Therapeutic role of melatonin in migraine prophylaxis: A systematic review.

Abstract:

BACKGROUND:Melatonin is the "clock factor" generated from pineal gland dominating regular circadian rhythm in humans. Migraine is one of the most severe and debilitating primary headache disorders. Thus far, many diseases have been found to associate with melatonin, including the migraine. Therefore, melatonin's therapeutic potential for migraine is drawing attention. OBJECTIVES:The aim of this study is to offer a systematic review of extant data of melatonin in migraine prophylaxis and to provide clinical implications and specific recommendations for future studies. DATA SOURCES AND STUDY METHODS:A systematic research was conducted in September 2018 by using PubMed and Google Scholar databases to search for science literature published after 1988. RESULTS:In all, 7 eligible articles were identified, including 4 randomized controlled studies and 3 observational studies. Due to high heterogeneities and limited number of studies, meta-analysis was not feasible, and only systematic review was performed. The results show that present evidence cannot claim melatonin's effectiveness according to the conflicting outcomes; however, the two negative outcomes of melatonin not different from placebo and melatonin inferior to amitriptyline are possible under-powering because of methodological, pharmacological, and therapeutic shortcomings. Observational studies also support melatonin's efficacy in migraine. As a result, melatonin is very likely to benefit migraine in prophylaxis and may have a similar effectiveness to other main preventive medications. Immediate-release melatonin 3 mg was established as effective, melatonin receptor agonist (Agomelatine) 25 mg and prolonged-release melatonin 4 mg were observed efficacious in observational studies. Melatonin displayed ineffective in the 2-month trial; thus, 3 months or more may be an enough duration for migraine therapy. Despite melatonin being generally safe, emerging literature is illustrating that a few severe adverse effects can be caused by melatonin, for example, liver injuries, reproductive system dysfunctions, and detrimental immunostimulation. CONCLUSIONS:Melatonin is very likely to be a promising alternative for migraine prophylaxis. Current literature examining melatonin's efficacy in migraine prevention is growing, but still limited. Future studies of perfect design in methodology, pharmacology, and therapeutics are needed to achieve a deeper awareness of melatonin's role in migraine as well as more studies to explore the safety issues of melatonin medicine.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Long R,Zhu Y,Zhou S

doi

10.1097/MD.0000000000014099

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

e14099

issue

3

eissn

0025-7974

issn

1536-5964

pii

00005792-201901180-00045

journal_volume

98

pub_type

杂志文章

相关文献

MEDICINE文献大全
  • Association between uterine leiomyoma and metabolic syndrome in parous premenopausal women: A case-control study.

    abstract::Previous studies have reported that uterine leiomyoma (UL) may share pathogenic features with obesity and hypertension, which are components of metabolic syndrome (MetS). We examined the association between UL and MetS in premenopausal parous women.This 1:1 case-control study was conducted on 615 asymptomatic women wi...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000005325

    authors: Tak YJ,Lee SY,Park SK,Kim YJ,Lee JG,Jeong DW,Kim SC,Kim IJ,Yi YH

    更新日期:2016-11-01 00:00:00

  • Hypokalemic Paralysis Complicated by Concurrent Hyperthyroidism and Chronic Alcoholism: A Case Report.

    abstract::Thyrotoxic periodic paralysis (TPP) is characterized by the presence of muscle paralysis, hypokalemia, and hyperthyroidism. We report the case of a young man with paralysis of the lower extremities, severe hypokalemia, and concurrent hyperthyroidism. TPP was suspected; therefore, treatment consisting of judicious pota...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000001689

    authors: Tsai MH,Lin SH,Leu JG,Fang YW

    更新日期:2015-09-01 00:00:00

  • Intravoxel incoherent motion diffusion-weighted imaging evaluated the response to concurrent chemoradiotherapy in patients with cervical cancer.

    abstract::To evaluate the application of multiple b values diffusion-weighted imaging based on biexponential signal decay model to predict the response to concurrent chemoradiotherapy in cervical cancer patients.This prospective study enrolled 28 patients (mean age: 50.89 ± 10.70 years) with cervical cancer confirmed by biopsy ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000017943

    authors: Bian H,Liu F,Chen S,Li G,Song Y,Sun M,Dong H

    更新日期:2019-11-01 00:00:00

  • Taxane-based chemotherapy and risk of breast cancer-related lymphedema: Protocol for a systematic review and meta-analysis.

