Personalised medicine in paediatric oncology: Ethical practice outside the clinical trial framework?

abstract：AIMS:This article compares the severity of illness scoring systems clinical risk index for babies (CRIB)-II and score for neonatal acute physiology with perinatal extension (SNAPPE)-II for discriminatory ability and goodness of fit in the same cohort of babies of less than 32 weeks gestation and aims to provide validat...

journal_title：Journal of paediatrics and child health

authors： Reid S,Bajuk B,Lui K,Sullivan EA,NSW and ACT Neonatal Intensive Care Units Audit Group, PSN.

更新日期：2015-05-01 00:00:00

abstract：:The following principles are now clearly defined in the management of children with developmental delay: (1) Multidisciplinary teams are more effective than individual therapeutic approaches. (2) The whole development of the child needs to be considered rather than a single deficient area alone. (3) Home-based program...

journal_title：Journal of paediatrics and child health

authors： Parry TS

更新日期：1992-10-01 00:00:00

abstract：OBJECTIVE:Severe otitis media and its sequelae are common in rural and remote Aboriginal children. Identification of acute otitis media (AOM) is likely to reduce the number of children who go on to develop chronic suppurative otitis media and associated complications. The aim of this study was to compare the diagnoses ...

journal_title：Journal of paediatrics and child health

authors： Gibney KB,Morris PS,Carapetis JR,Skull SA,Leach AJ

更新日期：2003-09-01 00:00:00

abstract：AIM:The aim of this study is to determine the association between waist circumference (WC) and childhood-masked hypertension. METHODS:A territory-wide, school-based cohort of 1385 Hong Kong students (672 boys and 713 girls) aged 8-17 years was analysed. The ambulatory blood pressure-monitoring assessment was performed...

journal_title：Journal of paediatrics and child health

authors： So HK,Yip GW,Choi KC,Li AM,Leung LC,Wong SN,Sung RY,Hong Kong ABP Working Group.

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVE:To identify risk factors for adverse outcomes from bacterial meningitis. METHODOLOGY:From a cohort of 166 children with bacterial meningitis who were studied prospectively, 130/158 (82%) survivors underwent neurological, neuropsychological, audiological and behaviour assessments 5-9 years following their ill...

journal_title：Journal of paediatrics and child health

authors： Grimwood K,Nolan TM,Bond L,Anderson VA,Catroppa C,Keir EH

更新日期：1996-10-01 00:00:00

abstract：OBJECTIVE:In 1981 the World Health Assembly (WHA) adopted the International Code of Marketing of Breast Milk Substitutes (the Code) to support breastfeeding. Despite improving trends, Hong Kong has low rates of breastfeeding compared to other developed countries. METHODS:We surveyed companies marketing breast milk sub...

journal_title：Journal of paediatrics and child health

authors： Nelson EA,Chan CW,Yu CM

更新日期：2004-07-01 00:00:00

abstract：:This report describes dual infection with Citrobacter freundii and Haemophilus influenzae type b causing septic arthritis and osteomyelitis of the elbow in a previously healthy 5-year-old boy. The patient was treated successfully with intravenous fosfomycin for 4 weeks. Infections with Citrobacter beyond the neonatal ...

journal_title：Journal of paediatrics and child health

authors： Stricker T,Fröhlich S,Nadal D

更新日期：1998-02-01 00:00:00

abstract：OBJECTIVE:This is a prospective, hospital based study over a period of one year, to examine the clinical profile of nephrotic children not on glucocorticoid therapy, but presenting with infection. METHODS:Sixty-eight children with 76 episodes of nephrotic syndrome were enrolled during the study year. They were examine...

journal_title：Journal of paediatrics and child health

authors： Alwadhi RK,Mathew JL,Rath B

更新日期：2004-01-01 00:00:00

abstract：AIM:Management of congenital pulmonary airway malformations (CPAM) is controversial, especially for asymptomatic patients. We aim to describe the clinical manifestations and management of CPAM at a tertiary paediatric hospital using a retrospective audit. METHODS:Infants with CPAM were identified on the Fetal Diagnost...

journal_title：Journal of paediatrics and child health

authors： Makhijani AV,Wong FY

更新日期：2018-03-01 00:00:00

abstract：:Hand-foot-and-mouth disease is a common, usually mild childhood illness caused by enteroviruses. Over the last five years, coxsackievirus A6 has been identified as a causative agent in outbreaks in Europe, South-East Asia and America. It has an atypical presentation compared with other enteroviruses, with more widespr...

