Interest in, willingness-to-pay for and willingness-to-recommend genetic testing for prostate cancer among affected men after radical prostatectomy.

Abstract:

:Knowledge about interest in genetic testing and willingness-to-pay for a genetic test among men affected from prostate cancer (PCa) is limited. This study aimed to gain insight into men's attitudes in genetic testing for PCa. 4699 men with PCa from the German multicenter prospective database "Familial Prostate Cancer" were included. Interest in, Willingness-to-pay for and Willingness-to-recommend a genetic test for PCa were quantified. Associations with several sociodemographic and psychosocial variables were evaluated by logistic regression. 76.8% of the affected men with a median follow-up of 12.9 years were interested in a genetic test for PCa. Newly identified variables significantly associated with interest were having sons (OR 1.66, p < 0.001) and a high perceived severity of the PCa (OR 1.40, p < 0.001). 19% of men were willing to pay more than 500 € for a genetic test. Men with higher education, men with a better self-reported economic situation and men with a lethal PCa in their family were more likely to be willing to pay a larger sum for a test. 84.9% of men were willing to recommend a test to their relatives. Interest in genetic testing for PCa among affected men was generally high with most men willing to recommend a test to their relatives. Various characteristics associated with interest and willingness-to-pay larger sums for genetic testing were uncovered and need to be addressed when designing both future educational material and genetic tests for PCa.

journal_name

Fam Cancer

journal_title

Familial cancer

authors

Mayer M,Selig K,Tüttelmann F,Dinkel A,Gschwend JE,Herkommer K

doi

10.1007/s10689-018-0101-7

subject

Has Abstract

pub_date

2019-04-01 00:00:00

pages

221-230

issue

2

eissn

1389-9600

issn

1573-7292

pii

10.1007/s10689-018-0101-7

journal_volume

18

pub_type

杂志文章
  • Promoter hypermethylation frequency and BRAF mutations distinguish hereditary non-polyposis colon cancer from sporadic MSI-H colon cancer.

    abstract:BACKGROUND:Colorectal cancers resulting from defective DNA mismatch repair can occur in both hereditary non-polyposis colon cancer (HNPCC) and in the sporadic setting. They are characterised by a high level of microsatellite instability (MSI-H) and superficially resemble each other in that they are frequently located i...

    journal_title:Familial cancer

    pub_type: 杂志文章

    doi:10.1023/B:FAME.0000039861.30651.c8

    authors: McGivern A,Wynter CV,Whitehall VL,Kambara T,Spring KJ,Walsh MD,Barker MA,Arnold S,Simms LA,Leggett BA,Young J,Jass JR

    更新日期:2004-01-01 00:00:00

  • Multiple skin hamartomata: a possible novel clinical presentation of SUFU neoplasia syndrome.

    abstract::Medulloblastoma tumours may arise sporadically or as part of an inherited syndrome. A subset of children with medulloblastoma carry germline and somatic mutations in the SUFU tumour suppressor gene located at 10q24. We report a 55 year old woman referred for investigation on the basis of skin lesions and a family hist...

    journal_title:Familial cancer

    pub_type: 杂志文章

    doi:10.1007/s10689-014-9752-1

    authors: Mann K,Magee J,Guillaud-Bataille M,Blondel C,Bressac-de Paillerets B,Yeatman J,Winship I

    更新日期:2015-03-01 00:00:00

  • A survey of APC mutations in Quebec.

    abstract::This is an 11-year survey of molecular analysis of APC germline mutations for the province of Quebec done at the Molecular Pathology Unit of the Jewish General Hospital which offers genetic testing for hereditary forms of colorectal cancer for the whole of Quebec province. We report on 47 unique mutations seen in 66 f...

    journal_title:Familial cancer

    pub_type: 杂志文章

    doi:10.1007/s10689-011-9468-4

    authors: Jarry J,Brunet JS,Laframboise R,Drouin R,Latreille J,Richard C,Gekas J,Maranda B,Monczak Y,Wong N,Pouchet C,Zaor S,Kasprzak L,Palma L,Wu MK,Tischkowitz M,Foulkes WD,Chong G

    更新日期:2011-12-01 00:00:00

  • Improving primary care identification of familial breast cancer risk using proactive invitation and decision support.

    abstract::Family history of breast cancer is a key risk factor, accounting for up to 10% of cancers. We evaluated the proactive assessment of familial breast cancer (FBC) risk in primary care. Eligible women (30 to 60 years) were recruited from eight English general practices. Practices were trained on FBC risk assessment. In f...

