Expression profiles of long noncoding RNAs associated with the NSUN2 gene in HepG2 cells.

abstract：:Magnesium, an important inorganic mineral component in bones, enhances osteoblast adhesion and osteogenic gene expression. Mg2+‑containing hydroxyapatite promotes mouse mesenchymal stem cell (MMSC) osteogenic differentiation. In the present study, MMSCs were cultured in media containing different concentrations of MgC...

journal_title：Molecular medicine reports

authors： Ni S,Xiong XB,Ni XY

更新日期：2020-11-01 00:00:00

abstract：:Quantitative polymerase chain reaction (qPCR) analysis is a commonly used method for the study of mRNA expression throughout the field of mesenchymal stem cell (MSC) research. This technology is simple and sensitive; however the results may vary significantly due to the use of various reference genes (RGs) as normaliz...

journal_title：Molecular medicine reports

authors： Li X,Yang Q,Bai J,Yang Y,Zhong L,Wang Y

更新日期：2015-02-01 00:00:00

abstract：:Glioma is the most common and aggressive of malignant brain tumours. MicroRNAs (miRNAs/miRs) are involved in tumour development of various human cancers, including glioma. Therefore, miRNAs may have potential tumour diagnostic, prognostic and therapeutic values in human glioma. miR‑103 is abnormally expressed in vario...

journal_title：Molecular medicine reports

authors： Wang L,Liu Y,Song J

更新日期：2018-03-01 00:00:00

abstract：:The apoptosis of alveolar epithelial cells is important in seawater aspiration‑induced acute lung injury (ALI). The present study aimed to investigate whether epigallocatechin-3-gallate (EGCG) is able to suppress apoptosis in alveolar epithelial cells in seawater aspiration‑induced ALI in vivo and in vitro, and the po...

journal_title：Molecular medicine reports

authors： Liu W,Dong M,Bo L,Li C,Liu Q,Li Z,Jin F

更新日期：2016-01-01 00:00:00

abstract：:Emerging evidence has suggested that intermedin (IMD), a novel member of the calcitonin gene‑related peptide (CGRP) family, has a wide range of cardioprotective effects. The present study investigated the effects of long‑term administration of IMD on cardiac function and sympathetic neural remodeling in heart failure ...

journal_title：Molecular medicine reports

authors： Xu B,Xu H,Cao H,Liu X,Qin C,Zhao Y,Han X,Li H

更新日期：2017-08-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) possess three characteristics critical to tissue regeneration; multipotency, low immunogenicity and an undifferentiated status, providing plasticity. However, increasing evidence has indicated that induction of an immune response in vivo can injure and reject MSC‑based tissues. Toll‑like ...

journal_title：Molecular medicine reports

authors： Yang Y,Wang Y,Li L,Bao J,Chen F,Zhang L

更新日期：2015-12-01 00:00:00

abstract：:The present study aimed to identify the differentially expressed genes (DEGs) between lung adenocarcinoma and normal lung tissues, and between lung squamous cell carcinoma and normal lung tissues, with the purpose of identifying potential biomarkers for the treatment of lung cancer. The gene expression profile (GSE604...

journal_title：Molecular medicine reports

authors： Lu C,Chen H,Shan Z,Yang L

更新日期：2016-08-01 00:00:00

abstract：:Although monitoring and diagnosis of fetal diseases in utero remains a challenge, metabolomics may provide an additional tool to study the etiology and pathophysiology of fetal diseases at a functional level. In order to explore specific markers of fetal disease, metabolites were analyzed in two separate sets of exper...

journal_title：Molecular medicine reports

authors： Huang J,Mo J,Zhao G,Lin Q,Wei G,Deng W,Chen D,Yu B

更新日期：2017-11-01 00:00:00

abstract：:Previous studies have shown that long non‑coding RNAs (lncRNAs) serve important roles in necrotizing enterocolitis (NEC). However, the underlying mechanisms remain largely unknown. In order to examine the potential role of lncRNAs in NEC, the present study investigated lncRNA and mRNA expression profiles in NEC lesion...

journal_title：Molecular medicine reports

authors： Chen W,Yan X,Tian T,Yan R,Wang X,Yu Z,Li Y,Zhang L,Han S

更新日期：2020-07-01 00:00:00

abstract：:Rhus javanica Linn, a traditional medicinal herb from the family Anacardiaceae, has been used in the treatment of liver diseases, cancer, parasitic infections, malaria and respiratory diseases in China, Korea and other Asian countries for centuries. In the present study, the protective effects of R. javanica ethanolic...

journal_title：Molecular medicine reports

authors： Yoon C,Koppula S,Yoo S,Yum M,Kim J,Lee J,Song M

更新日期：2016-01-01 00:00:00

abstract：:Lung fibrosis is associated with inflammation, apoptosis and oxidative damage. The transcription factor nuclear factor erythroid 2‑related factor‑2 (Nrf2) prevents damage to cells from oxidative stress by regulating the expression of antioxidant proteins. Sulforaphane (SFN), an Nrf2 activator, additionally regulates e...

