Association analysis of CHRNA3 polymorphisms with schizophrenia in a Chinese Han population: A case-control study.


:Schizophrenia (SCZ) is a highly heritable, chronic, severe psychiatric disorder associated with significant financial costs to families and societies. In this case-control study, we investigated the associations between seven SNPs in CHRNA3 gene and the risk of SCZ.A total of 1071 (384 cases and 687 controls) unrelated subjects were recruited for our association study. Seven candidate tagging SNPs in CHRNA3 gene (rs3743077, rs1317286, rs938682, rs12914385, rs2869546, rs3743075, rs8040868) selected in HapMap database were genotyped by Sequenom MassARRAY. Finally, association analysis was conducted under various models.According to our results, in genetic model analysis, rs12914385 and rs8040868 are associated with decreased risk of SCZ in female subgroup; rs3743075 is associated with decreased risk of SCZ in subgroup with age <45; while rs3743077 and rs2869546 are associated with increased risk of SCZ. Haplotype analysis suggested that the 3 variants comprised 1 block, and that the haplotype Ars938682Crs12914385Crs2869546 was significantly correlated with an increased risk of SCZ in the subgroup with age ≥45.Our data indicate potential associations between CHRNA3polymorphisms and SCZ susceptibility, and the significant variants identified in our study may be used as genetic biomarkers for SCZ susceptibility in Chinese Han population.


Medicine (Baltimore)




Li G,Bai M,Guo C,Zhu L,Wang L,Yuan D,Jin T,He Y




Has Abstract


2018-06-01 00:00:00
















  • Straight sinus dural arteriovenous fistula presenting with reversible parkinsonism: A case report and literature review.

    abstract:RATIONALE:A dural arteriovenous fistula (DAVF) refers to an abnormal direct connection between an intracranial artery and a dural venous sinus. A DAVF presenting with parkinsonism is rare, and is therefore easily misdiagnosed. Therefore, early consideration of DAVF in the differential diagnosis of reversible parkinsoni...


    pub_type: 杂志文章


    authors: Pu J,Si X,Ye R,Zhang B

    更新日期:2017-12-01 00:00:00

  • Flumazenil reduces respiratory complications during anesthesia emergence in children with preoperative upper respiratory tract infections.

    abstract::Despite its benignity, upper respiratory infections (URIs) 1 increase the risk of postoperative respiratory complications during the perioperative and postoperative periods. Flumazenil could improve the symptoms of respiratory obstruction.To evaluate the effect of flumazenil on the occurrence of respiratory complicati...


    pub_type: 杂志文章


    authors: Sun R,Wang G,Gao X,Wang S

    更新日期:2018-04-01 00:00:00

  • Colchicine therapy for deep vein thrombosis in a patient with vascular-type Behçet disease: A case report.

    abstract:RATIONALE:Behçet Disease (BD) is a chronic inflammatory vasculitis with thrombogenicity and multisystem involvement. Deep vein thrombosis (DVT) in the lower extremities is the most frequent manifestation of vascular involvement in BD. The causes of thrombosis vary widely and include congenital predisposition and acquir...


    pub_type: 杂志文章


    authors: Nonaka D,Takase H,Machii M,Ohno K

    更新日期:2020-04-01 00:00:00

  • The limited area decompression, intervertebral fusion, and pedicle screw fixation for treating degenerative lumbar spinal stenosis with instability: Follow-up at least 12 months an observational study.

    abstract::The aim of the study was to evaluate the clinical effect of the limited area decompression, intervertebral fusion, and pedicle screw fixation for treating degenerative lumbar spinal stenosis (DLSS) with instability. Hemilaminectomy decompression, intervertebral fusion, and pedicle screw fixation for treating DLSS with...


    pub_type: 杂志文章


    authors: Yang F,Ren E,Yang L,Wang Y,Hu X,Yang Y,Kang X

    更新日期:2019-12-01 00:00:00

  • Tumor-Like Liver Abscess Mimicking Malignancy With Lung Metastases in a Patient With Acute Renal Failure: A Case Report.

