当前位置： SCI文献检索 > ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY期刊下所有文献 > Embryonic stem cell- and transcriptomics-based in vitro analyses reveal that bisphenols A, F and S have similar and very complex potential developmental toxicities.

Embryonic stem cell- and transcriptomics-based in vitro analyses reveal that bisphenols A, F and S have similar and very complex potential developmental toxicities.

Abstract：

:Bisphenol A (BPA) is a very versatile industrial chemical. Many reports have associated BPA with several health effects. Some bisphenol alternatives have been introduced to replace BPA in its many applications. However, comprehensive toxicological evaluations for these replacements are still lacking. In this study, we examined the potential effects of BPA, bisphenol F (BPF) and bisphenol S (BPS), on embryonic development with an in vitro stem cell toxicology system and transcriptomics analyses. Mouse embryonic stem cells (mESCs) were differentiated via embryoid body formation, either globally towards the three primary germ layers and their lineages, or specifically into neuroectoderm/neural progenitor cells. During the differentiation, cells were treated with BPA, BPF, BPS, or DMSO control. Samples were collected at different time points, for qRT-PCR and RNA-seq analyses. BPA, BPF and BPS disrupted many processes, during mESC global and neural differentiations, in very similar manners. In fact, at each time point the three chemicals differentially regulated analogous gene categories, particularly the ones involved in cell-matrix and cell-cell adhesion, signal transduction pathways, and medical conditions such as cardiovascular diseases and cancer. Our findings demonstrate once more then BPA substitutes may not be very safe. They potentially have a very complex developmental toxicity, similarly to BPA, and seem more toxic than BPA itself. In addition, our results reveal that stem cell-based developmental toxicity assays can be very comprehensive.

journal_name

Ecotoxicol Environ Saf

journal_title

Ecotoxicology and environmental safety

authors

Yin N,Liang X,Liang S,Liang S,Yang R,Hu B,Cheng Z,Liu S,Dong H,Liu S,Faiola F

doi

10.1016/j.ecoenv.2019.03.115

subject

Has Abstract

pub_date

2019-07-30 00:00:00

pages

330-338

eissn

0147-6513

issn

1090-2414

pii

S0147-6513(19)30409-9

journal_volume

176

pub_type

杂志文章

相关文献

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY文献大全
  • Early life-stage and multigeneration toxicity study with bisphenol A and fathead minnows (Pimephales promelas).

    abstract：:Regulatory guidelines for long term testing to assess the toxicity of xenobiotic compounds such as bisphenol A (BPA) with fish have focused on survival, growth, and development in early life stages. Early life stages are critical windows of exposure, but do not address later phases in the life cycle, such as reproduct...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2011.05.010

    authors： Staples CA,Tilghman Hall A,Friederich U,Caspers N,Klecka GM

    更新日期：2011-09-01 00:00:00

  • Evaluation of a rodent peroxisome proliferator in two species of freshwater fish: rainbow trout (Onchorynchus mykiss) and Japanese medaka (Oryzias latipes)

    abstract：:Rainbow trout (Onchorynchus mykiss) and Japanese medaka (Oryzias latipes) were exposed to the hypolipidemic drug gemfibrozil, a known rodent peroxisome proliferator. Trout were injected (i.p.) daily for 2 weeks at doses of 0, 46, 87, or 152 mg/kg/day. Medaka were exposed to the nominal concentrations of 0, 1.25, 2.5, ...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/0147-6513(94)90026-4

    authors： Scarano LJ,Calabrese EJ,Kostecki PT,Baldwin LA,Leonard DA

    更新日期：1994-10-01 00:00:00

  • Microcystin-producing blooms--a serious global public health issue.

    abstract：:The investigation on microcystin topics is increasing due to the related ecological and public health risks. Recent investigation confirms a gap in establishing global patterns relating a particular environment to the bloom occurrence of a species and the production of certain microcystin variants. All the results con...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章,评审

    doi：10.1016/j.ecoenv.2004.04.006

    authors： de Figueiredo DR,Azeiteiro UM,Esteves SM,Gonçalves FJ,Pereira MJ

    更新日期：2004-10-01 00:00:00

  • Functional and ultrastructural cell pathology induced by fuel oil in cultured dolphin renal cells.

