Abstract:
:The effects of single and repeated electroconvulsive shock (ECS) on the binding of [3H]diprenorphine to rat brain membranes was studied. Repeated but not single ECS significantly increased the Bmax of [3H]diprenorphine binding when measured in the absence but not in the presence of NaCl. On a regional basis the effect of ECS was greatest in the olfactory bulb, nucleus accumbens, and striatum. More modest increases were found in the hippocampus, amygdala, septum, hypothalamus, and pyriform cortex. No significant effect was found in the brainstem and frontal cortex. Although the regional rank order of receptor increase does not match the receptor distribution of brain enkephalins, the receptor increase does parallel the regional increases in brain enkephalins following ECS.
journal_name
Mol Pharmacoljournal_title
Molecular pharmacologyauthors
Hitzemann RJ,Hitzemann BA,Blatt S,Meyerhoff JL,Tortella FC,Kenner JR,Belenky GL,Holaday JWsubject
Has Abstractpub_date
1987-05-01 00:00:00pages
562-6issue
5eissn
0026-895Xissn
1521-0111journal_volume
31pub_type
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