Abstract:
BACKGROUND:A Mendelian transmission produces phenotypic and genetic relatedness between family members, giving family-based analytical methods an important role in genetic epidemiological studies-from heritability estimations to genetic association analyses. With the advance in genotyping technologies, whole-genome sequence data can be utilized for genetic epidemiological studies, and family-based samples may become more useful for detecting de novo mutations. However, genetic analyses employing family-based samples usually suffer from the complexity of the computational/statistical algorithms, and certain types of family designs, such as incorporating data from extended families, have rarely been used. RESULTS:We present a Workbench for Integrated Superfast Association studies for Related Data (WISARD) programmed in C/C++. WISARD enables the fast and a comprehensive analysis of SNP-chip and next-generation sequencing data on extended families, with applications from designing genetic studies to summarizing analysis results. In addition, WISARD can automatically be run in a fully multithreaded manner, and the integration of R software for visualization makes it more accessible to non-experts. CONCLUSIONS:Comparison with existing toolsets showed that WISARD is computationally suitable for integrated analysis of related subjects, and demonstrated that WISARD outperforms existing toolsets. WISARD has also been successfully utilized to analyze the large-scale massive sequencing dataset of chronic obstructive pulmonary disease data (COPD), and we identified multiple genes associated with COPD, which demonstrates its practical value.
journal_name
BMC Med Genomicsjournal_title
BMC medical genomicsauthors
Lee S,Choi S,Qiao D,Cho M,Silverman EK,Park T,Won Sdoi
10.1186/s12920-018-0345-ysubject
Has Abstractpub_date
2018-04-20 00:00:00pages
39issue
Suppl 2issn
1755-8794pii
10.1186/s12920-018-0345-yjournal_volume
11pub_type
杂志文章abstract:BACKGROUND:Gulf War Illness (GWI) is a complex multi-symptom disorder that affects up to one in three veterans of this 1991 conflict and for which no effective treatment has been found. Discovering novel treatment strategies for such a complex chronic illness is extremely expensive, carries a high probability of failur...
journal_title:BMC medical genomics
pub_type: 杂志文章
doi:10.1186/s12920-015-0111-3
更新日期:2015-07-09 00:00:00
abstract:BACKGROUND:Currently, diagnosis of affected individuals with rare genetic disorders can be lengthy and costly, resulting in a diagnostic odyssey and in many patients a definitive molecular diagnosis is never achieved despite extensive clinical investigation. The recent advent and use of genomic medicine has resulted in...
journal_title:BMC medical genomics
pub_type: 杂志文章
doi:10.1186/1755-8794-6-32
更新日期:2013-09-17 00:00:00
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journal_title:BMC medical genomics
pub_type: 杂志文章
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更新日期:2016-06-10 00:00:00
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journal_title:BMC medical genomics
pub_type: 杂志文章
doi:10.1186/1755-8794-3-6
更新日期:2010-03-08 00:00:00
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journal_title:BMC medical genomics
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:BMC medical genomics
pub_type: 杂志文章
doi:10.1186/s12920-018-0384-4
更新日期:2018-08-20 00:00:00
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journal_title:BMC medical genomics
pub_type: 杂志文章
doi:10.1186/1755-8794-4-29
更新日期:2011-03-31 00:00:00
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journal_title:BMC medical genomics
pub_type: 杂志文章
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更新日期:2010-01-27 00:00:00
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journal_title:BMC medical genomics
pub_type: 杂志文章
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更新日期:2020-01-03 00:00:00
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journal_title:BMC medical genomics
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更新日期:2021-01-07 00:00:00
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journal_title:BMC medical genomics
pub_type: 杂志文章
doi:10.1186/s12920-015-0095-z
更新日期:2015-05-21 00:00:00
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journal_title:BMC medical genomics
pub_type: 杂志文章
doi:10.1186/1755-8794-1-62
更新日期:2008-12-18 00:00:00
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journal_title:BMC medical genomics
pub_type: 杂志文章
doi:10.1186/1755-8794-3-2
更新日期:2010-01-26 00:00:00
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pub_type: 杂志文章
doi:10.1186/1755-8794-1-45
更新日期:2008-09-29 00:00:00
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journal_title:BMC medical genomics
pub_type: 杂志文章
doi:10.1186/s12920-018-0411-5
更新日期:2018-11-20 00:00:00
abstract:BACKGROUND:Ciguatoxins (CTXs) are polyether marine neurotoxins found in multiple reef-fish species and are potent activators of voltage-gated sodium channels. It is estimated that up to 500,000 people annually experience acute ciguatera poisoning from consuming toxic fish and a small percentage of these victims will de...
journal_title:BMC medical genomics
pub_type: 杂志文章
doi:10.1186/s12920-015-0089-x
更新日期:2015-04-02 00:00:00
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journal_title:BMC medical genomics
pub_type: 杂志文章
doi:10.1186/s12920-018-0404-4
更新日期:2018-10-20 00:00:00
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journal_title:BMC medical genomics
pub_type: 杂志文章
doi:10.1186/1755-8794-6-S2-S2
更新日期:2013-01-01 00:00:00
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journal_title:BMC medical genomics
pub_type: 杂志文章
doi:10.1186/s12920-015-0102-4
更新日期:2015-06-24 00:00:00
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journal_title:BMC medical genomics
pub_type: 杂志文章
doi:10.1186/1755-8794-5-12
更新日期:2012-05-01 00:00:00
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journal_title:BMC medical genomics
pub_type: 杂志文章
doi:10.1186/s12920-018-0453-8
更新日期:2019-01-31 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-07-29 00:00:00
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journal_title:BMC medical genomics
pub_type: 杂志文章
doi:10.1186/s12920-019-0630-4
更新日期:2019-12-20 00:00:00
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journal_title:BMC medical genomics
pub_type: 杂志文章
doi:10.1186/s12920-019-0550-3
更新日期:2019-06-20 00:00:00
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journal_title:BMC medical genomics
pub_type: 杂志文章
doi:10.1186/1755-8794-7-39
更新日期:2014-06-25 00:00:00
abstract:BACKGROUND:Despite their singular origin, monozygotic twin pairs often display discordance for complex disorders including schizophrenia. It is a common (1%) and often familial disease with a discordance rate of ~50% in monozygotic twins. This high discordance is often explained by the role of yet unknown environmental...
journal_title:BMC medical genomics
pub_type: 杂志文章
doi:10.1186/s12920-015-0093-1
更新日期:2015-05-06 00:00:00
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journal_title:BMC medical genomics
pub_type: 杂志文章
doi:10.1186/s12920-019-0475-x
更新日期:2019-01-28 00:00:00
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journal_title:BMC medical genomics
pub_type: 杂志文章
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更新日期:2017-10-06 00:00:00
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journal_title:BMC medical genomics
pub_type: 杂志文章
doi:10.1186/s12920-020-00743-8
更新日期:2020-07-17 00:00:00
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journal_title:BMC medical genomics
pub_type: 杂志文章
doi:10.1186/1755-8794-7-29
更新日期:2014-05-30 00:00:00