Surveillance magnetic resonance imaging for isolated optic pathway gliomas: is gadolinium necessary?

Abstract:

BACKGROUND:Pediatric optic pathway gliomas are typically indolent but have a variable clinical course. Treatment is dictated by symptoms and changes on contrast-enhanced MRI examinations. Gadolinium retention in children has motivated parsimonious use of gadolinium-based contrast agents. OBJECTIVES:To determine surveillance MR factors that motivate changes in tumor-directed therapies and extrapolate cost-efficacy of a non-contrast follow-up protocol. MATERIALS AND METHODS:Using an imaging database search we identified children with isolated optic pathway gliomas and ≥3 follow-up contrast-enhanced MRIs. We reviewed medical records and imaging for: (1) coincident changes on contrast-enhanced MRI and tumor-directed therapy, (2) demographics and duration of follow-up, (3) motivations for intervention, (4) assessment of gadolinium-based contrast agents' utility and (5) health care utilization data. We assessed cost impact in terms of relative value unit (RVU) burden. RESULTS:We included 17 neurofibromatosis type 1 (NF1) and 21 non-NF1 patients who underwent a median 16.9 and 24.3 cumulative contrast-enhanced MR exams over 7.7 years and 8.1 years of follow-up, respectively. Eight children (one with NF1) had intervention based on contrast-enhanced MR findings alone. For these eight, increased tumor size was the only common feature, and it was apparent on non-contrast T2 sequences. For the median patient, a non-contrast follow-up protocol could result in 15.9 (NF1) and 23.3 (non-NF1) fewer gadolinium-based contrast agent administrations, and a 39% lower yearly RVU burden. CONCLUSION:Pediatric patients with isolated optic pathway gliomas undergo a large number of routine contrast-enhanced MR follow-up exams. Gadolinium might not be needed for these exams to inform management decisions. Secondary benefits of a non-contrast follow-up protocol include decreased cost and risk to the patient.

journal_name

Pediatr Radiol

journal_title

Pediatric radiology

authors

Maloney E,Stanescu AL,Perez FA,Iyer RS,Otto RK,Leary S,Steuten L,Phipps AI,Shaw DWW

doi

10.1007/s00247-018-4154-4

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

1472-1484

issue

10

eissn

0301-0449

issn

1432-1998

pii

10.1007/s00247-018-4154-4

journal_volume

48

pub_type

杂志文章
  • Gallbladder polyposis in metachromatic leukodystrophy.

    abstract::Gallbladder polyposis is a rare entity that can be associated with conditions such as metachromatic leukodystrophy (MLD), but the literature is sparse. We present a child with gallbladder polyposis who was diagnosed with MLD 15 months later despite normal neuroimaging and clinical examination initially. ...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/s00247-012-2523-y

    authors: Agarwal A,Shipman PJ

    更新日期:2013-03-01 00:00:00

  • Death associated with bronchography. Question role of heating the contrast agent.

    abstract::A young woman died following bronchography. The bilateral bronchogram done under general anesthesia without fluoroscopic control was associated with extensive small airway filling or "alveolarization" of the contrast medium. The oily Dionosil used had been heated in an autoclave. Experiments showed that the viscosity ...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/BF02387657

    authors: McAlister WH

    更新日期:1989-01-01 00:00:00

  • Retrospective comparison of gradient recalled echo R2* and spin-echo R2 magnetic resonance analysis methods for estimating liver iron content in children and adolescents.

    abstract:BACKGROUND:Serial surveillance of liver iron concentration (LIC) provides guidance for chelation therapy in patients with iron overload. The diagnosis of iron overload traditionally relies on core liver biopsy, which is limited by invasiveness, sampling error, cost and general poor acceptance by pediatric patients and ...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/s00247-015-3378-9

    authors: Serai SD,Fleck RJ,Quinn CT,Zhang B,Podberesky DJ

    更新日期:2015-10-01 00:00:00

  • Correlation of ductus arteriosus length and morphology between computed tomographic angiography and catheter angiography and their relation to ductal stent length.

    abstract:BACKGROUND:Patent ductus arteriosus (PDA) stent placement in infants with ductal-dependent pulmonary blood flow is being increasingly used in clinical practice. OBJECTIVE:To correlate computed tomographic (CT) angiography morphology and length of the PDA with catheter angiography and its relation to eventual PDA stent...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/s00247-020-04624-1

    authors: Jadhav SP,Aggarwal V,Masand PM,Diaz E,Zhang W,Qureshi AM

    更新日期:2020-05-01 00:00:00

  • Leiomyomatosis of oesophagus, congenital cataracts and hematuria. Report of a case with rectal involvement.

