Analysis of the Fibrinogen and Neutrophil-Lymphocyte Ratio in Esophageal Squamous Cell Carcinoma: A Promising Blood Marker of Tumor Progression and Prognosis.


:Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive malignancies in gastrointestinal tract cancers and even patients with early ESCC have a high metastatic potential. Difficulties are associated with clinically predicting tumor progression and prognosis based on conventional tumor markers determined from preoperative blood examinations. The aim of the present study was to measure plasma fibrinogen levels and the neutrophil-lymphocyte ratio (NLR) in blood and compare the clinical impacts of their combined values (fibrinogen and neutrophil-lymphocyte ratio score-F-NLR score) and the modified Glasgow Prognostic Score (mGPS) in patients with ESCC.We classified 238 patients with ESCC based on cut-off values for hyperfibrinogenemia (>400 mg/dL) and high NLR (>3.0) as F-NLR scores of 2 (both of these hematological abnormalities), 1 (one of these abnormalities), or 0 (neither abnormality). We also categorized patients based on cut-off values for high C-reactive protein (CRP) (>0.5 mg/dL) and hypoalbuminemia (<3.8 g/dL) as mGPS of 2 (elevated CRP and hypoalbuminemia), 1 (either elevated CRP or hypoalbuminemia), or 0 (neither elevated CRP nor hypoalbuminemia).The F-NLR score correlated with the depth of tumor invasion, lymph node metastasis, lymphovascular invasion, tumor size, and stage (all P < 0.05). Prognoses among the groups based on the F-NLR score and mGPS significantly differed (all P < 0.001). A multivariate analysis identified the depth of tumor invasion, lymph node metastasis, and F-NLR score as independent prognostic factors (P = 0.002, P = 0.007, and P = 0.037, respectively).The results of the present study showed that the F-NLR score is a promising blood predictor for tumor progression and outcomes in patients with ESCC.


Medicine (Baltimore)




Arigami T,Okumura H,Matsumoto M,Uchikado Y,Uenosono Y,Kita Y,Owaki T,Mori S,Kurahara H,Kijima Y,Ishigami S,Natsugoe S




Has Abstract


2015-10-01 00:00:00
















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    abstract::This study aimed to investigate the myocardial protective effect of liquid sodium phosphocreatine cardiac arrest in extracorporeal circulation surgery treating infants with atrial septal defects.Eighty-four infants with atrial septal defects who required extracorporeal circulation surgery treatment at our hospital fro...


    pub_type: 杂志文章


    authors: Yang F,Wang J,Zhai B

    更新日期:2020-07-10 00:00:00

  • Gram-negative bacillary pneumonia in the compromised host.

    abstract::The clinical and radiological characteristics of 217 consecutive episodes of gram-negative bacillary pneumonia occurring in 189 adult cancer patients between November 1968 and December 1974 were analyzed. The majority of patients had acute leukemia (54%). Fever larger than or equal to 101 degrees F was the single mos...


    pub_type: 杂志文章


    authors: Valdivieso M,Gil-extremera B,Zornoza J,Rodriquez V,Bodey GP

    更新日期:1977-05-01 00:00:00

  • Expression of IL-17 and its gene promoter methylation status are associated with the progression of chronic hepatitis B virus infection.

    abstract::To explore interleukin-17 (IL-17) and its epigenetic regulation during the progression of chronic hepatitis B virus (HBV) infection.A total of 162 patients with chronic HBV infection, including 75 with chronic hepatitis B (CHB), 54 with hepatitis B-associated liver cirrhosis and 33 with hepatitis B-associated hepatoce...


    pub_type: 杂志文章


    authors: Tian CH,Dai J,Zhang W,Liu Y,Yang Y

    更新日期:2019-06-01 00:00:00

  • Montelukast and budesonide combination for children with chronic cough-variant asthma.