    abstract:BACKGROUND:Many studies were performed to explore the correlation between taxane-based chemotherapy and the risk of breast cancer-related lymphedema (BCRL), however, with inconsistent results. Hence, the purpose of this study is to evaluate whether taxane-based chemotherapy is a risk factor for BCRL. METHODS:A compreh...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000016563

    authors: Zhang Z,Zhang X,Chen S,Jiang J,Qi R,Zhang X,Xi Y,Li M,Zheng H,Hua B

    更新日期:2019-07-01 00:00:00

  • Declining Inconsistent Condom Use but Increasing HIV and Syphilis Prevalence Among Older Male Clients of Female Sex Workers: Analysis From Sentinel Surveillance Sites (2010-2015), Guangxi, China.

    abstract::Clients of female sex workers (CFSWs) are a bridge population for the spread of HIV and syphilis to low or average risk heterosexuals. Most studies have examined the point prevalence of these infections in CFSWs. Limited evidence suggests that older age CFSWs are at a higher risk of acquiring sexually transmitted dise...

    journal_title:Medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MD.0000000000003726

    authors: Chen Y,Abraham Bussell S,Shen Z,Tang Z,Lan G,Zhu Q,Liu W,Tang S,Li R,Huang W,Huang Y,Liang F,Wang L,Shao Y,Ruan Y

    更新日期:2016-05-01 00:00:00

  • Comparison Between Ultrasound-Guided Supraclavicular and Interscalene Brachial Plexus Blocks in Patients Undergoing Arthroscopic Shoulder Surgery: A Prospective, Randomized, Parallel Study.

    abstract::Although supraclavicular brachial plexus block (SCBPB) was repopularized by the introduction of ultrasound, its usefulness in shoulder surgery has not been widely reported. The objective of this study was to compare motor and sensory blockades, the incidence of side effects, and intraoperative opioid analgesic require...

    journal_title:Medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MD.0000000000001726

    authors: Ryu T,Kil BT,Kim JH

    更新日期:2015-10-01 00:00:00

  • Unusual recurrent renal secondary hyperparathyroidism caused by hyperplastic autograft with supernumerary parathyroid adenoma: A case report.

    abstract:RATIONALE:Secondary hyperparathyroidism (SHPT) is often complicated with chronic renal failure. Though the total parathyroidectomy (TPTX) with forearm autotransplantation (FAT) has been commonly used to treatment refractory renal SHPT, the recurrence of SHPT is not infrequent, resulting from hyperplastic autograft, rem...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000016077

    authors: Zhang J,Dong MJ,Yang J,Tian D

    更新日期:2019-06-01 00:00:00

  • Pasteurella multocida infections. Report of 34 cases and review of the literature.

    abstract::Pasteurella multocida, a small, gram-negative coccobacillus , is part of the normal oral flora of many animals, including the dog and cat. P. multocida is the etiologic agent in a variety of infectious disease syndromes. We have reported 34 cases of infection caused by P. multocida and have reviewed the English litera...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Weber DJ,Wolfson JS,Swartz MN,Hooper DC

    更新日期:1984-05-01 00:00:00

  • Worse clinical outcomes following percutaneous coronary intervention with a high SYNTAX score: A systematic review and meta-analysis.

    abstract:BACKGROUND:The synergy between percutaneous coronary intervention (PCI) with TAXUS and Cardiac Surgery (SYNTAX) score is an angiographic tool which is used to determine the complexity of coronary artery disease (CAD). We aimed to compare PCI versus coronary artery bypass surgery (CABG) in patients with a high SYNTAX sc...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MD.0000000000007140

    authors: Bundhun PK,Bhurtu A,Huang F

    更新日期:2017-06-01 00:00:00

  • Primary hepatic ectopic pregnancy in a patient with polycystic ovary syndrome: A case report.

