Abstract:
:The in vitro comet assay with the permanent fish cell line RTL-W1 and the in situ micronucleus assay using erythrocytes from indigenous tilapia (Oreochromis niloticus) were used to detect genotoxicity in Tietê River sediments (São Paulo, Brazil). Either test was successful in identifying site-specific differences in genotoxicity, with a high correlation between in situ and in vitro results indicating the relevance of the latter even for environmental studies. Discharges from São Paulo city have major impact on genotoxic effects by sediment-bound contaminants; however, overall genotoxicity decreases downstream. The high genotoxic burden of the Tietê River warrants measures to reduce the input of toxic effluents.
journal_name
Ecotoxicol Environ Safjournal_title
Ecotoxicology and environmental safetyauthors
Rocha PS,Luvizotto GL,Kosmehl T,Böttcher M,Storch V,Braunbeck T,Hollert Hdoi
10.1016/j.ecoenv.2009.04.013subject
Has Abstractpub_date
2009-10-01 00:00:00pages
1842-8issue
7eissn
0147-6513issn
1090-2414pii
S0147-6513(09)00090-6journal_volume
72pub_type
杂志文章abstract::Effects of 17beta-estradiol and p-nonylphenol were examined in the immune and endocrine organs of Japanese quail embryos. The test compounds were injected into the yolk of embryonated eggs. Injection of estrogen resulted in (1) disappearance of lymphoid cells and flattened development of plicae in the bursa of Fabrici...
journal_title:Ecotoxicology and environmental safety
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pub_type: 杂志文章
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journal_title:Ecotoxicology and environmental safety
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journal_title:Ecotoxicology and environmental safety
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journal_title:Ecotoxicology and environmental safety
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journal_title:Ecotoxicology and environmental safety
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journal_title:Ecotoxicology and environmental safety
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journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
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journal_title:Ecotoxicology and environmental safety
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