Abstract:
:Hyperphosphatemia-induced vascular calcification and higher alkaline phosphatase (ALP) levels-related high-turnover bone diseases are linked to mortality among patients with chronic kidney disease (CKD). Nonetheless, no large epidemiological study in patients with CKD has been conducted to investigate the interaction and joint effect of hyperphosphatemia and higher ALP levels on mortality.We analyzed 11,912 maintenance hemodialysis patients from January 2005 to December 2010. Unadjusted and adjusted hazard ratios (aHRs) of death were calculated for different categories of serum phosphorus and ALP using the Cox regression model. The modification effect between serum phosphorus and ALP on mortality was determined using an interaction product term.Both hypophosphatemia (<3.0 mg/dL) and hyperphosphatemia (>7.0 mg/dL) were associated with incremental risks of death (aHR: 1.25 [95% confidence intervals (CIs): 1.09-1.44], and 1.15 [95% CI: 1.01-1.31], respectively) compared to the lowest hazard ratio (HR) group (5 mg/dL ≤ phosphorus<6 mg/dL). ALP levels were linearly associated with incremental risks for death (aHR: 1.58 [95% CI: 1.41-1.76] for the category of ALP>150 U/L). In the stratified analysis, patients with combined higher ALP (>150 U/L) and hyperphosphatemia (>7.0 mg/dL) had the greatest mortality risk (aHR: 2.25 [95% CI: 1.69-2.98] compared to the lowest HR group (ALP ≤ 60 U/L and 4 mg/dL ≤ phosphorus<5 mg/dL). Although the effect of hyperphosphatemia on mortality seemed stronger in higher ALP levels, the interaction was not statistically significant (P=0.22).The association between serum phosphorus levels and mortality was not limited to higher ALP levels. Regardless of serum ALP levels, we may control serum phosphorus levels merely toward the normal range. While considering the joint effect of ALP and hyperphosphatemia on mortality, the optimal phosphorus range should be stricter.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Chang JF,Feng YF,Peng YS,Hsu SP,Pai MF,Chen HY,Wu HY,Yang JYdoi
10.1097/MD.0000000000000106subject
Has Abstractpub_date
2014-10-01 00:00:00pages
e106issue
18eissn
0025-7974issn
1536-5964pii
00005792-201410040-00002journal_volume
93pub_type
杂志文章相关文献
MEDICINE文献大全abstract:BACKGROUND:Preterm infants are at an increased risk of sucking problems, swallowing difficulty, and poor nourishment. During the neonatal period, the neurobehavioral organization of a preterm baby is poor compared with that of appropriate gestational age infants. Kinesio Taping has been widely used for edema control, j...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000004458
更新日期:2016-08-01 00:00:00
abstract::Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive malignancies in gastrointestinal tract cancers and even patients with early ESCC have a high metastatic potential. Difficulties are associated with clinically predicting tumor progression and prognosis based on conventional tumor markers determine...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001702
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Traumatic brain injury (TBI) refers to head injuries that disrupt normal function of the brain. TBI commonly lead to a wide range of potential psychosocial functional deficits. Although psychosocial function after TBI is influenced by many factors, more and more evidence shows that social cognitive skills ar...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021154
更新日期:2020-07-17 00:00:00
abstract::Some patients with chronic obstructive pulmonary disease (COPD) have eosinophilic inflammation which may be evaluated via the measurement of fractional exhaled nitric oxide (FeNO) like asthma. The aim of this prospective study was to assess whether FeNO levels can be used to identify patients with COPD with eosinophil...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011922
更新日期:2018-11-01 00:00:00
abstract::Cytomegalovirus (CMV) infection is a significant cause of morbidity and mortality in the posttransplant setting; however, it is increasingly recognized in pediatric leukemia during chemotherapy. This study assessed the prevalence and associated factors of CMV infection in pediatric non-transplant leukemia patients.Thi...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014256
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Dyslipidemia is a common disorder in systemic lupus erythematosus (SLE) patients. It is still inconclusive whether antimalarial drugs could affect the serum lipids in SLE patients, therefore we conducted a systematic review and meta-analysis of available data to address this issue. METHODS:We comprehensivel...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000015030
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Esophageal carcinoma (EC) is one of the worst malignant digestive neoplasms with a strong tendency of invasion and metastasis. Despite the improvement of diagnostic and therapeutic methods in the past decades, the prognosis of EC remains unsatisfactory. Xiaoaiping injection (XAPI), a famous traditional Chine...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020984
