Abstract:
:Oxidative stress may contribute to the pathogenesis of congenital heart defects, but the role of dynamic thiol/disulphide homeostasis has not been evaluated. The objective of this study was to assess whether there are changes in thiol/disulphide homeostasis and nitric oxide levels in children with tetralogy of Fallot (TOF) and ventricular septal defect (VSD). A total of 47 children with congenital heart defects (24 TOF and 23 VSD) and 47 healthy age- and sex-matched controls were included in this study. Serum total thiol and native thiol levels were measured using a novel automatic spectrophotometric method. The amount of dynamic disulphide bonds and related ratios were calculated from these values. Serum nitric oxide levels were detected using a chemiluminescence assay. We found that the average native thiol, total thiol, and disulphide levels were decreased in patients with VSD when compared with healthy individuals (p < 0.001, p < 0.001, and p < 0.01, respectively). While native thiol levels were decreased (p < 0.01), disulphide levels were elevated in the TOF group (p < 0.05). We observed marked augmentation of disulphide/native thiol (p < 0.001) and disulphide/total thiol ratios (p < 0.01) in the TOF group. However, there was a significant decrease in native thiol/total thiol ratio in patients with TOF. No significant changes in these ratios were noted in the VSD group. We detected significant elevations in serum nitric oxide levels in children with TOF and VSD (p < 0.001 for all). These results are the first to demonstrate that thiol/disulphide homeostasis and nitric oxide are associated with TOF and VSD in children.
journal_name
Cardiol Youngjournal_title
Cardiology in the youngauthors
Temel MT,Demiryürek S,Saracaloglu A,Ozer CH,Kahraman HN,Coskun ME,Başpınar O,Demiryürek ATdoi
10.1017/S104795111900012Xsubject
Has Abstractpub_date
2019-04-01 00:00:00pages
499-504issue
4eissn
1047-9511issn
1467-1107pii
S104795111900012Xjournal_volume
29pub_type
杂志文章abstract:INTRODUCTION:Postural tachycardia syndrome is more frequently being recognised in adolescents and adults. However, its pathophysiology remains undefined. We evaluated our database for patterns in family history of clinical symptoms and associated disorders in these patients. MATERIALS AND METHODS:Patients with postura...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951120000165
更新日期:2020-03-01 00:00:00
abstract::This article is to commemorate and celebrate achievements of Professor Milan Šamánek who passed away on 29 April, 2020. Milan was an excellent and visionary paediatric cardiologist who helped to establish paediatric cardiology as a speciality in Czechoslovakia and several other east European countries in the late 1970...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951120001547
更新日期:2020-09-01 00:00:00
abstract:AIMS:Our aims were to use transthoracic three-dimensional echocardiography to assess the morphology of atrial septal defects in children prior to closure, and to compare the three-dimensional echocardiographic data with transcatheter and surgical findings. METHODS AND RESULTS:We used transthoracic three-dimensional ec...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/s1047951103000118
更新日期:2003-02-01 00:00:00
abstract:BACKGROUND:Neonates and infants with congenital and acquired cardiac disease often require placement of central venous lines for extended intravenous therapy. It may be advantageous to avoid the larger venous vessels of the head and neck and lower extremities in order to preserve these for future interventions and ther...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951110000090
更新日期:2010-06-01 00:00:00
abstract::The mitral-aortic intervalvular fibrosa is an area of fibrous continuity between the mitral and aortic valves. We present the first case of a congenital pseudoaneurysm in this region, detected prenatally as an isolated cardiac defect, which was followed-up conservatively postnatally. The diagnosis was confirmed by ech...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951117000890
更新日期:2017-05-29 00:00:00
abstract:BACKGROUND:CHDs form a complex and heterogeneous group of clinical entities, with high morbidity and mortality. With the advancement of surgical and invasive techniques and clinical treatment, the survival of these patients has increased significantly, and there are reports of a high prevalence of ocular abnormalities ...
