Abstract：
:Small cell carcinoma of the ovary, hypercalcemic type, (SCCOHT) is the most common undifferentiated ovarian cancer in women aged under 40 years. SCCOHT is a monogenic disease, characterized by germline and somatic SMARCA4 mutations. Recent studies have stressed its morphological and clinical similarity to malignant rhabdoid tumours, which are usually caused by mutations in the related gene, SMARCB1. While familial tumours are rare, the incidence of germline mutations is relatively high, with up to 43% of SCCOHTs and 35% of rhabdoid tumours caused by germline mutations in SMARCA4 and SMARCB1, respectively. We report two new familial cases of SCCOHT. Affected members in both families and the associated tumours were found to carry SMARCA4 germline and somatic mutations, respectively, leading to loss of SMARCA4 protein expression in the tumours. Despite the rarity of familial SCCOHT, the high incidence of germline mutations is important to note, as without a family history of the disease, the hereditary nature of SCCOHT may be missed, especially if the mutation was inherited from the father or acquired de novo. The similarity between SCCOHT and rhabdoid tumours should be recognized, as infant carriers of SMARCA4 mutations may be at risk for these tumours in addition to SCCOHT.
journal_name
Fam Cancerjournal_title
Familial cancerauthors
Witkowski L,Donini N,Byler-Dann R,Knost JA,Albrecht S,Berchuck A,McCluggage WG,Hasselblatt M,Foulkes WDdoi
10.1007/s10689-016-9957-6subject
Has Abstractpub_date
2017-07-01 00:00:00pages
395-399issue
3eissn
1389-9600issn
1573-7292pii
10.1007/s10689-016-9957-6journal_volume
16pub_type
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