更新日期:2020-06-26 00:00:00
abstract::Prolonged inspiratory to expiratory (I:E) ratio ventilation has been researched to reduce lung injury and improve oxygenation in surgical patients with one-lung ventilation (OLV) or carbon dioxide (CO2) pneumoperitoneum. We aimed to confirm the efficacy of the 1:1 equal ratio ventilation (ERV) compared with the 1:2 co...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000003269
更新日期:2016-03-01 00:00:00
abstract::The purpose of this study was to evaluate the efficacy and safety of transarterial embolization (TAE) for iatrogenic renal arterial pseudoaneurysm and arteriovenous fistula at our center.Our retrospective analysis included 27 patients who received TAE for iatrogenic renal arterial pseudoaneurysm and arteriovenous fist...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008187
更新日期:2017-10-01 00:00:00
abstract::Twenty-three patients with systemic lupus erythematosus (SLE) and ischemic bone necrosis are reported. All patients had received corticosteroids prior to the onset of ischemic necrosis, although one patient had received none for 13 years previously. Nineteen (83%) patients had multiple bone lesions including the femor...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/00005792-197605000-00004
更新日期:1976-05-01 00:00:00
abstract:BACKGROUND:Combinations of long-acting bronchodilators with different mechanisms of action are recommended to improve prognosis and reduce risk of adverse events of chronic obstructive pulmonary disease (COPD). It is unclear whether the new combination therapy with long-acting muscarinic antagonist (LAMA) tiotropium (T...
journal_title:Medicine
pub_type: 杂志文章,meta分析,收录出版
doi:10.1097/MD.0000000000019789
更新日期:2020-04-01 00:00:00
abstract::To investigate the pathogenesis of somatic solid cancer-related cerebral venous sinus thrombosis (CVST).A total of 174 patients with CVST were recruited from the hospital between January 2006 and December 2017 and divided into two groups: (1) somatic cancer-related CVST group, defined as active somatic solid cancer pa...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015134
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Cardiopulmonary bypass (CPB) is necessary for most cardiac surgery, which may lead to postoperative lung injury. The objective of this paper is to systematically evaluate whether ventilation during CPB would benefit patients undergoing cardiac surgery. METHODS:We searched randomized controlled trials (RCTs)...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000006454
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate the outcomes of patients with pathologic T0 esophageal carcinoma after neoadjuvant therapy and surgery. METHODS:We searched PubMed, Embase, Cochrane Library, and Medline databases from inception up to November 12, 2016. The meta-analysis was performed to compare odds ra...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000007342
更新日期:2017-06-01 00:00:00
abstract:RATIONALE:Postoperative intussusception is an unusual clinical entity and is rarely encountered as a complication following gastrectomy, especially radical total gastrectomy. PATIENT CONCERNS:A 74-year-old woman was admitted to our hospital with complaints of melena and hematemesis. And the endoscopic biopsy confirmed...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000008982
更新日期:2017-12-01 00:00:00
abstract::Electromyographic biofeedback (EMG-BF) therapy provides information on the state of contraction of the targeted muscles and relaxation of their antagonists, which can facilitate early active range of motion (RoM) after elbow surgery. Our aim in this study was to calculate the minimum detectable change (MDC) during EMG...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021889
更新日期:2020-08-21 00:00:00
abstract::The direct anterior approach (DAA) to total hip arthroplasty has been promoted as a minimally invasive alternative to the lateral approach, which we sought to verify by systematically reviewing and meta-analyzing the literature comparing clinical, radiographic, and surgical outcomes. Two reviewers independently search...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000002126
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Pentraxin 3 is an acute inflammatory protein of the long pentraxin subfamily. A meta-analysis was performed to assess diagnostic accuracy of pentraxin 3 for respiratory tract infections. METHODS:We identify studies examining diagnostic value of pentraxin 3 for respiratory tract infections by searching Pubme...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000019532
更新日期:2020-04-01 00:00:00
