Hematopoietic colony formation after allogeneic bone marrow transplantation: enhancement by cyclosporin A and anti-gamma-(immune) interferon antiserum in vitro.

abstract：:The selection of chemotherapy regimen for elderly patients with acute myeloid leukemia (AML) remains challenging. Here, we report that granulocyte colony-stimulating factor (G-CSF) upregulates the expression of microRNA (miR)-146a in a nuclear factor kappaB-dependent manner, leading to direct decreases in the expressi...

journal_title：Experimental hematology

authors： Li X,Xu L,Sheng X,Cai J,Liu J,Yin T,Xiao F,Chen F,Zhong H

更新日期：2018-12-01 00:00:00

abstract：:Autotaxin (ATX) has been reported to act as a motility and growth factor in a variety of cancer cells. The ATX protein acts as a secreted lysophospholipase D by converting lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA), which signals via G-protein-coupled receptors and has important functions in cell mig...

journal_title：Experimental hematology

authors： Ortlepp C,Steudel C,Heiderich C,Koch S,Jacobi A,Ryser M,Brenner S,Bornhäuser M,Brors B,Hofmann WK,Ehninger G,Thiede C

更新日期：2013-05-01 00:00:00

abstract：:We performed the present study to define the in vitro hemopoietic activity of murine recombinant (r) granulocyte colony-stimulating factor (G-CSF) using murine hemopoietic culture systems of normal bone marrow cells, fetal liver cells, and spleen cells of 5-fluorouracil (FU)-treated mice. Recombinant G-CSF supported o...

journal_title：Experimental hematology

authors： Suda T,Suda J,Kajigaya S,Nagata S,Asano S,Saito M,Miura Y

更新日期：1987-10-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to develop novel markers for enrichment of hematopoietic progenitors from bone marrow of swine. MATERIALS AND METHODS:We previously showed that pig bone marrow contains a "side population" (SP) of Hoechst dye-effluxing cells that resembles the hematopoietic stem cell (HSC)-containin...

journal_title：Experimental hematology

authors： Heinz M,Huang CA,Emery DW,Giovino MA,LeGuern A,Kurilla-Mahon B,Theodore P,Arn JS,Sykes M,Mulligan R,Down JD,Sachs DH,Goodell MA

更新日期：2002-07-01 00:00:00

abstract：OBJECTIVE:The present study was designed to compare directly the frequency of circulating LTC-IC and E-LTC-IC mobilized in peripheral blood (PB) after chemotherapy supported by either G-CSF (PB-G) or GM-CSF (PB-GM) in comparison to steady-state bone marrow (BM) and PB (PB-ST) values in the same patients. MATERIALS AND...

journal_title：Experimental hematology

authors： Benboubker L,Binet C,Cartron G,Bernard MC,Clement N,Delain M,Degenne M,Desbois I,Colombat P,Domenech J

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:Monocyte-derived dendritic cells (DCs) play important roles in the immune response against infections and malignancies. Human herpesvirus 6 (HHV-6) infects monocytes and is reactivated in immunodeficient patients. To clarify the mechanisms of HHV-6-induced immunodeficiency, we investigated the effect of HHV-6...

journal_title：Experimental hematology

authors： Niiya H,Lei J,Guo Y,Azuma T,Yakushijin Y,Sakai I,Hato T,Tohyama M,Hashimoto K,Yasukawa M

更新日期：2006-05-01 00:00:00

abstract：:A novel polypeptide with a molecular weight of 17 kd (17k protein) was identified in bone marrow cell cultures. The synthesis of 17k protein is elevated in cell cultures maintained under Dexter conditions, which support myelopoiesis. The predominance of macrophages in the stromal layer of these cultures and the observ...

journal_title：Experimental hematology

authors： Ruland LJ 3rd,Quesenberry PJ,Balian G

更新日期：1990-10-01 00:00:00

abstract：OBJECTIVE:Resveratrol (3,4',5,-trihydroxystilbene, RV), an ingredient of wine, is an inhibitor of the proliferation-linked enzyme ribonucleotide reductase (RR) and shows a broad spectrum of cytotoxic effects against human cancer cells. In order to enhance these effects, we introduced additional hydroxyl moieties into t...

journal_title：Experimental hematology

authors： Horvath Z,Murias M,Saiko P,Erker T,Handler N,Madlener S,Jaeger W,Grusch M,Fritzer-Szekeres M,Krupitza G,Szekeres T

更新日期：2006-10-01 00:00:00

abstract：:A transplanted tumor that induces granulocytosis and produces colony stimulating factor (CSF) was studied in mice during several passages. The sequence of events leading to granulocytosis was characterized. Band granulocytes were increased 3 days after tumor inoculation, while simultaneously CFU-s and CFU-c in bone ma...

journal_title：Experimental hematology

authors： Reincke U,Burlington H,Carsten AL,Cronkite EP,Laissue JA

更新日期：1978-04-01 00:00:00

abstract：OBJECTIVE:Using transplantation of a clonal population of cells derived from a single hematopoietic stem cell (HSC) of transgenic enhanced green fluorescent protein (EGFP) mice, we have documented the hematopoietic origin of myofibroblasts, such as kidney mesangial cells and brain microglial cells. Because myofibroblas...