    abstract::This study investigated the effectiveness and safety of montelukast combined budesonide (MCB) treatment for children with chronic cough-variant asthma (CCVA).In total, 82 cases of children with CCVA, aged 4 to 11 years were included in this study. All cases received either MCB or budesonide alone between May 2015 and ...


    pub_type: 杂志文章


    authors: Wang XP,Yang LD,Zhou JF

    更新日期:2018-07-01 00:00:00

  • Factors affecting bone age maturation during 3 years of growth hormone treatment in patients with idiopathic growth hormone deficiency and idiopathic short stature: Analysis of data from the LG growth study.

    abstract::To investigate the progression rate of bone age (BA) and associated factors during the first 3 years of growth hormone (GH) treatment in children with idiopathic GH deficiency (iGHD) and idiopathic short stature (ISS).Data for prepubertal children with iGHD and ISS who were treated with recombinant human GH were obtai...


    pub_type: 杂志文章,多中心研究


    authors: Kang MJ,Kim EY,Shim YS,Jeong HR,Lee HJ,Yang S,Hwang IT

    更新日期:2019-04-01 00:00:00

  • Endoscopic Findings of Small-Bowel Lesions in Familial Amyloid Polyneuropathy: A Case Report.

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    pub_type: 杂志文章


    authors: Asakura K,Yanai S,Nakamura S,Kawaski K,Eizuka M,Ishida K,Sugai T,Ueda M,Yamashita T,Ando Y,Matsumoto T

    更新日期:2016-03-01 00:00:00

  • Musculoskeletal ultrasound-guided physical therapy in hemiplegic shoulder pain: A CARE-compliant case report.

    abstract:RATIONALE:The use of musculoskeletal ultrasound (MU) method in the diagnosis of shoulder pain and injury and guidance of injection and pain blocking has been established. However, the treatment of posthemiplegic shoulder pain (HSP) with MU-guided precise physical therapy has not been reported. PATIENT CONCERNS:Here, w...


    pub_type: 杂志文章


    authors: Zhang J,Li Y,Wang H

    更新日期:2017-12-01 00:00:00

  • Management of Postoperative Pain in Medical Institutions in Shandong Province in China.

    abstract::The aim of the study was to investigate current situation of postoperative pain management in medical institutions in Shandong Province.A questionnaire was developed on the basis of guidelines of acute pain and pain quality assessment scale. The questionnaire was used to obtain information regarding the nature and sca...


    pub_type: 杂志文章


    authors: Liu D,Ma J,Zhang Z,Yu A,Chen X,Feng C,Lei W

    更新日期:2016-02-01 00:00:00

  • Development and evaluation of a venous computed tomography radiomics model to predict lymph node metastasis from non-small cell lung cancer.

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    pub_type: 杂志文章


    authors: Cong M,Yao H,Liu H,Huang L,Shi G

    更新日期:2020-05-01 00:00:00

  • Tamoxifen for amyotrophic lateral sclerosis: A randomized double-blind clinical trial.

    abstract:INTRODUCTION:Amyotrophic lateral sclerosis (ALS) is the most common cause of motor neuron disease, and effective treatment for ALS is still lacking. Transactive response (TAR) -DNA-binding protein-43 (TDP-43) is aggregated in the neurons of ALS patients. Animal studies shown TDP-43 aggregation can be attenuated by enha...


    pub_type: 杂志文章,随机对照试验


    authors: Chen PC,Hsieh YC,Huang CC,Hu CJ

    更新日期:2020-05-29 00:00:00

  • Estrogen supplementation to progesterone as luteal phase support in patients undergoing in vitro fertilization: systematic review and meta-analysis.

