当前位置： SCI文献检索 > COMPUTATIONAL BIOLOGY AND CHEMISTRY期刊下所有文献 > Mutually exclusive binding of APPL(PH) to BAR domain and Reptin regulates β-catenin dependent transcriptional events.

Mutually exclusive binding of APPL(PH) to BAR domain and Reptin regulates β-catenin dependent transcriptional events.

Abstract：

:Reptin functions in a wide range of biological processes including chromatin remodelling, nucleolar organization and transcriptional regulation of WNT signalling. As β-catenin dependent transcriptional repression and activation events involve binding of Reptin and histone deacetylase 1 to APPL endocytic proteins, this complex has become an important target to identify molecules governing endocytic processes and WNT signalling. Here, we describe the structural basis of APPL binding to Reptin to explore their mode of binding in context with APPL1/APPL2 dimerization. There is an evidence that both PH and BAR domains of APPL proteins exhibit alternately conserved regions involved in hetero-dimerization process and our in-silico data also corroborate this fact. Moreover, APPL2(PH) domain binds to the BAR domain region encompassing a nuclear localization signal. We conclude that APPL(PH) binding to BAR domain and Reptin is mutually exclusive which regulates the nucleocytoplasmic shuttling of Reptin. Furthermore, Reptin is unable to bind with membrane-associated APPL proteins. These observations were further expanded by experimental approaches where we identified a novel point mutation D316N lying in the APPL1(PH) domain which resulted in a significantly reduced binding with Reptin. By luciferase assays, we observed that overexpression of APPL1(D316N) and APPL1(WT) stimulated β-catenin/TCF dependent transcriptional activity in a similar manner which suggested that binding of Reptin to APPL1 is not necessary for β-catenin dependent target gene expression. Overall, our data attempt to highlight a comparative role of APPL proteins in controlling β-catenin dependent transcription mechanism which may improve our understanding of gene regulation.

journal_name

Comput Biol Chem

journal_title

Computational biology and chemistry

authors

Rashid S,Parveen Z,Ferdous S,Bibi N

doi

10.1016/j.compbiolchem.2013.05.005

subject

Has Abstract

pub_date

2013-12-01 00:00:00

pages

48-55

eissn

1476-9271

issn

1476-928X

pii

S1476-9271(13)00056-X

journal_volume

47

pub_type

杂志文章

相关文献

COMPUTATIONAL BIOLOGY AND CHEMISTRY文献大全
  • Predicting interspecies transmission of avian influenza virus based on wavelet packet decomposition.

    abstract：:Using wavelet packet decomposition, the energy coefficients in the fifth level of viral protein sequences were achieved to predict interspecies transmission. Since avian-origin influenza viruses could have high sequence similarities with human-origin avian influenza virus and could have the phenotype of interspecies t...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2018.11.029

    authors： Qiang X,Kou Z

    更新日期：2019-02-01 00:00:00

  • Exploring the effect of aplidin on low molecular weight protein tyrosine phosphatase by molecular docking and molecular dynamic simulation study.

    abstract：:The low molecular weight protein tyrosine phosphatase (LMW-PTP) could regulate many signaling pathways, and it had drawn attention as a potential target for cancer. As previous report has indicated that the aplidin could inhibit the LMW-PTP, and thus, the relevant cancer caused by the abnormal regulation of the LMW-PT...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2019.107123

    authors： Sun YZ,Wu JW,Lu XH,Ma Y,Wang RL

    更新日期：2019-12-01 00:00:00

  • Dynamics of p53 and Wnt cross talk.

    abstract：:We present the mechanism of interaction of Wnt network module, which is responsible for periodic somitogenesis, with p53 regulatory network, which is one of the main regulators of various cellular functions, and switching of various oscillating states by investigating p53-Wnt model. The variation in Nutlin concentrati...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2015.07.014

    authors： Zubbair Malik M,Ali S,Alam MJ,Ishrat R,Brojen Singh RK

    更新日期：2015-12-01 00:00:00

  • Self-organizing map of gene regulatory networks for cell phenotypes during reprogramming.

    abstract：:The induced pluripotent cells (iPSCs) are derived from somatic cells by reprogramming their genetic profiles. Such a process requires coordinated dynamic expression of hundreds of genes and proteins. As both deterministic and stochastic elements control the reprogramming process, it is not easy to have a way to reflec...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2011.05.002

    authors： Zhang L,Zheng Y,Li D,Zhong Y

    更新日期：2011-08-10 00:00:00

  • GADS software for parametric linkage analysis of quantitative traits distributed as a point-mass mixture.