    journal_title:Familial cancer

    pub_type: 杂志文章

    doi:10.1007/s10689-020-00188-z

    authors: Qureshi N,Dutton B,Weng S,Sheehan C,Chorley W,Robertson JFR,Kendrick D,Kai J

    更新日期:2020-06-11 00:00:00

  • Identification of a rare germline NBN gene mutation by whole exome sequencing in a lung-cancer survivor from a large family with various types of cancer.

    abstract::Nijmegen breakage syndrome is an autosomal recessive disorder caused by biallelic mutation in NBN gene. It is characterized by microcephaly, growth retardation, immuno-deficiency and cancer predisposition. The monoallelic carriers of NBN gene are also reported to be at increased risk of developing various types of mal...

    journal_title:Familial cancer

    pub_type: 杂志文章

    doi:10.1007/s10689-016-9954-9

    authors: Marafie MJ,Dashti M,Al-Mulla F

    更新日期:2017-07-01 00:00:00

  • Frameshift mutation in the PTCH2 gene can cause nevoid basal cell carcinoma syndrome.

    abstract::Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant disorder characterized by developmental defects and tumorigenesis. The gene responsible for NBCCS is PTCH1, encoding a receptor for the secreted protein, sonic hedgehog. Recently, a Chinese family with NBCCS carrying a missense mutation in PTCH2, a ...

    journal_title:Familial cancer

    pub_type: 杂志文章

    doi:10.1007/s10689-013-9623-1

    authors: Fujii K,Ohashi H,Suzuki M,Hatsuse H,Shiohama T,Uchikawa H,Miyashita T

    更新日期:2013-12-01 00:00:00

  • The 1100delAT BRCA1 and the 8765delAG BRCA2 mutations: occurrence in high-risk non-Ashkenazi Jews and haplotype comparison of Jewish and non-Jewish carriers.

    abstract::Few mutations have been described in BRCA1 and BRCA2 in high-risk non-Ashkenazi Jews. In a Libyan family the 1100delAT BRCA1 mutation was detected and the 8765delAG BRCA2 mutation was previously described in two Jewish-Yemenite-families. In this study, the rate of these mutations in high-risk Jews of North African and...

    journal_title:Familial cancer

    pub_type: 杂志文章

    doi:10.1023/B:FAME.0000026837.32470.b4

    authors: Gal I,Gershoni Baruch R,Haber D,Dagan E,Eisenberg-Barzilai S,Zidan J,Friedman E

    更新日期:2004-01-01 00:00:00

  • Analysis of 3297 individuals suggests that the pathogenic germline 5'-UTR variant BRCA1 c.-107A > T is not common in south-east Germany.

    abstract::In this study we aim to determine the prevalence of the recently identified pathogenic BRCA1 variant c.-107A > T in the south-east German population. This variant causes the epigenetic silencing of the BRCA1 promotor and has been detected in two independent families from the UK without a germline BRCA1 or BRCA2 pathog...

    journal_title:Familial cancer

    pub_type: 杂志文章

    doi:10.1007/s10689-020-00175-4

    authors: Laner A,Benet-Pages A,Neitzel B,Holinski-Feder E

    更新日期:2020-07-01 00:00:00

  • Prophylactic oophorectomy in Ontario.

    abstract:OBJECTIVE:To determine the indications, patterns of practice, and complication rates for prophylactic oophorectomy in Ontario. METHODS:From hospital discharge abstracts, 82 hospitals were identified where at least one patient had a prophylactic oophorectomy since 1992. Ethics approval for the chart review was obtained...

    journal_title:Familial cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1023/a:1021174604905

    authors: Elit L,Rosen B,Goel V,McLaughlin J,Fung MK,Shime J,Narod S

    更新日期:2001-01-01 00:00:00

  • Cleft lip/palate and hereditary diffuse gastric cancer: report of a family harboring a CDH1 c.687 + 1G > A germline mutation and review of the literature.

    abstract::Hereditary diffuse gastric cancer (HDGC) is an autosomal-dominantly inherited cancer syndrome associated with a high risk for diffuse gastric and lobular breast cancer, caused by heterozygous CDH1 germline mutations. Of note, also cleft lip/palate (CLP) has been described in few HDGC families. Here we report on an ext...

    journal_title:Familial cancer

    pub_type: 杂志文章,评审

    doi:10.1007/s10689-018-0111-5

    authors: Obermair F,Rammer M,Burghofer J,Malli T,Schossig A,Wimmer K,Kranewitter W,Mayrbaeurl B,Duba HC,Webersinke G

    更新日期:2019-04-01 00:00:00

  • A functional varient in microRNA-146a is associated with risk of esophageal squamous cell carcinoma in Chinese Han.