    abstract:RATIONALE:Hepatic ectopic pregnancy is an extremely rare ectopic pregnancy. This study aimed to report a case of primary hepatic pregnancy in a patient with polycystic syndrome. PATIENT CONCERNS:A 30-year-old woman presented with vaginal bleeding after 63 days of amenorrhea. DIAGNOSIS:The patient was initially diagno...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000019649

    authors: Zhang N,Yang L,Wang Y,Li X,Zhang C,Xu J

    更新日期:2020-03-01 00:00:00

  • Signet ring cell carcinoma of early gastric cancer, is endoscopic treatment really risky?

    abstract::Signet ring cell carcinoma (SRC) is a poorly differentiated cancer of the stomach. Generally, poorly differentiated cancer is believed to show poor prognosis and aggressive behavior. Recently, however, there is debate on the aggressiveness of SRC in early gastric cancer (EGC). We therefore studied postoperation biopsi...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000007532

    authors: Kang SH,Kim JS,Moon HS,Lee ES,Kim SH,Sung JK,Lee BS,Jeong HY

    更新日期:2017-08-01 00:00:00

  • External fixation combined with delayed internal fixation in treatment of tibial plateau fractures with dislocation.

    abstract::The aim of this study was to evaluate the clinical efficacy of external fixation, delayed open reduction, and internal fixation in treating tibial plateau fracture with dislocation.Clinical data of 34 patients diagnosed with tibial plateau fracture complicated with dislocation between January 2009 and May 2015 were re...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000008221

    authors: Tao X,Chen N,Pan F,Cheng B

    更新日期:2017-10-01 00:00:00

  • CONSORT: May stereotactic intracavity administration of antibiotics shorten the course of systemic antibiotic therapy for brain abscesses?

    abstract:BACKGROUND:Despite advances in surgical techniques in the management of the brain abscess, continuous systemic long-term antibiotics are necessary and crucial. This study was designed to evaluate the effect of intracavity administration of high-dose antibiotics on the course of antibiotic therapy. METHODS:Between 2003...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000006359

    authors: Yu X,Liu R,Wang Y,Zhao H,Chen J,Zhang J,Hu C

    更新日期:2017-05-01 00:00:00

  • Combined alkaline phosphatase and phosphorus levels as a predictor of mortality in maintenance hemodialysis patients.

    abstract::Hyperphosphatemia-induced vascular calcification and higher alkaline phosphatase (ALP) levels-related high-turnover bone diseases are linked to mortality among patients with chronic kidney disease (CKD). Nonetheless, no large epidemiological study in patients with CKD has been conducted to investigate the interaction ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000000106

    authors: Chang JF,Feng YF,Peng YS,Hsu SP,Pai MF,Chen HY,Wu HY,Yang JY

    更新日期:2014-10-01 00:00:00

  • Estimated Glomerular Filtration Rate Trajectories in HIV-Infected Subjects Treated With Different Ritonavir-Boosted Protease Inhibitors and Tenofovir Disoproxil Fumarate or Abacavir.

    abstract::The aim of the study was to evaluate in human immunodeficiency virus (HIV)-infected patients estimated glomerular filtration rate (eGFR) trajectories during treatment with different protease inhibitors (PIs) or a non-nucleoside reverse transcriptase inhibitor (NNRTI) plus tenofovir (TDF) or abacavir (ABC) and lamivudi...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000003780

    authors: Gianotti N,Galli L,Poli A,Salpietro S,Nozza S,Carbone A,Merli M,Ripa M,Lazzarin A,Castagna A

    更新日期:2016-05-01 00:00:00

  • Prediction of novel target genes and pathways involved in tall cell variant papillary thyroid carcinoma.

    abstract:BACKGROUND:Tall cell variant papillary thyroid carcinoma (TCPTC) is reportedly associated with aggressive clinicopathological parameters and poor outcomes; however, the molecular mechanisms underlying TCPTC remain poorly understood. METHODS:The gene mutation types and mRNA expression profiles of patients with TCPTC we...