    abstract：:Investigations were undertaken to elucidate in a marine mammal renal cell culture system the toxicity and some of the mechanisms of cytopathology in a standardized preparation following exposure to No. 1 fuel oil. Cell survivability of a cultured SP1K renal cell line from the Atlantic spotted dolphin Stenella plagiodo...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1006/eesa.2000.1950

    authors： Pfeiffer CJ,Sharova LV,Gray L

    更新日期：2000-10-01 00:00:00

  • Biological and biochemical effects of chronic exposure to very low levels of dietary cypermethrin (Cymbush) on honeybee colonies (Hymenoptera: Apidae).

    abstract：:Cymbush (100 g of pure cypermethrin/liter of petroleum ether) was added to sucrose syrup at 12.5 microg/L and given to honeybee colonies (Apis mellifera mellifera, L.) in their diet for 5 months (July to November). Many perturbations have been recorded in treated groups in contrast to controls placed in the same area....

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1006/eesa.1999.1812

    authors： Bendahou N,Fleche C,Bounias M

    更新日期：1999-10-01 00:00:00

  • Sediment genotoxicity in the Tietê River (São Paulo, Brazil): in vitro comet assay versus in situ micronucleus assay studies.

    abstract：:The in vitro comet assay with the permanent fish cell line RTL-W1 and the in situ micronucleus assay using erythrocytes from indigenous tilapia (Oreochromis niloticus) were used to detect genotoxicity in Tietê River sediments (São Paulo, Brazil). Either test was successful in identifying site-specific differences in g...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2009.04.013

    authors： Rocha PS,Luvizotto GL,Kosmehl T,Böttcher M,Storch V,Braunbeck T,Hollert H

    更新日期：2009-10-01 00:00:00

  • Silver nanoparticle toxicity in silkworms: Omics technologies for a mechanistic understanding.

    abstract：:The widespread use of silver nanoparticles (AgNPs) has raised public concern due to their potential toxic effects on humans and the environment. Although some studies have evaluated the toxicity of nanomaterials in vertebrates, studies on their hazardous effects on insects are limited. Here we focused on different con...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2019.01.055

    authors： Chen L,Meng X,Gu J,Fan W,Abdlli N,Peprah FA,Wang N,Zhu F,Lü P,Ma S,Chen K

    更新日期：2019-05-15 00:00:00

  • Genotoxic effects and serum abnormalities in residents of regions proximal to e-waste disposal facilities in Jinghai, China.

    abstract：:Electronic waste (e-waste) disposal is a growing problem in China, and its effects on human health are a concern. To determine the concentrations of pollutants in peripheral blood and genetic aberrations near an e-waste disposal area in Jinghai, China, blood samples were collected from 30 (age: 41±11.01 years) and 28 ...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2014.03.034

    authors： Li K,Liu S,Yang Q,Zhao Y,Zuo J,Li R,Jing Y,He X,Qiu X,Li G,Zhu T

    更新日期：2014-07-01 00:00:00

  • Maleic acid assisted improvement of metal chelation and antioxidant metabolism confers chromium tolerance in Brassica juncea L.

    abstract：:Chromium (Cr) is a highly toxic environmental pollutant that negatively affects plant growth and development. Thus, remediating Cr from soil or increasing plant tolerance against Cr stress is urgent. Organic acids are recognized as agents of phytoremediation and as exogenous protectants, but using maleic acid (MA) to ...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2017.06.010

    authors： Mahmud JA,Hasanuzzaman M,Nahar K,Rahman A,Hossain MS,Fujita M

    更新日期：2017-10-01 00:00:00

  • Promoting the productivity and quality of brinjal aligned with heavy metals immobilization in a wastewater irrigated heavy metal polluted soil with biochar and chitosan.