journal_title：Molecular medicine reports

authors： Yan B,Ma Z,Shi S,Hu Y,Ma T,Rong G,Yang J

更新日期：2017-06-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic and irreversible interstitial lung disease with a poor prognosis and limited therapeutic options. Over the past decade, research efforts have focused on the pathogenetic mechanisms involved in this enigmatic lung disease. Rheumatoid arthritis (RA) is a chronic inflammat...

journal_title：Molecular medicine reports

authors： Vasarmidi E,Sarantoulaki S,Trachalaki A,Margaritopoulos G,Bibaki E,Spandidos DA,Tzanakis N,Antoniou K

更新日期：2018-10-01 00:00:00

abstract：:Connexin 43 (Cx43) is the main gap junction protein in astrocytes and exerts the same effects on growth inhibition in astrocytoma and glioma as microRNA-146a (miR-146a) in glioma. β2-adrenergic receptor (AR) signaling modulates Cx43 expression in myocytes via components downstream of protein kinase A (PKA) and exchang...

journal_title：Molecular medicine reports

authors： Khaksarian M,Mostafavi H,Soleimani M,Karimian SM,Ghahremani MH,Joghataee MT,Khorashadizadeh M,Aligholi H,Attari F,Hassanzadeh G

更新日期：2015-08-01 00:00:00

abstract：:Various studies have investigated hepatic carcinoma cachexia, however, there is little published information regarding the effect of Chinese Medicine carcinoma cachexia. The present study was performed to investigate the effect of modified Chinese herbal compound jianpijiedu (MJPJD) on a mouse model of ascites‑induced...

journal_title：Molecular medicine reports

authors： Sun B,Luo H,Deng L,Zhang S,Chen Z

更新日期：2016-10-01 00:00:00

abstract：:Aquaporins (AQPs) are known to be important in cancer progression. The present study used a cDNA microarray to demonstrate that AQP3, a member of the AQP family, was overexpressed in prostate cancer cells. In order to determine the role of AQP3 in prostate cancer, AQP3 expression was silenced by transfection with smal...

journal_title：Molecular medicine reports

authors： Chen J,Wang Z,Xu D,Liu Y,Gao Y

更新日期：2015-04-01 00:00:00

abstract：:CD44 is closely linked to breast cancer progression; however, the regulatory functions of microRNAs (miRs) in breast cancer have yet to be fully elucidated. In order to investigate the regulation of CD44 by miRs in breast cancer, the present study isolated CD44+ and CD44- breast cancer cells by flow cytometry, reveali...

journal_title：Molecular medicine reports

authors： Yang Z,Chen D,Nie J,Zhou S,Wang J,Tang Q,Yang X

更新日期：2016-06-01 00:00:00

abstract：:We investigated the effects of mechanical strain on the progressive ankylosis (ANK) gene and extracellular nucleotide phosphatase/phosphodiesterase (ENPP)1 mRNA expression and TGF-β1 protein expression in rat endplate chondrocytes in vitro. Endplate chondrocytes were isolated and cultured in vitro. Following identific...

journal_title：Molecular medicine reports

authors： Xu HG,Hu CJ,Wang H,Liu P,Yang XM,Zhang Y,Wang LT

更新日期：2011-09-01 00:00:00

abstract：:Findings of previous studies have revealed that intestinal mucosal mast cells (IMMCs) are involved in small intestinal ischemia‑reperfusion injury (IIRI). However, time-course changes of mast cell counts and mast cell function in this process remain unclear. The present study aimed to observe the number of IMMCs and t...

journal_title：Molecular medicine reports

authors： Ge M,Gan X,Liu D,Zhang W,Gao W,Huang P,Hei Z

更新日期：2013-08-01 00:00:00

abstract：:The loss of neurotrophic factor support has been shown to contribute to the development of the central nervous system. Glial cell line‑derived neurotrophic factor (GDNF), a potent neurotrophic factor, is closely associated with apoptosis and exerts neuroprotective effects on numerous populations of cells. However, the...

journal_title：Molecular medicine reports

authors： Cui W,Zhang Y,Lu D,Ren M,Yuan G

更新日期：2016-01-01 00:00:00

abstract：:Galectin‑3, a galactoside‑binding protein, is highly expressed in carotid plaques and plays an important role in the atherosclerotic lesions. The phenotype transformation of vascular smooth muscle cells is the basic pathological change of atherosclerosis. This study investigated the effects of exogenous galectin‑3 on ...