    abstract::Isolated oesophageal leiomyomatosis in children is very rare. The association between leiomyomatosis of oesophagus and female genital tract and an Alport like hematuric nephritis has been recognized as a distinct entity by Garcia-Torres and Guarner. Since then few other cases of this syndrome have been observed. Conge...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/BF02012602

    authors: Lerone M,Dodero P,Romeo G,Martucciello G,Caffarena PE,Brisigotti M,Toma P,Taccone A,Silengo M

    更新日期:1991-01-01 00:00:00

  • Local physeal widening on MR imaging: an incidental finding suggesting prior metaphyseal insult.

    abstract:OBJECTIVE:To offer a descriptive review which characterizes and evaluates the significance of local physeal widening, (cartilaginous signal extending from the physis into the adjacent metaphysis), identified on magnetic resonance (MR) imaging. MATERIALS AND METHODS:MR images (recollected from exams performed between 1...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/s002470050206

    authors: Laor T,Hartman AL,Jaramillo D

    更新日期:1997-08-01 00:00:00

  • Ingestion of multiple magnets: hazardous foreign bodies for children.

    abstract::We report a case of perforation, fistula formation, and small bowel obstruction in a 2-year-old child who had ingested 32 small magnets. Multiple magnets will attract one another through the bowel wall and lead to pressure necrosis with complications. We recommend early surgical intervention before the onset of gastro...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/s00247-005-0056-3

    authors: Uchida K,Otake K,Iwata T,Watanabe H,Inoue M,Hatada T,Kusunoki M

    更新日期:2006-03-01 00:00:00

  • Non-accidental injury: confusion with temporary brittle bone disease and mild osteogenesis imperfecta.

    abstract::Accurate diagnosis of non-accidental injury (NAI) can be reached in the majority of cases by careful appraisal of the social and family history, combined with painstaking clinical roentgenographic and other imaging evaluations. Careful review of the scientific literature clearly indicates that collagen analysis to exc...

    journal_title:Pediatric radiology

    pub_type: 杂志文章,评审

    doi:10.1007/s002470050079

    authors: Ablin DS,Sane SM

    更新日期:1997-02-01 00:00:00

  • Precervical myositis ossificans in an infant secondary to child abuse.

    abstract::We present a 10-week-old girl with myositis ossificans circumscripta (MO) of the neck secondary to nonaccidental trauma. This condition is rarely seen in infants; furthermore, the majority of MO lesions develop in the extremities rather than the head and neck region. We will detail the US-guided biopsy technique used ...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/s00247-011-2270-5

    authors: Harmon J,Rabe AJ,Nichol KK,Shiels WE

    更新日期:2012-07-01 00:00:00

  • Multicentric/massive idiopathic osteolysis in a 17-year-old girl.

    abstract::An unusual case of multicentric/multifocal osteolysis with unique clinical and radiographic features in a 17-year-old girl is reported. The brother of the patient who was probably also affected could not be examined. ...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/BF02010815

    authors: Kozlowski K,Bacha L,Brachimi L,Massen R

    更新日期:1990-01-01 00:00:00

  • The role of MRI in the evaluation of the fetal brain with an emphasis on biometry, gyration and parenchyma.

    abstract::The aim of this review is to emphasize the role of fetal MR in the evaluation of the supratentorial space. The advantages of MRI compared to US are stressed in three fields of application: cerebral biometry, sulcation and cerebral parenchyma. In each field, normal data are displayed and MR applications with patterns o...

    journal_title:Pediatric radiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00247-004-1249-x

    authors: Garel C

    更新日期:2004-09-01 00:00:00

  • Hemangiomas revisited: the useful, the unusual and the new. Part 1: overview and clinical and imaging characteristics.

    abstract::Hemangiomas are common vascular tumors occurring in children. Though most of the lesions present in infants and young children with a typical appearance, it is important to understand that they all do not behave in the same way. Rather, they are a group of vascular lesions with different clinico-pathological subtypes,...

    journal_title:Pediatric radiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00247-011-2076-5

    authors: Restrepo R,Palani R,Cervantes LF,Duarte AM,Amjad I,Altman NR

    更新日期:2011-07-01 00:00:00

  • Imaging of total colonic Hirschsprung disease.

    abstract:BACKGROUND:Hirschsprung disease (HD) is a functional obstruction of the bowel caused by the absence of intrinsic enteric ganglion cells. The diagnosis of total colonic HD (TCHD) based on contrast enemas is difficult in newborns because radiological findings vary. OBJECTIVE:To evaluate the radiographic and contrast ene...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/s00247-008-0952-4

    authors: Stranzinger E,DiPietro MA,Teitelbaum DH,Strouse PJ

    更新日期:2008-11-01 00:00:00

  • Reversible acute methotrexate leukoencephalopathy: atypical brain MR imaging features.