journal_title:Cardiology in the young
pub_type: 杂志文章,meta分析,评审
doi:10.1017/S104795111500044X
更新日期:2016-03-01 00:00:00
abstract::A female neonate, born at term, presented with complex cardiac anatomy dominated by right isomerism and infra-diaphragmatic totally anomalous pulmonary venous connection. Surgical repair was performed using circulatory arrest under deep hypothermia. In the postoperative period, the patient could not be weaned off mech...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951105001836
更新日期:2005-12-01 00:00:00
abstract:OBJECTIVE:To examine early outcomes for pulmonary atresia with intact ventricular septum undergoing single-ventricle palliation and to determine risk factors for mortality. DESIGN:Retrospective observational study. SETTING:Tertiary paediatric critical care unit. INTERVENTION:Risk factors for mortality were sought fo...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951110000077
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Syncope is common in children and adolescents and most commonly represents neurocardiogenic syncope. No information has been reported regarding the effect of syncope on health-related quality of life in children. METHODS:This was a retrospective cohort study of patients seen in the Heart Institute Syncope C...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951112000133
更新日期:2012-10-01 00:00:00
abstract::We describe what is, to the best of our knowledge, a previously unreported association in patients with similar facial features, skin and joint laxity, of lengthening and tortuosity of systemic, pulmonary and coronary vessels. We evaluated 12 patients with similar phenotypes, from eight different families. Detailed ec...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/s1047951100008854
更新日期:2000-11-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to investigate the relations between the P-wave dispersion and diastolic functions in type 1 diabetic children. PATIENTS:A total of 33 diabetic patients without any cardiovascular disease, with a mean age of 12.3 plus or minus 4.2 years, and 29 healthy controls, with a mean age of 1...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S104795110999031X
更新日期:2010-04-01 00:00:00
abstract::Tetralogy of Fallot is only rarely associated with aortic valvar disease. We present a child who had uncomplicated repair of tetralogy of Fallot at 16 months of age, and who developed mild aortic stenosis three years later, with mild to moderate aortic incompetence being seen two years subsequent to that event. No aor...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:
更新日期:2003-06-01 00:00:00
abstract::Large volumes of data and multiple computing platforms are now universal components of paediatric cardiovascular medicine, but are in a constant state of evolution. Often, multiple sets of related data reside in disconnected "silos", resulting in clinical, administrative, and research activities that may be duplicativ...
journal_title:Cardiology in the young
pub_type: 杂志文章,评审
doi:10.1017/S1047951116001268
更新日期:2017-05-01 00:00:00
abstract::Primary vascular tumour of the heart is rare, especially in neonates and infants. We report a male premature newborn with a right atrial tumour associated with a large amount of pericardial effusion detected by screening foetal echography. Diagnosis of capillary haemangioma was confirmed by histopathological examinati...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951114002121
更新日期:2015-10-01 00:00:00
abstract::Endothelial dysfunction has been reported in hypoxaemic patients with the Eisenmenger syndrome, but a direct correlation between levels of endothelial markers and the severity of hypoxaemia has not been explored. With this in mind, we compared the levels in the plasma of tissue-type plasminogen activator, thrombomodul...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951105001381
更新日期:2005-10-01 00:00:00
abstract::Tracheobronchial compression of cardiovascular origin is an uncommon and frequently unrecognised cause of respiratory distress in children. The compression may be due to encircling vessels or dilated neighbouring cardiovascular structures. Bronchoscopy and detailed radiography, especially computed tomography and magne...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951112000765
更新日期:2013-04-01 00:00:00
abstract::A two-year-old boy with a background history of Down syndrome and partial atrioventricular septal defect presented with acute respiratory distress requiring intubation and mechanical ventilation. He continued to deteriorate, despite ventilation; direct laryngoscopy, bronchoscopy, and computed tomography demonstrated s...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951114000468
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVES:Our aim was to assess the immediate and short term results of closure of moderate and large patent arterial ducts using the self-expanding and repositionable Amplatzer device. METHOD:We attempted closure in 25 patients (10 Females and 15 males) using the Amplatzer occluder. Their median age was 48 months wi...
