PBK/TOPK overexpression and survival in solid tumors: A PRISMA-compliant meta-analysis.

Abstract:

BACKGROUND:The prognostic significance of PBK/TOPK overexpression in solid tumors remains controversial. Therefore, we carried out a meta-analysis to evaluate the impact of PBK/TOPK overexpression in solid tumors on patients' overall survival (OS) and disease-free survival (DFS). METHODS:Relevant articles were identified through searching the PubMed, Embase and Web of Science up to May 2017. The pooled hazard ratio (HR) with 95% confidence interval (CI) was used to estimate the effects. RESULTS:In this meta-analysis, 12 studies involving 1571 participants were included, PBK/TOPK overexpression was significantly associated with poor OS (pooled HR = 1.91, 95%CI = 1.22-3.00, P = .005) and short DFS (pooled HR = 1.95, 95%CI = 1.46-2.58, P < .001). CONCLUSIONS:PBK/TOPK overexpression was associated with poor survival in human solid tumors which may be a valuable prognosis biomarker and a potential therapeutic target of solid tumors.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Xu M,Xu S

doi

10.1097/MD.0000000000014766

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

e14766

issue

10

eissn

0025-7974

issn

1536-5964

pii

00005792-201903080-00049

journal_volume

98

pub_type

杂志文章,meta分析

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