Abstract：
:Monoacylglycerol lipase (MAGL) is a main regulator of the endocannabinoid system within the central nervous system (CNS). Recently, [11C]SAR127303 was developed as a promising radioligand for MAGL imaging. In this study, we aimed to quantify regional MAGL concentrations in the rat brain using positron emission tomography (PET) with [11C]SAR127303. An irreversible two-tissue compartment model (2-TCMi, k4 = 0) analysis was conducted to estimate quantitative parameters (k3, Ki2-TCMi, and λk3). These parameters were successfully obtained with high identifiability (<10 %COV) for the following regions ranked in order from highest to lowest: cingulate cortex > striatum > hippocampus > thalamus > cerebellum > hypothalamus ≈ pons. In vitro autoradiographs using [11C]SAR127303 showed a heterogeneous distribution of radioactivity, as seen in the PET images. The Ki2-TCMi and λk3 values correlated relatively highly with in vitro binding (r > 0.4, P < 0.005). The Ki2-TCMi values showed high correlation and low underestimation (<10%) compared with the slope of a Patlak plot analysis with linear regression (KiPatlak). In conclusion, we successfully estimated regional net uptake value of [11C]SAR127303 reflecting MAGL concentrations in rat brain regions for the first time.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Yamasaki T,Mori W,Zhang Y,Hatori A,Fujinaga M,Wakizaka H,Kurihara Y,Wang L,Nengaki N,Ohya T,Liang SH,Zhang MRdoi
10.1016/j.neuroimage.2018.05.015subject
Has Abstractpub_date
2018-08-01 00:00:00pages
313-320eissn
1053-8119issn
1095-9572pii
S1053-8119(18)30413-0journal_volume
176pub_type
杂志文章相关文献
NEUROIMAGE文献大全abstract：:This article reviews studies demonstrating enhancement with transcranial direct current stimulation (tDCS) of attention, learning, and memory processes in healthy adults. Given that these are fundamental cognitive functions, they may also mediate stimulation effects on other higher-order processes such as decision-mak...
journal_title：NeuroImage
pub_type： 杂志文章,评审
doi：10.1016/j.neuroimage.2013.07.083
更新日期：2014-01-15 00:00:00
abstract：:Temporal connectives (before/after) give us the freedom to describe a sequence of events in different orders. Studies have suggested that 'before-initiating' sentences, in which events are expressed in an order inconsistent with their actual order of occurrence, might need additional computation(s) during comprehensio...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2011.11.039
更新日期：2012-02-15 00:00:00
abstract：:Neocortical cholinergic afferents are proposed to influence both selective attention and emotional processing. In a study of healthy adults we used event-related fMRI while orthogonally manipulating attention and emotionality to examine regions showing effects of cholinergic modulation by the anticholinesterase physos...
journal_title：NeuroImage
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s1053-8119(03)00302-1
更新日期：2003-09-01 00:00:00
abstract：:The stop-signal task is a prototypical experiment to study cognitive processes that mediate successful performance in a rapidly changing environment. By means of simultaneous recording and combined analysis of electroencephalography and functional magnetic resonance imaging on single trial level, we provide a comprehe...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2011.03.039
更新日期：2011-06-01 00:00:00
abstract：:The purpose of this study was to investigate human brain activity during the reading of ancient Japanese texts using functional magnetic resonance imaging. Thirty right-handed normal Japanese subjects performed two reading tasks: covert reading of (1) ancient and (2) modern Japanese text. Common areas are activated du...
journal_title：NeuroImage
pub_type： 临床试验,杂志文章
doi：10.1016/j.neuroimage.2005.01.041
更新日期：2005-06-01 00:00:00
abstract：UNLABELLED:Functional magnetic resonance imaging (fMRI) studies have revealed the existence of robust, interconnected brain networks exhibiting correlated low frequency fluctuations during rest, which can be derived by examining inherent spatio-temporal patterns in functional scans independent of any a priori model. In...
journal_title：NeuroImage
pub_type： 临床试验,杂志文章
doi：10.1016/j.neuroimage.2015.05.051
更新日期：2015-09-01 00:00:00
abstract：:Functional activation patterns of an auditory working memory task were examined prior to and after 5 days of training (1 h/day). A control group with no training was scanned twice at the same intervals to assess test-retest effects. Based on behavioral improvement scores, the training group (n = 14) was divided into "...