abstract::The refinement in surgical techniques combined with the preoperative management has improved the resectability rate of perihilar cholangiocarcinoma (pCCA). However, the prognosis of pCCA with curative resection is still dismal. This meta-analysis was performed to investigate the prognostic clinicopathological factors ...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000011999
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:Currently, there is some clinical evidence supporting the use of acupuncture in alleviating pain and dysfunction in patients with lumbar spinal stenosis (LSS). However, the question of whether acupuncture could be efficacious for ageing patients remains unanswered. We designed a randomized controlled study t...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000021444
更新日期:2020-07-31 00:00:00
abstract:BACKGROUND:Coronavirus disease 2019 (COVID-19) is a potentially fatal disease. clinical practice shows that Chinese Patent Medicine (CPM) has played an important role in the outbreak, Among them, Jinhua Qinggan granules, Lianhua Qingwen capsule, and Xuebiqing injection have an effect in treating COVID-19 patients, but ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022277
更新日期:2020-09-18 00:00:00
abstract:BACKGROUND:Warm needle acupuncture (WNA) is a traditional Chinese medicine (TCM) therapy which combines technical advantages of acupuncture and moxibustion. Climacteric insomnia is a common symptom in climacteric women, which can seriously affect the physical and mental health of patients. Relevant studies have been re...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000015637
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:To verify the accuracy of serum dickkopf-1 protein (DKK-1) in the diagnosis of hepatocellular carcinoma (HCC) by an updated meta-analysis. METHODS:We searched potential eligible studies in PubMed and Embase before July 8, 2018. Sensitivity (SN), specificity (SP), positive likelihood ratio (PLR), negative li...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000016725
更新日期:2019-08-01 00:00:00
abstract:RATIONALE:We report on a patient who showed delayed degeneration of the left fornical crus with verbal memory impairment following mild traumatic brain injury (TBI), which was demonstrated by diffusion tensor tractography (DTT). PATIENT CONCERNS:: fter flexion and hyperextension of her head to the opposite side, the pa...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000009219
更新日期:2017-12-01 00:00:00
abstract::Since little has been reported about complications of spinal anesthesia in adult tethered cord syndrome (TCS), we sought to delineate the characteristics of the condition.A total of 4 cases of adult TCS after spinal anesthesia were reviewed. The medical charts of the patients were obtained. Anesthesia, which was combi...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004289
更新日期:2016-07-01 00:00:00
abstract::The purpose of this study was to investigate the association of herpes zoster infection with peptic ulcer disease in a Korean population.The Korean National Health Insurance Service selects samples directly from the entire Korean population database, and 1,125,691 participants with 114,369,638 medical claim codes were...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000019318
更新日期:2020-02-01 00:00:00
abstract::To investigate the age, gender, time, and etiology differences of traumatic lower limb fractures (TLLFs) in a population of children (≤18 years old), we retrospectively reviewed 936 children who had TLLFs and who came to our university-affiliated hospitals from 2001 to 2010. This study enrolled 657 males (70.2%) and 2...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017123
更新日期:2019-09-01 00:00:00
abstract::It is common to treat bromhidrosis by surgery, but postoperative complications such as subcutaneous exudate and subcutaneous hematoma can occur and lead to delayed healing of the wound and eventually lead to the formation of unattractive scars. In this study, we evaluated our new surgical treatment for bromhidrosis, w...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015865
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:This study will examine the effects of oxymatrine on the proliferation of human liver cancer Bel-7404 cells (HLCBC). METHODS:This study will search electronic bibliographic databases available in PUBMED, EMBASE, Cochrane Library, Scopus, Cumulative Index to Nursing and Allied Health Literature, China Biolog...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000020181
更新日期:2020-06-05 00:00:00
abstract::The benefit of prebiopsy empirical antibiotics for patients with infectious spondylitis and the effect on clinical outcome are not well known. This study assessed the impact of prebiopsy empirical antibiotics in patients with infectious spondylitis. We retrospectively reviewed 41 adult in-patients with infectious spon...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003343
更新日期:2016-04-01 00:00:00