Abstract:
:Nitric oxide (NO) possesses potent anti-inflammatory properties; however, an over-production of NO will promote inflammation and induce cell and tissue dysfunction. Thus, the ability to precisely regulate NO production could prove beneficial in controlling damage. In this study, advantage was taken of the well characterized inflammatory response caused by an intestinal parasite, Trichinella spiralis, to study the relationship between intestinal inflammation and the regulation of nitric oxide synthase-type 2 (NOS-2) expression. Our study revealed that a specific gut inflammatory reaction results in inhibition of NOS-2 expression. Characteristics of this inhibition are: 1) local jejunal inflammation induced by T. spiralis systemically inhibits NOS-2 gene transcription, protein expression, and enzyme activity; 2) the inhibition blunts endotoxin-stimulated NOS-2 expression; 3) the inhibition does not extend to the expression of other isoforms of NOS, to paxillin, a housekeeper protein, or to cyclooxygenase-2, another protein induced by proinflammatory cytokines; 4) the inhibition is unlikely related to the formation of specific anti-parasite antibodies; and 5) the inhibition may involve substances other than stress-induced corticosteroids. Elucidation of such potent endogenous NOS-2 down-regulatory mechanisms could lead to the development of new strategies for the therapy of inflammatory conditions characterized by the overproduction of NO.
journal_name
Mol Pharmacoljournal_title
Molecular pharmacologyauthors
Bian K,Harari Y,Zhong M,Lai M,Castro G,Weisbrodt N,Murad Fdoi
10.1124/mol.59.4.939keywords:
subject
Has Abstractpub_date
2001-04-01 00:00:00pages
939-47issue
4eissn
0026-895Xissn
1521-0111journal_volume
59pub_type
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journal_title:Molecular pharmacology
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journal_title:Molecular pharmacology
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更新日期:1994-06-01 00:00:00
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journal_title:Molecular pharmacology
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更新日期:1992-07-01 00:00:00
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journal_title:Molecular pharmacology
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更新日期:1990-09-01 00:00:00
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journal_title:Molecular pharmacology
pub_type: 杂志文章
doi:
更新日期:1994-08-01 00:00:00
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journal_title:Molecular pharmacology
pub_type: 杂志文章
doi:
更新日期:1991-11-01 00:00:00
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更新日期:2006-12-01 00:00:00
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journal_title:Molecular pharmacology
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
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更新日期:1987-01-01 00:00:00
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