journal_title：Journal of paediatrics and child health

authors： Hayman R,Shepherd M,Tarring C,Best E

更新日期：2014-10-01 00:00:00

abstract：:This manuscript describes two interesting patients who had exercise-induced symptoms that unmasked an alternative underlying diagnosis. The first is an 8-year-old boy who was treated for asthma all his life but really had exercise-induced stridor (labelled as wheeze) causing significant exercise limitation, which was ...

journal_title：Journal of paediatrics and child health

authors： Pandit CA,Batterby E,Van Asperen P,Cooper P,Selvadurai H,Fitzgerald DA

更新日期：2014-10-01 00:00:00

abstract：AIM:To determine the perceptions, attitudes and knowledge of Australian health-care workers (HCWs) regarding the novel, swine-origin influenza A (H1N1) virus (S-OIV) outbreak that reached the country in early May 2009. METHODS:Self-administered, anonymous Web-based survey conducted during the early stages of the S-OIV...

journal_title：Journal of paediatrics and child health

authors： Tebruegge M,Pantazidou A,Ritz N,Connell T,Bryant P,Donath S,Curtis N

更新日期：2010-11-01 00:00:00

abstract：:Bloody nipple discharge is a rare but distressing finding in neonates and infants. We report an 8-month-old boy who showed bilateral bloody nipple discharge for 5 months without signs of infection. Ultrasound examination revealed dilated mammary ducts. This benign phenomenon is most likely caused by mammary duct ectas...

journal_title：Journal of paediatrics and child health

authors： Weimann E

更新日期：2003-03-01 00:00:00

abstract：:A severe cutaneous eruption in an unwell patient can be a major cause of physician anxiety. With numerous differential diagnoses, an early accurate diagnosis can be challenging. infectious causes are the most important to exclude in a timely manner and drug rash and eosinophilia with systemic symptoms (DRESS) is anoth...

journal_title：Journal of paediatrics and child health

authors： Rosenbaum J,Alex G,Roberts H,Orchard D

更新日期：2010-04-01 00:00:00

abstract：AIM:This study aims to examine the influence of formula milk promotion via the media from Thailand to Lao People's Democratic Republic (PDR), where a cultural and linguistic proximity are shared. METHODS:A cross-sectional study was conducted through a structured questionnaire survey and focus group discussion (FGD) wi...

journal_title：Journal of paediatrics and child health

authors： Phoutthakeo P,Otsuka K,Ito C,Sayamoungkhoun P,Kounnavong S,Jimba M

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:Children referred for persistent cough were evaluated for the referring and final diagnosis, and the extent of the use of medications prior to referral and the side effects encountered. METHODS:Data on children seen by respiratory paediatricians for persistent cough (> or =4 weeks) in a tertiary respiratory ...

journal_title：Journal of paediatrics and child health

authors： Thomson F,Masters IB,Chang AB

更新日期：2002-12-01 00:00:00

abstract：OBJECTIVE:To detail the acute and chronic paediatric service and community-orientated activities and responsibilities of community-based general paediatricians. METHODOLOGY:Data were collected over the 12 months July 1996 to June 1997 relevant to (i) acute neonatology and paediatrics, (ii) the different community paed...

journal_title：Journal of paediatrics and child health

authors： Hewson PH,Anderson PK,Dinning AH,Jenner BM,McKellar WJ,Weymouth RD,Gollan RA

更新日期：1999-02-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine the applicability of the published clinical cut-off scores of the Child Behaviour Checklist (CBCL) for the classification of behaviour disorders. METHODOLOGY:Child Behaviour Checklists were obtained for 1342 subjects newly referred to the six major mental health centres...

journal_title：Journal of paediatrics and child health

authors： Nolan TM,Bond L,Adler R,Littlefield L,Birleson P,Marriage K,Mawdsley A,Salo R,Tonge BJ

更新日期：1996-10-01 00:00:00

abstract：AIMS:Adrenal cortical tumours remain a rare entity with inconsistent consensus about treatment and follow up. This article reviews 25 years of experience in the Royal Children's Hospital, Melbourne, Australia. METHODS:All records with the diagnosis of adrenal adenoma or carcinoma between 1976 and 2001 were reviewed, e...

journal_title：Journal of paediatrics and child health

authors： McDonnell CM,Zacharin MR

更新日期：2003-12-01 00:00:00

abstract：:Eight full-term infants (mean gestation 39.9 weeks [range 37-42] and mean birthweight 3642 g [range 3060-4200]) with severe respiratory failure (median oxygenation index 28 [range 16-65] and median arterial/alveolar PO2 ratio (a/APO2) 0.094 [range 0.038-0.165]) and pulmonary barotrauma were treated with Dexamethasone,...