    abstract::The worldwide incidence of Klebsiella pneumoniae liver abscess (KLA) is increasing. It is important to accurately diagnose this life-threatening disease to provide timely and appropriate treatment. Here we report the case of a 38-year-old man with acute renal failure and a tumor-like liver abscess and septic pulmonary...


    pub_type: 杂志文章


    authors: Wang CH,Sun CK,Jiang JS,Tsai MH

    更新日期:2016-03-01 00:00:00

  • Tradeoff between noise reduction and inartificial visualization in a model-based iterative reconstruction algorithm on coronary computed tomography angiography.

    abstract::We aimed to evaluate the image quality performance of coronary CT angiography (CTA) under the different settings of forward-projected model-based iterative reconstruction solutions (FIRST).Thirty patients undergoing coronary CTA were included. Each image was reconstructed using filtered back projection (FBP), adaptive...


    pub_type: 杂志文章


    authors: Hirata K,Utsunomiya D,Kidoh M,Funama Y,Oda S,Yuki H,Nagayama Y,Iyama Y,Nakaura T,Sakabe D,Tsujita K,Yamashita Y

    更新日期:2018-05-01 00:00:00

  • Neutrophil to lymphocyte ratio predicts island sign in patients with intracranial hemorrhage.

    abstract::Our previously studies indicated that inflammatory responses are involved in the hematoma expansion (HE) after intracranial hemorrhage (ICH) ictus. Here, we aim to evaluate the correlations among the ratio of neutrophil to lymphocyte ratio (NLR), HE, and island sign in patients with ICH.Patients with spontaneous ICH w...


    pub_type: 杂志文章


    authors: Zhang F,Qian J,Tao C,Wang Y,Lin S,You C,Yang M

    更新日期:2018-11-01 00:00:00

  • Volume-Based F-18 FDG PET/CT Imaging Markers Provide Supplemental Prognostic Information to Histologic Grading in Patients With High-Grade Bone or Soft Tissue Sarcoma.

    abstract::The aim of the study is to assess the prognostic value of different volume-based calculations of tumor metabolic activity in the initial assessment of patients with high-grade bone sarcomas (BS) and soft tissue sarcomas (STS) using F-18 FDG PET/CT.A single-site, retrospective study from 2002 to 2012 including 92 patie...


    pub_type: 杂志文章


    authors: Andersen KF,Fuglo HM,Rasmussen SH,Petersen MM,Loft A

    更新日期:2015-12-01 00:00:00

  • Case report of intestinal non-rotation, heterotaxy, and polysplenia in a patient with pancreatic cancer.

    abstract:RATIONALE:Heterotaxy with polysplenia is an extremely rare congenital condition resulting from abnormal arrangement of organs in the abdominal and thoracic cavities during embryologic development. When a malignancy such as pancreatic cancer develops under these conditions, surgical resection becomes particularly comple...


    pub_type: 杂志文章


    authors: Pagkratis S,Kryeziu S,Lin M,Hoque S,Bucobo JC,Buscaglia JM,Georgakis GV,Sasson AR,Kim J

    更新日期:2017-12-01 00:00:00

  • Somatostatin Analogue Treatment of a TSH-Secreting Adenoma Presenting With Accelerated Bone Metabolism and a Pericardial Effusion: A Case Report.

    abstract::Increased bone turnover and other less frequent comorbidities of hyperthyroidism, such as heart failure, have only rarely been reported in association with central hyperthyroidism due to a thyrotropin (TSH)-secreting pituitary adenoma (TSHoma). Treatment is highly empirical and relies on eliminating the tumor and the ...


    pub_type: 杂志文章


    authors: Mousiolis AC,Rapti E,Grammatiki M,Yavropoulou M,Efstathiou M,Foroglou N,Daniilidis M,Kotsa K

    更新日期:2016-01-01 00:00:00

  • Congenital diaphragmatic hernia in association with congenital short esophagus: A case report.

