A review on noscapine, and its impact on heme metabolism.

Abstract:

:This review introduces the Noscapine, which is being used as an antitussive drug for a long time has been recently discovered as a novel tubulin-binding, anti-angiogenic anticancer drug that causes cell cycle arrest and induces apoptosis in cancer cells both in vitro as well as in vivo. Noscapine is a multifunctional molecule i.e. it possesses various functional moieties. We maneuvered various amenable sites and have synthesized analogs, which might prove to be more efficacious and less cytotoxic. Moreover, development of oral controlled release anticancer formulation of noscapine is severely hampered due to short biological half-life (<2-h), poor absorption, low aqueous solubility, and extensive first pass metabolism, thereby requiring large doses for effective treatment.

journal_name

Curr Drug Metab

journal_title

Current drug metabolism

authors

Singh H,Singh P,Kumari K,Chandra A,Dass SK,Chandra R

doi

10.2174/1389200211314030010

subject

Has Abstract

pub_date

2013-03-01 00:00:00

pages

351-60

issue

3

eissn

1389-2002

issn

1875-5453

pii

CDM-EPUB-20120824-11

journal_volume

14

pub_type

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