PBK/TOPK overexpression and survival in solid tumors: A PRISMA-compliant meta-analysis.


BACKGROUND:The prognostic significance of PBK/TOPK overexpression in solid tumors remains controversial. Therefore, we carried out a meta-analysis to evaluate the impact of PBK/TOPK overexpression in solid tumors on patients' overall survival (OS) and disease-free survival (DFS). METHODS:Relevant articles were identified through searching the PubMed, Embase and Web of Science up to May 2017. The pooled hazard ratio (HR) with 95% confidence interval (CI) was used to estimate the effects. RESULTS:In this meta-analysis, 12 studies involving 1571 participants were included, PBK/TOPK overexpression was significantly associated with poor OS (pooled HR = 1.91, 95%CI = 1.22-3.00, P = .005) and short DFS (pooled HR = 1.95, 95%CI = 1.46-2.58, P < .001). CONCLUSIONS:PBK/TOPK overexpression was associated with poor survival in human solid tumors which may be a valuable prognosis biomarker and a potential therapeutic target of solid tumors.


Medicine (Baltimore)




Xu M,Xu S




Has Abstract


2019-03-01 00:00:00
















  • The top-cited systematic reviews/meta-analyses in tuberculosis research: A PRISMA-compliant systematic literature review and bibliometric analysis.

    abstract:BACKGROUND:The top-cited systematic reviews/meta-analyses in tuberculosis research have not been identified. The objective of this study was to identify the 100 top-cited systematic reviews/meta-analyses in tuberculosis research, and to understand factors resulting in highly cited works, and establish trends in systema...


    pub_type: 杂志文章,评审


    authors: Zhang Y,Huang J,Du L

    更新日期:2017-02-01 00:00:00

  • A case report of pelviscopic resection of invasive hydatidiform mole.

    abstract:RATIONALE:Invasive moles occur in the fertile period, with about 95% occurring after previous mole removal and the remaining 5% occurring after several other pregnancies. PATIENT CONCERNS:A 27-year-old patient developed a rare invasive mole two months after a missed abortion. DIAGNOSES:A transvaginal ultrasound scan ...


    pub_type: 杂志文章


    authors: Lee HJ,Kim YS

    更新日期:2019-10-01 00:00:00

  • Dementia Risk in Irradiated Patients With Head and Neck Cancer.

    abstract::Patients with head and neck cancer are treated through surgery, radiotherapy (RT), and chemotherapy (CT). Carotid artery damage and neurotoxicity were previously observed in these patients. This study estimated the dementia risk associated with different treatment modalities in a head and neck cancer population with l...


    pub_type: 杂志文章


    authors: Chen JH,Yen YC,Liu SH,Lee FP,Lin KC,Lai MT,Wu CC,Chen TM,Yuan SP,Chang CL,Wu SY

    更新日期:2015-11-01 00:00:00

  • Various clinical features of patients with anti-Hu associated paraneoplastic neurological syndromes: An observational study.

    abstract::To describe and analyze the clinical features and prognosis of patients with anti-Hu associated paraneoplastic neurological syndromes (PNS).The symptoms, MRI findings, cerebrospinal fluid (CSF) changes, electroencephalogram (EEG) characteristics and prognoses of 9 well-diagnosed anti-Hu associated PNS patients were an...


    pub_type: 杂志文章


    authors: Li J,Lin W

    更新日期:2018-05-01 00:00:00

  • Universal antibiotic prophylaxis may no longer be necessary for patients with acute variceal bleeding: A retrospective observational study.

    abstract::A few decades ago, antibiotic prophylaxis for patients with acute variceal bleeding was reported beneficial. However, endoscopic and systemic therapy for variceal bleeding has dramatically improved since then, so the necessity of prophylactic antibiotics can be questioned. In this study, we reevaluated the efficacy of...


    pub_type: 杂志文章


    authors: Ueno M,Kayahara T,Sunami T,Takayama H,Takabatake H,Morimoto Y,Yamamoto H,Mizuno M

