Abstract:
:This report describes the preliminary characterization of a bioassay for testing the antimicrobial activity of amphibian skin peptides against the chytrid fungus, Batrachochytrium dendrobatidis. Peptide secretions from Xenopus laevis were induced by subcutaneous injections of norepinephrine. Partially purified secretions were quantified and incubated at various dilutions with 10(7) cells/mL of freshly isolated zoospores for 7 days. Peptide bioactivity was measured as cell growth inhibition over the incubation period. The concentration that inhibited growth by 80% or greater (IC(80)), based on the linear portion of the growth curve, averaged 457+/-158 microg/mL. Growth curve slopes of best-fit line equations for individual samples were less variable within control groups than the average IC(80) value, and are viewed as a more reliable indicator of peptide mixture bioactivity. This assay may be useful for evaluating the impact of environmental chemicals on amphibian host resistance to potentially lethal skin infections.
journal_name
Ecotoxicol Environ Safjournal_title
Ecotoxicology and environmental safetyauthors
Gibble RE,Rollins-Smith L,Baer KNdoi
10.1016/j.ecoenv.2007.10.016subject
Has Abstractpub_date
2008-10-01 00:00:00pages
506-13issue
2eissn
0147-6513issn
1090-2414pii
S0147-6513(07)00256-4journal_volume
71pub_type
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pub_type: 杂志文章
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