Abstract:
PURPOSE:To investigate whether the evaluation of tumors, lymphoid cell-rich organs, and immune-related adverse events (IRAE) with F-FDG PET/CT can predict the efficacy and outcome of immunotherapy. METHODS:Forty patients who underwent F-FDG-PET/CT scans before and after therapy with immune checkpoint inhibitors from December 2013 to December 2016 were retrospectively enrolled (malignant melanoma, n = 21; malignant lymphoma, n = 11; renal cell carcinoma, n = 8). SUVmax of the baseline and first restaging scans were evaluated in tumors, spleen, bone marrow, thyroid and pituitary glands, and were correlated to best overall response in the first year after therapy; IRAE-affected areas were also evaluated. RESULTS:Interval change between the baseline and first restaging scans showed that patients with a clinical benefit had a significant decrease in tumor parameters (P < 0.001). All patients with an increase of SUVmax in the thyroid of more than 1.5 (n = 5) on the first restaging scan had a complete response (CR) in 1 year. Patients with CR within 1 year (n = 22) were significantly associated with a favorable long-term outcome (P = 0.002). Nine patients with IRAE findings had CR at final evaluation. Among IRAE, thyroiditis was seen significantly earlier than arthritis (P = 0.040). CONCLUSIONS:The decrease of tumor parameters at early time-point PET scans was seen in patients with immunotherapy who had clinical benefit within 1 year. PET-detectable IRAE was useful for prediction of a favorable outcome. Early development of thyroiditis may particularly represent an early response indicator to immunotherapy.
journal_name
Clin Nucl Medjournal_title
Clinical nuclear medicineauthors
Nobashi T,Baratto L,Reddy SA,Srinivas S,Toriihara A,Hatami N,Yohannan TK,Mittra Edoi
10.1097/RLU.0000000000002453subject
Has Abstractpub_date
2019-04-01 00:00:00pages
e272-e279issue
4eissn
0363-9762issn
1536-0229journal_volume
44pub_type
杂志文章abstract::Intravenous injection of Tc-99m-labeled radionuclides permits angioscintigraphic and blood pool visualization of both supra- and infradiaphragmatic organs. By adding this procedure to routine bone scans an improvement in the diagnostic yield of incidentally observed renal abnormalities was achieved. Several illustrati...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198003000-00002
更新日期:1980-03-01 00:00:00
abstract::The aim of this study was to make a comparison between the uptake of Tc-99m MIBI and Tl-201 in evaluation of musculoskeletal lesions. Fourteen cases were studied. Each study consisted of a Tl-201 study followed by a Tc-99m MIBI scan. In addition, a whole-body bone scan was performed in each patient to visualize bone m...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199602000-00008
更新日期:1996-02-01 00:00:00
abstract::The purpose of this report was to determine the pattern of thallium (T1-201) uptake in pigmented villonodular synovitis (PVNS) and giant cell tumor of the tendon sheath (GCTTS) and to evaluate for features that might help to distinguish these lesions from malignant disease. Scintigraphic images from patients subsequen...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/01.rlu.0000093083.77866.5c
更新日期:2003-11-01 00:00:00
abstract::Eleven patients who underwent nuclear medicine bone scanning were reviewed to determine the incidence of bone scan abnormalities associated with hepatoblastoma. Of these, six patients had abnormal bone scan findings--four with focal involvement. Correlating plain radiographs and/or follow-up nuclear bone scans were av...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199312000-00004
更新日期:1993-12-01 00:00:00
abstract:PURPOSE:The purpose of the present study was to investigate F-18 FDG uptake patterns, and to see whether joint F-18 FDG uptake reflected disease activity in patients with collagen vascular diseases (CVD)-associated arthritis. MATERIALS AND METHODS:A total of 72 patients with CVD-associated arthritis and 30 control sub...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e318212c858
更新日期:2011-05-01 00:00:00
abstract::Double-inlet left ventricle (DILV) is a congenital heart disease that only a single left ventricle and a rudimentary right ventricle are developed. Because of lack of anatomic landmark, interpretation of Tl myocardial perfusion imaging in DILV is essentially challenging for unusual anomaly. We report the case of a 44-...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001961
更新日期:2018-03-01 00:00:00
abstract::A 42-year-old woman suffered shortness of breath and whole-body pain, more prominent in both thighs. After the initial assessment, a paraneoplastic syndrome was considered clinically, and FDG PET/CT was performed to search culprit malignancy. The images did not reveal any focal lesion typical of solid hypermetabolic m...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001727
