Abstract:
:Oral administration remains the most preferred route for the treatment of many diseases due to its convenience and adaptability. However, the presystemic metabolism may be an important barrier that prevents lipophilic drugs from achieving their pharmacological effects following oral delivery. Nano-based drug delivery system provides an effective strategy to reduce the presystemic metabolism and increase the systemic exposure of lipophilic drugs. In this review, we described the physiological factors affecting the presystemic metabolism of lipophilic drugs, intestinal transport of nanosystems, strategy of nanosystems to avoid the presystemic metabolism, and the current application of various oral nanosystems including lipid and polymeric nanocarriers. The nano-based drug delivery system has a lot of potential for reducing the presystemic metabolism and enhancing the bioavailability of orally administrated lipophilic drugs.
journal_name
Curr Drug Metabjournal_title
Current drug metabolismauthors
Zhang Z,Gao F,Jiang S,Ma L,Li Ydoi
10.2174/138920012802850100subject
Has Abstractpub_date
2012-10-01 00:00:00pages
1110-8issue
8eissn
1389-2002issn
1875-5453pii
CDM-EPUB-20120228-003journal_volume
13pub_type
杂志文章,评审abstract::In vitro models of the liver using isolated primary hepatocytes have been used as screens for measuring the metabolism, toxicity and efficacy of xenobiotics, for studying hepatocyte proliferation, and as bioartificial liver support systems. Yet, primary isolated hepatocytes rapidly lose liver specific functions when m...
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更新日期:2008-07-01 00:00:00
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