    abstract::MicroRNAs are a new class of non-proteincoding, small RNAs that function as tumor suppressors or oncogenes. They participate in diverse biological pathways and function as gene regulators. A G>C polymorphism (rs2910164), which is located in the sequence of miR-146a precursor, results in a change from G:U to C:U in its...

    journal_title:Familial cancer

    pub_type: 杂志文章

    doi:10.1007/s10689-010-9370-5

    authors: Guo H,Wang K,Xiong G,Hu H,Wang D,Xu X,Guan X,Yang K,Bai Y

    更新日期:2010-12-01 00:00:00

  • Association of genetic variations in RTN4 3'-UTR with risk for clear cell renal cell carcinoma.

    abstract::Nogo proteins play an important role in the apoptosis of cells, especially in tumor cells. The present study was conducted to evaluate whether the TATC (rs71682980) and CAA (rs34917480) insertion/deletion polymorphisms of RTN4 3'-UTR are associated with clear cell renal cell carcinoma (ccRCC). These two polymorphisms ...

    journal_title:Familial cancer

    pub_type: 杂志文章

    doi:10.1007/s10689-017-0005-y

    authors: Pu Y,Chen P,Zhou B,Zhang P,Wang Y,Song Y,Zhang L

    更新日期:2018-01-01 00:00:00

  • A case of contralateral breast cancer and skin cancer associated with NBN heterozygous pathogenic variant c.698_701delAACA.

    abstract::Approximately 39.6% of people will be diagnosed with cancer during their lifetime. Several factors including, lifestyle, environment and genetics may play a role in its development. Understanding these causes will greatly improve treatment methods, prevention, and survival rates of these patients. Our patient, who has...

    journal_title:Familial cancer

    pub_type: 杂志文章

    doi:10.1007/s10689-017-9982-0

    authors: Gass J,Jackson J,Macklin S,Blackburn P,Hines S,Atwal PS

    更新日期:2017-10-01 00:00:00

  • Uptake of predictive testing among relatives of BRCA1 and BRCA2 families: a multicenter study in northeastern Spain.

    abstract::Identifying a BRCA mutation among families with hereditary breast and ovarian cancer enables distinguishing those who may benefit from a specific medical management. This study aimed to evaluate the uptake of predictive testing among close relatives of a proband in Spanish families with a BRCA1 or BRCA2 mutation, and ...

    journal_title:Familial cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10689-009-9313-1

    authors: Sanz J,Ramón y Cajal T,Torres A,Darder E,Gadea N,Velasco A,Fortuny D,López C,Fisas D,Brunet J,Alonso MC,Balmaña J

    更新日期:2010-09-01 00:00:00

  • Chemoprevention of familial adenomatous polyposis.

    abstract::Familial adenomatous polyposis (FAP) has always been first and foremost a surgical disease, whose treatment with colectomy has long been known to reduce risk of premature cancer death. The notion of reducing polyp burden and potentially delaying surgical intervention has spawned a host of "chemoprevention" trials. In ...

    journal_title:Familial cancer

    pub_type: 杂志文章,评审

    doi:10.1007/s10689-016-9901-9

    authors: Lynch PM

    更新日期:2016-07-01 00:00:00

  • Hereditary medullary thyroid carcinoma syndromes: experience from western India.

    abstract::The data from the Indian subcontinent on Medullary thyroid carcinoma (MTC) and associated endocrinopathies in hereditary MTC (HMTC) syndromes are limited. Hence, we analyzed clinical and biochemical characteristics, management, and outcomes of HMTC and other associated endocrinopathies [Pheochromocytoma (PCC) and Prim...

    journal_title:Familial cancer

    pub_type: 杂志文章

    doi:10.1007/s10689-020-00219-9

    authors: Diwaker C,Sarathi V,Jaiswal SK,Shah R,Deshmukh A,Thomas AE,Prakash G,Malhotra G,Patil V,Lila A,Shah N,Bandgar T

    更新日期:2021-01-04 00:00:00

  • Low accuracy of self-reported family history of melanoma in high-risk patients.

    abstract::Family history of melanoma is a major melanoma risk factor. However, self-reported family histories for some cancers, including melanoma, are commonly inaccurate. We used a unique database, the Utah Population Database (UPDB), as well as the Utah Cancer Registry to determine the accuracy of self-reported family histor...

    journal_title:Familial cancer

    pub_type: 杂志文章

    doi:10.1007/s10689-020-00187-0

    authors: Flint ND,Bishop MD,Smart TC,Strunck JL,Boucher KM,Grossman D,Secrest AM

    更新日期:2020-05-21 00:00:00

  • Adult weight gain and central obesity in women with and without a family history of breast cancer: a case control study.

