Abstract:
BACKGROUND:The prognostic significance of PBK/TOPK overexpression in solid tumors remains controversial. Therefore, we carried out a meta-analysis to evaluate the impact of PBK/TOPK overexpression in solid tumors on patients' overall survival (OS) and disease-free survival (DFS). METHODS:Relevant articles were identified through searching the PubMed, Embase and Web of Science up to May 2017. The pooled hazard ratio (HR) with 95% confidence interval (CI) was used to estimate the effects. RESULTS:In this meta-analysis, 12 studies involving 1571 participants were included, PBK/TOPK overexpression was significantly associated with poor OS (pooled HR = 1.91, 95%CI = 1.22-3.00, P = .005) and short DFS (pooled HR = 1.95, 95%CI = 1.46-2.58, P < .001). CONCLUSIONS:PBK/TOPK overexpression was associated with poor survival in human solid tumors which may be a valuable prognosis biomarker and a potential therapeutic target of solid tumors.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Xu M,Xu Sdoi
10.1097/MD.0000000000014766subject
Has Abstractpub_date
2019-03-01 00:00:00pages
e14766issue
10eissn
0025-7974issn
1536-5964pii
00005792-201903080-00049journal_volume
98pub_type
杂志文章,meta分析相关文献
MEDICINE文献大全abstract::As detection rates of non-albicans Candida species are increasing, determining their pathogen profiles and antifungal susceptibilities is important for antifungal treatment selection. We identified the antifungal susceptibility patterns and predictive factors for mortality in candidemia.A multicenter retrospective ana...
journal_title:Medicine
pub_type: 杂志文章,多中心研究
doi:10.1097/MD.0000000000019494
更新日期:2020-03-01 00:00:00
abstract:RATIONALE:Tooth extraction is a common dental surgical procedure. There is a possibility that various complications often occur during third molar tooth extractions. PATIENT CONCERNS:The authors report herein 2 cases of migration of a high-speed dental hand-piece bur during mandibular third molar extraction-one case w...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000019177
更新日期:2020-02-01 00:00:00
abstract::Recent studies have revealed a link between estradiol (E2) and glucose homeostasis. We aimed to assess the association between cord blood hormone levels and the risk of gestational diabetes mellitus (GDM).A total of 204 pregnant women with GDM and 204 pregnant women without GDM (control) were included in the study. Ma...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006962
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:To investigate the radiation dose and image quality for iterative reconstruction combined with the CARE kV technique in chest computed tomography (CT) scanning for physical examination. METHODS:A total of 130 patients who underwent chest CT scanning were randomly chosen and the quality reference value was s...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000006175
更新日期:2017-03-01 00:00:00
abstract::The purpose of this study is to evaluate the susceptibility trend of vancomycin, teicoplanin, daptomycin, and linezolid against methicillin-resistant Staphylococcus aureus (MRSA) blood isolates of different clones over an 11-year period.From 2000 to 2010, all bloodstream MRSA isolates from Chang Gung Memorial Hospital...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005060
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Graves ophthalmopathy (GO) is one of the remaining enigmas in thyroidology. Glucocorticoids (GCs) are strongly recommended but their effects are not completely satisfactory and adverse reactions can occur. Tripterygium glycosides (TG) is a promising component extracted from Tripterygium wilfordii Hook F (TwH...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000018242
更新日期:2019-12-01 00:00:00
abstract::Vitamin D deficiency has been associated with several adverse outcomes mainly in the outpatient setting. The objective of this study was to examine the prevalence of vitamin D deficiency and its association with risk of adverse clinical outcomes in a large prospective cohort of medical inpatients.We collected clinical...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003533
更新日期:2016-05-01 00:00:00
abstract::[This corrects the article DOI: 10.1097/MD.0000000000004251.]. ...
journal_title:Medicine
pub_type: 已发布勘误
doi:10.1097/MD.0000000000005665
更新日期:2016-12-09 00:00:00
abstract:INTRODUCTION:The Klippel-Trenaunay syndrome (KTS) is a rare congenital disorder. The obstetric course of women with KTS varies. Complications include bleeding, disseminated intravascular coagulation (DIC), thromboembolic events, etc. PATIENT CONCERNS:: Here, we report a case of late puerperal hemorrhage of a Chinese pu...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000018378
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:To evaluate the effect of probiotic supplementation on functional constipation in children. METHODS:We performed electronic searches in PubMed, Embase, and Cochrane Library without language restriction to identify relevant studies from the time of inception of these databases to March 2018. The relative ris...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000012174
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:To determine the diagnostic accuracy of techniques with chronic thromboembolic pulmonary hypertension (CTEPH) patients via a protocol for systemic review and network meta-analysis. METHODS:We will search PubMed, EMBASE, Web of Science, and Google Scholar from inception to October 1, 2018. The reference list...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000016787
更新日期:2019-08-01 00:00:00
abstract::Mastocytosis is a rare disease characterized by clonal neoplastic proliferation of mast cells (MCs). It ranges from skin lesions as cutaneous mastocytosis (CM) which may spontaneously regress to highly aggressive neoplasms with multiorgan involvement corresponding to some aggressive systemic mastocytosis (ASM), mast c...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010642
更新日期:2018-05-01 00:00:00
abstract:RATIONALE:Choroidal detachment is a major postoperative complication of trabeculectomy. Postoperative choroidal detachment occurs with low intraocular pressure (IOP), and is naturally resolved by elevation of IOP. We report a case of chronic chorioretinal detachment (CRD) in the eye with uveitic glaucoma after trabecul...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000018652
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Oropharyngeal mucositis is considered to be an inevitable and the most troubling side effect of head and neck irradiation, which is caused by the direct toxic action of radiation on oral mucosa. Several randomized controlled trials (RCTs) have investigated the efficacy of zinc sulfate in prevention of radiat...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000013310