    abstract：:Depleting aquifers, lack of planning and low socioeconomic status of Pakistani farmers have led them to use wastewater (WW) for irrigating their crops causing food contamination with heavy metals and ultimately negative effects on human health. This study evaluates the effects of chitosan (CH) and biochar (BC) on grow...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2018.05.082

    authors： Turan V,Khan SA,Mahmood-Ur-Rahman,Iqbal M,Ramzani PMA,Fatima M

    更新日期：2018-10-01 00:00:00

  • Heavy metal concentrations in Enchytraeidae (Oligochaeta) in the Niepołomice Forest.

    abstract：:Enchytraeidae were investigated as a part of a broad study of Niepolomice Forest ecosystem functioning. Animals were collected in oak-hornbeam (Tilio-Carpinetum) and in mixed oak-pine (Pino-Quercetum) stands. The highest cadmium concentration was observed in oak-hornbeam from the northern part of the forest (32.33+/-2...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2003.08.006

    authors： Rozen A,Sobczyk Ł,Kapusta P,Niklińska M

    更新日期：2004-01-01 00:00:00

  • Genetic and morphological diversity in populations of Nucella lapillus (L.; neogastropoda) in response to tributyltin contamination.

    abstract：:During the past three decades, North Atlantic populations of dogwhelks have been severely reduced in numbers, due to imposex and female sterility caused by TBT. We examined the relationship between the known history of female sterility and the present genetic diversity (measured by five allozyme-loci) and phenotypic v...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2005.11.006

    authors： Plejdrup JK,Simonsen V,Pertoldi C,Schøyen M,Bayley M

    更新日期：2006-06-01 00:00:00

  • Impact of calcium and magnesium substituted strontium nano-hexaferrite on mineral uptake, magnetic character, and physiology of barley (Hordeum vulgare L.).

    abstract：:In this study, calcium and magnesium substituted strontium nano-hexaferrites (Sr0.96Mg0.02Ca0.02Fe12O19, SrMgCa nano-HF) were synthesized by the sol-gel auto-combustion method and their impact on the nutrient uptake, magnetic character and physiology of barley (Hordeum vulgare L.), a crop plant, was investigated. Stru...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2019.109751

    authors： Tombuloglu H,Slimani Y,Tombuloglu G,Almessiere M,Sozeri H,Demir-Korkmaz A,AlShammari TM,Baykal A,Ercan I,Hakeem KR

    更新日期：2019-12-30 00:00:00

  • Development of an assay for testing the antimicrobial activity of skin peptides against the amphibian chytrid fungus (Batrachochytrium dendrobatidis) using Xenopus laevis.

    abstract：:This report describes the preliminary characterization of a bioassay for testing the antimicrobial activity of amphibian skin peptides against the chytrid fungus, Batrachochytrium dendrobatidis. Peptide secretions from Xenopus laevis were induced by subcutaneous injections of norepinephrine. Partially purified secreti...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2007.10.016

    authors： Gibble RE,Rollins-Smith L,Baer KN

    更新日期：2008-10-01 00:00:00

  • Bioefficacy of essential oil from Polygonum hydropiper L. against mosquitoes, Anopheles stephensi and Culex quinquefasciatus.

    abstract：:The biological activity of essential oil extracted from the leaves of Polygonum hydropiper and a compound, confertifolin, isolated from this plant was bioassayed against larva of mosquitoes, Anopheles stephensi and Culex quinquefasciatus. The essential oil showed the LC50 values of 189 and 243ppm; 217 and 242ppm, conf...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2013.06.028

    authors： Maheswaran R,Ignacimuthu S

    更新日期：2013-11-01 00:00:00

  • Impact of perinatal bisphenol A and 17β estradiol exposure: Comparing hormone receptor response.

    abstract：:Hormonal regulation controls mammary gland (MG) development. Therefore some hormone-related factors can disrupt the early phases of MGs development, making the gland more susceptible to long term modifications in its response to circulating hormones. Endocrine disruptors, such as bisphenol A (BPA), are able to cause a...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2019.109918

    authors： Leonel ECR,Campos SGP,Guerra LHA,Bedolo CM,Vilamaior PSL,Calmon MF,Rahal P,Amorim CA,Taboga SR

    更新日期：2020-01-30 00:00:00

  • Human co-exposure to mercury vapor and methylmercury in artisanal mercury mining areas, Guizhou, China.