    更新日期:2020-05-01 00:00:00

  • Effect of educational interventions on health in childhood: A meta-analysis of randomized controlled trials.

    abstract:BACKGROUND:The purpose of this study was to summarize the evidences from randomized controlled trials (RCTs) investigating the effects of educational interventions in overweight/obesity childhood by using meta-analytic approach. METHODS:PubMed, Embase, and the Cochrane Library databases were searched from the inceptio...


    pub_type: 杂志文章,meta分析,评审


    authors: Wang X,Zhou G,Zeng J,Yang T,Chen J,Li T

    更新日期:2018-09-01 00:00:00

  • Intracranial solitary fibrous tumor mimicking meningioma: A case report.

    abstract:RATIONALE:Solitary fibrous tumor is a rare mesenchymal tumor. This case report describes the diagnosis and treatment of this tumor. PATIENT CONCERNS:A 31-year-old patient presented with epileptic seizure and headache 1 day prior to the visit and showed transient right limb hemiplegia for 6 hours that was resolved afte...


    pub_type: 杂志文章


    authors: Cheng L,Ni H,Dai Y

    更新日期:2020-12-11 00:00:00

  • Allograft hemorrhage as a manifestation of carbapenem-resistant Klebsiella pneumonia infection in kidney transplant recipients: Case series.

    abstract:RATIONALE:Carbapenem-resistant Klebsiella pneumonia (CRKP) infections have been a concerning threat, especially in organ transplant patients with very high mortality. Allograft hemorrhage associated with CRKP infection has never been described. PATIENT CONCERNS:A total of 6 recipients tested positive for CRKP were ide...


    pub_type: 杂志文章


    authors: Wang Z,Qian Y,Bai H,Yang J,Li X

    更新日期:2020-03-01 00:00:00

  • Hedgehog Signaling in Pancreatic Fibrosis and Cancer.

    abstract::The hedgehog signaling pathway was first discovered in the 1980s. It is a stem cell-related pathway that plays a crucial role in embryonic development, tissue regeneration, and organogenesis. Aberrant activation of hedgehog signaling leads to pathological consequences, including a variety of human tumors such as pancr...


    pub_type: 杂志文章,评审


    authors: Bai Y,Bai Y,Dong J,Li Q,Jin Y,Chen B,Zhou M

    更新日期:2016-03-01 00:00:00

  • Meta-analysis of correlationship between HLA-G 3'UTR 14-bp Ins/Del polymorphism and virus susceptibility.

    abstract:BACKGROUND:There is a considerable amount of literature on the potential relationship between human leukocyte antigen-G 14-bp Ins/Del polymorphism and virus infection; however, results from these studies were inconclusive. OBJECTIVES:A meta-analysis was carried out to determine whether the 14-bp Ins/Del polymorphism i...


    pub_type: 杂志文章,meta分析


    authors: Lv H,Lv H,Lin Z,Chen L,Zhu M,Hong D

    更新日期:2018-09-01 00:00:00

  • D-lactic acidosis. A review of clinical presentation, biochemical features, and pathophysiologic mechanisms.

    abstract::This report describes a case of d-lactic acidosis observed by the authors and then reviews all case reports of d-lactic acidosis in the literature in order to define its clinical and biochemical features and pathogenetic mechanisms. The report also reviews the literature on metabolism of d-lactic acid in humans. The c...


    pub_type: 杂志文章,评审


    authors: Uribarri J,Oh MS,Carroll HJ

    更新日期:1998-03-01 00:00:00

  • Cherubism With Bilateral Mandible and Maxilla Involvement: A Case Report.

    abstract::Cherubism is a rare, nonneoplastic, self-limiting fibro-osseous that occurs in children. Affected children usually appear normal at birth. Lesions are characterized by the replacement of bone with fibrovascular tissue containing many multinucleated giant cells. Most studies have reported cherubism to be familial and w...