更新日期:2017-08-01 00:00:00
abstract::The current study was initiated to define whether Tc-99m leukocyte imaging, compared to In-111 chloride imaging, could provide additional information on the hematopoietic activity of the bone marrow in diffuse hematologic disorders. A total of 11 patients with hematologic disorders were studied both with Tc-99m leukoc...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199212000-00007
更新日期:1992-12-01 00:00:00
abstract::A retrospective analysis of 104 chest radionuclide angiography (CRNA) studies establishes the utility of this procedure in the evaluation of pulmonary malignancies and benign masses. Remarkable abnormalities in the perfusion of the lungs were identified in 36 (58%) of 62 cases that were not predictably normal or predi...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198409000-00005
更新日期:1984-09-01 00:00:00
abstract::A retrospective review of two years' experience with radionuclide screening to detect lower gastrointestinal bleeding sites was conducted at New York's Montefiore Medical Center. Of 82 studies performed in 63 patients, 13 identified active bleeding sites. Only three of eight angiograms obtained in these 13 patients we...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198309000-00001
更新日期:1983-09-01 00:00:00
abstract::Necrotizing autoimmune myopathy (NAM) is a relatively newly recognized subgroup of idiopathic inflammatory myopathies. The common histopathologic features are myocyte necrosis without significant inflammation. Necrotizing autoimmune myopathy can be associated with connective tissue disorders but can also be triggered ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001955
更新日期:2018-02-01 00:00:00
abstract::Bone scintigraphy is very sensitive in detecting metastases in an early stage, when changes in osteoblast function precede morphologic changes. In many oncologic situations, however, osteoarticular abnormal changes seen on the bone scan are not caused by tumor infiltration. They may be due to tumor associated conditio...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章,评审
doi:10.1097/00003072-199310000-00001
更新日期:1993-10-01 00:00:00
abstract::A 68-year-old man with a history of malignant melanoma in the right axilla underwent FDG PET/CT. The images demonstrated a focally increased activity in the subcutaneous tissue anterior to the distal left tibia, suggestive of metastasis. However, a gouty tophus was diagnosed pathologically after biopsy. ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000000682
更新日期:2015-06-01 00:00:00
abstract::Tc-99m galactosyl-neoglycoalbumin (NGA) is a new liver imaging agent that specifically binds to a hepatocyte specific membrane receptor, the hepatic binding protein. Scintigraphy with Tc-99m NGA is a noninvasive method that provides functional images of the liver. This report deals with one case of fulminant hepatic f...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199504000-00009
更新日期:1995-04-01 00:00:00
abstract::F-FDG PET is a tool widely used in many indications, mainly for staging malignant neoplasm. A correct interpretation of images requires knowledge of physiological uptake. The most frequently encountered can be found in head and neck area (language, masticator muscles, and ocular muscles). Many of them can be limited t...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000000883
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:We aim to retrospectively evaluate the impact of hormone therapy (HT) on FDG avidity of metastatic lesions in patients with breast cancer (BC) undergoing PET/CT. PATIENTS AND METHODS:Three hundred eight patients with BC were scanned with PET/CT at 2 Italian institutions (mean time from diagnosis 4 yrs, rang...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e318287353e
更新日期:2014-02-01 00:00:00
abstract::Hepatic pyocyst is a rare but potentially life-threatening complication of autosomal dominant polycystic kidney disease. With extensive hepatic cystic disease, localization of a pyocyst and targeted aspiration or drainage is often a diagnostic challenge. Two patients with autosomal dominant polycystic kidney disease a...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000000402
更新日期:2014-07-01 00:00:00
abstract:PURPOSE:To compare the accuracy of three camera-assisted methods for the measurement of Tc-99m mercaptoacetyltriglycine (MAG3) clearance. MATERIALS AND METHODS:MAG3 renal scintigraphy was performed in 21 adults with different degrees of renal function. Posterior views were obtained that included the heart and the kidn...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-200109000-00001
更新日期:2001-09-01 00:00:00
