Abstract：
:The cis and trans isomers of the photoisomerizable compound, 3,3'-bis-[alpha-(trimethylammonium)methyl]azobenzene (Bis-Q), were purified by high-performance liquid chromatography using the ion-pair partitioning technique on a reverse-phase column. Solutions of cis-Bis-Q are stable at -20 degrees; at 25 degrees, thermal isomerization proceeds at a rate of 0.65%/day. cis-Bis-Q is less than 1% as potent a nicotinic agonist as the trans configuration. At concentrations of 1.5 microM or less, cis-Bis-Q exerts little or no blockade of the conductances induced by agonists. In voltage-clamped Electrophorus electroplaques exposed to cis-Bis-Q, laser flashes induce cis leads to trans photoisomerizations and increase the agonist-induced current by a factor of 20 within a few milliseconds.
journal_name
Mol Pharmacoljournal_title
Molecular pharmacologyauthors
Nerbonne JM,Sheridan RE,Chabala LD,Lester HAsubject
Has Abstractpub_date
1983-03-01 00:00:00pages
344-9issue
2eissn
0026-895Xissn
1521-0111journal_volume
23pub_type
杂志文章abstract：:The endogenous bronchodilator, S-nitrosoglutathione (GSNO), increases expression, maturation, and function of both the wild-type and the DeltaF508 mutant of the cystic fibrosis transmembrane conductance regulatory protein (CFTR). Though transcriptional mechanisms of action have been identified, GSNO seems also to have...
journal_title：Molecular pharmacology
pub_type： 杂志文章
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abstract：:The Notch family consists of four highly conserved transmembrane receptors. The release of the active intracellular domain requires the enzymatic activity of γ-secretase. Notch is involved in embryonic development and in many physiologic processes of normal cells, in which it regulates growth, apoptosis, and different...
journal_title：Molecular pharmacology
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pub_type： 杂志文章
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更新日期：2000-03-01 00:00:00
abstract：:The CYP2C genes are extensively regulated at the transcriptional stage. The present study shows for the first time that CYP2Cs are also regulated post-transcriptionally by microRNAs (miRNAs). By using online search engines, we found potential miRNA response elements (MREs) in the 3'-untranslated region (3'-UTR) of the...
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journal_title：Molecular pharmacology
pub_type： 杂志文章
doi：10.1124/mol.106.026815
更新日期：2006-10-01 00:00:00
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更新日期：2000-02-01 00:00:00
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journal_title：Molecular pharmacology
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更新日期：1996-09-01 00:00:00
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更新日期：1992-04-01 00:00:00
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journal_title：Molecular pharmacology
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更新日期：1995-01-01 00:00:00
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更新日期：2006-11-01 00:00:00
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journal_title：Molecular pharmacology
pub_type： 杂志文章
doi：
更新日期：1995-03-01 00:00:00
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journal_title：Molecular pharmacology
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doi：
更新日期：1994-07-01 00:00:00
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pub_type： 杂志文章
doi：
更新日期：1991-11-01 00:00:00
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doi：
更新日期：1993-06-01 00:00:00
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journal_title：Molecular pharmacology
pub_type： 杂志文章
doi：
更新日期：1989-04-01 00:00:00
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doi：
更新日期：1996-03-01 00:00:00
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journal_title：Molecular pharmacology
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更新日期：1993-11-01 00:00:00
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journal_title：Molecular pharmacology
pub_type： 杂志文章
doi：
更新日期：1998-06-01 00:00:00
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doi：
更新日期：1996-02-01 00:00:00
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journal_title：Molecular pharmacology
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doi：
更新日期：1991-06-01 00:00:00
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journal_title：Molecular pharmacology
pub_type： 杂志文章
doi：
更新日期：1982-11-01 00:00:00
