Abstract:
:Aggressive B-cell non-Hodgkin lymphoma (aNHL) accounts for ∼50% of all NHL cases. The only potentially curative, broadly available treatment for patients with relapse, failing frontline treatment, is high-dose therapy followed by autologous stem cell transplantation (ASCT); patients ineligible for/who have failed ASCT have limited standard-of-care options. We conducted a structured review of treatments for relapsed/refractory patients with aNHL based on literature published between 2006 and 2017. Of the 22 publications identified for inclusion, most described phase II, single-arm trials (N = 25-217), and only three were randomized studies (phase II [N = 96], phase II/III [N = 111] and phase III [N = 338]). The majority of treatments evaluated resulted in only modest efficacy (median progression-free survival, 2.1-20.0 months) and ultimately poor health outcomes (median overall survival, 25 weeks-15.5 months). In conclusion, there is an unmet need for novel, effective, and tolerable treatments for patients with relapsed/refractory aNHL who are ineligible for/have failed ASCT.
journal_name
Leuk Lymphomajournal_title
Leukemia & lymphomaauthors
Salles GA,Pettengell R,Cordoba R,Długosz-Danecka M,Jurczak W,Tilly Hdoi
10.1080/10428194.2018.1564828subject
Has Abstractpub_date
2019-07-01 00:00:00pages
1610-1625issue
7eissn
1042-8194issn
1029-2403journal_volume
60pub_type
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