    abstract::Adult weight gain and central obesity can increase breast cancer risk. We determined the prevalence of adult weight gain and central obesity amongst women with a family history (FH) as compared to women with a population risk to determine whether adiposity could contribute to their increased risk. Adult weight gain, w...

    journal_title:Familial cancer

    pub_type: 杂志文章

    doi:10.1007/s10689-007-9122-3

    authors: Harvie MN,Bokhari S,Shenton A,Ashcroft L,Evans G,Swindell R,Howell A

    更新日期:2007-01-01 00:00:00

  • Selective COX-2 inhibition affects fatty acids, but not COX mRNA expression in patients with FAP.

    abstract::Familial adenomatous polyposis (FAP) provides a model for sporadic colorectal cancer development. Cyclooxygenase (COX) inhibition may ameliorate polyp development, but rofecoxib was withdrawn due to cardiovascular side effects. Although this selective COX-2 inhibitor, like diet, may alter the fatty acid and eicosanoid...

    journal_title:Familial cancer

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s10689-010-9365-2

    authors: Almendingen K,Larsen LN,Fausa O,Bratlie J,Høstmark AT,Aabakken L

    更新日期:2010-12-01 00:00:00

  • Hereditary diffuse gastric cancer: cancer risk and the personal cost of preventive surgery.

    abstract::Germline CDH1 mutation carriers are at risk for early-onset diffuse gastric cancer (DGC) and female carriers have an additional risk of lobular breast cancer. The reported literature GC risk of 70% has led to the recommendation for germline mutation carriers to undergo prophylactic total gastrectomy (PTG). The objecti...

    journal_title:Familial cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10689-019-00133-9

    authors: Kaurah P,Talhouk A,MacMillan A,Lewis I,Chelcun-Schreiber K,Yoon SS,Huntsman D

    更新日期:2019-10-01 00:00:00

  • Association of the BRCA1 promoter polymorphism rs11655505 with the risk of familial breast and/or ovarian cancer.

    abstract::Germline mutations in the BRCA1 tumor suppressor gene predispose affected individuals to breast cancer; however, incomplete cancer penetrance and the presence of phenocopies in BRCA1 families also indicate genetic and environmental modifiers of breast cancer risk. In this study, we have tested the single nucleotide po...

    journal_title:Familial cancer

    pub_type: 杂志文章

    doi:10.1007/s10689-013-9647-6

    authors: Bielinska B,Gaj P,Kluska A,Nowakowska D,Balabas A,Dabrowska M,Niwinska A,Gruchota J,Zub R,Skasko E,Steffen J,Ostrowski J,Siedlecki JA

    更新日期:2013-12-01 00:00:00

  • Standards of care in diagnosis and testing for hereditary colon cancer.

    abstract::Inherited colorectal cancer predisposition involves a rather heterogeneous range of rare, yet relatively well-defined disorders, including Familial Adenomatous Polyposis (FAP), Hereditary Non-polyposis Colorectal Cancer (HNPCC) or Lynch syndrome, Peutz-Jeghers syndrome, Juvenile Polyposis, and their respective variant...

    journal_title:Familial cancer

    pub_type: 杂志文章

    doi:10.1007/s10689-007-9159-3

    authors: Lynch PM

    更新日期:2008-01-01 00:00:00

  • Immunohistochemical null-phenotype for mismatch repair proteins in colonic carcinoma associated with concurrent MLH1 hypermethylation and MSH2 somatic mutations.

    abstract::Microsatellite instability, a well-established driver pathway in colorectal carcinogenesis, can develop in both sporadic and hereditary conditions via different molecular alterations in the DNA mismatch repair (MMR) genes. MMR protein immunohistochemistry (IHC) is currently widely used for the detection of MMR deficie...

    journal_title:Familial cancer

    pub_type: 杂志文章

    doi:10.1007/s10689-017-0031-9

    authors: Wang T,Stadler ZK,Zhang L,Weiser MR,Basturk O,Hechtman JF,Vakiani E,Saltz LB,Klimstra DS,Shia J

    更新日期:2018-04-01 00:00:00

  • Inequities in multi-gene hereditary cancer testing: lower diagnostic yield and higher VUS rate in individuals who identify as Hispanic, African or Asian and Pacific Islander as compared to European.

    abstract::The identification of germline pathogenic/likely pathogenic (P/LP) variants in cancer predisposition genes can guide treatment and management decisions for the individual being tested and potentially at-risk relatives. Prior studies have raised concerns of racial/ethnic disparities in the detection rates of P/LP varia...