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    pub_type: 杂志文章,meta分析,评审


    authors: Zhang XM,Lv F,Wang P,Huang XM,Liu KF,Pan Y,Dong NJ,Ji YR,She H,Hu R

    更新日期:2015-02-01 00:00:00

  • Integrase inhibitor-based regimens result in more rapid virologic suppression rates among treatment-naïve human immunodeficiency virus-infected patients compared to non-nucleoside and protease inhibitor-based regimens in a real-world clinical setting: A r

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    pub_type: 杂志文章


    authors: Jacobson K,Ogbuagu O

    更新日期:2018-10-01 00:00:00

  • Altered Spontaneous Brain Activity in Betel Quid Dependence: A Resting-state Functional Magnetic Resonance Imaging Study.

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    pub_type: 杂志文章


    authors: Liu T,Li JJ,Zhao ZY,Yang GS,Pan MJ,Li CQ,Pan SY,Chen F

    更新日期:2016-02-01 00:00:00

  • Differences of bleedings after percutaneous coronary intervention using femoral closure and radial compression devices.

    abstract::Bleedings represent most relevant complications being correlated with significant rates of adverse clinical outcomes in patients undergoing percutaneous coronary intervention (PCI). To reduce bleeding and improve prognosis various types of vascular closure devices (VCD) are frequently applied. This study aims to compa...


    pub_type: 杂志文章


    authors: Kim SH,Behnes M,Baron S,Shchetynska-Marinova T,Tekinsoy M,Mashayekhi K,Hoffmann U,Borggrefe M,Akin I

    更新日期:2019-05-01 00:00:00

  • A recurrence-free survivor with chemotherapy-refractory small cell lung cancer after pneumonectomy: A case report and review of the literature.

    abstract:RATIONALE:The optimal therapeutic regimen for chemotherapy-refractory and node-positive small-cell lung cancer (SCLC) is criticizable for the lack of evidence. PATIENT CONCERNS:A patient with locally advanced SCLC was insensitive to the first-line chemotherapy of etoposide, irinotecan, and cisplatin. DIAGNOSES:The pa...


    pub_type: 杂志文章,评审


    authors: Pan Y,Kong FW,Wang H,Wang X,Zhang H,Wu WB,Zhang M

    更新日期:2017-11-01 00:00:00

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    abstract::Human serotonin receptor 4 (HTR4) encodes a 5-HT4 receptor involved in learning, memory, depression, anxiety, and feeding behavior. The aim of this study was to investigate the association between the deoxyribonucleic acid (DNA) methylation of HTR4 promoter and autism spectrum disorder (ASD), a disease characterized b...


    pub_type: 杂志文章


    authors: Hu Z,Ying X,Huang L,Zhao Y,Zhou D,Liu J,Zhong J,Huang T,Zhang W,Cheng F,Duan S

    更新日期:2020-01-01 00:00:00

  • Trends in dacryocystitis in China: A STROBE-compliant article.

    abstract::The aim of the study was to review the distribution, current trends, and microbiological characteristics of bacterial pathogens isolated from dacryocystitis patients in China during the last 15 years.This is a retrospective multiple-center noncomparative case series. The medical records of 15,452 consecutive patients ...


    pub_type: 杂志文章,多中心研究


    authors: Chen L,Fu T,Gu H,Jie Y,Sun Z,Jiang D,Yu J,Zhu X,Xu J,Hong J

    更新日期:2018-06-01 00:00:00

  • Integrative exploration of genomic profiles for triple negative breast cancer identifies potential drug targets.

    abstract:BACKGROUND:Triple negative breast cancer (TNBC) is high-risk due to its rapid drug resistance and recurrence, metastasis, and lack of targeted therapy. So far, no molecularly targeted therapeutic agents have been clinically approved for TNBC. It is imperative that we discover new targets for TNBC therapy. OBJECTIVES:A...


    pub_type: 杂志文章


    authors: Wang X,Guda C

    更新日期:2016-07-01 00:00:00

  • The impact of general/visceral obesity on completion of mesorectum and perioperative outcomes of laparoscopic TME for rectal cancer: A STARD-compliant article.