    abstract：:Often the quantitative data coming from proteomics and metabolomics studies have irregular distribution with a spike. None of the wide used methods for human QTL mapping are applicable to such traits. Researchers have to reduce the sample, excluding the spike, and analyze only continuous measurements. In this study, w...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2011.11.004

    authors： Axenovich TI,Zorkoltseva IV

    更新日期：2012-02-01 00:00:00

  • Domain boundary prediction based on profile domain linker propensity index.

    abstract：:Successful prediction of protein domain boundaries provides valuable information not only for the computational structure prediction of multi-domain proteins but also for the experimental structure determination. In this work, a novel index at the profile level is presented, namely, the profile domain linker propensit...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2006.01.001

    authors： Dong Q,Wang X,Lin L,Xu Z

    更新日期：2006-04-01 00:00:00

  • Analysis of compensatory substitution and gene evolution on the MAGEA/CSAG-palindrome of the primate X chromosomes.

    abstract：:The human X chromosome contains a large number of inverted repeat DNA palindromes. Although arbitrary substitutions destroyed the inverted repeat structure of MAGEA/CSAG-palindrome during the evolutionary process of the primates, most of the substitutions are compensatory. Using maximum parsimony, it is demonstrated t...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2012.11.002

    authors： Qi Y,Lu H,Ai D

    更新日期：2013-02-01 00:00:00

  • Identification of epilepsy from intracranial EEG signals by using different neural network models.

    abstract：:In this work, a framework is provided for identifying intracranial electroencephalography (iEEG) seizures based on discrete wavelet transform (DWT) analysis of iEEG signals using forward propagation and feedback neural networks. The performance of 5 different data sets combination classifications is studied using the ...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2020.107310

    authors： Gong C,Zhang X,Niu Y

    更新日期：2020-06-19 00:00:00

  • Ambush hypothesis revisited: Evidences for phylogenetic trends.

    abstract：:Recoding events occur in competition with standard readout of the transcript, and are site-specific. Recoding is the reprogramming of mRNA translation by localized alterations in the standard translational rules. Frame-shifting is one class of recoding and defined as protein translations that start not at the first, b...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2009.04.002

    authors： Singh TR,Pardasani KR

    更新日期：2009-06-01 00:00:00

  • Cryptic tRNAs in chaetognath mitochondrial genomes.

    abstract：:The chaetognaths constitute a small and enigmatic phylum of little marine invertebrates. Both nuclear and mitochondrial genomes have numerous originalities, some phylum-specific. Until recently, their mitogenomes seemed containing only one tRNA gene (trnMet), but a recent study found in two chaetognath mitogenomes two...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2016.04.007

    authors： Barthélémy RM,Seligmann H

    更新日期：2016-06-01 00:00:00

  • Zooming-in on cancer metabolic rewiring with tissue specific constraint-based models.

    abstract：:The metabolic rearrangements occurring in cancer cells can be effectively investigated with a Systems Biology approach supported by metabolic network modeling. We here present tissue-specific constraint-based core models for three different types of tumors (liver, breast and lung) that serve this purpose. The core mod...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2016.03.002

    authors： Di Filippo M,Colombo R,Damiani C,Pescini D,Gaglio D,Vanoni M,Alberghina L,Mauri G

    更新日期：2016-06-01 00:00:00

  • Design, synthesis and biological evaluation of novel thiazol-2-yl benzamide derivatives as glucokinase activators.

    abstract：:Glucokinase (GK) is the main enzyme which controls the blood glucose levels in a safe and narrow physiological range in humans. GK activators are the novel type of therapeutic agents which act on GK enzyme and show their anti-diabetic potential. The present work was planned to synthesize and evaluate the antidiabetic ...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2018.02.018

    authors： Charaya N,Pandita D,Grewal AS,Lather V

    更新日期：2018-04-01 00:00:00

  • Borrowing information from relevant microarray studies for sample classification using weighted partial least squares.

    abstract：:With an increasing number of publicly available microarray datasets, it becomes attractive to borrow information from other relevant studies to have more reliable and powerful analysis of a given dataset. We do not assume that subjects in the current study and other relevant studies are drawn from the same population ...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2005.04.002

    authors： Huang X,Pan W,Han X,Chen Y,Miller LW,Hall J

    更新日期：2005-06-01 00:00:00

  • Synthesis, biological evaluation, and computational studies of novel fused six-membered O-containing heterocycles as potential acetylcholinesterase inhibitors.

