当前位置： SCI文献检索 > BMC Medical Genomics期刊下所有文献 > Gene expression signatures in childhood acute leukemias are largely unique and distinct from those of normal tissues and other malignancies.

Gene expression signatures in childhood acute leukemias are largely unique and distinct from those of normal tissues and other malignancies.

Abstract：

BACKGROUND:Childhood leukemia is characterized by the presence of balanced chromosomal translocations or by other structural or numerical chromosomal changes. It is well know that leukemias with specific molecular abnormalities display profoundly different global gene expression profiles. However, it is largely unknown whether such subtype-specific leukemic signatures are unique or if they are active also in non-hematopoietic normal tissues or in other human cancer types. METHODS:Using gene set enrichment analysis, we systematically explored whether the transcriptional programs in childhood acute lymphoblastic leukemia (ALL) and myeloid leukemia (AML) were significantly similar to those in different flow-sorted subpopulations of normal hematopoietic cells (n = 8), normal non-hematopoietic tissues (n = 22) or human cancer tissues (n = 13). RESULTS:This study revealed that e.g., the t(12;21) [ETV6-RUNX1] subtype of ALL and the t(15;17) [PML-RARA] subtype of AML had transcriptional programs similar to those in normal Pro-B cells and promyelocytes, respectively. Moreover, the 11q23/MLL subtype of ALL showed similarities with non-hematopoietic tissues. Strikingly however, most of the transcriptional programs in the other leukemic subtypes lacked significant similarity to approximately 100 gene sets derived from normal and malignant tissues. CONCLUSIONS:This study demonstrates, for the first time, that the expression profiles of childhood leukemia are largely unique, with limited similarities to transcriptional programs active in normal hematopoietic cells, non-hematopoietic normal tissues or the most common forms of human cancer. In addition to providing important pathogenetic insights, these findings should facilitate the identification of candidate genes or transcriptional programs that can be used as unique targets in leukemia.

journal_name

BMC Med Genomics

journal_title

BMC medical genomics

authors

Andersson A,Edén P,Olofsson T,Fioretos T

doi

10.1186/1755-8794-3-6

subject

Has Abstract

pub_date

2010-03-08 00:00:00

pages

issn

1755-8794

pii

1755-8794-3-6

journal_volume

pub_type

杂志文章

在线工具

Gene expression signatures in childhood acute leukemias are largely unique and distinct from those of normal tissues and other malignancies.