    pub_type: 杂志文章


    authors: Yu Z,Zhai M,Gan W,Zhang H,Zhou Y,Wen H

    更新日期:2015-12-01 00:00:00

  • Non-traumatic perforation of the jejunum in a human immunodeficiency virus-infected patient receiving combination antiretroviral therapy: A case report.

    abstract:RATIONALE:Non-traumatic bowel perforation caused by cytomegalovirus (CMV) and Mycobacterium avium complex (MAC) infections has become rare among patients with acquired immunodeficiency syndrome (AIDS) in the era of combination antiretroviral therapy (cART); however, CMV-associated and MAC-related immune reconstitution ...


    pub_type: 杂志文章


    authors: Lee YC,Chiou CC,Wang JT,Yang YC,Tung SH,Hsieh SM

    更新日期:2019-12-01 00:00:00

  • Association Between the MUC5B Promoter Polymorphism rs35705950 and Idiopathic Pulmonary Fibrosis: A Meta-analysis and Trial Sequential Analysis in Caucasian and Asian Populations.

    abstract::Idiopathic pulmonary fibrosis (IPF) is a progressive disease with a poor prognosis. A number of studies reported the association between MUC5B promoter polymorphism rs35705950 and IPF, but substantial inconsistent findings were observed and the strength of association remains unclear.The aim of the study was to invest...


    pub_type: 杂志文章,meta分析


    authors: Zhu QQ,Zhang XL,Zhang SM,Tang SW,Min HY,Yi L,Xu B,Song Y

    更新日期:2015-10-01 00:00:00

  • Multiple cerebral gliomas mimicking central nervous system inflammatory demyelinating diseases: A rare case with review of literature.

    abstract:RATIONALE:Multiple cerebral gliomas (MCGs), usually classified into multifocal and multicentric subtypes, represent major diagnostic challenges as their clinical, radiologic, and pathohistological features are not uniform, often mimicking brain metastatic tumors or central nervous system inflammatory demyelinating dise...


    pub_type: 杂志文章,评审


    authors: Xiong YJ,Zhao XL,Wang XY,Pan DJ,Tian DS

    更新日期:2017-12-01 00:00:00

  • An unruptured posterior communicating artery aneurysm ruptured during angiography: A case report.

    abstract:INTRODUCTION:Cerebrovascular imaging is the gold standard for diagnosis of intracranial aneurysms. Rupture of intracranial aneurysm is rare in cerebrovascular angiography, especially in unruptured intracranial aneurysm. PATIENT CONCERNS:A 74-year-old woman was admitted to the hospital for sudden onset of left eyelid p...


    pub_type: 杂志文章


    authors: Guo S,Wu X

    更新日期:2019-11-01 00:00:00

  • Efficacy of short-term moderate or high-dose rosuvastatin in preventing contrast-induced nephropathy: A meta-analysis of 15 randomized controlled trials.

    abstract:BACKGROUND:The prophylactic efficacy of statin pretreatment for the prevention of contrast-induced nephropathy (CIN) in patients undergoing coronary angiography (CAG) or percutaneous coronary intervention (PCI) remains controversial. The aim of the study was to perform a meta-analysis of randomized controlled trials (R...


    pub_type: 杂志文章,meta分析,评审


    authors: Liang M,Yang S,Fu N

    更新日期:2017-07-01 00:00:00

  • Abnormal octadeca-carbon fatty acids distribution in erythrocyte membrane phospholipids of patients with gastrointestinal tumor.

    abstract::Fatty acid (FA) composition is closely associated with tumorigenesis and neoplasm metastasis. This study was designed to investigate the differences of phospholipid FA (PLFA) composition in erythrocyte and platelet cell membranes in both gastrointestinal (GI) tumor patients and healthy controls.In this prospective stu...