    abstract:BACKGROUND:Unusual acute symptomatic and reversible early-delayed leukoencephalopathy has been reported to be induced by methotrexate (MTX). OBJECTIVE:We aimed to identify the occurrence of such atypical MTX neurotoxicity in children and document its MR presentation. MATERIALS AND METHODS:We retrospectively reviewed ...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/s00247-005-0015-z

    authors: Ziereisen F,Dan B,Azzi N,Ferster A,Damry N,Christophe C

    更新日期:2006-03-01 00:00:00

  • Whole-body magnetic resonance imaging in the evaluation of children with fever without a focus.

    abstract:BACKGROUND:Fever without a focus is defined as a temperature of 38° C or higher as the single presenting symptom. After extensive investigation, a large percentage (12-67%) of cases remain undiagnosed. OBJECTIVE:To assess the diagnostic value of whole-body magnetic resonance imaging (WB-MRI) in children with fever wit...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/s00247-020-04889-6

    authors: Delgado J,Chauvin NA,Bedoya MA,Patel SJ,Anupindi SA

    更新日期:2021-01-29 00:00:00

  • Spontaneous rupture of the esophagus in the newborn.

    abstract::Two cases of neonatal spontaneous rupture of the esophagus are described, one of which is associated with a duodenal stenosis. Seventeen cases have been reported. They present clinically with non-specific signs of respiratory insufficiency and radiologically by a right-sided hydropneumothorax. Esophageal opacification...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/BF02386871

    authors: Dubos JP,Bouchez MC,Kacet N,Liesse A,Lequien P,Remy J

    更新日期:1986-01-01 00:00:00

  • A retrospective segmentation analysis of placental volume by magnetic resonance imaging from first trimester to term gestation.

    abstract:BACKGROUND:Abnormalities of the placenta affect 5-7% of pregnancies. Because disturbances in fetal growth are often preceded by dysfunction of the placenta or attenuation of its normal expansion, placental health warrants careful surveillance. There are limited normative data available for placental volume by MRI. OBJ...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/s00247-018-4213-x

    authors: León RL,Li KT,Brown BP

    更新日期:2018-12-01 00:00:00

  • Diffuse interstitial lung fibrosis from childhood and adolescence to adult life.

    abstract::Sixty-two patients with interstitial lung fibrosis in the age range 2 to 34 years were followed up from 3 to 26 years. The authors stress the important role of an experienced radiologist, who may make a correct diagnosis on the basis of a plain chest radiograph and who plays an important role in follow-up studies beca...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/BF00971813

    authors: Rubín A,Krepela K,Janousková A,Biganovská V

    更新日期:1981-01-01 00:00:00

  • Outpacing movement - ultrafast volume coverage in neuropediatric magnetic resonance imaging.

    abstract:BACKGROUND:Conventional MRI sequences are often affected in neuropediatric imaging by unavoidable movements. Therefore, children younger than 6 years usually have to be examined under sedation/anesthesia. A new real-time MRI technique with automatic slice advancement allows for motion-robust T2-weighted volume coverage...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/s00247-020-04771-5

    authors: Gräfe D,Roth C,Weisser M,Krause M,Frahm J,Voit D,Hirsch FW

    更新日期:2020-11-01 00:00:00

  • Aneurysmal bone cyst of the spine in children. MRI imaging at 0.5 tesla.

    abstract::Two patients with aneurysmal bone cysts of the spine demonstrate striking similarities when examined with magnetic resonance imaging (MRI), while the plain radiographs and images on computed tomography (CT) are quite different. Gadolinium DTPA enhanced T1W images were especially helpful in the definition of the lesion...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/BF02015620

    authors: Caro PA,Mandell GA,Stanton RP

    更新日期:1991-01-01 00:00:00

  • Unusual manifestations of Langerhans cell histiocytosis of the head and neck. Case report with pseudoaneurysm of external carotid artery, tracheal, mandibular, and sphenoid involvement.

    abstract::Langerhans cell histiocytosis of the head and neck is an uncommon histiocytic proliferative disorder that often clinically resembles an inflammatory process. A pseudoaneurysm of the external carotid artery was found by contrast-enhanced CT and confirmed by Doppler ultrasonography and angiography in a 9 year old girl w...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/BF02020220

    authors: Herman TE,Shackelford GD,Borders JL,Dehner LP

    更新日期:1993-01-01 00:00:00

  • Real-time and Doppler US after pediatric segmental liver transplantation : II. Hepatic vein stenosis.

