various diseases. However, the underlying molecular mechanisms related to ferroptosis in renal I/R injury remain unclear. In the present study, we inv...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-03135-z
更新日期:2020-10-28 00:00:00
abstract::Podocyte apoptosis is a major mechanism that leads to proteinuria in many chronic kidney diseases. However, the concert mechanisms that cause podocyte apoptosis in these kidney diseases are not fully understood. The Rho family of small GTPases has been shown to be required in maintaining podocyte structure and functio...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2016.51
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abstract::Effective management of breast cancer depends on early diagnosis and proper monitoring of patients' response to therapy. However, these goals are difficult to achieve because of the lack of sensitive and specific biomarkers for early detection and for disease monitoring. Accumulating evidence in the past several years...
journal_title:Cell death & disease
pub_type: 杂志文章,评审
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abstract::We previously showed that injury by partial duct ligation (PDL) in adult mouse pancreas activates Neurogenin 3 (Ngn3)(+) progenitor cells that can differentiate to β cells ex vivo. Here we evaluate the role of Ngn3(+) cells in β cell expansion in situ. PDL not only induced doubling of the β cell volume but also increa...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2013.52
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abstract::Spermatogenesis associated serine rich 2 (SPATS2) has been reported to contribute to the tumorigenesis of multiple malignancies. The molecular function of SPATS2 in hepatocellular carcinoma (HCC) is still not fully understood. In this study, we aimed to investigate the expression pattern and function roles of SPATS2 i...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-03039-y
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-2358-7
更新日期:2020-03-02 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2012.29
更新日期:2012-04-12 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
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abstract::Bidirectional non-protein-coding RNAs are ubiquitously transcribed from the genome. Convergent sense and antisense transcripts may regulate each other. Here, we examined the convergent cis-noncoding rRNAs (nc-rRNAs) in A5 and E9 lung cancer models. Sense nc-rRNAs extending from rDNA intergenic region to internal trans...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2012.19
更新日期:2012-03-15 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2016.332
更新日期:2016-12-01 00:00:00
abstract::Autophagy is a major self-degradative process that maintains cellular homeostasis and function in mammalian cells. Autophagic dysfunction occurs in the early pathogenesis of Alzheimer's disease (AD) and directly regulates amyloid-β (Aβ) metabolism. Although it has been proven that the cytokine IFN-γ enhances autophagy...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-2644-4
更新日期:2020-06-08 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2013.285
更新日期:2013-08-08 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-03002-x
更新日期:2020-09-25 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章,评审
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更新日期:2014-12-04 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-2574-1
更新日期:2020-05-19 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.501
更新日期:2017-10-05 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-1619-9
更新日期:2019-05-24 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2016.322
更新日期:2016-11-03 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-0793-5
更新日期:2018-07-03 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-02743-z
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-0803-7
更新日期:2018-07-09 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2013.408
更新日期:2013-10-24 00:00:00
abstract::KLF5 is frequently deleted and downregulated in prostate cancer, and recently it has been reported that KLF5 loss is enriched in the aggressive branches of prostate cancer evolution. However, why KLF5 loss is associated with prostate cancer aggressiveness is still not clear. Herein, we analyzed KLF5 expression in TCGA...
journal_title:Cell death & disease
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-03084-7
更新日期:2020-10-23 00:00:00
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journal_title:Cell death & disease
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-02860-9
更新日期:2020-08-14 00:00:00