    journal_title:Familial cancer

    pub_type: 杂志文章

    doi:10.1007/s10689-019-00144-6

    authors: Ndugga-Kabuye MK,Issaka RB

    更新日期:2019-10-01 00:00:00

  • High frequency of BRCA1 founder mutations in Polish women with nonfamilial breast cancer.

    abstract::Possession of a BRCA1/2 mutation increases risk of contralateral breast and ovarian cancer recurrence and may have an impact on health management decisions, such as imaging screening, preventive surgical interventions and systemic therapies. A hospital-based study was conducted to assess the frequency and spectrum of ...

    journal_title:Familial cancer

    pub_type: 杂志文章

    doi:10.1007/s10689-012-9560-4

    authors: Gaj P,Kluska A,Nowakowska D,Bałabas A,Piątkowska M,Dabrowska M,Niwińska A,Ostrowski J

    更新日期:2012-12-01 00:00:00

  • Low contribution of BRCA1/2 genomic rearrangement to high-risk breast cancer in the Korean population.

    abstract::Genomic rearrangement occasionally affects the BRCA1/2 genes in Caucasian breast cancer patients. However, the incidence of BRCA1/2 genomic rearrangement in Asians, including the Korean population, has not been well established. Here, we investigated the contribution of BRCA1/2 genomic rearrangement to high-risk breas...

    journal_title:Familial cancer

    pub_type: 杂志文章

    doi:10.1007/s10689-009-9279-z

    authors: Seong MW,Cho SI,Noh DY,Han W,Kim SW,Park CM,Park HW,Kim SY,Kim JY,Park SS

    更新日期:2009-01-01 00:00:00

  • Sarcoma in neurofibromatosis 2: case report and review of the literature.

    abstract::Neurofibromatosis type 2 (NF2) is associated with the development of several types of benign nervous system tumours, while malignancies are rare. We report a 22-year-old man who presented with retroperitoneal and spinal high-grade sarcomas with epithelial features. Samples showed a mixed epithelioid and spindled cell ...

    journal_title:Familial cancer

    pub_type: 杂志文章,评审

    doi:10.1007/s10689-018-0084-4

    authors: Linder C,Smith MJ,Bulman M,Wallace A,Freemont AJ,Mangham DC,Evans DGR

    更新日期:2019-01-01 00:00:00

  • Co-occurrence of Lynch syndrome and juvenile polyposis syndrome confirmed by multigene panel testing.

    abstract::Through germline multigene panel testing, we discovered the co-occurrence of Lynch syndrome due to a PMS2 mutation and juvenile polyposis syndrome due to a BMPR1A mutation in a young man with synchronous bladder and colorectal cancers and a family history of colorectal polyps. To our knowledge, this is the first repor...

    journal_title:Familial cancer

    pub_type: 杂志文章

    doi:10.1007/s10689-017-0012-z

    authors: Silva-Smith R,Sussman DA

    更新日期:2018-01-01 00:00:00

  • Characterizing germline APC and MUTYH variants in Ashkenazi Jews compared to other individuals.

    abstract::Germline variants in the APC and MUTYH genes contribute to colorectal cancer (CRC) and adenoma risk, though may occur with varying frequencies in individuals of different ancestries. The aim of this study was to evaluate the prevalence of APC, monoallelic MUTYH and biallelic MUTYH germline variants in Ashkenazi Jewish...

    journal_title:Familial cancer

    pub_type: 杂志文章

    doi:10.1007/s10689-020-00198-x

    authors: Ukaegbu C,Levi Z,Fehlmann TD,Uno H,Chittenden A,Inra JA,Grover S,Kastrinos F,Syngal S,Yurgelun MB

    更新日期:2020-08-03 00:00:00

  • The hereditary nature of small cell carcinoma of the ovary, hypercalcemic type: two new familial cases.

    abstract::Small cell carcinoma of the ovary, hypercalcemic type, (SCCOHT) is the most common undifferentiated ovarian cancer in women aged under 40 years. SCCOHT is a monogenic disease, characterized by germline and somatic SMARCA4 mutations. Recent studies have stressed its morphological and clinical similarity to malignant rh...

    journal_title:Familial cancer

    pub_type: 杂志文章

    doi:10.1007/s10689-016-9957-6

    authors: Witkowski L,Donini N,Byler-Dann R,Knost JA,Albrecht S,Berchuck A,McCluggage WG,Hasselblatt M,Foulkes WD

    更新日期:2017-07-01 00:00:00