    abstract：:Mercury (Hg) concentrations were determined in human urine and hair samples from Gouxi (GX, n=25) and Laowuchang (LWC, n=18), Tongren, Guizhou, China, to evaluate human exposure from artisanal Hg mining. Geometric means of urinary Hg (U-Hg) were 216 and 560 μg g(-1) Creatinine (μg g(-1) Cr) for artisanal mining worker...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2010.10.030

    authors： Li P,Feng X,Shang L,Qiu G,Meng B,Zhang H,Guo Y,Liang P

    更新日期：2011-03-01 00:00:00

  • Effects of nanomaterials on metal toxicity: Case study of graphene family on Cd.

    abstract：:The risk of heavy metal cadmium (Cd) on aquatic organisms has drawn widespread attentions, but the effects of nanomaterials (e.g. graphene (G)) on Cd toxicity are rarely clarified. It was known that mixture of contaminants may exhibit more severe impact than the individual metal. Here, we conducted a study systematica...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2020.110448

    authors： Zhang Y,Duan X,Bai L,Quan X

    更新日期：2020-05-01 00:00:00

  • Hepatic glutathione S-transferase activity in flounder collected from contaminated and reference sites along the Polish coast.

    abstract：:The aim of the present study was to examine the activity of hepatic glutathione S-transferase (GST) in flounder, Platichthys flesus, as a potential biomarker of exposure to xenobiotics present in the environment. The fish were collected along known pollution gradients and from areas regarded relatively free of anthrop...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2005.07.022

    authors： Napierska D,Kopecka J,Podolska M,Pempkowiak J

    更新日期：2006-11-01 00:00:00

  • The genetic toxicology of organic compounds in natural waters and wastewaters.

    abstract：:This review was drawn from the literature describing genotoxic organic compounds in natural water (rivers, lakes, streams) and wastewater, as well as from recent discussions with industrial scientists and environmental regulators. Testing of wastewaters for genotoxicity may become a routine requirement for some indust...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章,评审

    doi：10.1016/0147-6513(91)90051-p

    authors： Stahl RG Jr

    更新日期：1991-08-01 00:00:00

  • Impact of nitrophenols on the photosynthetic electron transport chain and ATP content in Nostoc muscorum and Chlorella vulgaris.

    abstract：:Concentration-dependent inhibition of the photosynthetic electron transport chain (photosystem I (PS I), photosystem II (PS II) and whole chain reaction) and ATP content was observed in Nostoc muscorum and Chlorella vulgaris grown with o-nitrophenol, m-nitrophenol, or 2,4-dinitrophenol. Although the extents of inhibit...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2003.11.002

    authors： Umamaheswari A,Venkateswarlu K

    更新日期：2004-06-01 00:00:00

  • Silver nanoparticles regulate Arabidopsis root growth by concentration-dependent modification of reactive oxygen species accumulation and cell division.

    abstract：:Silver nanoparticles (AgNPs) are widely used in industry, increasing their potential level in the environment. Plant root, the key organ absorbing water and nutrients, are directly exposed to the soil. Little is known about AgNP-mediated effects on plant root growth. Here, we show that AgNPs are absorbed by root and m...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2019.110072

    authors： Wang L,Sun J,Lin L,Fu Y,Alenius H,Lindsey K,Chen C

    更新日期：2020-03-01 00:00:00

  • In vitro toxicity of isolated strains and cyanobacterial bloom biomasses over Paramecium caudatum (ciliophora): Lessons from a non-metazoan model organism.

    abstract：:Cyanobacteria have been considered a major global threat because of their widespread ability to proliferate and contaminate inland and marine waters with toxic metabolites. For this reason, to avoid risks to humans and environmental health, regulatory legislation and guidelines have been established based on extensive...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2020.110937

    authors： Boas LDAV,Senra MVX,Fernandes K,Gomes AMDA,Pedroso Dias RJ,Pinto E,Fonseca AL

    更新日期：2020-10-01 00:00:00

  • Metabolic enzyme activities, metabolism-related genes expression and bioaccumulation in juvenile white shrimp Litopenaeus vannamei exposed to benzo[a]pyrene.