更新日期:2018-11-01 00:00:00
abstract::Unplanned readmissions may be avoided by accurate risk prediction and appropriate resources could be allocated to high risk patients. The Length of stay, Acuity of admission, Charlson comorbidity index, Emergency department visits in past six months (LACE) index was developed to predict hospital readmissions in Canada...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006728
更新日期:2017-05-01 00:00:00
abstract::The vascular endothelial growth factor (VEGF) level in human circulation may reflect the severity of endothelial dysfunction in patients with diabetes mellitus, which leads to diabetic microvascular complications.We determined plasma VEGF levels as well as metabolic control and inflammatory factors in 26 healthy subje...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010415
更新日期:2018-04-01 00:00:00
abstract:RATIONALE:Spinal involvement in adult Langerhans cell histiocytosis (LCH) is rare, and epidural involvement is unusual. LCH is mostly indistinguishable from other spinal lesions such as infection, lymphoma, and metastasis. So, it could be easily misdiagnosed without suspicion. PATIENT CONCERNS:We report a case of a 33...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000018794
更新日期:2020-01-01 00:00:00
abstract::There is no known study regarding the usefulness of each blood pressure (BP) component based on stratification by age and sex for predicting cardiovascular (CV) events among hypertensive populations without chronic kidney disease (CKD) or diabetes mellitus (DM). This study was performed to investigate the association ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016676
更新日期:2019-08-01 00:00:00
abstract::Recent studies have investigated the most efficacious dose of intravenous tissue plasminogen activator (IV-tPA) for acute ischemic stroke (AIS) patients. There remains no definitive consensus concerning the superior efficacious IV-tPA dose (standard- vs. low-dose), prompting us to perform a meta-analysis comparing the...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000002412
更新日期:2015-12-01 00:00:00
abstract::The present study investigated the effectiveness of a Carisolv III + 0.5% sodium hypochlorite (NaOCl)-based root canal irrigant for smear layer removal.Forty maxillary incisors were randomly divided into 4 groups (n = 10 per group). The canals in group A (experimental) were prepared with 0.5% NaOCl, and Carisolv III a...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020372
更新日期:2020-05-29 00:00:00
abstract:RATIONALE:Filling materials for partial defect of the breast have rarely been developed because of safety and durability. PATIENT CONCERNS:Two female patients (ages, 53 and 50 years) with breast cancer underwent partial mastectomy with sentinel lymph node biopsy. DIAGNOSIS:Core needle biopsy revealed an invasive duct...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021217
更新日期:2020-07-31 00:00:00
abstract::There is a shortage of data in everyday clinical practice about the anticoagulant effects caused by the new oral anticoagulants (NOAs). Our aim was to estimate the intensity of anticoagulant activity induced by rivaroxaban 20 mg qd and dabigatran 110 mg bid among patients with nonvalvular atrial fibrillation (NV-AF).W...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003037
更新日期:2016-04-01 00:00:00
abstract::Although it is an invasive and unpleasant procedure, esophagogastroduodenoscopy (EGD) is still the gold standard for esophageal varices (EV) detection. The aim of this study was to investigate liver stiffness measurement (LSM) and spleen diameter as simple noninvasive tools for EV prediction in chronic hepatitis C pat...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008621
更新日期:2017-11-01 00:00:00
abstract:RATIONALE:Infertility is a common medical condition that affects nearly 15% of the world population. Non-obstructive azoospermia (NOA) is one of the most severe forms of male infertility. Some common structural variants, single nucleotide polymorphisms (SNPs), and genetic factors were reported to be associated with NOA...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021107
更新日期:2020-07-31 00:00:00
abstract:INTRODUCTION:The market for dietary supplements in the sports sector has been growing rapidly for several years, though there is still lacking evidence regarding their claimed benefits. One group is that of nitric oxide increasing supplements, so-called "NO-boosters," which are claimed to improve the supply of oxygen a...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022318
更新日期:2020-10-09 00:00:00
abstract:BACKGROUND:Severe acute respiratory syndrome coronavirus 2 viral infection resulting in corona virus disease 2019 (COVID-19) disease has recently been designated by the World Health Organization as a global pandemic. Some doctors are using convalescent plasma (CP) therapies to treat COVID-19 patients. However, whether ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022017
更新日期:2020-11-06 00:00:00
abstract::The aim of this study was to estimate the prevalence of psychostimulant use in the French medical community and their motives. A population-based cross-sectional study using a self-administered online survey was done. A total of 1718 French students and physicians (mean age, 26.84±7.19 years, 37.1% men) were included....
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003366
更新日期:2016-04-01 00:00:00
abstract:RATIONALE:The precise cause of granulomatosis with polyangiitis (GPA) remains unclear. Herein we present a case of refractory GPA occurring after trauma. PATIENT CONCERNS:A 43-year-old man suffered fractures of the left orbital in an accident, and then received surgical repair. At a postoperative follow-up, he develop...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014189
更新日期:2019-01-01 00:00:00
abstract:RATIONALE:PNETs (primitive neuroectodermal tumors) are a family of highly malignant neoplasms characterized by small round cells of neuroepithelial origin. They usually involve bone and soft tissues, and have a higher incidence in childhood. PATIENT CONCERNS:In this case report, we describe the obstetric and oncologic...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000009505
更新日期:2018-01-01 00:00:00
abstract::Numerous studies document significant improvement in motor symptoms in patients with Parkinson's disease (PD) after deep brain stimulation of the subthalamic nucleus (STN-DBS). However, little is known about the initial effects of STN-DBS on nonmotor domains.Our objective was to elucidate the initial effects of STN-DB...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000009750
更新日期:2018-02-01 00:00:00