journal_title：Experimental hematology

authors： Ebihara Y,Masuya M,Larue AC,Fleming PA,Visconti RP,Minamiguchi H,Drake CJ,Ogawa M

更新日期：2006-02-01 00:00:00

abstract：:In chronic eosinophilic leukemia, the transforming oncoprotein FIP1L1-PDGFRA is a major target of therapy. In most patients, the tyrosine kinase inhibitor (TKI) imatinib induces complete remission. For patients who are intolerant or resistant, novel TKIs have been proposed. We examined the in vitro effects of 14 kinas...

journal_title：Experimental hematology

authors： Sadovnik I,Lierman E,Peter B,Herrmann H,Suppan V,Stefanzl G,Haas O,Lion T,Pickl W,Cools J,Vandenberghe P,Valent P

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVE:It is well known that hypoxic stress strongly enhances erythropoiesis, but the effect of hypoxia on erythroid progenitors has not been examined precisely. In the present study, using the erythropoietin-dependent cell line UT-7/Epo, which has characteristics of erythroid progenitors, we investigated a novel ro...

journal_title：Experimental hematology

authors： Mikami M,Sadahira Y,Haga A,Otsuki T,Wada H,Sugihara T

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVES:Processing of epigenomic transcriptional information by cell cycle phase G(1) and decision-making at checkpoint G(1)/S are the final organizational steps preceding gene replication in transcriptional reorientation programs (i.e., switches from proliferation to cycle arrest and neoplastic transformation). Fur...

journal_title：Experimental hematology

authors： Prindull G

更新日期：2008-11-01 00:00:00

abstract：:We have assessed the potential use of the mononuclear cell (MNC) content as the sole assessment of graft quality in 35 patients receiving BEAM (carmustine, etoposide, cytosine arabinoside, melphalan) chemotherapy and autologous peripheral blood progenitor cell (PBPC) transplantation for malignant lymphoma. PBPCs were ...

journal_title：Experimental hematology

authors： Smith RJ,Sweetenham JW

更新日期：1995-12-01 00:00:00

abstract：:The prostaglandin E (PGE) enhancement of erythroid colony formation by human bone marrow erythroid progenitor cells (BFU-E) is mediated by a T8+ subset of lymphocytes. Medium was conditioned by bone marrow and blood T-lymphocytes and T-lymphocyte subsets (T8+, T8-, T4+, and T4- cells) in the absence or presence of PGE...

journal_title：Experimental hematology

authors： Lu L,Pelus LM,Piacibello W,Moore MA,Hu W,Broxmeyer HE

更新日期：1987-08-01 00:00:00

abstract：BACKGROUND:Autologous bone marrow transplantation is an important therapy for patients with acute myelogenous leukemia (AML). However, leukemia in the graft may contribute to posttransplant relapse. Treatment of the graft with 4-hydroperoxycyclophosphamide (4HC) is sometimes used to decrease numbers of infused leukemia...

journal_title：Experimental hematology

authors： Miller CB,Rowlings PA,Zhang MJ,Jones RJ,Piantadosi S,Keating A,Armitage JO,Calderwood S,Harris RE,Klein JP,Lazarus HM,Linker CA,Sobocinski KA,Weisdorf D,Horowitz MM

更新日期：2001-11-01 00:00:00

abstract：:To investigate the effect of interferon on the proliferation of normal erythroid precursor cells, various interferon preparations were added to mouse fetal liver cells cultured in a liquid microculture system. The effect of interferon was studied using cellular tritiated thymidine incorporation both in the presence an...

journal_title：Experimental hematology

authors： Smith KA,Fredrickson TN,Mobraaten LE,DeMaeyer E

更新日期：1977-09-01 00:00:00

abstract：:Radiation damage to femoral hemopoietic stroma in mice was measured 6 weeks after irradiation and reconstitution with syngeneic bone marrow by quantitation of fibroblastic progenitor cells (CFUF), and by assaying hemopoietic progenitors and CFUF numbers in regenerated subcutaneous femur implants. A dose-dependent effe...

journal_title：Experimental hematology

authors： Piersma AH,Ploemacher RE,Brockbank KG

更新日期：1983-10-01 00:00:00

abstract：:We analyzed the accessory function of malignant B cells from non-Hodgkin's lymphomas (NHLs). Among the 70 samples of malignant B cells included, four patterns of expression of the costimulatory molecules CD80 and CD86 were distinguished (+/+, +/-, -/+ and -/-). In two-thirds of the cases, CD80, CD86, or both were expr...

journal_title：Experimental hematology

authors： Chaperot L,Plumas J,Jacob MC,Bost F,Molens JP,Sotto JJ,Bensa JC

更新日期：1999-03-01 00:00:00

abstract：OBJECTIVE:Granulocyte macrophage colony-stimulating factor (GM-CSF) has been shown to specifically stimulate proliferation of CD34(+) hematopoietic progenitor cells. Although signal transducers and activators of transcription 3 (STAT3) is believed essential for transduction of GM-CSF-induced cell proliferation, the sig...