journal_title：NeuroImage
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.neuroimage.2005.11.046
更新日期：2006-05-15 00:00:00
abstract：:Establishing brain-behavior associations that map brain organization to phenotypic measures and generalize to novel individuals remains a challenge in neuroimaging. Predictive modeling approaches that define and validate models with independent datasets offer a solution to this problem. While these methods can detect ...
journal_title：NeuroImage
pub_type： 杂志文章,评审
doi：10.1016/j.neuroimage.2019.02.057
更新日期：2019-06-01 00:00:00
abstract：:Continuous EEG activity has been used increasingly as a marker of mental and cognitive states, with previous work linking particular neural patterns to conditions of arousal or fatigue. This approach is more commonly used to assess task-related, as opposed to resting-state activity. In this study, we recorded the EEG ...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2013.03.018
更新日期：2013-08-01 00:00:00
abstract：:Theories of the positive symptoms of schizophrenia hypothesize a role for aberrant reinforcement signaling driven by dysregulated dopamine transmission. Recently, we provided evidence of aberrant reward learning in symptomatic, but not asymptomatic patients with schizophrenia, using a novel paradigm, the Salience Attr...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2009.11.075
更新日期：2010-04-01 00:00:00
abstract：:Memory crucially depends on the way information is processed during encoding. Differences in processes during encoding not only lead to differences in memory performance but also rely on different brain networks. Although these assumptions are corroborated by several previous fMRI and ERP studies, little is known abou...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2013.04.121
更新日期：2013-10-01 00:00:00
abstract：:Resting-state connectivity measures the temporal coherence of the spontaneous neural activity of spatially distinct regions, and is commonly measured using BOLD-fMRI. The BOLD response follows neuronal activity, when changes in the relative concentration of oxygenated and deoxygenated haemoglobin cause fluctuations in...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2020.117196
更新日期：2020-11-01 00:00:00
abstract：:Auditory information communicated through vocalizations, music, or sounds in the environment is commonly used to orient and direct attention to different locations in extrapersonal space. The neural networks subserving attention to auditory space remain poorly understood in comparison to our knowledge about attention ...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2005.10.050
更新日期：2006-04-15 00:00:00
abstract：:Understanding the neurocognitive basis of risk-taking behavior is an important issue, especially in economic decision-making. Classical behavioral studies have shown that risk-attitude changes across different contexts, but little is so far known about the brain correlates of processing of outcomes across such context...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2009.08.068
更新日期：2010-01-15 00:00:00
abstract：:The widely used Logan plot in radioligand receptor dynamic PET studies produces marked noise-induced negative biases in the estimates of total distribution volume (DV(T)) and binding potential (BP). To avoid the inconsistencies in the estimates from the Logan plot, a new graphical analysis method was proposed and char...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2008.09.021
更新日期：2009-02-01 00:00:00
abstract：:Cortical activity evoked by repeated identical sensory stimulation is extremely variable. The source of this variability is often assigned to "random ongoing background activity" which is considered to be irrelevant to the processing of the stimuli and can therefore be eliminated by ensemble averaging. In this work, w...
journal_title：NeuroImage
pub_type： 临床试验,杂志文章
doi：10.1016/S1053-8119(03)00367-7
更新日期：2003-10-01 00:00:00
abstract：:Understanding how language networks change during childhood is important for theories of cognitive development and for identifying the neural causes of language impairment. Despite this, there is currently little systematic evidence regarding the typical developmental trajectory for language from the field of neuroima...