journal_title:Cardiology in the young
pub_type: 临床试验,杂志文章
doi:10.1017/s1047951100009124
更新日期:2000-05-01 00:00:00
abstract::An interarterial course of anomalous left main coronary artery originating from the right aortic coronary sinus of valsalva is a rare condition among anomalous aortic origin of the coronary artery. Various surgical options are available. We performed an alternative procedure, that is, mobilisation of the pulmonic root...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951111002113
更新日期:2012-10-01 00:00:00
abstract::We present a case of circumferential fracture of aortic coarctation stent with severe re-stentosis presenting 16 years after initial stent implantation with end-stage renal disease. The patient was treated with a covered stent using the stent-in-stent technique. The use of an ultra-high-pressure balloon was proved nec...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951115001079
更新日期:2016-02-01 00:00:00
abstract::Sialidosis, a rare autosomal recessive disorder, is caused by a deficiency of NEU1 encoded enzyme alpha-N-acetyl neuraminidase. We report a premature male with neonatal-onset type II sialidosis which was associated with left ventricular dysfunction. The clinical presentation and subsequent progression which culminated...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951120004953
更新日期:2021-01-28 00:00:00
abstract:OBJECTIVE:We aimed to apply systems engineering principles to address hospital-acquired infections in the paediatric intensive care setting. DESIGN:Mixed method approach involving four steps: perform time-motion study of cardiac intensive care unit (CICU) care processes, establish a meaningful schema to classify obser...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951120003777
更新日期:2020-11-10 00:00:00
abstract::Herein, we present the first case of dilated cardiomyopathy due to premature constriction of the ductus arteriosus. A fetal echocardiography showed narrowing in the ductus arteriosus, and colour Doppler flow mapping could not identify blood flow through the ductus. Neonatal echocardiography revealed a left ventricular...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951118001002
更新日期:2018-09-01 00:00:00
abstract::Heart failure in children is a complex clinical syndrome with multiple aetiologies. The underlying disorders that lead to heart failure in children differ significantly from those in adults. Some clinical biomarkers for heart failure status and prognosis appear to be useful in both age groups. This review outlines the...
journal_title:Cardiology in the young
pub_type: 杂志文章,评审
doi:10.1017/S1047951115000839
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Risk for neurodevelopmental delay in infants and children with CHD is well established, but longer-term outcomes are equivocal. A meta-analysis was conducted to establish whether cognitive deficits remain beyond childhood - into teenage and young adult years. Methods and results A total of 18 unique samples,...
journal_title:Cardiology in the young
pub_type: 杂志文章,meta分析
doi:10.1017/S104795111700230X
更新日期:2018-03-01 00:00:00
abstract::A 29-year-old gravida1 para1 woman presented with increasing fatigue. Multi-modality imaging demonstrated the left coronary artery arising from the main pulmonary artery with large collateral vessels in the interventricular septum, in keeping with unrepaired anomalous left coronary artery from the pulmonary artery. Ca...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951117000932
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Perceived correlation between the coronary arterial anatomy in patients with complete transposition, and the outcome of the arterial switch procedure, has made preoperative identification of their patterns standard practice. PURPOSE:Our purpose was to assess the accuracy of preoperative echocardiographic id...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/s1047951102000537
更新日期:2002-05-01 00:00:00
abstract:BACKGROUND:Fungal endocarditis classically involves dense heterogenous vegetations. However, several patients with fungal infections were noted to have myocardial changes ranging from focal brightening to nodular thickening of chordae or papillary muscles. This study evaluates whether these findings are associated with...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951120003674
更新日期:2020-11-13 00:00:00
abstract::We report here the case of a 27-year-old woman with Noonan syndrome presenting with ventricular fibrillation. After successful defibrillation, echocardiography revealed hypertrophic cardiomyopathy associated with left ventricular outflow tract obstruction. Normal echocardiographic cardiac structure and function were r...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S1047951110001708
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Neonates undergoing heart surgery for CHD are at risk for postoperative gastrointestinal complications and aspiration events. There are limited data regarding the prevalence of aspiration after neonatal cardiothoracic surgery; thus, the effects of aspiration events on this patient population are not well und...
journal_title:Cardiology in the young
pub_type: 杂志文章
doi:10.1017/S104795111600278X
更新日期:2017-09-01 00:00:00