Abstract:
OBJECTIVES:Obesity is associated with periodontitis, but the mechanisms underlying this association have yet to be unraveled. The present investigation was to evaluate a common rat model, in which obesity is induced by high-fat, high-sucrose diet (HFSD), for its applicability in periodontal research. MATERIALS AND METHODS:Ten male Wistar rats were fed a 3-month HFSD along with a matching control group. Afterwards, the body weight, adipocyte morphology, leptin and adiponectin levels in adipose tissue, gingiva, and serum as well as the serum levels of triglyceride, cholesterol, and glucose were analyzed. For statistical analyses, parametric and non-parametric tests were applied (p < 0.05). RESULTS:Body weight was significantly higher in the HFSD group after dieting as compared to control. HFSD caused a significant increase in serum triglyceride, low-density lipoprotein cholesterol, and leptin levels and a significant decrease in high-density lipoprotein cholesterol. Furthermore, adipose tissue from HFSD rats exhibited significantly larger adipocytes, displayed a significant upregulation of leptin and, surprisingly, elevated adiponectin levels, which is in contrast to chronic obesity in humans. Although leptin and adiponectin were also observed in gingival biopsies, no obvious differences between the groups were found. CONCLUSIONS:Although this rat diet-induced obesity model is characterized by changes typical of obesity, it also has limitations, which have to be considered when data, especially with regard to adipokines, are extrapolated to humans. CLINICAL RELEVANCE:The rodent diet-induced obesity model may be useful for unraveling pathomechanisms underlying the association between obesity and periodontal destruction but conclusions have to be drawn with caution.
journal_name
Clin Oral Investigjournal_title
Clinical oral investigationsauthors
Damanaki A,Nokhbehsaim M,Hiththetiya K,Memmert S,Gao J,Nguyen KA,Götz W,Jäger A,Wahl G,Deschner Jdoi
10.1007/s00784-018-2514-ysubject
Has Abstractpub_date
2019-02-01 00:00:00pages
937-946issue
2eissn
1432-6981issn
1436-3771pii
10.1007/s00784-018-2514-yjournal_volume
23pub_type
杂志文章abstract:BACKGROUND:Interleukin 8 (IL-8) is a pro-angiogenic, pro-inflammatory mediator that belongs to the family of chemokines. Due to its pro-angiogenic characteristic, it may play a vital role in tumour angiogenesis and progression. OBJECTIVES:This study was designed to estimate the levels of salivary IL-8 in oral precance...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-012-0723-3
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate factors associated with the incidence of erosive tooth wear (ETW) among adults at different ages in Tokyo using multifactorial logistic regression analysis. MATERIALS AND METHODS:The study sample consisted of a total of 1108 subjects aged 15 to 89 years in Tokyo, Japan....
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-017-2065-7
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVES:There is an increasing number of oral squamous cell carcinoma (OSCC) associated with HPV-16. However, p16 expression by immunohistochemistry as the current gold standard for a surrogate marker for virus infection reveals unsatisfying diagnostic accuracy. The aim of this study was to investigate a new rapid t...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03601-0
更新日期:2020-10-23 00:00:00
abstract:OBJECTIVES:C-shaped root canal configuration is an unusual root canal morphology and one of the most often anatomical variations in root canal systems of second mandibular molars. The purpose of this study was to assess the prevalence, symmetry and configuration of C-shaped canals in first and second mandibular molars ...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-016-1993-y
更新日期:2017-07-01 00:00:00
abstract::The aims of this study were to evaluate clinically and microbiologically the effects of two resin-modified glass-ionomer cements (RMGICs) used as liners after incomplete dentine caries removal and to identify Streptococcus mutans and Streptococcus sobrinus strains isolated from dentine samples, before and after indire...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-009-0304-2
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVES:Facial asymmetries in oculoauriculovertebral spectrum (OAVS) patients might require surgical corrections that are mostly based on qualitative approach and surgeon's experience. The present study aimed to develop a quantitative 3D CT imaging-based procedure suitable for maxillo-facial surgery planning in OAVS...
journal_title:Clinical oral investigations
pub_type: 杂志文章,评审
doi:10.1007/s00784-015-1660-8
更新日期:2016-03-01 00:00:00
abstract::This retrospective study investigated the frequency and time history of chipping or facings failure of three-unit and four-unit tooth-supported metal ceramic (MC) fixed partial prostheses (FPDs). Six hundred fifty-four MC FPDs were inserted according to a standardized treatment protocol at the Department of Prosthodon...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-011-0511-5
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:The aim of this prospective, randomized, clinical study was to assess the effect of photobiomodulation therapy (PBM) with low-level laser irradiation (LLLI) on postoperative pain after endodontic treatment. MATERIALS AND METHODS:Sixty patients, diagnosed with irreversible pulpitis in lower molar teeth, parti...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-018-2435-9
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:To identify salivary metabolite biomarkers to differentiate patients with oral squamous cell carcinoma and oral epithelial dysplasia (OSCC/OED) from those with persistent suspicious oral mucosal lesions (PSOML). SUBJECTS AND METHODS:Whole unstimulated saliva samples were collected from age-, sex-, and race-m...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2777-3
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:This study compared the effects of mold material and diameter on the thickness of cured composite remnants and depth of cure (DOC) of resin-based composites (RBC). MATERIAL AND METHODS:One Polywave® curing light was used to photo-cure two shades of the same "bulk-fill" RBC in 4, 6, or 10-mm internal diameter...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-015-1672-4
更新日期:2016-09-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-014-1294-2
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to validate a standardized pragmatic approach to manage new oral anticoagulants (NOACs) in patients who undergo dental extractions. MATERIALS AND METHODS:This prospective case-control study in patients undergoing dental extraction included 26 patients (mean age 76 years, 57% male) ...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-016-2010-1
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVES:In this single-blinded, prospective, randomized, controlled clinical trial, the effectiveness of an ozone gas or NaOCl/CHX disinfection protocol was compared within the root canal treatment of apical periodontitis. MATERIALS AND METHODS:Sixty permanent teeth were randomly allocated to one technique. The cli...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-016-1849-5
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate through a systematic review the extraction of third molars as a risk factor for temporomandibular disorders (TMDs). TYPES OF STUDIES REVIEWED:Randomized and nonrandomized controlled clinical trials where patients underwent third molar extraction and with qualitative eva...