    journal_title:Medicine

    pub_type: 临床试验,杂志文章

    doi:10.1097/MD.0000000000013802

    authors: Xia F,Jiang B,Chen Y,Du X,Peng Y,Wang W,Wang Z,Li X

    更新日期:2018-12-01 00:00:00

  • Predictive factors for hospitalization of nonurgent patients in the emergency department.

    abstract::Nonurgent emergency department (ED) patients are a controversial issue in the era of ED overcrowding. However, a substantial number of post-ED hospitalizations were found, which prompted for investigation and strategy management. The objective of this study is to identify risk factors for predicting the subsequent hos...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000004053

    authors: Ng CJ,Liao PJ,Chang YC,Kuan JT,Chen JC,Hsu KH

    更新日期:2016-06-01 00:00:00

  • Pooled analysis of efficacy and safety of ureteral stent removal using an extraction string.

    abstract:OBJECTIVE:We conducted a Pooled analysis to investigate the efficacy and safety of ureteral stent removal using an extraction string. METHODS:A systematic review was performed by using the Preferred Reporting Items for Systematic Reviews and Pooled analyses. The sources including EMBASE, MEDLINE, and the Cochrane Cont...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000017169

    authors: Sun X,Dong L,Chen T,Huang Z,Zhang X,Wu J,Lin C,Cui Y

    更新日期:2019-09-01 00:00:00

  • Celiac disease serology and gut microbiome following proton pump inhibitor treatment.

    abstract:BACKGROUND:Celiac disease is an autoimmune enteropathy characterized by an aberrant immune response to ingested gluten in genetically predisposed individuals. Studies have pointed to a rising prevalence of celiac disease in recent decades. Changes in diet and use of medication that may impact the gut microbiome have be...

    journal_title:Medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MD.0000000000021488

    authors: Jang S,Lebwohl B,Abrams JA,Green PHR,Freedberg DE,Alaedini A

    更新日期:2020-08-28 00:00:00

  • Microcirculation function assessed by adenosine triphosphate stress myocardial contrast echocardiography and prognosis in patients with nonobstructive coronary artery disease.

    abstract:BACKGROUND:Recent studies have demonstrated that coronary microcirculation dysfunction (CMVD) is closely correlated with adverse clinical outcomes. In this study, quantitative stress myocardial contrast echocardiography (MCE) was used to evaluate the CMVD and to investigate its association with the prognosis of patient...

    journal_title:Medicine

    pub_type: 临床试验,杂志文章

    doi:10.1097/MD.0000000000015990

    authors: Yang N,Su YF,Li WW,Wang SS,Zhao CQ,Wang BY,Liu H,Guo M,Han W

    更新日期:2019-07-01 00:00:00

  • A systematic review and network meta-analysis protocol of neoadjuvant treatments for patients with gastric cancer.

    abstract:BACKGROUND:National Comprehensive Cancer Network (NCCN) guidelines recommend surgery, chemotherapy, and radiation therapy for gastric cancer patients. Neoadjuvant treatments as the administration of therapeutic agents before a main treatment gained in more and more attention. However, the role of neoadjuvant treatments...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000010392

    authors: Long B,Yu ZY,Li Q,Du HR,Wang ZJ,Zhan H,Jiao ZY

    更新日期:2018-04-01 00:00:00

  • Case report: The first case of Achromobacter xylosoxidans-related tunnel infection in a patient receiving peritoneal dialysis.

    abstract:RATIONALE:Achromobacter xylosoxidans infection is mostly reported in immunocompromised patients. Until now, it is still rarely reported in patients undergoing peritoneal dialysis. PATIENT CONCERNS:This is the 1st case of A xylosoxidans infection due to tunnel infection of a Tenckhoff catheter. DIAGNOSIS:The diagnosis...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000006654

    authors: Tsai JL,Tsai SF

    更新日期:2017-04-01 00:00:00

  • Dichorionic twin pregnancy with sirenomelia and chromosomal anomaly in 1 fetus: A case report.

