Abstract:
:Casiopeinas are a group of copper-based compounds designed to be used as less toxic, more efficient chemotherapeutic agents. In this study, we analyzed the in vitro effects of Casiopeina II-gly on the expression of canonical biological pathways. Using microarray data from HeLa cell lines treated with Casiopeina II-gly, we identified biological pathways that are perturbed after treatment. We present a novel approach integrating pathway analysis and network theory: The Pathway Crosstalk Network. We constructed a network with deregulated pathways, featuring links between those pathways that crosstalk with each other. We identified modules grouping deregulated pathways that are functionally related. Through this approach, we were able to identify three features of Casiopeina treatment: (a) Perturbation of signaling pathways, related to induction of apoptosis; (b) perturbation of metabolic pathways, and (c) activation of immune responses. These findings can be useful to drive new experimental exploration on their role in adverse effects and efficacy of Casiopeinas.
journal_name
Comput Biol Chemjournal_title
Computational biology and chemistryauthors
de Anda-Jáuregui G,Espinal-Enríquez J,Hur J,Alcalá-Corona SA,Ruiz-Azuara L,Hernández-Lemus Edoi
10.1016/j.compbiolchem.2018.11.021subject
Has Abstractpub_date
2019-02-01 00:00:00pages
127-132eissn
1476-9271issn
1476-928Xpii
S1476-9271(18)30370-0journal_volume
78pub_type
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