    pub_type: 杂志文章


    authors: Lin S,Li T,Liu X,Wei S,Liu Z,Hu S,Liu Y,Tan H

    更新日期:2017-06-01 00:00:00

  • A Causal Role of Genetically Elevated Circulating Interleukin-10 in the Development of Digestive Cancers: Evidence from Mendelian Randomization Analysis Based on 29,307 Subjects.

    abstract::Recent studies have observed a high level of circulating interleukin-10 (IL-10) in patients with digestive cancers, yet whether elevated IL-10 is causally associated with digestive cancers so far remained unresolved. We therefore meta-analyzed available observational studies with Mendelian randomization method to expl...


    pub_type: 杂志文章,meta分析,评审


    authors: Niu W,Pang Q,Lin T,Wang Z,Zhang J,Tai M,Zhang L,Zhang L,Gu M,Liu C,Qu K

    更新日期:2016-02-01 00:00:00

  • Stiff-person syndrome coexisting with critical illness polyneuropathy: A case report.

    abstract:RATIONALE:Stiff-person syndrome (SPS) is an uncommon neurological disorder with autoimmune features. Here, we report a 60-year-old man with SPS associated with critical illness polyneuropathy (CIP). CIP was diagnosed during an episode of acute respiratory failure secondary to muscular rigidity and spasms, which has rar...


    pub_type: 杂志文章


    authors: Cai Q,Wu C,Xu W,Liang Y,Liao S

    更新日期:2020-12-11 00:00:00

  • Clinical analysis of 56 patients with rhupus syndrome: manifestations and comparisons with systemic lupus erythematosus: a retrospective case-control study.

    abstract::To investigate the clinical features of Rhupus syndrome, we retrospectively reviewed the medical records of 56 patients with Rhupus who were hospitalized at the Peking Union Medical College Hospital, Beijing, China, between January 2000 and March 2013. We analyzed the clinical manifestations of Rhupus syndrome and com...


    pub_type: 杂志文章


    authors: Li J,Wu H,Huang X,Xu D,Zheng W,Zhao Y,Liu W,Zeng X

    更新日期:2014-08-01 00:00:00

  • Risk factors associated with hepatic osteopathy in HBV related cirrhosis measured by liver stiffness: An Observational study.

    abstract::To investigate the differences in bone mineral density between patients with liver cirrhosis and healthy control, and to analyze the risk factors of hepatic osteoporosis in patients with HBV related liver cirrhosis.A total of 189 patients with liver cirrhosis and 207 health controls were enrolled. The bone mineral den...


    pub_type: 杂志文章


    authors: Zhang W,Gong H,Su Z,Zhang X,Cao S

    更新日期:2019-08-01 00:00:00

  • Low Response of Renin-Angiotensin System to Sodium Intake Intervention in Chinese Hypertensive Patients.

    abstract::The interactions of sodium balance and response of renin-angiotensin-aldosterone system are important for maintaining the hemodynamic stability in physiological conditions. However, the influence of short-term sodium intake intervention in the response of renin-angiotensin system (RAS) on hypertensive patients is stil...


    pub_type: 临床试验,杂志文章


    authors: Feng W,Cai Q,Yuan W,Liu Y,Bardeesi ASA,Wang J,Chen J,Huang H

    更新日期:2016-02-01 00:00:00

  • Expression Profiles and Clinical Significance of MicroRNAs in Papillary Renal Cell Carcinoma: A STROBE-Compliant Observational Study.

    abstract::Papillary renal cell carcinoma (pRCC) is the second most prevalent subtype of kidney cancers. In the current study, we analyzed the global microRNA (miRNA) expression profiles in pRCC, with the aim to evaluate the relationship of miRNA expression with the progression and prognosis of pRCC.A total of 163 treatment-naïv...


    pub_type: 杂志文章


    authors: Ge YZ,Xu LW,Xu Z,Wu R,Xin H,Zhu M,Lu TZ,Geng LG,Liu H,Zhou CC,Yu P,Zhao YC,Hu ZK,Zhao Y,Zhou LH,Wu JP,Li WC,Zhu JG,Jia RP