    abstract：:The purpose of this study was to investigate the impact of benzo[a]pyrene (BaP) on metabolic detoxification system and bioaccumulation of white shrimp Litopenaeus vannamei. In this study, juvenile white shrimp L. vannamei were exposed for 21 days at four different concentrations of 0, 0.03, 0.3 and 3μg/L. Detoxificati...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2014.02.016

    authors： Ren X,Pan L,Wang L

    更新日期：2014-06-01 00:00:00

  • Adaptation of bacteria Escherichia coli in presence of quaternary ammonium ionic liquids.

    abstract：:This paper presents the adaptation of Escherichia coli Gram-negative bacteria to increased concentrations of ionic liquids. Theophylline-based quaternary ammonium salts were used as an example of an ionic liquid that on the one hand includes an anion of natural origin and on the other hand is characterized by amphiphi...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2018.08.048

    authors： Borkowski A,Gutowski Ł,Syczewski M,Cłapa T,Czerwonka G

    更新日期：2018-11-30 00:00:00

  • Contamination and distribution of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/F) in agriculture fields in Ya-Er Lake area, China.

    abstract：:The contamination and distribution of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) from two agricultural fields of a heavily polluted lake area in China (Ya-Er Lake) are presented. The vertical distribution pattern of total PCDD/Fs in soil cores reveals that the maximum concentration was in the layer ...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1006/eesa.2002.2202

    authors： Wu WZ,Schramm KW,Xu Y,Kettrup A

    更新日期：2002-09-01 00:00:00

  • Chemosensory mediated behaviors and gene transcription profiles in wild yellow perch (Perca flavescens) from metal contaminated lakes.

    abstract：:The olfactory system of fish is sensitive to the toxic effects of low concentrations of contaminants. To investigate the effects of long-term metal exposure on olfaction in wild yellow perch (Perca flavescens), fish from one clean (Geneva Lake) and two metal-contaminated lakes (Ramsey and Hannah lakes) were collected ...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2014.04.045

    authors： Azizishirazi A,Dew WA,Bougas B,Dashtban M,Bernatchez L,Pyle GG

    更新日期：2014-08-01 00:00:00

  • Heavy metal partitioning in sediments and bioaccumulation in commercial fish species of three major reservoirs of river Cauvery delta region, India.

    abstract：:Chemical partitioning of heavy metals (Fe, Mn, Cu, Cr, Pb, Zn, Ni) were determined in surface sediments of three reservoirs at the Delta region of Cauvery River, India. The abundance of metals in sediments varied in the following descending order: Fe, Mn, Cr, Zn, Cu, Ni, and Pb. Higher concentrations of Zn, Pb, Fe, Mn...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2014.11.032

    authors： Dhanakumar S,Solaraj G,Mohanraj R

    更新日期：2015-03-01 00:00:00

  • Effects of ibuprofen and carbamazepine on the ion transport system and fatty acid metabolism of temperature conditioned juveniles of Solea senegalensis.

    abstract：:The increasing presence of pharmaceuticals in aquatic environments in the last decades, derived from human and veterinary use, has become an important environmental problem. Previous studies have shown that ibuprofen (IB) and carbamazepine (CBZ) modify physiological and biochemical processes in Senegalese sole (Solea ...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/j.ecoenv.2017.11.023

    authors： González-Mira A,Torreblanca A,Hontoria F,Navarro JC,Mañanós E,Varó I

    更新日期：2018-02-01 00:00:00

  • Cold and drought stress in combination with pyrene exposure: studies with Protaphorura armata (Collembola: Onychiuridae).

    abstract：:Adult survival of the springtail Protaphorura armata exposed to pyrene, a common soil pollutant, was investigated in combination with cold and drought stress, in three separate experiments. (1) A drought stress imposed subsequent to pyrene exposure in soil resulted in a significant decrease in springtail survival, whe...

    journal_title：Ecotoxicology and environmental safety

    pub_type： 杂志文章

    doi：10.1016/S0147-6513(02)00144-6

    authors： Sjursen H,Holmstrup M

    更新日期：2004-02-01 00:00:00