    abstract:RATIONALE:Congenital diaphragmatic hernia (CDH) associated congenital anomalies are present in about 25%. Congenital short esophagus (CSE) is a relatively rare condition. Both CDH and congenital intrathoracic stomach caused by CSE can be diagnosed in utero. However, CSE can be easily misdiagnosed in utero. PATIENT CON...


    pub_type: 杂志文章


    authors: Xia B,Hong C,Tang J,Liu C,Yu G

    更新日期:2017-12-01 00:00:00

  • Cardiac myxoma. A review.

    abstract::Cardiac myxoma is a true intracardiac neoplasm, which is histologically benign but which on occasion may exhibit behavior suggestive of a true malignancy. It is the most common form of primary cardiac tumor, accounting for 50% of such neoplasms. Seventy-five percent of myxomas are found in the left atrium, typically a...


    pub_type: 杂志文章,评审


    authors: Markel ML,Waller BF,Armstrong WF

    更新日期:1987-03-01 00:00:00

  • Anterolateral tibial plateau osteotomy as a new approach for the treatment of posterolateral tibial plateau fracture: A case report.

    abstract:RATIONALE:It is challenging to visualize and reduce a posterolateral tibial plateau fracture through an anterolateral approach as the tibial plateau fragments are often covered by the fibular head and ligamentous structures. PATIENT CONCERNS:In this case report, we describe a patient with a depression fracture of the ...


    pub_type: 杂志文章


    authors: Sun DH,Zhao Y,Zhang JT,Zhu D,Qi BC

    更新日期:2018-01-01 00:00:00

  • Unmet challenges in treating hypertension in patients with borderline personality disorder: A systematic review.

    abstract:BACKGROUND:Caregivers encounter serious and substantial challenges in managing hypertension in patients with subclinical or clinical borderline personality disorder (BPD). These challenges include therapeutic conflicts resulting from harmful drug-drug, and drug-disease interactions. Current guidelines provide no recomm...


    pub_type: 杂志文章


    authors: Roininen SM,Cheetham M,Mueller BU,Battegay E

    更新日期:2019-09-01 00:00:00

  • Efficacy of 18-fluoro deoxy glucose-positron emission tomography computed tomography for the detection of colonic neoplasia proximal to obstructing colorectal cancer.

    abstract::Identification of secondary colonic neoplasia proximal to obstructing colorectal cancer is essential for determining the range of colorectal resection.We examined the accuracy of 18-fluoro deoxy glucose-positron emission tomography (FDG-PET) for detection of colonic neoplasia.We recruited patients with obstructing col...


    pub_type: 杂志文章


    authors: Hojo D,Tanaka T,Takahashi M,Murono K,Emoto S,Kaneko M,Sasaki K,Otani K,Nishikawa T,Hata K,Kawai K,Momose T,Nozawa H

    更新日期:2018-08-01 00:00:00

  • Characteristics of Small Intestinal Diseases on Single-Balloon Enteroscopy: A Single-Center Study Conducted Over 6 Years in China.

    abstract::The small intestine has been considered inaccessible for a long term. The development of single-balloon endoscopy has greatly improved the diagnosis and treatment possibilities for small intestinal diseases.In this study, we aimed to explore the demographic characteristics and small intestinal diseases of patients who...


    pub_type: 杂志文章


    authors: Tao Z,Liu GX,Cai L,Yu H,Min XJ,Gan HT,Yang K,Sq L,Yan J,Chen L,Tan QH,Wu JC,Huang XL

    更新日期:2015-10-01 00:00:00

  • Influence of patient and provider factors on the workload of on-call physicians: A general internal medicine cohort observational study.

    abstract::Factors associated with the physician workload are scarcely reported. The study aims to investigate the associated factors of on-call physician workload based on a published conceptual framework.The study was conducted in a general internal medicine unit of National Taiwan University Hospital. On-call physician worklo...


