Abstract:
BACKGROUND:Acute Kidney Injury (AKI) is a sudden decrease in kidney function. In the early period, the highest percentage of AKI occurs among newborns hospitalized in the neonatal intensive care units, especially premature neonates. The prognosis of AKI depends on the type and severity of the cause of an injury, the accuracy and the time of diagnosis and treatment. The concentration of serum creatinine is still the main diagnostic test, although it changes in the course of AKI later than glomerular filtration rate GFR. In addition, the reliability of the determination of creatinine level is limited because it depends on many factors. New studies have presented other, more useful laboratory markers of renal function that can be measured in serum and/or in urine. OBJECTIVE:The aim of the work was to present the latest data about tubular and glomerular biomarkers of acute kidney injury in newborns. METHODS:We undertook a structured search of bibliographic databases for peer-reviewed research literature by using focused review topics. According to the conceptual framework, the main idea of research literature has been summarized and presented in this study. RESULTS:The concentrations of some novel biomarkers are higher in serum and/or urine of term and preterm newborns with AKI, especially in the course of perinatal asphyxia. CONCLUSION:In this systematic review of the literature, we have highlighted the usefulness of biomarkers in predicting tubular and/or glomerular injury in newborns. However, novel biomarkers need to prove their clinical applicability, accuracy, and cost-effectiveness prior to their implementation in clinical practice.
journal_name
Curr Drug Metabjournal_title
Current drug metabolismauthors
Kamianowska M,Szczepański M,Wasilewska Adoi
10.2174/1389200220666190321142417subject
Has Abstractpub_date
2019-01-01 00:00:00pages
332-349issue
5eissn
1389-2002issn
1875-5453pii
CDM-EPUB-97499journal_volume
20pub_type
杂志文章abstract::The combined treatment with anticonvulsant and antidepressant drugs is reported in both neurologic and psychiatric practice; it is, therefore, evident that the issue of managing such type of polytherapy is frequently encountered by clinicians. To review current literature on pharmacokinetic interactions between antico...
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journal_title:Current drug metabolism
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journal_title:Current drug metabolism
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journal_title:Current drug metabolism
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更新日期:2011-09-01 00:00:00
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更新日期:2013-07-01 00:00:00
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journal_title:Current drug metabolism
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更新日期:2014-01-01 00:00:00
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更新日期:2014-01-01 00:00:00
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journal_title:Current drug metabolism
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更新日期:2018-01-01 00:00:00
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journal_title:Current drug metabolism
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更新日期:2008-06-01 00:00:00
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更新日期:2011-02-01 00:00:00
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更新日期:2005-06-01 00:00:00
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