Abstract：
:Functional classification of genes represents one of the most basic problems in genome analysis and annotation. Our analysis of some of the popular methods for functional classification of genes shows that these methods are not always consistent with each other and may not be specific enough for high-resolution gene functional annotations. We have developed a method to integrate genomic neighborhood information of genes with their sequence similarity information for the functional classification of prokaryotic genes. The application of our method to 93 proteobacterial genomes has shown that (i) the genomic neighborhoods are much more conserved across prokaryotic genomes than expected by chance, and such conservation can be utilized to improve functional classification of genes; (ii) while our method is consistent with the existing popular schemes as much as they are among themselves, it does provide functional classification at higher resolution and hence allows functional assignments of (new) genes at a more specific level; and (iii) our method is fairly stable when being applied to different genomes.
journal_name
Comput Biol Chemjournal_title
Computational biology and chemistryauthors
Wu H,Mao F,Olman V,Xu Ydoi
10.1016/j.compbiolchem.2008.02.007subject
Has Abstractpub_date
2008-06-01 00:00:00pages
176-84issue
3eissn
1476-9271issn
1476-928Xpii
S1476-9271(08)00019-4journal_volume
32pub_type
杂志文章abstract：BACKGROUND:Metastasis is the main cause of breast cancer (BC) lethality, especially in early stages, led to improvements in therapeutic procedures. Lately, by improvements in our perception of biological processes and immune system new classes of vaccines are emerged that grant us the opportunity of designing resolute ...
journal_title：Computational biology and chemistry
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journal_title：Computational biology and chemistry
pub_type： 杂志文章
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journal_title：Computational biology and chemistry
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journal_title：Computational biology and chemistry
pub_type： 杂志文章
doi：10.1016/j.compbiolchem.2014.11.007
更新日期：2015-02-01 00:00:00
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journal_title：Computational biology and chemistry
pub_type： 杂志文章
doi：10.1016/j.compbiolchem.2007.03.007
更新日期：2007-06-01 00:00:00
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journal_title：Computational biology and chemistry
pub_type： 杂志文章
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更新日期：2017-06-01 00:00:00
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journal_title：Computational biology and chemistry
pub_type： 杂志文章
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更新日期：2014-10-01 00:00:00
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更新日期：2017-06-01 00:00:00
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pub_type： 杂志文章
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journal_title：Computational biology and chemistry
pub_type： 杂志文章
doi：10.1016/j.compbiolchem.2008.02.001
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journal_title：Computational biology and chemistry
pub_type： 杂志文章
doi：10.1016/j.compbiolchem.2007.02.005
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journal_title：Computational biology and chemistry
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abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...
journal_title：Computational biology and chemistry
pub_type： 撤回出版物
doi：10.1016/j.compbiolchem.2016.02.010
更新日期：2016-02-17 00:00:00