journal_title：Molecular medicine reports

authors： Tian L,Chen K,Cao J,Han Z,Wang Y,Gao L,Fan Y,Wang C

更新日期：2017-06-01 00:00:00

abstract：:Neural stem cells (NSCs) have the potential to give rise to offspring cells and hypoxic injury can impair the function of NSCs. The present study investigated the effects of mesenchymal stem cell (MSC)‑derived extracellular vesicles (EVs) on NSC injury, as well as the underlying mechanisms. MSC‑EVs were isolated and i...

journal_title：Molecular medicine reports

authors： Li F,Zhang J,Liao R,Duan Y,Tao L,Xu Y,Chen A

更新日期：2020-11-01 00:00:00

abstract：:It is well known that the local renin-angiotensin system (RAS) is activated in the diabetic state, which results in an increase in the level of oxidative stress injury to pancreatic β cells. The angiotensin‑converting enzyme 2 (ACE2)/angiotensin (1‑7) [Ang (1‑7)]/Mas axis is a negative regulator of the classical renin...

journal_title：Molecular medicine reports

authors： Zhang F,Liu C,Wang L,Cao X,Wang YY,Yang JK

更新日期：2016-09-01 00:00:00

abstract：:The expression of Ferroportin (Fpn) was examined at different time points in rats following focal cerebral ischemia treated with or without the traditional Chinese medicine Naotaifang. Initially, rats were randomly divided into 2, 6, 12, 24 and 72 h groups following middle cerebral artery occlusion (MCAO) and the mRNA...

journal_title：Molecular medicine reports

authors： Liao J,Xia X,Wang GZ,Shi YM,Ge JW

更新日期：2015-06-01 00:00:00

abstract：:Interleukin-33 (IL-33) promotes migration of cancer cells through downregulating the expression of E-cadherin. Previous studies have demonstrated that IL‑33 stimulates the proliferation of trophoblasts. However, the effect of IL‑33 on the adhesion and invasion of trophoblasts has not been investigated in detail. In th...

journal_title：Molecular medicine reports

authors： Wang XH,Liu W,Fan DX,Hu WT,Li MQ,Zhu XY,Jin LP

更新日期：2017-10-01 00:00:00

abstract：:Quantification of testosterone serves an important role in the differential diagnosis of androgen‑related endocrine diseases. Mass spectrometry exhibits higher accuracy and lower variability than immunoassays, especially at low testosterone concentrations. The present study developed and validated an isotope dilution ...

journal_title：Molecular medicine reports

authors： Sun G,Xue J,Li L,Li X,Cui Y,Qiao B,Wei D,Li H

更新日期：2020-08-01 00:00:00

abstract：:Extraocular dissemination is the main cause of death in patients with retinoblastoma (RB) in developing countries, and there are few molecular markers that are useful for the evaluation of minimal disseminated disease. The GD2 ganglioside is known to be expressed by RB cells that metastasize in bone marrow, and the ac...

journal_title：Molecular medicine reports

authors： Laurent VE,Otero LL,Vazquez V,Camarero S,Gabri MR,Labraga M,De Dávila MT,Chantada GL,Alonso DF

更新日期：2010-03-01 00:00:00

abstract：:Hyperbaric oxygen (HBO) is known to increase the survival of skin flaps by promoting neovascularization; however, the detailed mechanisms involved are not fully understood. In the present study, we aimed to characterize the effects of HBO treatment on neovascularization and skin flap survival. We also analyzed the mec...

journal_title：Molecular medicine reports

authors： Liu X,Liang F,Yang J,Li Z,Hou X,Wang Y,Gao C

更新日期：2013-10-01 00:00:00

abstract：:Advanced glycation end products (AGEs) are a contributing factor in the angiogenesis that is characteristic of proliferative diabetic retinopathy. However, a previous study made a promising observation that domain I‑IV of β2‑glycoprotein I (DI‑IV) inhibits angiogenesis in human umbilical vein cells. The present study ...

journal_title：Molecular medicine reports

authors： Wang QQ,Zhou SJ,Meng ZX,Wang J,Chen R,Lv L,Li CJ,Yu DM,Yu P

更新日期：2015-03-01 00:00:00

abstract：:The non-steroidal anti-inflammatory drug-activated gene (NAG-1) is a newly identified member of the transforming growth factor (TGF)-β superfamily and plays significant roles in regulating proliferation and pro-apoptotic activities. In the present study, we studied the regulation of NAG-1 by troglitazone in the cultur...

journal_title：Molecular medicine reports

authors： Wang C,Wang J,Bai P

更新日期：2011-01-01 00:00:00

abstract：:Glaucoma is a group of progressive optic neuropathies that have in common characteristic optic nerve head changes, loss of retinal ganglion cells and visual field defects. Among the large family of glaucomas, primary open‑angle glaucoma (POAG) is the most common type, a complex and heterogeneous disorder with environm...

journal_title：Molecular medicine reports

authors： Trivli A,Zervou MI,Goulielmos GN,Spandidos DA,Detorakis ET

更新日期：2020-08-01 00:00:00