Abstract：
:The photolytic and photocatalytic transformation of an antipsychotic drug asenapine with the use of H2O2 and TiO2 was studied. A method employing irradiation with a simulated full solar spectrum in the photostability chamber was applied, then the reverse-phase ultra high performance liquid chromatography with diode array detector, coupled with electrospray quadrupole time-of-flight mass spectrometer (RP-UHPLC-DAD - ESI-Q-TOF) was used for the quantitative and qualitative analysis of the processes. The developed quantitative method was fully validated, according to the International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) guidelines, and the kinetic parameters of asenapine photodecomposition were compared. Nineteen phototransformation products were detected, and their probable structures - mainly hydroxylated and oxidized asenapine derivatives - were suggested. On the basis of the elucidated structures the computational prediction of their toxicity at the various endpoints, as well as bioconcentration factors and biodegradability was performed. The obtained results were then subjected to the principal component analysis (PCA). This chemometric technique facilitated comparison of the applied models, calculated properties of the TPs, and enabled visualization of relationships between them.
journal_name
Ecotoxicol Environ Safjournal_title
Ecotoxicology and environmental safetyauthors
Trawiński J,Skibiński Rdoi
10.1016/j.ecoenv.2018.07.010subject
Has Abstractpub_date
2018-10-30 00:00:00pages
272-286eissn
0147-6513issn
1090-2414pii
S0147-6513(18)30604-3journal_volume
162pub_type
杂志文章abstract：:In this study, a new electrochemical method was used to simultaneously efficient removal of Mn2+ and NH4+-N in wastewater with Cu plate as cathode. The effects of various reaction parameters on the concentrations of Mn2+, NH4+-N and by-products (NO3--N and NO2--N, free chlorine and residual chlorine), as well as the r...
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journal_title：Ecotoxicology and environmental safety
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journal_title：Ecotoxicology and environmental safety
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journal_title：Ecotoxicology and environmental safety
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journal_title：Ecotoxicology and environmental safety
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journal_title：Ecotoxicology and environmental safety
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journal_title：Ecotoxicology and environmental safety
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2004.09.005
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journal_title：Ecotoxicology and environmental safety
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journal_title：Ecotoxicology and environmental safety
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journal_title：Ecotoxicology and environmental safety
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journal_title：Ecotoxicology and environmental safety
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journal_title：Ecotoxicology and environmental safety
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doi：10.1006/eesa.1998.1728
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/S0147-6513(03)00101-5
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journal_title：Ecotoxicology and environmental safety
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journal_title：Ecotoxicology and environmental safety
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journal_title：Ecotoxicology and environmental safety
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doi：10.1016/j.ecoenv.2009.09.005
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
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journal_title：Ecotoxicology and environmental safety
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1006/eesa.1993.1015
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1006/eesa.2002.2151
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abstract：:Thallium (Tl) is a toxic element, but little is known about microbial communities' response to TI mobilization and sequestration. Here, we characterize the microbial communities and their feedbacks to Tl-pollution in riverbank soils to understand the distribution of microbial metal tolerance. These soils have been aff...
journal_title：Ecotoxicology and environmental safety
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abstract：:1,2-Hexanediol is commonly used in the cosmetic industry as a preservative, an emollient, and a moisturizing agent. However, studies on the scientific toxicity of 1,2-hexanediol are limited. In this study, we evaluated the potential toxic effects of 1,2-hexanediol using phytotoxicity and cytotoxicity testing methods. ...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
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journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2005.11.007
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abstract：:The swimming behavior of the freshwater rotifer Brachionus calyciflorus exposed to copper (Cu), pentachlorophenol (PCP), 3,4-dichloroaniline (DCA), and lindane, for periods ranging from 5 min to 5 hr, was examined. A swimming behavior test is described which is based on the rotifers' movement rates as they swim over a...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1006/eesa.1994.1050
更新日期：1994-08-01 00:00:00
abstract：:Silver nanoparticles (AgNPs) are widely used in industry, increasing their potential level in the environment. Plant root, the key organ absorbing water and nutrients, are directly exposed to the soil. Little is known about AgNP-mediated effects on plant root growth. Here, we show that AgNPs are absorbed by root and m...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
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abstract：:The microbiome in artificial lake water and its impact on mercury (Hg) methylation remain largely unknown. We selected the largest artificial lake in southeastern china, Changshou Lake (CSL), which has high background levels of Hg, for our investigation of Hg transformation microorganisms. Five different sections of t...
journal_title：Ecotoxicology and environmental safety
pub_type： 杂志文章
doi：10.1016/j.ecoenv.2018.05.018
更新日期：2018-09-30 00:00:00