abstract::We report a 58-year-old man whose incidentally discovered papillary thyroid carcinoma in the left lobe showed high FDG and low FLT uptake on PET/CT. The SUVmax was 19.7 for FDG and 3.0 for FLT. The Ki-67 labeling index of the tumor was 1.9%. Thus, the low FLT uptake might be attributed to the low proliferative activit...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e318252d80f
更新日期:2012-06-01 00:00:00
abstract::This report describes a new approach to the evaluation of brain perfusion reserve using Tc-99m HMPAO SPECT. Consecutive brain Tc-99m HMPAO SPECT studies before and after acetazolamide (Diamox) administration were performed within 30 minutes on 19 patients with significant vascular occlusive lesions. Thirteen patients ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199108000-00008
更新日期:1991-08-01 00:00:00
abstract::Dual radionuclide imaging of the neck (Tc-99m pertechnetate and TI-201 thallous chloride) was performed in 22 patients with chemical evidence of hyperparathyroidism (elevated blood calcium and parathormone [PTH] levels). Of these, 19 of 22 had localization of a TI-201 "excess" area on radiothallium-radiotechnetium sub...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198504000-00003
更新日期:1985-04-01 00:00:00
abstract::Two patients are presented in whom pulmonary accumulation of Ga-67 led to an early diagnosis of miliary tuberculosis and its prompt treatment. Their chest radiographs were unremarkable and thus noncontributory to the diagnostic process. ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199112000-00006
更新日期:1991-12-01 00:00:00
abstract::Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy) is a rare systemic histiocytic disorder of unknown etiology characterized by the accumulation of enlarged non-Langerhans histiocytes within lymph nodes and extranodal sites. The histiocytes display characteristic emperipolesis (nondestructive eng...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001921
更新日期:2018-02-01 00:00:00
abstract::Twenty five In-111 oxine platelet imaging procedures were performed in 21 renal transplant patients to assess the value of this study for diagnosis of renal transplant rejection in recipients receiving cyclosporine (CYS) for immunosuppression. Fourteen biopsies were performed, and an extensive, in-depth review of the ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198612000-00007
更新日期:1986-12-01 00:00:00
abstract::Measurement of relative renal function in azotemic patients can be misleading due to elevated background activity and delayed renal concentration of radiotracer. When there is delayed excretion of the tracer and obvious splenic or hepatic activity superimposed over one of the kidneys, it often is advantageous to delay...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199305000-00002
更新日期:1993-05-01 00:00:00
abstract::Ga-prostate-specific membrane antigen (PSMA) ligand is a well-known tracer used in prostate cancer. Nevertheless, there are reports of unusual Ga-PSMA uptake in variety of benign lesions. We report a case of prostate cancer in which Ga-PSMA PET/CT revealed tracer avidity in the enhancing walls of cystic lesions in the...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001990
更新日期:2018-04-01 00:00:00
abstract::The authors evaluated the clinical applications of Tc-99m methoxy isobutyl isonitrile (MIBI) in the simultaneous assessment of ventricular function and myocardial perfusion in patients with congenital heart disease. Global ventricular function was assessed by first-pass ECG gated study. Myocardial perfusion was evalua...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199401000-00009
更新日期:1994-01-01 00:00:00
abstract::Scar involvement is a rare but characteristic cutaneous manifestation of sarcoidosis. The concurrent presence of FDG-avid lymphadenopathy and scar involvement (the "scar sign") is a useful finding on FDG PET/CT to suggest sarcoidosis, especially when biopsy specimens are difficult to obtain. A 46-year-old woman who pr...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e31827a22e0
更新日期:2013-03-01 00:00:00
abstract::An unusual posterior extension of the right lobe of the liver mimicked a retroperitoneal mass on CT scanning. Tc-99m SC SPECT imaging documented normal liver uptake within the suspected mass, proving that it was an anomalous extension of the right lobe of the liver rather than a pathologic lesion. This unusual liver v...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199008000-00008
更新日期:1990-08-01 00:00:00
abstract::A 66-year-old man with castration-resistant prostate cancer was evaluated with F-prostate-specific membrane antigen (PSMA) 1007 PET/CT, which revealed extensive PSMA-positive skeletal metastases in the skull, thorax, spine, pelvis, and extremities. He was then treated Lu-PSMA-617 therapy. Twenty-four-hour SPECT/CT rev...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002982
更新日期:2020-05-01 00:00:00