    abstract：:An efficient, borax-catalyzed protocol for the synthesis of novel 4-aryl-substituted-4H-pyran derivatives fused to α-pyrone ring in a one-pot is described. By this achievement, some novel 4-aryl substituted 4H-pyrans fused to the α-pyrone ring as potential acetylcholinesterase inhibitors (AChEIs) with good to excellen...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2019.04.004

    authors： Pourshojaei Y,Abiri A,Eskandari R,Dourandish F,Eskandari K,Asadipour A

    更新日期：2019-06-01 00:00:00

  • Prediction of novel pluripotent proteins involved in reprogramming of male Germline stem cells (GSCs) into multipotent adult Germline stem cells (maGSCs) by network analysis.

    abstract：:Germline stem cells (GSCs) are known to transmit genetic information from parents to offspring. These GSCs can undergo reprogramming to transform themselves into pluripotent stem cells, called as Multipotent adult Germline stem cells (maGSCs). The mechanism of the reprogramming of GSCs to maGSCs is elusive. To investi...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2018.08.001

    authors： Guttula PK,Agarwal A,Maharana U,Gupta MK

    更新日期：2018-10-01 00:00:00

  • The complex task of choosing a de novo assembly: lessons from fungal genomes.

    abstract：:Selecting the values of parameters used by de novo genomic assembly programs, or choosing an optimal de novo assembly from several runs obtained with different parameters or programs, are tasks that can require complex decision-making. A key parameter that must be supplied to typical next generation sequencing (NGS) a...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2014.08.014

    authors： Gallo JE,Muñoz JF,Misas E,McEwen JG,Clay OK

    更新日期：2014-12-01 00:00:00

  • Computational characterization and design of SARS coronavirus receptor recognition and antibody neutralization.

    abstract：:The sequential determination of crystal structures of the SARS coronavirus spike receptor-binding domain (RBD) in complex with its cellular receptor or neutralizing antibody opened a door for the design and development of antiviral competitive inhibitors. Based on those complex structures, we conduct computational cha...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2007.02.005

    authors： Zhang Y,Zheng N,Zhong Y

    更新日期：2007-04-01 00:00:00

  • Isolation and in silico prediction of potential drug-like compounds from Anethum sowa L. root extracts targeted towards cancer therapy.

    abstract：:Anethum sowa L. has been used as a spice herb in the Asian and European culinary systems to add flavour and taste. The studied plant has diverse folkloric medicinal value. Present study was designed to isolate phytochemicals from the hexane, chloroform and ethyl acetate extracts of the roots by various chromatographic...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2018.11.025

    authors： Saleh-E-In MM,Roy A,Al-Mansur MA,Mahmood Hasan C,Rahim MM,Sultana N,Ahmed S,Islam MR,van Staden J

    更新日期：2019-02-01 00:00:00

  • Complex phylogenetic profiling reveals fundamental genotype-phenotype associations.

    abstract：:We have developed a computational technique refereed to as complex phylogenetic profiling. Our approach combines logic analyses of gene phylogenetic profiles and phenotype data. Logic analysis of phylogenetic profiles identifies sets of proteins whose presence or absence follows certain logic relationships. Our approa...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2008.07.003

    authors： Antonov AV,Mewes HW

    更新日期：2008-12-01 00:00:00

  • Computational insight into dengue virus NS2B-NS3 protease inhibition: A combined ligand- and structure-based approach.

    abstract：:The NS2B-NS3 protease is essential for the replication process of Dengue Virus, which make it an attractive target for anti-virus drugs. Since a considerable number of NS2B-NS3 protease inhibitors have been reported so far, it is significant for the discovery of more effective antivirus compounds with the essential st...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2018.09.010

    authors： Chen J,Jiang H,Li F,Hu B,Wang Y,Wang M,Wang J,Cheng M

    更新日期：2018-12-01 00:00:00

  • Protein function prediction using neighbor relativity in protein-protein interaction network.

    abstract：:There is a large gap between the number of discovered proteins and the number of functionally annotated ones. Due to the high cost of determining protein function by wet-lab research, function prediction has become a major task for computational biology and bioinformatics. Some researches utilize the proteins interact...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2012.12.003

    authors： Moosavi S,Rahgozar M,Rahimi A

    更新日期：2013-04-01 00:00:00

  • Workflow based framework for life science informatics.