    pub_type: 杂志文章


    authors: Hsu NC,Huang CC,Jerng JS,Hsu CH,Yang MC,Chang RE,Ko WJ,Yu CJ

    更新日期:2016-08-01 00:00:00

  • Cardiac malignant peripheral nerve sheath tumor on computed tomography and magnetic resonance imaging: A case report.

    abstract:RATIONALE:Malignant peripheral nerve sheath tumor (MPNST) is a very rare sarcoma of the heart, and few cases have been reported. Herein, we retrospectively reviewed clinical manifestations, imaging features and management of our patient and other reported cases. PATIENT CONCERNS:A 32-year-old woman was referred to the...


    pub_type: 杂志文章


    authors: Li S,Qiu Y,Yu J,Liang C,Peng L

    更新日期:2019-11-01 00:00:00

  • Comparison of curettage and bone grafting combined with elastic intramedullary nailing vs curettage and bone grafting in the treatment of long bone cysts in children.

    abstract::To compare the efficacy of curettage and bone grafting combined with elastic intramedullary nailing (EIN) vs curettage and bone grafting in the treatment of long bone cysts in children and to clarify the necessity of using EIN in the treatment of bone cysts.Sixty-two patients were involved in this study from Jan. 2009...


    pub_type: 杂志文章


    authors: Zhang K,Wang Z,Zhang Z

    更新日期:2019-06-01 00:00:00

  • The pancreatic juice length in the stent tube as the predicting factor of clinical relevant postoperative pancreatic fistula after pancreaticoduodenectomy.

    abstract::Several risk factors for pancreatic fistula had been widely reported, but there was no research focusing on the exocrine output of remnant gland.During the study period of January 2015 to September 2016, 82 patients accepted pancreaticoduodenectomy (PD, end-to-end dunking pancreaticojejunostomy with internal stent tub...


    pub_type: 杂志文章


    authors: Wang H,Xiu D,Tao M

    更新日期:2017-11-01 00:00:00

  • Risk assessment model for invasive breast cancer in Hong Kong women.

    abstract::No risk assessment tool is available for identifying high risk population of breast cancer (BCa) in Hong Kong. A case-control study including 918 BCa cases and 923 controls was used to develop the risk assessment model among Hong Kong Chinese women.Each participant received an in-depth interview to obtain their lifest...


    pub_type: 杂志文章


    authors: Wang F,Dai J,Li M,Chan WC,Kwok CC,Leung SL,Wu C,Li W,Yu WC,Tsang KH,Law SH,Lee PM,Wong CK,Shen H,Wong SY,Yang XR,Tse LA

    更新日期:2016-08-01 00:00:00

  • Costs of Physician-Hospital Integration.

    abstract::Given that the enactment of the Patient Protection and Affordable Care Act of 2010 is expected to generate forces toward physician-hospital integration, this study examined an understudied, albeit important, area of costs incurred in physician-hospital integration. Such costs were analyzed through 24 semi-structured i...


    pub_type: 杂志文章


    authors: Cho NE

    更新日期:2015-10-01 00:00:00

  • Kawasaki disease shock syndrome complicated with bilateral lung consolidation in a child: A case report.

    abstract:INTRODUCTION:Kawasaki disease (KD) is a systemic inflammatory disease. Standard imaging features of KD include interstitial and lobular inflammatory lesions in the lungs, while KD shock syndrome (KDSS), complicated with substantial consolidation and atelectasis in the lung, is rarely reported. PATIENTS CONCERNS:Herein...


    pub_type: 杂志文章


    authors: Song Y,Wei W,Liu L,Wang Y,Shi X,Li L

    更新日期:2020-07-17 00:00:00

  • Gastric mucormycosis complicated by a gastropleural fistula: A case report and review of the literature.

    abstract:RATIONALE:Mucormycosis is a rare opportunistic fungal infection with poor prognosis. The incidence of mucormycosis has been increasing, and it is a threat to immunocompromised hosts. We present a case of gastric mucormycosis complicated by a gastropleural fistula during immunosuppressive treatment for adult-onset Still...