    abstract:BACKGROUND:Accurate diagnosis of hepatic vein (HV) stenosis by real-time and color Doppler US (CD-US) after segmental liver transplantation in children can decrease morbidity because it allows unnecessary biopsy, obstruction or thrombosis and loss of the graft to be avoided. OBJECTIVE:To evaluate CD-US parameters to p...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/s00247-007-0731-7

    authors: Suzuki L,de Oliveira IR,Widman A,Gibelli NE,Carnevale FC,Maksoud JG,Hubbard AM,Cerri GG

    更新日期:2008-04-01 00:00:00

  • Diagnostic efficacy of single-pass split-bolus multidetector computed tomography in pediatric oncology: a valid alternative to a standard monophasic protocol.

    abstract:: ...

    journal_title:Pediatric radiology

    pub_type: 评论,信件

    doi:10.1007/s00247-018-4234-5

    authors: Scialpi M,Schiavone R

    更新日期:2019-01-01 00:00:00

  • Imaging findings in pediatric adrenocortical carcinoma.

    abstract:BACKGROUND:Adrenocortical carcinoma (ACC), a tumor that is rare among children, causes clinically evident hormonal disturbances. Imaging methods are used to stage disease and to plan surgical resection. OBJECTIVE:To describe the findings of the various imaging methods used to evaluate ACC. MATERIALS AND METHODS:We re...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/s002470050013

    authors: Ribeiro J,Ribeiro RC,Fletcher BD

    更新日期:2000-01-01 00:00:00

  • Thickened cortical bones in congenital neutropenia.

    abstract::Congenital neutropenia is an uncommon entity which may be familial and has a wide spectrum of clinical expression. Three sisters with the severe form of the disease, that suffered from recurrent infections which lead to their demise, are described. Review of their radiographs revealed the presence of cortical thickeni...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/BF02388088

    authors: Boechat MI,Gormley LS,O'Laughlin BJ

    更新日期:1987-01-01 00:00:00

  • Measurements of cervical lymph nodes in children on computed tomography.

    abstract:BACKGROUND:No normal measurements or specific size criteria have been described for cervical lymph nodes in children. OBJECTIVE:To determine the normal measurements of cervical lymph nodes in children on CT. MATERIALS AND METHODS:We included 142 children (ages 1-17 years) who underwent cervical CT examination after h...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/s00247-019-04595-y

    authors: Spijkers S,Littooij AS,Nievelstein RAJ

    更新日期:2020-04-01 00:00:00

  • Anatomy and injuries of the pediatric wrist: beyond the basics.

    abstract::Ligamentous injuries of the pediatric wrist, once thought to be relatively uncommon, are increasingly recognized in the context of acute high-energy mechanism trauma and chronic axial loading, including those encountered in both recreational and high-performance competitive sports. Recent advances in MR-based techniqu...

    journal_title:Pediatric radiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00247-018-4111-2

    authors: Maloney E,Zbojniewicz AM,Nguyen J,Luo Y,Thapa MM

    更新日期:2018-06-01 00:00:00

  • Inflammatory myofibroblastic tumor of the lung: a rare cause of atelectasis in children.

    abstract::Although rare, inflammatory myofibroblastic tumor is the most common primary lung mass in children. We report the case of an 11-year-old boy investigated for persistent cough and dyspnea with complete left lung atelectasis mimicking pneumonia. CT and MRI showed an endobronchial mass of the left main bronchus. The boy ...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/s00247-012-2508-x

    authors: Dhouib A,Barrazzone C,Reverdin A,Anooshiravani M,Hanquinet S

    更新日期:2013-03-01 00:00:00

  • Thymic ultrasound. II. Diagnosis of aberrant cervical thymus.

    abstract:BACKGROUND:The aberrant cervical thymus is an uncommon entity to be considered in the differential diagnosis of neck masses in children, so a preoperative diagnosis has rarely been made. OBJECTIVE:The purpose of this study was to assess the ultrasound features of aberrant cervical thymus and determine if recognition o...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/s002470100468

    authors: Han BK,Yoon HK,Suh YL

    更新日期:2001-07-01 00:00:00

  • Contrast enemas after necrotising enterocolitis: a case for prophylaxis?

    abstract::During a 4-year period 9 out of 35 patients deteriorated following a contrast enema after necrotising enterocolitis (NEC). Two developed Klebsiella septicaemia with one subsequent death. Following the latter two cases the paediatric surgeons instituted intravenous prophylactic antibiotics (benzyl penicillin, metronida...

    journal_title:Pediatric radiology

    pub_type: 杂志文章

    doi:10.1007/BF02015352

    authors: Brand IR,Arthur RJ

    更新日期:1992-01-01 00:00:00