Treatment of refractory T-cell chronic lymphocytic leukemia with purine nucleoside analogues.

Abstract:

:This report describes two cases of T-cell chronic lymphocytic leukemia (T-CLL) treated with purine nucleoside analogues. One patient had CD8+, CD3+ large granular lymphocytosis (LGL) producing transfusion-dependent anemia and was refractory to chemotherapy. Treatment with four cycles of fludarabine produced a clinical complete remission and a molecular genetic partial remission that has been durable for > 15 months. The other patient had CD4+ T-prolymphocytic leukemia and was unresponsive to both fludarabine and 2-chlorodeoxyadenosine. Further trials of these agents are warranted in T-CLL, especially the LGL variant.

journal_name

Leuk Lymphoma

journal_title

Leukemia & lymphoma

authors

Witzig TE,Weitz JJ,Lundberg JH,Tefferi A

doi

10.3109/10428199409049659

subject

Has Abstract

pub_date

1994-06-01 00:00:00

pages

137-9

issue

1-2

eissn

1042-8194

issn

1029-2403

journal_volume

14

pub_type

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