    pub_type: 杂志文章,评审


    authors: Uchida T,Okamoto M,Fujikawa K,Yoshikawa D,Mizokami A,Mihara T,Kondo A,Ohba K,Kurohama K,Nakashima M,Sekine I,Nakamura S,Miyazaki Y,Kawakami A

    更新日期:2019-11-01 00:00:00

  • A randomized controlled trial on the impact of moderate-intensity continuous aerobic exercise on the depression status of middle-aged patients with congestive heart failure.

    abstract:BACKGROUND:Depression prevalence rates in congestive heart failure (CHF) patients have increased in the last few years. Depression is a leveled and independent risk factor for hospital readmission, decreased function, and patient mortality for patients with CHF. Major depressive disorder can be diagnosed in CHF patient...


    pub_type: 杂志文章,随机对照试验


    authors: Abdelbasset WK,Alqahtani BA

    更新日期:2019-04-01 00:00:00

  • Nontraumatic avulsion of aortic valve commissure as a cause of acute aortic valve regurgitation: A case report.

    abstract:BACKGROUND:Avulsion of the aortic valve commissure as a cause of acute aortic valve regurgitation is mostly due to trauma, infective endocarditis, or ascending aortic dissection. Nontraumatic avulsion of the aortic valve commissure is very rare. We reviewed the literature and analyzed potential risk factors of nontraum...


    pub_type: 杂志文章


    authors: Chang RY,Chen CC,Hsu WP,Hsiao PC,Tsai HL,Hsiao PG,Wu JD,Guo HR

    更新日期:2016-10-01 00:00:00

  • Upper gastrointestinal ectopic variceal bleeding treated with various endoscopic modalities: Case reports and literature review.

    abstract:RATIONALE:Ectopic variceal bleeding is a rare (2-5%) but fatal gastrointestinal bleed in patients with portal hypertension. Patients with ectopic variceal bleeding manifest melena, hematochezia, or hematemesis, which require urgent managements. Definitive therapeutic modalities of ectopic varices are not yet standardiz...


    pub_type: 杂志文章


    authors: Park SW,Cho E,Jun CH,Choi SK,Kim HS,Park CH,Rew JS,Cho SB,Kim HJ,Han M,Cho KM

    更新日期:2017-01-01 00:00:00

  • A 53-year-old man with a sclerosing rib lesion: A case report.

    abstract:RATIONALE:Sclerosing osteomyelitis of Garré is a rare condition that occurs most commonly in tubular bones and the mandible. Its nontypical symptoms, low morbidity, and insidious process make its diagnosis difficult at an early stage. In this article, we reported a case of chronic sclerosing osteomyelitis which occurre...


    pub_type: 杂志文章


    authors: Bai S,Zhang H,Li Z,Li D,Li H

    更新日期:2017-11-01 00:00:00

  • Role of injection laryngoplasty in preventing post-stroke aspiration pneumonia, case series report.

    abstract:INTRODUCTION:Injection laryngoplasty is a common procedure for patients with vocal fold dysfunction, but the literature on its benefits has been mainly focused on those related to structural lesions or laryngeal nerve involvement. Stroke patients may be at increased risk of aspiration due to insufficient vocal fold mot...


    pub_type: 杂志文章


    authors: Han YJ,Jang YJ,Park GY,Joo YH,Im S

    更新日期:2020-02-01 00:00:00

  • Reversible severe fatty liver induced by capecitabine: A case report.

    abstract:RATIONALE:Capecitabine (CAP) is a chemotherapeutic agent used to treat breast and gastrointestinal cancers. The most common adverse reactions of CAP primarily included gastrointestinal and dermatological effects. Whereas, the CAP-induced fatty liver had never been reported. PATIENT CONCERNS:In this study, a-69-year ol...


    pub_type: 杂志文章


    authors: Jiang Y,He Q,Li S,Shi C,Yang X

    更新日期:2017-11-01 00:00:00