journal_title：NeuroImage
pub_type： 杂志文章,评审
doi：10.1016/j.neuroimage.2015.07.046
更新日期：2015-12-01 00:00:00
abstract：:A well-recognized problem with the echo-planar imaging (EPI) technique most commonly used for functional magnetic resonance imaging (fMRI) studies is geometric distortion caused by magnetic field inhomogeneity. This makes it difficult to achieve an accurate registration between a functional activation map calculated f...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1006/nimg.2001.1054
更新日期：2002-05-01 00:00:00
abstract：:MRI is a powerful modality to detect neuroanatomical differences that result from mutations and treatments. Knowing which genes drive these differences is important in understanding etiology, but candidate genes are often difficult to identify. We tested whether spatial gene expression data from the Allen Brain Instit...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2017.08.065
更新日期：2017-12-01 00:00:00
abstract：:Brain oscillations are supposedly crucial for normal cognitive functioning and alterations are associated with cognitive dysfunctions. To demonstrate their causal role on behavior, entrainment approaches in particular aim at driving endogenous oscillations via rhythmic stimulation. Within this context, transcranial el...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2015.06.026
更新日期：2015-09-01 00:00:00
abstract：:The purpose of this study was to identify brain regions underlying internally generated anticipatory biases toward locations where significant events are expected to occur. Subjects fixated centrally and responded to peripheral targets preceded by a spatially valid (predictive), invalid (misleading), or neutral centra...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/s1053-8119(02)00012-5
更新日期：2003-03-01 00:00:00
abstract：:Two primary areas of damage have been implicated in apraxia of speech (AOS) based on the time post-stroke: (1) the left inferior frontal gyrus (IFG) in acute patients, and (2) the left anterior insula (aIns) in chronic patients. While AOS is widely characterized as a disorder in motor speech planning, little is known ...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2009.01.015
更新日期：2009-06-01 00:00:00
abstract：:Quantitative BOLD (qBOLD) is a technique for mapping oxygen extraction fraction (OEF) and deoxygenated blood volume (DBV) in the human brain. Recent measurements using an asymmetric spin echo (ASE) based qBOLD approach produced estimates of DBV which were systematically higher than measurements from other techniques. ...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2019.116035
更新日期：2019-11-01 00:00:00
abstract：:Emotional experience in healthy men has been shown to rely on a brain network including subcortical as well as cortical areas in a complex interaction, which may be substantially influenced by many internal personal and external factors such as individuality, gender, stimulus material and task instructions. The diverg...
journal_title：NeuroImage
pub_type： 临床试验,杂志文章
doi：10.1016/j.neuroimage.2005.01.014
更新日期：2005-05-15 00:00:00
abstract：:Dynamic functional connectivity (DFC) aims to maximize resolvable information from functional brain scans by considering temporal changes in network structure. Recent work has demonstrated that static, i.e. time-invariant resting-state and task-based FC predicts individual differences in behavior, including attention....
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2018.11.057
更新日期：2019-03-01 00:00:00
abstract：:Mood disorders are highly heritable and have been linked to brain regions of emotion processing. Over the past few years, an enormous amount of imaging genetics studies has demonstrated the impact of risk genes on brain regions and systems of emotion processing in vivo in healthy subjects as well as in mood disorder p...
journal_title：NeuroImage
pub_type： 杂志文章,评审
doi：10.1016/j.neuroimage.2010.02.019
更新日期：2010-11-15 00:00:00
abstract：:The diffusion tensor is a commonly used model for diffusion-weighted MR image data. The parameters are typically estimated by ordinary or weighted least squares on log-transformed data, assuming normal or log-normal distribution of measurement errors respectively. This may not be adequate when using high b-values and ...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2008.05.053
更新日期：2008-10-01 00:00:00
abstract：:The aim of this study was to explore non-invasive imaging methods to detect post-injury structural axonal plasticity. Brain injury was launched by status epilepticus induced by intraperitoneal injection of either kainic acid or pilocarpine. Several months later, ex vivo diffusion tensor magnetic resonance imaging (DTI...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2010.02.077
更新日期：2010-06-01 00:00:00
abstract：INTRODUCTION:We assessed the usefulness of the P300 wave as endophenotype for schizophrenia by means of a meta-analysis of the literature as well as our own family study. METHOD:Meta-analysis: We conducted a systematic search for articles published between 1983 and 2003 that reported P300 measures in non-psychotic rel...
journal_title：NeuroImage
pub_type： 杂志文章,meta分析
doi：10.1016/j.neuroimage.2005.05.022
更新日期：2005-10-01 00:00:00
abstract：:In this work we demonstrate the feasibility of applying small-angle X-ray scattering computed tomography (SAXS-CT) for non-invasive molecular imaging of myelin sheaths in a rat brain. Our results show that the approach yields information on several quantities, including the relative myelin concentration, its periodici...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2011.04.013
更新日期：2011-07-01 00:00:00