journal_title：Journal of paediatrics and child health

authors： Barr P

更新日期：1991-12-01 00:00:00

abstract：OBJECTIVES:Paediatric oncology patients often require repeated bone marrow aspirates and lumbar punctures. These procedures commonly require sedation and analgesia. The Australian and New Zealand College of Anaesthetists and the American Academy of Pediatrics have published guidelines that provide recommendations on mo...

journal_title：Journal of paediatrics and child health

authors： Barnes C,Downie P,Chalkiadis G,Camilleri S,Monagle P,Waters K

更新日期：2002-04-01 00:00:00

abstract：:Many Aboriginal women do not recall their last menstrual period date, so alternative methods of estimating gestational age are necessary for optimal obstetric and neonatal care. In this retrospective review of 605 Aboriginal infants born at the Royal Darwin Hospital, the gestational age was estimated by the Dubowitz m...

journal_title：Journal of paediatrics and child health

authors： Sayers SM,Powers JR

更新日期：1992-08-01 00:00:00

abstract：AIMS:Although suctioning is a standard airway maintenance procedure, there are significant associated risks, such as loss of lung volume due to high negative suction pressures. This study aims to assess the extent and duration of change in end-expiratory level (EEL) resulting from endotracheal tube (ETT) suction and to...

journal_title：Journal of paediatrics and child health

authors： Hough JL,Shearman AD,Liley H,Grant CA,Schibler A

更新日期：2014-11-01 00:00:00

abstract：:Ultrasound techniques have been developed since the past century and are becoming more useful in different areas of medical knowledge. More recently, lung ultrasound gained importance throughout artefacts analysis to help clinical evaluation at bedside and became subject of interest in the paediatric intensive care an...

journal_title：Journal of paediatrics and child health

authors： Dominguez A,Gaspar HA,Preto M,Ejzenberg FE

更新日期：2018-09-01 00:00:00

abstract：AIMS:The aims of this study were to develop and evaluate a shorter gestational age estimation method based on the Dubowitz scoring system (DSS) that could be taught easily to untrained health-care workers. METHODS:Using the DSS, seven criteria were identified that explained 90% of the variance in gestational age estim...

journal_title：Journal of paediatrics and child health

authors： Allan RC,Sayers S,Powers J,Singh G

更新日期：2009-01-01 00:00:00

abstract：:Clinicians practising in different regions of the world are often impressed at marked differences in disease patterns witnessed. The bases of most obvious differences are usually socio-economic and genetic, but culture and environment can be equally important. Documenting and assessing such differences is more than ju...

journal_title：Journal of paediatrics and child health

authors： Ng PC,Fok TF,Nelson E

更新日期：1996-10-01 00:00:00

abstract：AIM:Left vocal cord paralysis (LVCP) is variably reported post ligation of patent ductus arteriosus (PDA). Our objective was to determine the incidence of LVCP and identify predictive factors and associated morbidities in preterm infants post PDA ligation. METHODS:This is a retrospective cohort study of infants less t...

journal_title：Journal of paediatrics and child health

authors： Pharande P,Karthigeyan S,Walker K,D'Cruz D,Badawi N,Luig M,Winlaw D,Popat H

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVES:To evaluate the habits of betel quid use and areca nut chewing among school-aged children in Karachi, Pakistan. Areca nut (betel nut) is chewed by itself, in various scented preparations, and in betel quid (containing betel leaf, areca nut, slaked lime, condiments, sweeteners and sometimes tobacco) in variou...

journal_title：Journal of paediatrics and child health

authors： Shah SM,Merchant AT,Luby SP,Chotani RA

更新日期：2002-10-01 00:00:00

abstract：AIM:The aim of this paper was to study the prevalence of a regular source of primary care for Victorian children attending one of four emergency departments (EDs) and to determine associated characteristics, including ED use. METHODS:Responses were collected via an electronic survey from parents attending EDs with the...

journal_title：Journal of paediatrics and child health

authors： Turbitt E,Freed GL

更新日期：2016-03-01 00:00:00

abstract：AIM:To determine health-care-seeking behaviour for childhood illnesses in a resource-poor setting. METHOD:Cross-sectional survey was conducted in the children emergency room in a Nigerian tertiary hospital. Socio-demographic data and details of the place and type of care given to ill children before presentation in th...

journal_title：Journal of paediatrics and child health

authors： Tinuade O,Iyabo RA,Durotoye O

更新日期：2010-05-01 00:00:00