    abstract:RATIONALE:Sirenomelia is a rare congenital malformation that threatens fetal survivals. The cases in which twin with sirenomelia and chromosomal abnormality have been seldomly reported. We reported a dichorionic twin case in which one twin had sirenomelia, the other twin had a normal phenotype, and they had different c...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000024229

    authors: Ting Y,Xue-Lan L,Chun-Bao W,Ting Z,Fen L,Zhen H

    更新日期:2021-01-08 00:00:00

  • Effects of Referral Bias on Estimates of Anal Intraepithelial Neoplasia Progression and Regression Rates in a 3-State Markov Model.

    abstract::The study aim is to compare anal intraepithelial neoplasia (AIN) progression and regression rates in a cytology inception cohort to estimates based on the subcohort referred for ≥1 high-resolution anoscopies (HRAs).A cytology-based retrospective cohort was assembled including the anal cytology histories and invasive a...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000001476

    authors: Mathews WC,Cachay ER,Agmas W,Jackson C

    更新日期:2015-09-01 00:00:00

  • Nutritional therapy and effect assessment of infants with primary intestinal lymphangiectasia: Case reports.

    abstract:RATIONALE:Intestinal lymphangiectasia (IL) is a rare enteropathy involving the expansion and rupture of intestinal lymphatic channels. Although several reports have studied cases of primary IL (PIL), this condition is very rare, and is even less commonly encountered in infants. This study aimed to investigate the nutri...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000009240

    authors: Li S,Liu X,He Y,Li Q,Ji L,Shen W,Tong G

    更新日期:2017-12-01 00:00:00

  • Association of Periodontitis and Subsequent Depression: A Nationwide Population-Based Study.

    abstract::Periodontitis is a systemic and chronic inflammatory disease associated with multiple physical conditions. Distress and depression are other problems affecting the progression of periodontitis. However, the causal relationship between depression and periodontitis has not been adequately investigated. This aim of this ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000002347

    authors: Hsu CC,Hsu YC,Chen HJ,Lin CC,Chang KH,Lee CY,Chong LW,Kao CH

    更新日期:2015-12-01 00:00:00

  • Infections with Acinetobacter calcoaceticus (Herellea vaginicola): clinical and laboratory studies.

    abstract::In a retrospective review of 53 patients, 58 episodes of infection due to Acinetobacter calcoaceticus var. anitratus (Herellea vaginicola) were studied. Although the organism is widely distributed in nature, it is of relatively low virulence since colonization is more frequently noted than infection and since most inf...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/00005792-197703000-00001

    authors: Glew RH,Moellering RC Jr,Kunz LJ

    更新日期:1977-03-01 00:00:00

  • Nonmedical Use of Cough Syrup Among Secondary Vocational School Students: A National Survey in China.

    abstract::Nonmedical use of cough syrup (NUCS) among secondary vocational school (SVS) students has been an increasing concern for public health in China, but no data were available. This cross-sectional study aimed to investigate the epidemiological characters of NUCS as well as its risk factors among SVS students in China.Fro...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000002969

    authors: Wu Q,Yu J,Yang C,Chen J,Yang L,Zhang H,Teng S,Li J,Yan D,Cao J,Zhao Y,Wang Z

    更新日期:2016-03-01 00:00:00

  • Treatment of chronic obstructive pulmonary disease in patients with different fractional exhaled nitric oxide levels.

    abstract::Some patients with chronic obstructive pulmonary disease (COPD) have eosinophilic inflammation which may be evaluated via the measurement of fractional exhaled nitric oxide (FeNO) like asthma. The aim of this prospective study was to assess whether FeNO levels can be used to identify patients with COPD with eosinophil...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000011922

    authors: Wu YK,Su WL,Huang CY,Yang MC,Chen SY,Lan CC

    更新日期:2018-11-01 00:00:00

  • Neutropenia following intravenous immunoglobulin therapy in adult patients with immune thrombocytopenic purpura: A single center experience and literature review.

    abstract::The purpose of this study was to evaluate neutropenia following intravenous immunoglobulin (IVIG) therapy in adults with immune thrombocytopenic purpura (ITP).Our analysis included 88 patients with ITP, who received IVIG from January 2006 to March 2016, at Pusan National University Hospital in Korea. Their white blood...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000018624

    authors: Oh SB,Shin HJ

    更新日期:2020-01-01 00:00:00