Abstract：
:A growing number of whole genome sequencing projects, in combination with development of phylogenetic methods for reconstructing gene evolution, have provided us with a window into genomes that existed millions, and even billions, of years ago. Ancestral Genomes (http://ancestralgenomes.org) is a resource for comprehensive reconstructions of these 'fossil genomes'. Comprehensive sets of protein-coding genes have been reconstructed for 78 genomes of now-extinct species that were the common ancestors of extant species from across the tree of life. The reconstructed genes are based on the extensive library of over 15 000 gene family trees from the PANTHER database, and are updated on a yearly basis. For each ancestral gene, we assign a stable identifier, and provide additional information designed to facilitate analysis: an inferred name, a reconstructed protein sequence, a set of inferred Gene Ontology (GO) annotations, and a 'proxy gene' for each ancestral gene, defined as the least-diverged descendant of the ancestral gene in a given extant genome. On the Ancestral Genomes website, users can browse the Ancestral Genomes by selecting nodes in a species tree, and can compare an extant genome with any of its reconstructed ancestors to understand how the genome evolved.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Huang X,Albou LP,Mushayahama T,Muruganujan A,Tang H,Thomas PDdoi
10.1093/nar/gky1009subject
Has Abstractpub_date
2019-01-08 00:00:00pages
D271-D279issue
D1eissn
0305-1048issn
1362-4962pii
5146195journal_volume
47pub_type
杂志文章abstract：:Activating sequence factor 1 (ASF-1) is a nuclear DNA-binding activity that is found in monocots and dicots. It interacts with several TGACG-containing elements that have been characterized from viral and T-DNA genes, the prototypes of which are the as-1 element of the CaMV 35S promoter and the ocs element from the oc...
journal_title：Nucleic acids research
pub_type： 杂志文章
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doi：10.1093/nar/gkr486
更新日期：2011-09-01 00:00:00
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journal_title：Nucleic acids research
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doi：10.1093/nar/gks573
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkw348
更新日期：2016-07-08 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/9.12.2761
更新日期：1981-06-25 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkv584
更新日期：2015-07-27 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/6.9.3119
更新日期：1979-07-11 00:00:00
abstract：:Archival formalin-fixed, paraffin-embedded and ethanol-fixed tissues represent a potentially invaluable resource for gene expression analysis, as they are the most widely available material for studies of human disease. Little data are available evaluating whether RNA obtained from fixed (archival) tissues could produ...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/30.2.e4
更新日期：2002-01-15 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/21.3.381
更新日期：1993-02-11 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkt1273
更新日期：2014-03-01 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkab009
更新日期：2021-01-28 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkaa1023
更新日期：2021-01-08 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/24.13.2585
更新日期：1996-07-01 00:00:00
abstract：:The Deciphering the Mechanisms of Developmental Disorders (DMDD) consortium is a research programme set up to identify genes in the mouse, which if mutated (or knocked-out) result in embryonic lethality when homozygous, and initiate the study of why disruption of their function has such profound effects on embryo deve...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkv1138
更新日期：2016-01-04 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/12.16.6547
更新日期：1984-08-24 00:00:00
abstract：:Several electrophoretic and chromatographic systems have been investigated and compared for sequence analysis of oligodeoxyribonucleotides. Three systems were found to be useful for the separation of a series of sequential degradation products resulting from a labeled oligonucleotide: (I) 2-D electrophoresisdagger; (I...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/1.3.331
更新日期：1974-03-01 00:00:00
abstract：:Gene Ontology (GO) is the most widely accepted attempt to construct a unified and structured vocabulary for the description of genes and their products in any organism. Annotation by GO terms is performed in most of the current genome projects, which besides generality has the advantage of being very convenient for co...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkg582
更新日期：2003-07-01 00:00:00
abstract：:Thermal elution poly(U)-Sepharose chromatography was utilized to fractionate yeast mRNA based on poly(A) size. Analysis of the in vitro translation products of the fractionated RNAs in a wheat-embryo cell-free protein synthesis system shows a heterogeneous but equal distribution of these abundant translatable mRNAs in...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/8.17.3841
更新日期：1980-09-11 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/3.7.1715
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/18.13.3813
更新日期：1990-07-11 00:00:00
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pub_type： 杂志文章
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更新日期：2005-01-26 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/4.7.2407
更新日期：1977-07-01 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkq1239
更新日期：2011-04-01 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/8.1.67
更新日期：1980-01-11 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkt1037
更新日期：2014-02-01 00:00:00
abstract：:By means of a combination of ion-exchange and sequence-specific affinity chromatography techniques, we have purified to homogeneity two protein complexes binding in a human DNA region (B48) previously recognized to contain a DNA replication origin. The DNA sequence used for the protein purification (B48 binding site) ...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/21.14.3257
更新日期：1993-07-11 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkq364
更新日期：2010-10-01 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/14.24.9729
更新日期：1986-12-22 00:00:00
abstract：:Evidence will be presented to show that the allyl group is suitable for the protection of a 3'-terminal phosphodiester function. The latter will be demonstrated by the synthesis, via a phosphotriester approach, of two cyclic tetraribonucleotides [r(AAAA) and r(UAMe2UAMe2)], two cyclic hexadeoxyribonucleotides [d(CGCGC...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/16.10.4607
更新日期：1988-05-25 00:00:00
abstract：:Nematode.net (http://nematode.net) is a publicly available resource dedicated to the study of parasitic nematodes. In 2000, the Genome Center at Washington University (GC) joined a consortium including the Nematode Genomics group in Edinburgh, and the Pathogen Sequencing Unit of the Sanger Institute to generate expres...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkn744
更新日期：2009-01-01 00:00:00