journal_title：Experimental hematology

authors： Gu L,Chiang KY,Zhu N,Findley HW,Zhou M

更新日期：2007-06-01 00:00:00

abstract：:Mouse hematopoietic stem cells (HSCs) are highly enriched in the rare (approximately 0.05%) Thy-1.1(lo)Lin(-/lo)Sca-1+ fraction of hematopoietic tissues. It has been demonstrated that Thy-1.1(lo)Lin(-/lo)Sca-1+ cells are the only HSCs in C57BL/Ka-Thy-1.1 bone marrow. In this study, we separated C57/Ka-Thy-1.1 bone mar...

journal_title：Experimental hematology

authors： Uchida N,Jerabek L,Weissman IL

更新日期：1996-04-01 00:00:00

abstract：:The transcription factor SCL is critically required for establishing hematopoiesis and for proper endothelial development, but not for maintenance of hematopoietic stem cells or endothelial cells in the adult. Conflicting data exists regarding the developmental function of SCL, namely, whether it acts as a master regu...

journal_title：Experimental hematology

authors： Ismailoglu I,Yeamans G,Daley GQ,Perlingeiro RC,Kyba M

更新日期：2008-12-01 00:00:00

abstract：:Media conditioned by B-lymphocytes of patients with chronic lymphocytic leukemia (B-CLL) induced the formation of multilineage colonies (CFU-GEMM) in cultures of human target marrow cells. Maximum levels of stem cell colony-stimulating activity (CFU-GEMMCSA) were detected by day 3 of leukemic B-cell cultures, remainin...

journal_title：Experimental hematology

authors： Merchav S,Nagler A,Tatarsky I

更新日期：1987-02-01 00:00:00

abstract：:Early hematopoietic progenitor cells adhere to bone marrow stromal cells (BMSCs) mainly through VLA-4/VCAM-1 interactions. However, many adhesion molecules are expressed by these cell types. Cell adhesion molecules not only mediate adhesion; some are also capable of triggering cellular signaling events. These signals ...

journal_title：Experimental hematology

authors： Oostendorp RA,Spitzer E,Reisbach G,Dörmer P

更新日期：1997-04-01 00:00:00

abstract：:A right atrial catheter was implanted into 15 patients undergoing bone marrow transplantation as a treatment for acute leukemia. The catheter remained in position for 79 +/- 34 days. No catheter-related septicemia was observed. It appears that this catheter is helpful in supporting bone marrow transplant recipients. ...

journal_title：Experimental hematology

authors： Blume KG,Bross KJ,Riihimaki DU,Schmidt GM

更新日期：1978-08-01 00:00:00

abstract：:To understand the regulatory mechanisms involved in the development of hematopoietic stem cells, we cultured lineage-negative, c-Kit+ Sca-1+ stem cells sorted from bone marrow cells by a fluorescence-activated cell sorter (FACS) on layers of bone marrow stromal cell lines established from SV40 T-antigen gene transgeni...

journal_title：Experimental hematology

authors： Koguma M,Matsuda K,Okuyama R,Yanai N,Obinata M

更新日期：1998-04-01 00:00:00

abstract：:Seven patients received cancer chemotherapy with high-dose cyclophosphamide (HD-CTX) associated with either recombinant human granulocyte colony-stimulating factor (rhG-CSF), rh interleukin-3 (rhIL-3), rh granulocyte-macrophage CSF (rhGM-CSF) plus rh erythropoietin (rhEpo), rhIL-3 plus rhGM-CSF, or rhIL-3 plus rhG-CSF...

journal_title：Experimental hematology

authors： Siena S,Bregni M,Bonsi L,Sklenar I,Bagnara GP,Bonadonna G,Gianni AM

更新日期：1993-11-01 00:00:00

abstract：OBJECTIVE:Approximately 60% of all anaplastic large-cell lymphomas (ALCL) contain a specific t(2;5)(p23;q35) chromosomal translocation leading to overexpression of NPM-ALK. As the chimeric tyrosine kinase is involved in tumorigenesis and pathogenesis of ALCL, we were interested to inhibit NPM-ALK expression using an ex...

journal_title：Experimental hematology

authors： Hübinger G,Wehnes E,Xue L,Morris SW,Maurer U

更新日期：2003-03-01 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) can be generated from various types of cells with transduction of defined transcription factors. Patient-derived iPSCs are becoming commonly utilized for understanding the molecular pathways involved in disease and for the development of novel targeted therapies. With the use of ...

journal_title：Experimental hematology

authors： Arai S,Miyauchi M,Kurokawa M

更新日期：2015-08-01 00:00:00

abstract：:Fourteen patients with chronic granulocytic leukemia received bone marrow grafts from HLA identical siblings. Ten patients were in blast crisis prior to grafting, three were in an accelerated phase of their disease, and one was aplastic secondary to chemotherapy. Prior to transplant all patients were conditioned with ...

journal_title：Experimental hematology

authors： Doney K,Buckner CD,Sale GE,Ramberg R,Boyd C,Thomas ED

更新日期：1978-10-01 00:00:00