    abstract：:Workflow technology is a generic mechanism to integrate diverse types of available resources (databases, servers, software applications and different services) which facilitate knowledge exchange within traditionally divergent fields such as molecular biology, clinical research, computational science, physics, chemist...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章,评审

    doi：10.1016/j.compbiolchem.2007.08.009

    authors： Tiwari A,Sekhar AK

    更新日期：2007-10-01 00:00:00

  • Hybrid docking-QSAR studies of DPP-IV inhibition activities of a series of aminomethyl-piperidones.

    abstract：:In this study, the dipeptidyl peptidase-IV (DPP-IV) inhibition activities of a series of novel aminomethyl-piperidones were investigated by molecular docking studies and modeled by quantitative structure-activity relationship (QSAR) methodology. Molecular docking studies were used to find the best conformations of the...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2016.08.003

    authors： Amini Z,Fatemi MH,Gharaghani S

    更新日期：2016-10-01 00:00:00

  • Genome-wide identification and expression analysis of StTCP transcription factors of potato (Solanum tuberosum L.).

    abstract：:The plant-specific TCP transcription factors, which play critical roles in diverse aspects of biological processes, have been identified and analyzed in various plant species. However, no systematical study of TCP family genes in potato (Solanum tuberosum L.) has been undertaken. In this study, a total of 31 non-redun...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2018.11.009

    authors： Wang Y,Zhang N,Li T,Yang J,Zhu X,Fang C,Li S,Si H

    更新日期：2019-02-01 00:00:00

  • Phosphorylation mapping of laminin α1-chain: Kinases in association with active sites.

    abstract：:Laminin-111 is a trimeric glycoprotein of the extracellular matrix (ECM) that holds a significant role in cell adhesion, migration and differentiation. Laminin-111 is the most studied laminin isoform, composed of three chains; α1, β1 and γ1. Phosphorylation is the most common eukaryotic post - translational modificati...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2019.04.012

    authors： Galliou PA,Verrou KM,Koliakos G

    更新日期：2019-06-01 00:00:00

  • Computational investigations of folded self-avoiding walks related to protein folding.

    abstract：:Various subsets of self-avoiding walks naturally appear when investigating existing methods designed to predict the 3D conformation of a protein of interest. Two such subsets, namely the folded and the unfoldable self-avoiding walks, are studied computationally in this article. We show that these two sets are equal an...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2013.10.001

    authors： Bahi JM,Guyeux C,Mazouzi K,Philippe L

    更新日期：2013-12-01 00:00:00

  • On interaction of arginine, cysteine and guanine with a nano-TiO2 cluster.

    abstract：:Nanoscopic properties of TiO2 augmented with its physicochemical properties and biocompatibility make it a material interest in the biomedical field. Efficient methods to design of such materials require a thorough understanding of associated nano-bio interfaces. In the present study, density functional theory calcula...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2020.107236

    authors： Sai Phani Kumar V,Verma M,Deshpande PA

    更新日期：2020-06-01 00:00:00

  • A benchmark of optimally folded protein structures using integer programming and the 3D-HP-SC model.

    abstract：:The Protein Structure Prediction (PSP) problem comprises, among other issues, forecasting the three-dimensional native structure of proteins using only their primary structure information. Most computational studies in this area use synthetic data instead of real biological data. However, the closer to the real-world,...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2019.107192

    authors： Hattori LT,Gutoski M,Vargas Benítez CM,Nunes LF,Lopes HS

    更新日期：2020-02-01 00:00:00

  • Aconitum and Delphinium sp. alkaloids as antagonist modulators of voltage-gated Na+ channels. AM1/DFT electronic structure investigations and QSAR studies.

    abstract：:Early pharmacological studies of Aconitum and Delphinium sp. alkaloids suggested that these neurotoxins act at site 2 of voltage-gated Na(+) channel and allosterically modulate its function. Understanding structural requirements for these compounds to exhibit binding activity at voltage-gated Na(+) channel has been im...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2007.10.003

    authors： Turabekova MA,Rasulev BF,Levkovich MG,Abdullaev ND,Leszczynski J

    更新日期：2008-04-01 00:00:00

  • MATEPRED-A-SVM-Based Prediction Method for Multidrug And Toxin Extrusion (MATE) Proteins.

    abstract：:The growth and spread of drug resistance in bacteria have been well established in both mankind and beasts and thus is a serious public health concern. Due to the increasing problem of drug resistance, control of infectious diseases like diarrhea, pneumonia etc. is becoming more difficult. Hence, it is crucial to unde...

    journal_title：Computational biology and chemistry

    pub_type： 杂志文章

    doi：10.1016/j.compbiolchem.2015.07.011

    authors： Tamanna,Ramana J

    更新日期：2015-10-01 00:00:00