    更新日期:2015-04-01 00:00:00

  • Association between the use of antibiotics and efficacy of gemcitabine plus nab-paclitaxel in advanced pancreatic cancer.

    abstract::It is unclear whether the use of antibiotics is related to the efficacy of gemcitabine plus nab-paclitaxel (GnP). Therefore, we investigated the association between the use of antibiotics and efficacy of GnP.We conducted a retrospective single center study from January 2014 to December 2018 in Hokkaido University Hosp...


    pub_type: 杂志文章


    authors: Nakano S,Komatsu Y,Kawamoto Y,Saito R,Ito K,Nakatsumi H,Yuki S,Sakamoto N

    更新日期:2020-09-25 00:00:00

  • Assessing the relationship between the use of nonsteroidal antiinflammatory drugs and necrotizing fasciitis caused by group A streptococcus.

    abstract::Group A streptococcal (GAS) necrotizing fasciitis is a rapidly progressive soft tissue infection. Elderly and chronically ill individuals are at greatest risk, particularly when skin breakdown is present. Reports suggest that nonsteroidal antiinflammatory drugs (NSAIDs) increase the risk of developing GAS necrotizing ...


    pub_type: 杂志文章,评审


    authors: Aronoff DM,Bloch KC

    更新日期:2003-07-01 00:00:00

  • A Congenital Peribronchial Myofibroblastic Tumor Detected in a Premature Infant at 28 Weeks but That Resolved in the Late Stage of Pregnancy: A Case Report.

    abstract::A congenital peribronchial myofibroblastic tumor (CPMT) is a rare benign tumor arising from the lungs. Although CPMT is a benign tumor, it is characterized by rapid growth, and is easily misdiagnosed during the prenatal period when the symptoms are nonspecific. The authors present a rare case of CPMT in a premature in...


    pub_type: 杂志文章


    authors: Xia B,Yu G,Hong C,Zhang L,Tang J,Liu C

    更新日期:2015-10-01 00:00:00

  • Diagnostic value of radionuclide in bone metastasis after breast cancer surgery: A protocol of systematic review.

    abstract:BACKGROUND:The objective of this study is to evaluate the accuracy of radionuclide in diagnosis of bone metastasis (BM) after breast cancer surgery (BCS). METHODS:The electronic databases (Cochrane Library, MEDLINE, EMBASE, Web of Science, CBM, and CNKI) will be systematically and comprehensively searched until June 1...


    pub_type: 杂志文章


    authors: Lian QX,Zhao W,Li G,Jin LJ,Nie HJ

    更新日期:2020-08-14 00:00:00

  • Omalizumab an effective and safe alternative therapy in severe refractory atopic dermatitis: A case report.

    abstract:RATIONALE:Atopic dermatitis is a frequent, relapsing, chronic inflammatory skin condition with a deep negative impact on quality of life. Three are the major pathological factors driving its complex pathogenesis: the skin barrier disruption, the altered Th2 cell response and itching. Current management of the disease i...


    pub_type: 杂志文章


    authors: Sirufo MM,De Martinis M,Ginaldi L

    更新日期:2018-06-01 00:00:00

  • Rates of initial and recurrent thromboembolic disease among patients with malignancy versus those without malignancy. Risk analysis using Medicare claims data.

    abstract::Although the association between malignancy and thromboembolic disease is well established, the relative risk of developing initial and recurrent deep vein thrombosis (DVT) or pulmonary embolism (PE) among patients with malignancy versus those without malignancy has not been clearly defined. The Medicare Provider Anal...


    pub_type: 杂志文章


    authors: Levitan N,Dowlati A,Remick SC,Tahsildar HI,Sivinski LD,Beyth R,Rimm AA

    更新日期:1999-09-01 00:00:00