journal_title:Clinical oral investigations
pub_type: 杂志文章,评审
doi:10.1007/s00784-020-03277-6
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVES:The study aimed at assessing, as primary objective, the periapical status and quality of root fillings, and, as secondary objective, the endodontic treatment need of a German urban population in a cross-sectional study 20 years after the first one. MATERIALS AND METHODS:Clinical and radiographic data of 353...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2566-z
更新日期:2019-03-01 00:00:00
abstract:PURPOSE:Root migration occurs after most third molar coronectomy and a portion may be exposed in the oral cavity. This study compared the root migration rate, surgical morbidities after third molar coronectomy with or without adjunctive guided bone regeneration (GBR). METHODS:A split-mouth randomized clinical trial wa...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-018-2594-8
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to compare the effect of one-stage full-mouth disinfection (FMD) and conventional quadrant scaling in four weekly sessions (QS) on periodontal clinical parameters and halitosis among individuals with advanced chronic periodontitis. MATERIALS AND METHODS:In this randomized cont...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-016-1959-0
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to assess current opinions, applied techniques, and materials for the restoration of endodontically treated teeth (ETT) in a nationwide survey in Germany. MATERIAL AND METHODS:Completed questionnaires from 1,648 dentists were returned (response rate 63%). RESULTS:In general, po...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-015-1505-5
更新日期:2016-03-01 00:00:00
abstract::Dear Professor Dr. Matthias Hannig. Editor-in-Chief Clinical Oral Investigations. Following the publication of our paper by Calvo Guirado et al, 2015 [1] in Clinical Oral Investigations, it came to light that a certain part of the text at the materials and methods and results sections were similar. ...
journal_title:Clinical oral investigations
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00784-018-2763-9
更新日期:2019-01-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-015-1669-z
更新日期:2016-09-01 00:00:00
abstract::The aim of this study was to evaluate the influence of caries-detecting dyes on the microleakage of adhesive materials. Sixty cubic class V cavities were prepared on buccal and lingual surfaces of 30 human third molars. Coronal margins were located in enamel and gingival margins in cementum. The teeth were randomly di...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-002-0182-3
更新日期:2002-12-01 00:00:00
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journal_title:Clinical oral investigations
pub_type: 杂志文章,评审
doi:10.1007/s00784-015-1663-5
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVES:This case series compared the clinical survival of tooth-implant-supported (TI-S) and tooth-supported (T-S) three-unit fixed dental prostheses (FDPs) with zirconia frameworks and described the incidence of biological and technical complications. MATERIALS AND METHODS:Forty-four patients received 27 TI-S FDP...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-015-1594-1
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVES:To assess how to control, detect, and treat secondary caries. This review serves to inform a joint ORCA/EFCD consensus process. METHODS:Systematic and non-systematic reviews were performed or consulted and narratively synthesized. RESULTS:Secondary (or recurrent) caries is defined as a lesion associated wi...
journal_title:Clinical oral investigations
pub_type: 杂志文章,评审
doi:10.1007/s00784-020-03268-7
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVES:This study aims to compare the clinical outcomes of a combination of enamel matrix derivatives (EMD) and a synthetic bone graft (biphasic calcium phosphate) with EMD alone in wide and deep one- and two-wall intrabony defects 36 months after treatment. MATERIAL AND METHODS:Thirty patients with chronic period...
journal_title:Clinical oral investigations
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00784-015-1522-4
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to compare mechanical sensitivity on the tongue using quantitative sensory testing (QST) and psychological factors using the General Health Questionnaire (GHQ) between burning mouth syndrome (BMS) patients and healthy participants. MATERIALS AND METHODS:Participants comprised 20 fe...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2488-9
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVES:This study aimed to estimate the dental age (DA) using the London Atlas, Willems, and Nolla methods and to compare their accuracies. METHODS:The DA was estimated using the aforementioned methods on panoramic radiograms of a total of 919 Eastern Turkish patients aged 6-14 years, of whom 459 were female and 4...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-021-03788-w
更新日期:2021-01-18 00:00:00
abstract:OBJECTIVES:The aim of this study was to compare the push-out bond strength of three calcium silicate cements to dentine after two different irrigation regimes. MATERIALS AND METHODS:One hundred eighty 2-mm-thick root sections were prepared. The sections were divided into three main groups (n = 60). In group A, the sec...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-013-1082-4
更新日期:2014-05-01 00:00:00
abstract::Fluoride is used in dentistry as a prophylactic agent to reduce caries rates due to the demineralization/remineralization effect and its influence on the metabolism of cariogenic bacteria. The purpose of this study was to evaluate the cytotoxic effects of sodium fluoride (NaF) on three different cell lines and the ant...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-002-0157-4
更新日期:2002-06-01 00:00:00
abstract:OBJECTIVE:The aim of this article is to compare the influence of surface treatment on the integration (at 2, 4 and 8 weeks) of 120 dental implants inserted in 60 tibiae of rabbits. MATERIALS AND METHODS:Four different surfaces were double-blind tested: blasted, acid-etched and discrete crystal deposition (DCD) (group ...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-014-1241-2
更新日期:2015-03-01 00:00:00