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    pub_type: 杂志文章


    authors: Chen B,Zhang Y,Zhao S,Yang T,Wu Q,Jin C,He Y,Wang Z

    更新日期:2016-09-01 00:00:00

  • Comparison of postoperative coagulation profiles and outcome for sugammadex versus pyridostigmine in 992 living donors after living-donor hepatectomy.

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    authors: Moon YJ,Kim SH,Kim JW,Lee YK,Jun IG,Hwang GS

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  • A case report of acute inferior myocardial infarction in a patient with severe hemophilia A after recombinant factor VIII infusion.

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    pub_type: 杂志文章


    authors: Zupančić-Šalek S,Vodanović M,Pulanić D,Skorić B,Matytsina I,Klovaite J

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  • Association between paced QRS duration and atrial fibrillation after permanent pacemaker implantation: A retrospective observational cohort study.

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    authors: Xing F,Jiang J,Hu X,Feng C,He J,Dong Y,Ma Y,Tang A

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  • Antenatal infection and intraventricular hemorrhage in preterm infants: A meta-analysis.

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    authors: Huang J,Meng J,Choonara I,Xiong T,Wang Y,Wang H,Qu Y,Mu D

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  • Characteristics and outcomes of patients hospitalized with interstitial lung diseases in Spain, 2014 to 2015.

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    pub_type: 杂志文章


    authors: Pedraza-Serrano F,Jiménez-García R,López-de-Andrés A,Hernández-Barrera V,Sánchez-Muñoz G,Puente-Maestu L,de-Miguel-Díez J

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  • Severe tetanus following ulcerated skin cancer: Case report.

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    pub_type: 杂志文章


    authors: Wang J,Yang Y,Yang C,Lv W,Xu S,Shi F,Shan A

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    pub_type: 杂志文章


    authors: Martín Algarra S,Soriano V,Fernández-Morales L,Berciano-Guerrero MÁ,Mujika K,Manzano JL,Puértolas Hernández T,Soria A,Rodríguez-Abreu D,Espinosa Arranz E,Medina Martínez J,Márquez-Rodas I,Rubió-Casadevall J,Ortega ME,Jurado G

    更新日期:2017-12-01 00:00:00

  • Phenotype of NK Cells Determined on the Basis of Selected Immunological Parameters in Children Treated due to Acute Lymphoblastic Leukemia.

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    pub_type: 杂志文章


    authors: Koltan S,Debski R,Koltan A,Grzesk E,Tejza B,Eljaszewicz A,Gackowska L,Kubicka M,Kolodziej B,Kurylo-Rafinska B,Kubiszewska I,Wiese M,Januszewska M,Michalkiewicz J,Wysocki M,Styczynski J,Grzesk G

    更新日期:2015-12-01 00:00:00

  • Continuous cervical epidural block: Treatment for intractable hiccups.

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    pub_type: 杂志文章


    authors: Kim JE,Lee MK,Lee DK,Choi SS,Park JS

    更新日期:2018-02-01 00:00:00

  • Prognostic value of serum albumin for patients with acute aortic dissection: A retrospective cohort study.

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    pub_type: 杂志文章


    authors: Gao Y,Li D,Cao Y,Zhu X,Zeng Z,Tang L

    更新日期:2019-02-01 00:00:00

  • Drug resistance mutations and viral load in human immunodeficiency virus type 2 and dual HIV-1/HIV-2 infected patients in Ghana.

    abstract::Antiretroviral therapy (ART) and drug resistance studies worldwide have focused almost exclusively on human immunodeficiency virus type 1 (HIV-1). As a result, there is limited information on ART and drug resistance in HIV-2 patients. In Ghana, the HIV epidemic is characterized by the domination of HIV-1, with cocircu...


    pub_type: 杂志文章


    authors: Abana CZ,Sagoe KWC,Bonney EY,Maina EK,Aziati ID,Agbosu E,Mawuli G,Styer LM,Ishikawa K,Brandful JAM,Ampofo WK

    更新日期:2019-02-01 00:00:00